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The map label for this gene is degS [H]

Identifier: 119946503

GI number: 119946503

Start: 3560859

End: 3561965

Strand: Direct

Name: degS [H]

Synonym: Ping_2880

Alternate gene names: 119946503

Gene position: 3560859-3561965 (Clockwise)

Preceding gene: 119946502

Following gene: 119946511

Centisome position: 78.1

GC content: 41.55

Gene sequence:

>1107_bases
ATGAACTTTAAAACGCGCTTGCTGTATTTTTTAAAACCCATTTTTTGGGGGATTATTATTGCGATATTAATCGTTTATGG
CGCACGGTTAGGGACAGTTTTAACATCGCTTTTAGCCAACGATAAAGTCGCAAGTTATAGCGAATCAGTCAAAAAAGCAT
CCCCTGCAGTGGTTAATATTTACTCTCAACAATATGTAGACTCGACTTTCAACAACAACAAACAACAGCTTCAACCGACG
GGGTTAGGATCCGGCATTATTGTTGATAAAAAAGGTTACATTTTAACCAACTACCATGTTATTAAACAGGCTGATCAGAT
ACTTATCGCTTTACAGGACGGCCGTCTCTTTACCGCCACTGTGGTCGGGAGTGATGTAATAACCGACTTAGCGGTACTGC
AAATTGAGGGCAATAACCTGCCGGTGATCCCTCAGAACAGTCAATATAATCCTCAAGTTGGCGATATAGTACTCGCTATT
GGTAATCCCTATAACTTAGGGCAAACCATCACTCAGGGTGTTATCAGTGCCACCGGACGCAGTGGTATGAGTTCATCTGG
CCGTCAGGATTTCCTGCAGACAGATGCGGCTATTAACGAAGGAAACTCAGGGGGAGCATTAATTAATAGCCGAGGTGAGT
TAGTTGGTATTAATACCTCTGAATTTTACAGTCGTCGTCAAAATATTAGTTATGGTATTAGTTTTGCTATTCCCTATCAG
CTTTCGCAGCGGATAATGAACAGCCTAATTAGAGATGGTCGCGTTATTCGTGGCTCCTTAGGTATAGTGGCCGAAAATTT
AGATCCGCTTTTAGCGCGTCTTTGGGGCTTAAAAGCACAAAACAGCACCATCATAAAAGAAGTTCAGGAAGGAGGACCTG
CTAGTATTGCGGGGGTTGAAGTCAATGATATTTTACTAAAAATCAATAATACGGCTGTTGAAAACTTAATTTTTGCGATG
GATATGGTGGCAGAAATACCGCCAGGCACAAAGGCCGTATTAACGGTATTACGTAAAGGAGAGGAAATGGATATCGACGT
CATTATTGGCGAGCTGAGTAATCCCCCTCAAAATACAAATAGCACTGACAAAGAAATTAACCCTTAA

Upstream 100 bases:

>100_bases
TTTTTACCAATTTCTCAATAACATACAATAAACACCCTTCCCTCTCCTATTTTGTATATAATCTTTGTTGTCACTTTCAC
TTATCGACCTGGTTAACAAA

Downstream 100 bases:

>100_bases
TAGAACAAAAAAAAGGGAAGCACTAAGCTTCCCTTTTTTTGTTATTCACAGCATCAAAACAGCCTGTAAAAAATGAATTA
ACGTTAATTTTCAATACGCT

Product: periplasmic serine protease DegS

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 368; Mature: 368

Protein sequence:

>368_residues
MNFKTRLLYFLKPIFWGIIIAILIVYGARLGTVLTSLLANDKVASYSESVKKASPAVVNIYSQQYVDSTFNNNKQQLQPT
GLGSGIIVDKKGYILTNYHVIKQADQILIALQDGRLFTATVVGSDVITDLAVLQIEGNNLPVIPQNSQYNPQVGDIVLAI
GNPYNLGQTITQGVISATGRSGMSSSGRQDFLQTDAAINEGNSGGALINSRGELVGINTSEFYSRRQNISYGISFAIPYQ
LSQRIMNSLIRDGRVIRGSLGIVAENLDPLLARLWGLKAQNSTIIKEVQEGGPASIAGVEVNDILLKINNTAVENLIFAM
DMVAEIPPGTKAVLTVLRKGEEMDIDVIIGELSNPPQNTNSTDKEINP

Sequences:

>Translated_368_residues
MNFKTRLLYFLKPIFWGIIIAILIVYGARLGTVLTSLLANDKVASYSESVKKASPAVVNIYSQQYVDSTFNNNKQQLQPT
GLGSGIIVDKKGYILTNYHVIKQADQILIALQDGRLFTATVVGSDVITDLAVLQIEGNNLPVIPQNSQYNPQVGDIVLAI
GNPYNLGQTITQGVISATGRSGMSSSGRQDFLQTDAAINEGNSGGALINSRGELVGINTSEFYSRRQNISYGISFAIPYQ
LSQRIMNSLIRDGRVIRGSLGIVAENLDPLLARLWGLKAQNSTIIKEVQEGGPASIAGVEVNDILLKINNTAVENLIFAM
DMVAEIPPGTKAVLTVLRKGEEMDIDVIIGELSNPPQNTNSTDKEINP
>Mature_368_residues
MNFKTRLLYFLKPIFWGIIIAILIVYGARLGTVLTSLLANDKVASYSESVKKASPAVVNIYSQQYVDSTFNNNKQQLQPT
GLGSGIIVDKKGYILTNYHVIKQADQILIALQDGRLFTATVVGSDVITDLAVLQIEGNNLPVIPQNSQYNPQVGDIVLAI
GNPYNLGQTITQGVISATGRSGMSSSGRQDFLQTDAAINEGNSGGALINSRGELVGINTSEFYSRRQNISYGISFAIPYQ
LSQRIMNSLIRDGRVIRGSLGIVAENLDPLLARLWGLKAQNSTIIKEVQEGGPASIAGVEVNDILLKINNTAVENLIFAM
DMVAEIPPGTKAVLTVLRKGEEMDIDVIIGELSNPPQNTNSTDKEINP

Specific function: Senses the OMP signal triggered by the accumulation of unassembled porins in the envelope and then initiates rseA degradation by cleaving it in its periplasmic domain, making it an attractive substrate for subsequent cleavage by rseP [H]

COG id: COG0265

COG function: function code O; Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain

Gene ontology:

Cell location: Periplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PDZ (DHR) domain [H]

Homologues:

Organism=Homo sapiens, GI4506141, Length=323, Percent_Identity=32.1981424148607, Blast_Score=119, Evalue=4e-27,
Organism=Homo sapiens, GI22129776, Length=286, Percent_Identity=32.5174825174825, Blast_Score=117, Evalue=2e-26,
Organism=Homo sapiens, GI7019477, Length=316, Percent_Identity=32.5949367088608, Blast_Score=114, Evalue=1e-25,
Organism=Homo sapiens, GI24308541, Length=193, Percent_Identity=36.7875647668394, Blast_Score=112, Evalue=5e-25,
Organism=Escherichia coli, GI1789630, Length=346, Percent_Identity=48.8439306358381, Blast_Score=310, Evalue=1e-85,
Organism=Escherichia coli, GI1789629, Length=320, Percent_Identity=39.0625, Blast_Score=201, Evalue=6e-53,
Organism=Escherichia coli, GI1786356, Length=279, Percent_Identity=39.7849462365591, Blast_Score=198, Evalue=5e-52,
Organism=Drosophila melanogaster, GI24646839, Length=289, Percent_Identity=32.8719723183391, Blast_Score=127, Evalue=9e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001478
- InterPro:   IPR009003
- InterPro:   IPR011783
- InterPro:   IPR001254
- InterPro:   IPR001940 [H]

Pfam domain/function: PF00595 PDZ; PF00089 Trypsin [H]

EC number: 3.4.21.-

Molecular weight: Translated: 39794; Mature: 39794

Theoretical pI: Translated: 5.18; Mature: 5.18

Prosite motif: PS50106 PDZ

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNFKTRLLYFLKPIFWGIIIAILIVYGARLGTVLTSLLANDKVASYSESVKKASPAVVNI
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCEEEE
YSQQYVDSTFNNNKQQLQPTGLGSGIIVDKKGYILTNYHVIKQADQILIALQDGRLFTAT
HHHHHHHHHHCCCHHEECCCCCCCCEEEECCCEEEECCHHHHCCCEEEEEEECCCEEEEE
VVGSDVITDLAVLQIEGNNLPVIPQNSQYNPQVGDIVLAIGNPYNLGQTITQGVISATGR
ECCHHHHCEEEEEEECCCCCCCCCCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHCCC
SGMSSSGRQDFLQTDAAINEGNSGGALINSRGELVGINTSEFYSRRQNISYGISFAIPYQ
CCCCCCCHHHHHHHHHHHCCCCCCCEEEECCCCEEECCHHHHHHHHCCCCCCEEEEECHH
LSQRIMNSLIRDGRVIRGSLGIVAENLDPLLARLWGLKAQNSTIIKEVQEGGPASIAGVE
HHHHHHHHHHHCCEEEEECCCHHHCCHHHHHHHHHCCCCCCHHHHHHHHCCCCCEEEEEE
VNDILLKINNTAVENLIFAMDMVAEIPPGTKAVLTVLRKGEEMDIDVIIGELSNPPQNTN
EEEEEEEECCHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCEEEEEEECCCCCCCCCC
STDKEINP
CCCCCCCC
>Mature Secondary Structure
MNFKTRLLYFLKPIFWGIIIAILIVYGARLGTVLTSLLANDKVASYSESVKKASPAVVNI
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCEEEE
YSQQYVDSTFNNNKQQLQPTGLGSGIIVDKKGYILTNYHVIKQADQILIALQDGRLFTAT
HHHHHHHHHHCCCHHEECCCCCCCCEEEECCCEEEECCHHHHCCCEEEEEEECCCEEEEE
VVGSDVITDLAVLQIEGNNLPVIPQNSQYNPQVGDIVLAIGNPYNLGQTITQGVISATGR
ECCHHHHCEEEEEEECCCCCCCCCCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHCCC
SGMSSSGRQDFLQTDAAINEGNSGGALINSRGELVGINTSEFYSRRQNISYGISFAIPYQ
CCCCCCCHHHHHHHHHHHCCCCCCCEEEECCCCEEECCHHHHHHHHCCCCCCEEEEECHH
LSQRIMNSLIRDGRVIRGSLGIVAENLDPLLARLWGLKAQNSTIIKEVQEGGPASIAGVE
HHHHHHHHHHHCCEEEEECCCHHHCCHHHHHHHHHCCCCCCHHHHHHHHCCCCCEEEEEE
VNDILLKINNTAVENLIFAMDMVAEIPPGTKAVLTVLRKGEEMDIDVIIGELSNPPQNTN
EEEEEEEECCHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCEEEEEEECCCCCCCCCC
STDKEINP
CCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases); Serine endopeptidases [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]