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The map label for this gene is lpd [H]

Identifier: 119946546

GI number: 119946546

Start: 3607061

End: 3608485

Strand: Reverse

Name: lpd [H]

Synonym: Ping_2925

Alternate gene names: 119946546

Gene position: 3608485-3607061 (Counterclockwise)

Preceding gene: 119946547

Following gene: 119946545

Centisome position: 79.14

GC content: 43.79

Gene sequence:

>1425_bases
ATGAGTAAAGAAATTAAAGCACAAGTTGTAATATTAGGTTCAGGTCCTGCAGGATATTCAGCCGCCTTTCGCGCCGCTGA
TTTGGGATTAGAAACAGTTATAATAGAAAAATACAGCACATTGGGTGGCGTTTGTTTGAATGTTGGTTGTATCCCATCTA
AAGCACTGTTGCATGTATCAAAAGTGATAGAAGAAGCCAAAGCACTTTCTGAACATGGTGTTTTATTTGGTGAGCCGTCA
ACGGATATCGATAAAATCCGAATCTGGAAAGATAAAGTGGTTACGCAACTTACCGGTGGCCTGCAAGGCATGGCTAAAAT
GCGTAAAGTGACAGTAGTGAATGGCTTTGGTAAATTCACTGGCGCCAATACCATTGAGGTCCAGGGTGACGATGAAAACA
CCACTATTACTTTTGATAATGCCATTATTGCAGCGGGGTCTCGTCCGATTAAATTACCTTTCGTACCGCATGATGATCCG
CGTGTATGGGATTCAACCGATGCACTAGAGCTGCGCTCAGTGCCAAAACGCCTGCTTGTGTTAGGCGGTGGTATCATCGG
TCTGGAAATGGGAACTGTGTATAAATCACTAGGCTCTGAGGTTGATGTGGTTGAGTTTGCAGATCAGTTAGTACCCGCTG
CCGATATTGATATCGTTCAGGTTTACACTAAAAAAGTGAAGAGCAAATTCAATATTATGCTGTCCACTAAAGTGACTGGC
GTTGAAGCCAAAGAAGATGCGCTTTATGTCTCTTTTGAAGGCAAGAATGCACCTAGCGAAGCAAAACCTTATGATGCTGT
ACTGGTTGCTGTTGGTCGTGTACCAAACGGTCTTTCTTTGGATGCTGAAAAAGCCGGTATTACTGTTACCGAACGCGGCT
TTATTGAAGTTGATAAGCAGCTGCGCACTAACGTGCCGCACATCCATGCGATTGGTGATGTCGTTGGTCAGCCAATGCTT
GCCCATAAAGGGACGCATGAAGGACATGTTGCAGCAGAAGTGATTGCCGGTAAAAAACATTACTTTGATCCTAAAACAAT
CCCTTCAGTTGCTTACACTGAACCAGAAATGGGTTGGGTTGGTCTGACTGAAAAAGAAGCCAAAGAGCAGGGCATTAACT
ATGAGAAATCTGTTTTCCCATGGGCGGCTTCCGGTCGTGCAATAGCATCTGATTGTACTGCGGGTATGACTAAGCTTATC
TTTGATAAAGATACGCATCGTGTTATCGGTGGTGCAGTTGTGGGCACTAATGGCGGCGAACTGTTAGGCGAAATTGGTCT
GGCGATTGAGATGGGTTGTGATGCTGAAGATATGGCTTTAACTATCCATGCACATCCTACACTTAATGAGTCAGTTGGCC
TTGCTGCTGAAATTTATGAAGGTTCAATTACAGATTTACCAAATGCAAAAGCGGTAAAAAAATAA

Upstream 100 bases:

>100_bases
GCATTTGTCGACCTTTTATTTTGCATTTATTTGACAATAAAATAGACTCGCAAAACTTCAATCGTTTTTCTGGCGTAACG
GCTAAAATATAGAGGTCAAA

Downstream 100 bases:

>100_bases
ATAATTGATTGTTTGAATTGATATCAGAAAGGCGCTTTTTTAAGCGCCTTTTTTTATGGCTATAATTCGGCTGTCGGCTG
TTGGATATCAGCTATCAGCT

Product: dihydrolipoamide dehydrogenase

Products: NA

Alternate protein names: Dihydrolipoamide dehydrogenase; E3 component of 2-oxoglutarate dehydrogenase complex [H]

Number of amino acids: Translated: 474; Mature: 473

Protein sequence:

>474_residues
MSKEIKAQVVILGSGPAGYSAAFRAADLGLETVIIEKYSTLGGVCLNVGCIPSKALLHVSKVIEEAKALSEHGVLFGEPS
TDIDKIRIWKDKVVTQLTGGLQGMAKMRKVTVVNGFGKFTGANTIEVQGDDENTTITFDNAIIAAGSRPIKLPFVPHDDP
RVWDSTDALELRSVPKRLLVLGGGIIGLEMGTVYKSLGSEVDVVEFADQLVPAADIDIVQVYTKKVKSKFNIMLSTKVTG
VEAKEDALYVSFEGKNAPSEAKPYDAVLVAVGRVPNGLSLDAEKAGITVTERGFIEVDKQLRTNVPHIHAIGDVVGQPML
AHKGTHEGHVAAEVIAGKKHYFDPKTIPSVAYTEPEMGWVGLTEKEAKEQGINYEKSVFPWAASGRAIASDCTAGMTKLI
FDKDTHRVIGGAVVGTNGGELLGEIGLAIEMGCDAEDMALTIHAHPTLNESVGLAAEIYEGSITDLPNAKAVKK

Sequences:

>Translated_474_residues
MSKEIKAQVVILGSGPAGYSAAFRAADLGLETVIIEKYSTLGGVCLNVGCIPSKALLHVSKVIEEAKALSEHGVLFGEPS
TDIDKIRIWKDKVVTQLTGGLQGMAKMRKVTVVNGFGKFTGANTIEVQGDDENTTITFDNAIIAAGSRPIKLPFVPHDDP
RVWDSTDALELRSVPKRLLVLGGGIIGLEMGTVYKSLGSEVDVVEFADQLVPAADIDIVQVYTKKVKSKFNIMLSTKVTG
VEAKEDALYVSFEGKNAPSEAKPYDAVLVAVGRVPNGLSLDAEKAGITVTERGFIEVDKQLRTNVPHIHAIGDVVGQPML
AHKGTHEGHVAAEVIAGKKHYFDPKTIPSVAYTEPEMGWVGLTEKEAKEQGINYEKSVFPWAASGRAIASDCTAGMTKLI
FDKDTHRVIGGAVVGTNGGELLGEIGLAIEMGCDAEDMALTIHAHPTLNESVGLAAEIYEGSITDLPNAKAVKK
>Mature_473_residues
SKEIKAQVVILGSGPAGYSAAFRAADLGLETVIIEKYSTLGGVCLNVGCIPSKALLHVSKVIEEAKALSEHGVLFGEPST
DIDKIRIWKDKVVTQLTGGLQGMAKMRKVTVVNGFGKFTGANTIEVQGDDENTTITFDNAIIAAGSRPIKLPFVPHDDPR
VWDSTDALELRSVPKRLLVLGGGIIGLEMGTVYKSLGSEVDVVEFADQLVPAADIDIVQVYTKKVKSKFNIMLSTKVTGV
EAKEDALYVSFEGKNAPSEAKPYDAVLVAVGRVPNGLSLDAEKAGITVTERGFIEVDKQLRTNVPHIHAIGDVVGQPMLA
HKGTHEGHVAAEVIAGKKHYFDPKTIPSVAYTEPEMGWVGLTEKEAKEQGINYEKSVFPWAASGRAIASDCTAGMTKLIF
DKDTHRVIGGAVVGTNGGELLGEIGLAIEMGCDAEDMALTIHAHPTLNESVGLAAEIYEGSITDLPNAKAVKK

Specific function: The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of 3 enzymatic components:branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransfer

COG id: COG1249

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI91199540, Length=454, Percent_Identity=42.2907488986784, Blast_Score=333, Evalue=2e-91,
Organism=Homo sapiens, GI50301238, Length=454, Percent_Identity=27.9735682819383, Blast_Score=144, Evalue=2e-34,
Organism=Homo sapiens, GI33519430, Length=427, Percent_Identity=27.8688524590164, Blast_Score=120, Evalue=4e-27,
Organism=Homo sapiens, GI33519428, Length=427, Percent_Identity=27.8688524590164, Blast_Score=120, Evalue=4e-27,
Organism=Homo sapiens, GI33519426, Length=427, Percent_Identity=27.8688524590164, Blast_Score=120, Evalue=4e-27,
Organism=Homo sapiens, GI148277071, Length=427, Percent_Identity=27.8688524590164, Blast_Score=119, Evalue=5e-27,
Organism=Homo sapiens, GI148277065, Length=427, Percent_Identity=27.8688524590164, Blast_Score=119, Evalue=5e-27,
Organism=Homo sapiens, GI291045266, Length=451, Percent_Identity=27.7161862527716, Blast_Score=119, Evalue=7e-27,
Organism=Homo sapiens, GI22035672, Length=464, Percent_Identity=28.2327586206897, Blast_Score=114, Evalue=2e-25,
Organism=Homo sapiens, GI291045268, Length=443, Percent_Identity=25.7336343115124, Blast_Score=97, Evalue=2e-20,
Organism=Escherichia coli, GI1786307, Length=474, Percent_Identity=79.746835443038, Blast_Score=800, Evalue=0.0,
Organism=Escherichia coli, GI87082354, Length=467, Percent_Identity=28.6937901498929, Blast_Score=184, Evalue=1e-47,
Organism=Escherichia coli, GI87081717, Length=455, Percent_Identity=29.8901098901099, Blast_Score=180, Evalue=2e-46,
Organism=Escherichia coli, GI1789915, Length=439, Percent_Identity=28.246013667426, Blast_Score=154, Evalue=1e-38,
Organism=Caenorhabditis elegans, GI32565766, Length=449, Percent_Identity=39.8663697104677, Blast_Score=317, Evalue=8e-87,
Organism=Caenorhabditis elegans, GI17557007, Length=472, Percent_Identity=27.9661016949153, Blast_Score=135, Evalue=4e-32,
Organism=Caenorhabditis elegans, GI71983429, Length=436, Percent_Identity=25.6880733944954, Blast_Score=110, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI71983419, Length=436, Percent_Identity=25.6880733944954, Blast_Score=110, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI71982272, Length=435, Percent_Identity=24.367816091954, Blast_Score=108, Evalue=4e-24,
Organism=Saccharomyces cerevisiae, GI6321091, Length=456, Percent_Identity=41.4473684210526, Blast_Score=315, Evalue=8e-87,
Organism=Saccharomyces cerevisiae, GI6325240, Length=468, Percent_Identity=26.9230769230769, Blast_Score=169, Evalue=9e-43,
Organism=Saccharomyces cerevisiae, GI6325166, Length=455, Percent_Identity=29.010989010989, Blast_Score=160, Evalue=3e-40,
Organism=Drosophila melanogaster, GI21358499, Length=453, Percent_Identity=41.280353200883, Blast_Score=325, Evalue=3e-89,
Organism=Drosophila melanogaster, GI24640549, Length=469, Percent_Identity=27.0788912579957, Blast_Score=114, Evalue=1e-25,
Organism=Drosophila melanogaster, GI24640553, Length=467, Percent_Identity=26.7665952890792, Blast_Score=114, Evalue=1e-25,
Organism=Drosophila melanogaster, GI24640551, Length=470, Percent_Identity=27.2340425531915, Blast_Score=114, Evalue=2e-25,
Organism=Drosophila melanogaster, GI17737741, Length=476, Percent_Identity=26.2605042016807, Blast_Score=106, Evalue=3e-23,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1880 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 6,000 Molecules/Cell In: Glucose minimal

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR006258
- InterPro:   IPR004099
- InterPro:   IPR012999
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: =1.8.1.4 [H]

Molecular weight: Translated: 50439; Mature: 50308

Theoretical pI: Translated: 5.49; Mature: 5.49

Prosite motif: PS00076 PYRIDINE_REDOX_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKEIKAQVVILGSGPAGYSAAFRAADLGLETVIIEKYSTLGGVCLNVGCIPSKALLHVS
CCCCCEEEEEEEECCCCCCHHHHHHHHCCCEEEEEEHHHHHCCEEEEECCCCHHHHHHHH
KVIEEAKALSEHGVLFGEPSTDIDKIRIWKDKVVTQLTGGLQGMAKMRKVTVVNGFGKFT
HHHHHHHHHHHCCEEECCCCCCHHHEEEHHHHHHHHHHCCHHHHHHHEEEEEEECCCCCC
GANTIEVQGDDENTTITFDNAIIAAGSRPIKLPFVPHDDPRVWDSTDALELRSVPKRLLV
CCCEEEEECCCCCCEEEECCEEEECCCCCEEECCCCCCCCCCCCCCCCHHHHHHHHEEEE
LGGGIIGLEMGTVYKSLGSEVDVVEFADQLVPAADIDIVQVYTKKVKSKFNIMLSTKVTG
ECCCEEEEEHHHHHHHHCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHEEEEEEEEEEC
VEAKEDALYVSFEGKNAPSEAKPYDAVLVAVGRVPNGLSLDAEKAGITVTERGFIEVDKQ
CCCCCCEEEEEEECCCCCCCCCCCEEEEEEECCCCCCCCCCCHHCCEEEECCCCEEECHH
LRTNVPHIHAIGDVVGQPMLAHKGTHEGHVAAEVIAGKKHYFDPKTIPSVAYTEPEMGWV
HHCCCCEEEEHHHHHCCCHHHCCCCCCCCEEEHEEECCCCCCCCCCCCCCEECCCCCCEE
GLTEKEAKEQGINYEKSVFPWAASGRAIASDCTAGMTKLIFDKDTHRVIGGAVVGTNGGE
CCCHHHHHHHCCCCCCCCCCCCCCCCEEHHHHHHCCEEEEECCCCCEEECEEEEECCCHH
LLGEIGLAIEMGCDAEDMALTIHAHPTLNESVGLAAEIYEGSITDLPNAKAVKK
HHHHCCEEEEECCCCCCEEEEEEECCCCCCCCCCEEEEECCCCCCCCCCCCCCC
>Mature Secondary Structure 
SKEIKAQVVILGSGPAGYSAAFRAADLGLETVIIEKYSTLGGVCLNVGCIPSKALLHVS
CCCCEEEEEEEECCCCCCHHHHHHHHCCCEEEEEEHHHHHCCEEEEECCCCHHHHHHHH
KVIEEAKALSEHGVLFGEPSTDIDKIRIWKDKVVTQLTGGLQGMAKMRKVTVVNGFGKFT
HHHHHHHHHHHCCEEECCCCCCHHHEEEHHHHHHHHHHCCHHHHHHHEEEEEEECCCCCC
GANTIEVQGDDENTTITFDNAIIAAGSRPIKLPFVPHDDPRVWDSTDALELRSVPKRLLV
CCCEEEEECCCCCCEEEECCEEEECCCCCEEECCCCCCCCCCCCCCCCHHHHHHHHEEEE
LGGGIIGLEMGTVYKSLGSEVDVVEFADQLVPAADIDIVQVYTKKVKSKFNIMLSTKVTG
ECCCEEEEEHHHHHHHHCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHEEEEEEEEEEC
VEAKEDALYVSFEGKNAPSEAKPYDAVLVAVGRVPNGLSLDAEKAGITVTERGFIEVDKQ
CCCCCCEEEEEEECCCCCCCCCCCEEEEEEECCCCCCCCCCCHHCCEEEECCCCEEECHH
LRTNVPHIHAIGDVVGQPMLAHKGTHEGHVAAEVIAGKKHYFDPKTIPSVAYTEPEMGWV
HHCCCCEEEEHHHHHCCCHHHCCCCCCCCEEEHEEECCCCCCCCCCCCCCEECCCCCCEE
GLTEKEAKEQGINYEKSVFPWAASGRAIASDCTAGMTKLIFDKDTHRVIGGAVVGTNGGE
CCCHHHHHHHCCCCCCCCCCCCCCCCEEHHHHHHCCEEEEECCCCCEEECEEEEECCCHH
LLGEIGLAIEMGCDAEDMALTIHAHPTLNESVGLAAEIYEGSITDLPNAKAVKK
HHHHCCEEEEECCCCCCEEEEEEECCCCCCCCCCEEEEECCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10952301 [H]