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The map label for this gene is deoA

Identifier: 119946489

GI number: 119946489

Start: 3545220

End: 3546560

Strand: Direct

Name: deoA

Synonym: Ping_2865

Alternate gene names: 119946489

Gene position: 3545220-3546560 (Clockwise)

Preceding gene: 119946488

Following gene: 119946490

Centisome position: 77.75

GC content: 46.31

Gene sequence:

>1341_bases
ATGATATTATTGCCACAAGAAATTATTCGTAACAAACGTGATGGCAAAACCCTCAGCAGGCAAGAAATTGATTTTTTTAT
TAAAGGGATCACCGATAACTCAGTCACAGAAGGTCAAATTGCCGCCTTTGCGATGGCTGTCTATTTCCAGGATATGAACA
TGGATGAACGTGTTTTACTGGTATCTGCAATGCGTGATTCAGGGCAGGTAATAAACTGGCAGTCGCTTAATCTGAATGGT
CCCGTGGTGGATAAACATTCAACGGGCGGGGTTGGAGATGTCACATCACTGATATTAGGCCCGATGGTGGCCGCCTGTGG
CGGTTACGTGCCGATGATTTCAGGCCGTGGATTGGGTCATACCGGCGGCACGTTGGATAAGCTCGATGCTATTTCCGGTT
ATAAAACAACGCCCGATAGCCTGGATCATTTCCGCAAAATAGTCAAAGAAGTGGGTGTTGCAATTATCGGTCAAACGGGT
GATTTAGCGCCGGCTGATAAACGGTTTTATGCAACCCGTGATATTACCGCGACGGTGGAGTCCATTCCGTTAATAACCGC
ATCAATTTTATCGAAAAAATTGGCCGCAGGTATTGATGCCCTAGTAATGGACGTTAAAGCCGGCAGTGGTGCATTTATGC
CAACTTTTGAGCAGTCCGAGGCTTTGGCCAACAGTATTGTTGGCGTTGCTAATGGTGCTGGATGTAAAACCAGTGCTTTA
ATTACTAATATGGATCAGGTACTTGCCAGCAGTGCAGGTAATGCTGTTGAAGTACGTGAAGCCGTGCGCTTTCTTAAAGG
GGAAGTTGTTAATCCCCGTTTACATGAAGTCACCATGGCATTATGCGCTGAAATGCTGCTGTTAAGCGGCTTGGCAGCAG
ATATAAAAGAGGCTCAAGCAAAATTACAAAAAGTACTTGATAACGGTAAAGCCGCAGAAGTCTTTGCCAAAATGGTTGGC
GCGCTGGGCGGCCCCGCTGATTTTATTGAAAATCAGGATAATTATCTGCAAAAATCGGCCATTGTCCGTCCTGTTTATGC
CCAACATTCAGGGATTGTACAATCTATGGATACCAGAGCATTAGGGATGGCAGTGGTTAATCTGGGCGGAGGACGACATA
GTGCATCGGATTCGATTGATTATGCCGTTGGTCTCAGCGGTATACTCTCTTTGGGTGAGTCAGCAGACTCTGAAAAGCCG
CTGGCAATGATCCATGCACAGAGTGAGAAGCAGTTCAGCGAAGCACAGCGCGCCATTCAAAGCGCCATTATTTGTGGCAC
AGACAGTCTTCAAGCTCAGACTCAGGTTTATCGTCATATTCGTTTACCGGACATCTCTTAA

Upstream 100 bases:

>100_bases
AAATGCTAGTTGGTGAATTTTCAACAACGCGTATTAGCCATTATATAGCAGAAATTTAGACGTTCTGCAGCGGACTCGAA
AATCTACAGGAGTACAACAG

Downstream 100 bases:

>100_bases
ACTATAAAAGCGTTGAGGTTAGAGAGTTAAATCAACACAGCTCAAGCGAAACATTCGCTTGAGCTGAAAAATAACAGAGG
AATGAGTATGGAATTGGATT

Product: thymidine phosphorylase

Products: NA

Alternate protein names: TdRPase

Number of amino acids: Translated: 446; Mature: 446

Protein sequence:

>446_residues
MILLPQEIIRNKRDGKTLSRQEIDFFIKGITDNSVTEGQIAAFAMAVYFQDMNMDERVLLVSAMRDSGQVINWQSLNLNG
PVVDKHSTGGVGDVTSLILGPMVAACGGYVPMISGRGLGHTGGTLDKLDAISGYKTTPDSLDHFRKIVKEVGVAIIGQTG
DLAPADKRFYATRDITATVESIPLITASILSKKLAAGIDALVMDVKAGSGAFMPTFEQSEALANSIVGVANGAGCKTSAL
ITNMDQVLASSAGNAVEVREAVRFLKGEVVNPRLHEVTMALCAEMLLLSGLAADIKEAQAKLQKVLDNGKAAEVFAKMVG
ALGGPADFIENQDNYLQKSAIVRPVYAQHSGIVQSMDTRALGMAVVNLGGGRHSASDSIDYAVGLSGILSLGESADSEKP
LAMIHAQSEKQFSEAQRAIQSAIICGTDSLQAQTQVYRHIRLPDIS

Sequences:

>Translated_446_residues
MILLPQEIIRNKRDGKTLSRQEIDFFIKGITDNSVTEGQIAAFAMAVYFQDMNMDERVLLVSAMRDSGQVINWQSLNLNG
PVVDKHSTGGVGDVTSLILGPMVAACGGYVPMISGRGLGHTGGTLDKLDAISGYKTTPDSLDHFRKIVKEVGVAIIGQTG
DLAPADKRFYATRDITATVESIPLITASILSKKLAAGIDALVMDVKAGSGAFMPTFEQSEALANSIVGVANGAGCKTSAL
ITNMDQVLASSAGNAVEVREAVRFLKGEVVNPRLHEVTMALCAEMLLLSGLAADIKEAQAKLQKVLDNGKAAEVFAKMVG
ALGGPADFIENQDNYLQKSAIVRPVYAQHSGIVQSMDTRALGMAVVNLGGGRHSASDSIDYAVGLSGILSLGESADSEKP
LAMIHAQSEKQFSEAQRAIQSAIICGTDSLQAQTQVYRHIRLPDIS
>Mature_446_residues
MILLPQEIIRNKRDGKTLSRQEIDFFIKGITDNSVTEGQIAAFAMAVYFQDMNMDERVLLVSAMRDSGQVINWQSLNLNG
PVVDKHSTGGVGDVTSLILGPMVAACGGYVPMISGRGLGHTGGTLDKLDAISGYKTTPDSLDHFRKIVKEVGVAIIGQTG
DLAPADKRFYATRDITATVESIPLITASILSKKLAAGIDALVMDVKAGSGAFMPTFEQSEALANSIVGVANGAGCKTSAL
ITNMDQVLASSAGNAVEVREAVRFLKGEVVNPRLHEVTMALCAEMLLLSGLAADIKEAQAKLQKVLDNGKAAEVFAKMVG
ALGGPADFIENQDNYLQKSAIVRPVYAQHSGIVQSMDTRALGMAVVNLGGGRHSASDSIDYAVGLSGILSLGESADSEKP
LAMIHAQSEKQFSEAQRAIQSAIICGTDSLQAQTQVYRHIRLPDIS

Specific function: The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis

COG id: COG0213

COG function: function code F; Thymidine phosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family

Homologues:

Organism=Homo sapiens, GI166158925, Length=449, Percent_Identity=36.9710467706013, Blast_Score=268, Evalue=6e-72,
Organism=Homo sapiens, GI4503445, Length=449, Percent_Identity=36.9710467706013, Blast_Score=268, Evalue=6e-72,
Organism=Homo sapiens, GI166158922, Length=449, Percent_Identity=36.9710467706013, Blast_Score=268, Evalue=6e-72,
Organism=Escherichia coli, GI1790842, Length=439, Percent_Identity=66.7425968109339, Blast_Score=591, Evalue=1e-170,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): TYPH_PSYIN (A1SYK5)

Other databases:

- EMBL:   CP000510
- RefSeq:   YP_944169.1
- ProteinModelPortal:   A1SYK5
- SMR:   A1SYK5
- STRING:   A1SYK5
- GeneID:   4625647
- GenomeReviews:   CP000510_GR
- KEGG:   pin:Ping_2865
- eggNOG:   COG0213
- HOGENOM:   HBG288505
- OMA:   AEIFGRM
- PhylomeDB:   A1SYK5
- BioCyc:   PING357804:PING_2865-MONOMER
- HAMAP:   MF_01628
- InterPro:   IPR000312
- InterPro:   IPR017459
- InterPro:   IPR020072
- InterPro:   IPR013102
- InterPro:   IPR018090
- InterPro:   IPR000053
- InterPro:   IPR017872
- InterPro:   IPR013465
- Gene3D:   G3DSA:1.20.970.10
- Gene3D:   G3DSA:3.40.1030.10
- PANTHER:   PTHR10515
- PIRSF:   PIRSF000478
- SMART:   SM00941
- TIGRFAMs:   TIGR02643
- TIGRFAMs:   TIGR02644

Pfam domain/function: PF02885 Glycos_trans_3N; PF00591 Glycos_transf_3; PF07831 PYNP_C; SSF47648 Glyco_trans_3; SSF52418 Glyco_trans_3; SSF54680 PYNP_C

EC number: =2.4.2.4

Molecular weight: Translated: 47207; Mature: 47207

Theoretical pI: Translated: 5.66; Mature: 5.66

Prosite motif: PS00647 THYMID_PHOSPHORYLASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MILLPQEIIRNKRDGKTLSRQEIDFFIKGITDNSVTEGQIAAFAMAVYFQDMNMDERVLL
CCCCCHHHHCCCCCCCCHHHHHHHHHEEECCCCCCCCHHHHHHHHHHHHHCCCCCCCEEE
VSAMRDSGQVINWQSLNLNGPVVDKHSTGGVGDVTSLILGPMVAACGGYVPMISGRGLGH
EEECCCCCCEEEEEEECCCCCEECCCCCCCCHHHHHHHHHHHHHHHCCCEECCCCCCCCC
TGGTLDKLDAISGYKTTPDSLDHFRKIVKEVGVAIIGQTGDLAPADKRFYATRDITATVE
CCCCHHHHHHCCCCCCCHHHHHHHHHHHHHCCEEEECCCCCCCCCCCCEEECCCHHHHHH
SIPLITASILSKKLAAGIDALVMDVKAGSGAFMPTFEQSEALANSIVGVANGAGCKTSAL
HHHHHHHHHHHHHHHHCHHHHEEEEECCCCCCCCCCHHHHHHHHHHHHCCCCCCCCHHHH
ITNMDQVLASSAGNAVEVREAVRFLKGEVVNPRLHEVTMALCAEMLLLSGLAADIKEAQA
HHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KLQKVLDNGKAAEVFAKMVGALGGPADFIENQDNYLQKSAIVRPVYAQHSGIVQSMDTRA
HHHHHHHCCCHHHHHHHHHHHCCCCHHHHCCCHHHHHHHHHHCHHHHHHCCHHHHHHHHH
LGMAVVNLGGGRHSASDSIDYAVGLSGILSLGESADSEKPLAMIHAQSEKQFSEAQRAIQ
HHHHEEECCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCEEEEECCHHHHHHHHHHHHH
SAIICGTDSLQAQTQVYRHIRLPDIS
HHHHCCCCCHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MILLPQEIIRNKRDGKTLSRQEIDFFIKGITDNSVTEGQIAAFAMAVYFQDMNMDERVLL
CCCCCHHHHCCCCCCCCHHHHHHHHHEEECCCCCCCCHHHHHHHHHHHHHCCCCCCCEEE
VSAMRDSGQVINWQSLNLNGPVVDKHSTGGVGDVTSLILGPMVAACGGYVPMISGRGLGH
EEECCCCCCEEEEEEECCCCCEECCCCCCCCHHHHHHHHHHHHHHHCCCEECCCCCCCCC
TGGTLDKLDAISGYKTTPDSLDHFRKIVKEVGVAIIGQTGDLAPADKRFYATRDITATVE
CCCCHHHHHHCCCCCCCHHHHHHHHHHHHHCCEEEECCCCCCCCCCCCEEECCCHHHHHH
SIPLITASILSKKLAAGIDALVMDVKAGSGAFMPTFEQSEALANSIVGVANGAGCKTSAL
HHHHHHHHHHHHHHHHCHHHHEEEEECCCCCCCCCCHHHHHHHHHHHHCCCCCCCCHHHH
ITNMDQVLASSAGNAVEVREAVRFLKGEVVNPRLHEVTMALCAEMLLLSGLAADIKEAQA
HHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KLQKVLDNGKAAEVFAKMVGALGGPADFIENQDNYLQKSAIVRPVYAQHSGIVQSMDTRA
HHHHHHHCCCHHHHHHHHHHHCCCCHHHHCCCHHHHHHHHHHCHHHHHHCCHHHHHHHHH
LGMAVVNLGGGRHSASDSIDYAVGLSGILSLGESADSEKPLAMIHAQSEKQFSEAQRAIQ
HHHHEEECCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCEEEEECCHHHHHHHHHHHHH
SAIICGTDSLQAQTQVYRHIRLPDIS
HHHHCCCCCHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA