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The map label for this gene is livM [H]

Identifier: 119946609

GI number: 119946609

Start: 3686795

End: 3687967

Strand: Direct

Name: livM [H]

Synonym: Ping_2988

Alternate gene names: 119946609

Gene position: 3686795-3687967 (Clockwise)

Preceding gene: 119946608

Following gene: 119946610

Centisome position: 80.86

GC content: 47.49

Gene sequence:

>1173_bases
ATGAAAAATTTACTTCATTCACCTGGTTTTAAAAAACTTAACAGTTTACATTTTGTGATTGCGATTTTATTTATCACAAC
CCTGTATGTGACAGTGTGTAACTTAGCCTTTGCACCCGGCTCATTTTTTTATGTCAGTAATTATACTGTCTCCCTGCTCG
GAAAATATCTTTGTTATGCCCTGCTCGCACTGGCAGTCGATTTAGTCTGGGGATATTGCGGTATTTTAAGCTTGGGCCAC
GGCGCTTTTTTTGCGCTCGGCGGTTATGCTATGGGGATGTATCTGATGCGCCAGATAGGCGATCGCGGTGTCTACGGCAA
CCCGGATCTGCCCGATTTTATGGTCTTTCTAAATTGGACTGAATTGCCCTGGTACTGGGCGGGCTCGGATAATGTCCTGT
TTATGGTATTACTGGTCTTTGCCGGCCCCGGACTGCTTGCATACATTTTCGGTACGATGGCCTTTCGCTCCCGGGTAAGC
GGTGTCTACTTGTCGATTATAACCCAGGCAATGACCTATGCACTGATGCTGTCATTCTTCCGTAATGAAATGGGCTTTGG
CGGTAATAATGGCTTAACTGATTTTAAAGAGATTTTTGGTTTTTCATTGCAGTCACCGGATACCAAACTGGCACTGTTTG
TCGCCACAGCCGTTGCACTGGCTTTTGGATACGCAGTCAGCCATTTTATTGTTAACTCAAAAATGGGCCGAGTGGTCACC
GCGATTCGCGATGCTGAAGACCGAGTGCGTTTTGTTGGTTATAAACCCCAACATTACAAAGTGTGGATTTTTGTTGTCTC
GGCAATGCTGGCAGGTCTGGCGGGTGCACTCTATGTCCCCCAGGTCGGCATGATCAATCCCGGCGAATTTTCACCTCTGA
ATTCCATTGAGATTGTTATCTGGGTCGCCATCGGCGGACGCGGCACTTTATATGGCGCAATTATTGGCGCAGTCGTGGTC
AGTTATGCAAAAACACGTTTTACCGCGATTATGCCCGAAGTATGGCTATTTGGACTGGGTGGCCTGTTTGTTTTAGTCAC
CCTGTTATTACCCAAAGGAATTGCGGGTCTGTTTGCCAGTGTGCTCAATAAACTCGATCCACCCACACAGCCGGCAAACG
AGCCACAAGCCCCCTCCACCACTGCAACTACAGCCGCGGAGAGTAAATCATGA

Upstream 100 bases:

>100_bases
GGCCTGTTCTGGCTAATATCATCGTCCTGGTCGGGTTAGTCTTGTTTATTCAAAAACGACCTAAGGGCTTGTTTCCTCAA
AAAGGGAGGTCTGCTGAATA

Downstream 100 bases:

>100_bases
TAGTAAATAAACACGGCTCGCCCATCTCTTCAAAAGAGTCGATTAGCCCGGATACTTCGCACGGCATGATCTTATATGTG
GAAGGGGTCAGTGTGAGCTT

Product: ABC transporter inner-membrane translocator

Products: ADP; phosphate; L-valine [Cytoplasm]; ADP; L-iso-leucine [Cytoplasm]; L-leucine [Cytoplasm] [C]

Alternate protein names: LIV-I protein M [H]

Number of amino acids: Translated: 390; Mature: 390

Protein sequence:

>390_residues
MKNLLHSPGFKKLNSLHFVIAILFITTLYVTVCNLAFAPGSFFYVSNYTVSLLGKYLCYALLALAVDLVWGYCGILSLGH
GAFFALGGYAMGMYLMRQIGDRGVYGNPDLPDFMVFLNWTELPWYWAGSDNVLFMVLLVFAGPGLLAYIFGTMAFRSRVS
GVYLSIITQAMTYALMLSFFRNEMGFGGNNGLTDFKEIFGFSLQSPDTKLALFVATAVALAFGYAVSHFIVNSKMGRVVT
AIRDAEDRVRFVGYKPQHYKVWIFVVSAMLAGLAGALYVPQVGMINPGEFSPLNSIEIVIWVAIGGRGTLYGAIIGAVVV
SYAKTRFTAIMPEVWLFGLGGLFVLVTLLLPKGIAGLFASVLNKLDPPTQPANEPQAPSTTATTAAESKS

Sequences:

>Translated_390_residues
MKNLLHSPGFKKLNSLHFVIAILFITTLYVTVCNLAFAPGSFFYVSNYTVSLLGKYLCYALLALAVDLVWGYCGILSLGH
GAFFALGGYAMGMYLMRQIGDRGVYGNPDLPDFMVFLNWTELPWYWAGSDNVLFMVLLVFAGPGLLAYIFGTMAFRSRVS
GVYLSIITQAMTYALMLSFFRNEMGFGGNNGLTDFKEIFGFSLQSPDTKLALFVATAVALAFGYAVSHFIVNSKMGRVVT
AIRDAEDRVRFVGYKPQHYKVWIFVVSAMLAGLAGALYVPQVGMINPGEFSPLNSIEIVIWVAIGGRGTLYGAIIGAVVV
SYAKTRFTAIMPEVWLFGLGGLFVLVTLLLPKGIAGLFASVLNKLDPPTQPANEPQAPSTTATTAAESKS
>Mature_390_residues
MKNLLHSPGFKKLNSLHFVIAILFITTLYVTVCNLAFAPGSFFYVSNYTVSLLGKYLCYALLALAVDLVWGYCGILSLGH
GAFFALGGYAMGMYLMRQIGDRGVYGNPDLPDFMVFLNWTELPWYWAGSDNVLFMVLLVFAGPGLLAYIFGTMAFRSRVS
GVYLSIITQAMTYALMLSFFRNEMGFGGNNGLTDFKEIFGFSLQSPDTKLALFVATAVALAFGYAVSHFIVNSKMGRVVT
AIRDAEDRVRFVGYKPQHYKVWIFVVSAMLAGLAGALYVPQVGMINPGEFSPLNSIEIVIWVAIGGRGTLYGAIIGAVVV
SYAKTRFTAIMPEVWLFGLGGLFVLVTLLLPKGIAGLFASVLNKLDPPTQPANEPQAPSTTATTAAESKS

Specific function: Part of the binding-protein-dependent transport system for branched-chain amino acids. Probably responsible for the translocation of the substrates across the membrane [H]

COG id: COG4177

COG function: function code E; ABC-type branched-chain amino acid transport system, permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the binding-protein-dependent transport system permease family. LivHM subfamily [H]

Homologues:

Organism=Escherichia coli, GI1789865, Length=334, Percent_Identity=24.5508982035928, Blast_Score=79, Evalue=5e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001851
- InterPro:   IPR021807 [H]

Pfam domain/function: PF02653 BPD_transp_2; PF11862 DUF3382 [H]

EC number: NA

Molecular weight: Translated: 42393; Mature: 42393

Theoretical pI: Translated: 9.08; Mature: 9.08

Prosite motif: PS00079 MULTICOPPER_OXIDASE1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHCCCCCCCCCCCCCCCCCHHCCCCCCC
>Mature Secondary Structure
MKNLLHSPGFKKLNSLHFVIAILFITTLYVTVCNLAFAPGSFFYVSNYTVSLLGKYLCYA
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCHHHHHHHHHHHHH
LLALAVDLVWGYCGILSLGHGAFFALGGYAMGMYLMRQIGDRGVYGNPDLPDFMVFLNWT
HHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHEEEEEEC
ELPWYWAGSDNVLFMVLLVFAGPGLLAYIFGTMAFRSRVSGVYLSIITQAMTYALMLSFF
CCCEEEECCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RNEMGFGGNNGLTDFKEIFGFSLQSPDTKLALFVATAVALAFGYAVSHFIVNSKMGRVVT
HHHCCCCCCCCCHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AIRDAEDRVRFVGYKPQHYKVWIFVVSAMLAGLAGALYVPQVGMINPGEFSPLNSIEIVI
HHHCHHHHEEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEE
WVAIGGRGTLYGAIIGAVVVSYAKTRFTAIMPEVWLFGLGGLFVLVTLLLPKGIAGLFAS
EEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHH
VLNKLDPPTQPANEPQAPSTTATTAAESKS
HHHHCCCCCCCCCCCCCCCCCHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; L-valine [Periplasm]; H2O; ATP; L-iso-leucine [Periplasm]; L-leucine [Periplasm] [C]

Specific reaction: ATP + L-valine [Periplasm] + H2O = ADP + phosphate + L-valine [Cytoplasm] ATP + L-iso-leucine [Periplasm] + H2O = ADP + phosphate + L-iso-leucine [Cytoplasm] ATP + L-leucine [Periplasm] + H2O = ADP + phosphate + L-leucine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 2195019; 8041620; 9278503 [H]