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The map label for this gene is nhaK [H]

Identifier: 119946367

GI number: 119946367

Start: 3362628

End: 3363908

Strand: Direct

Name: nhaK [H]

Synonym: Ping_2741

Alternate gene names: 119946367

Gene position: 3362628-3363908 (Clockwise)

Preceding gene: 119946366

Following gene: 119946373

Centisome position: 73.75

GC content: 39.34

Gene sequence:

>1281_bases
ATGACGGTCTACGCAACTCTATGTTTTTTAGCCGCAGCAGCGATGCTAATTACATTCTTAAACAGTAAGATAGGTAAGAT
GCAAAGTACTATTGCAATTACCGCAGGCTCCTTAATCTTATCTTTACTAATAGTTATTGCGGGTAAAAATGGCTTTTCTC
CATTACAAGAGATTGCCTCGGAGCAGCTTGCTAAAATTGATTTTAACAGTTTTCTGCTAAATGGTATTTTGGGCTTTTTA
TTATTTGCAGGTGGTTTAGGTATTAAGCTCGGTAATATCAAAGATCAAAAATGGGAAATCGCTGTACTCGCATTAGGGGC
GACTTTATTTTCAACCTTTTTTATCGGTTATGTGCTGTTTTATATCTGTCAATTTTTAGATTTCCAGTTCGACCTTATCT
ACTGTCTGTTATTTGGTGCGCTTATATCCCCTACCGACCCTATTGCAGTACTTGCGATTGTTAAAAAGCTTAATGCTCCA
AAACGTATATCGACACAAATTGAAGGCGAGTCATTATTCAATGATGGGTTTGGGCTGGTTATTTTTGTTACACTTTACAG
CATTGCATTTTCAGATACCCAGCCGACCGCTTTAAGCATTACAGAGTTATTTTTGCATGAAGCCATAGGCGGGATTATAT
ACGGACTTGCATTAGGTTTATTGTTCCATTATTTGATCAGTGCCACCAATGATCACTCGATGGAATTATTGCTGACGCTT
GGTATCCCCAGTGCAGGTTATGTTTTTGCTCCTATTATTGGCGTTTCCGGCCCGCTTGCTATGGTTGTCTCAGGTATTAT
GATTGGCAACTGGACGCGTATTAATGGCTTCTCCAAAGAAAGTATCAAACTGCTCGATCATTTTTGGGAGCTGATTGATG
AATTTTTAAACGGCATTCTTTTTCTATTGATTGGTTTAAGTATGTTGGAATACAGCTTCCATCGGGAAGATTGGGTTTTA
ATGGTGATTGCTGTTCCATTAACATTAACAGCACGTTACCTCAGTATTAAATTCTCTTATGTGGCTTTTAAACGATTCCG
TGAATATAACCCTTACTCTGTGTCGGTATTAACCTGGGGAGGCTTGCGTGGTGGATTGGCGTTAGCGATGGCAATGGCAA
TCCCAGCCGGTGTTATAATTATCCCGAGCAAACAAATAGATGTGCGCGAAATCATTCTGGTGATGACCTACTCAGCTGTA
TTTTTCTCAATTTTAGTACAAGGTTCAACCATCACGCCGCTGATTAATAAAGCGAAAGCATGGCAGGAAAAACAAAAATA
G

Upstream 100 bases:

>100_bases
ATTATTTACAGCCGACAGCCTTATAGCTTTACTGCTGACAGCCGACAGCCTATATAGCTCCTTTAAACTAAACTTATTTA
CTAATATACGAGAACTCTAA

Downstream 100 bases:

>100_bases
TCATTAATACCTAACAGGGTCTTTGATTTGGTGATAGCCGTTAAAACAACTTGTTCCTATCACTATTCCATTAATGATCG
GGCAAAGCCCTTTTTTTATC

Product: sodium/hydrogen exchanger

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 426; Mature: 425

Protein sequence:

>426_residues
MTVYATLCFLAAAAMLITFLNSKIGKMQSTIAITAGSLILSLLIVIAGKNGFSPLQEIASEQLAKIDFNSFLLNGILGFL
LFAGGLGIKLGNIKDQKWEIAVLALGATLFSTFFIGYVLFYICQFLDFQFDLIYCLLFGALISPTDPIAVLAIVKKLNAP
KRISTQIEGESLFNDGFGLVIFVTLYSIAFSDTQPTALSITELFLHEAIGGIIYGLALGLLFHYLISATNDHSMELLLTL
GIPSAGYVFAPIIGVSGPLAMVVSGIMIGNWTRINGFSKESIKLLDHFWELIDEFLNGILFLLIGLSMLEYSFHREDWVL
MVIAVPLTLTARYLSIKFSYVAFKRFREYNPYSVSVLTWGGLRGGLALAMAMAIPAGVIIIPSKQIDVREIILVMTYSAV
FFSILVQGSTITPLINKAKAWQEKQK

Sequences:

>Translated_426_residues
MTVYATLCFLAAAAMLITFLNSKIGKMQSTIAITAGSLILSLLIVIAGKNGFSPLQEIASEQLAKIDFNSFLLNGILGFL
LFAGGLGIKLGNIKDQKWEIAVLALGATLFSTFFIGYVLFYICQFLDFQFDLIYCLLFGALISPTDPIAVLAIVKKLNAP
KRISTQIEGESLFNDGFGLVIFVTLYSIAFSDTQPTALSITELFLHEAIGGIIYGLALGLLFHYLISATNDHSMELLLTL
GIPSAGYVFAPIIGVSGPLAMVVSGIMIGNWTRINGFSKESIKLLDHFWELIDEFLNGILFLLIGLSMLEYSFHREDWVL
MVIAVPLTLTARYLSIKFSYVAFKRFREYNPYSVSVLTWGGLRGGLALAMAMAIPAGVIIIPSKQIDVREIILVMTYSAV
FFSILVQGSTITPLINKAKAWQEKQK
>Mature_425_residues
TVYATLCFLAAAAMLITFLNSKIGKMQSTIAITAGSLILSLLIVIAGKNGFSPLQEIASEQLAKIDFNSFLLNGILGFLL
FAGGLGIKLGNIKDQKWEIAVLALGATLFSTFFIGYVLFYICQFLDFQFDLIYCLLFGALISPTDPIAVLAIVKKLNAPK
RISTQIEGESLFNDGFGLVIFVTLYSIAFSDTQPTALSITELFLHEAIGGIIYGLALGLLFHYLISATNDHSMELLLTLG
IPSAGYVFAPIIGVSGPLAMVVSGIMIGNWTRINGFSKESIKLLDHFWELIDEFLNGILFLLIGLSMLEYSFHREDWVLM
VIAVPLTLTARYLSIKFSYVAFKRFREYNPYSVSVLTWGGLRGGLALAMAMAIPAGVIIIPSKQIDVREIILVMTYSAVF
FSILVQGSTITPLINKAKAWQEKQK

Specific function: Transporter involved in the efflux of sodium, potassium, lithium and rubidium [H]

COG id: COG0025

COG function: function code P; NhaP-type Na+/H+ and K+/H+ antiporters

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. Nhak (TC 2.A.36.3.2) subfamily [H]

Homologues:

Organism=Homo sapiens, GI15529998, Length=338, Percent_Identity=26.9230769230769, Blast_Score=99, Evalue=9e-21,
Organism=Homo sapiens, GI148727259, Length=324, Percent_Identity=25.3086419753086, Blast_Score=96, Evalue=6e-20,
Organism=Homo sapiens, GI27777632, Length=343, Percent_Identity=24.7813411078717, Blast_Score=82, Evalue=1e-15,
Organism=Homo sapiens, GI41872703, Length=444, Percent_Identity=24.3243243243243, Blast_Score=79, Evalue=7e-15,
Organism=Homo sapiens, GI194239733, Length=312, Percent_Identity=24.3589743589744, Blast_Score=75, Evalue=9e-14,
Organism=Homo sapiens, GI27734935, Length=374, Percent_Identity=22.9946524064171, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI294997330, Length=419, Percent_Identity=24.1050119331742, Blast_Score=74, Evalue=3e-13,
Organism=Homo sapiens, GI110227626, Length=419, Percent_Identity=24.1050119331742, Blast_Score=73, Evalue=5e-13,
Organism=Homo sapiens, GI14211919, Length=426, Percent_Identity=23.7089201877934, Blast_Score=72, Evalue=9e-13,
Organism=Homo sapiens, GI4759144, Length=333, Percent_Identity=26.7267267267267, Blast_Score=71, Evalue=2e-12,
Organism=Homo sapiens, GI5454070, Length=364, Percent_Identity=24.1758241758242, Blast_Score=68, Evalue=1e-11,
Organism=Escherichia coli, GI1790501, Length=331, Percent_Identity=25.3776435045317, Blast_Score=82, Evalue=5e-17,
Organism=Caenorhabditis elegans, GI71999819, Length=343, Percent_Identity=24.198250728863, Blast_Score=105, Evalue=3e-23,
Organism=Caenorhabditis elegans, GI71999821, Length=343, Percent_Identity=24.198250728863, Blast_Score=105, Evalue=3e-23,
Organism=Caenorhabditis elegans, GI71999817, Length=343, Percent_Identity=24.198250728863, Blast_Score=105, Evalue=4e-23,
Organism=Caenorhabditis elegans, GI25150332, Length=326, Percent_Identity=24.5398773006135, Blast_Score=101, Evalue=7e-22,
Organism=Caenorhabditis elegans, GI71990924, Length=376, Percent_Identity=26.8617021276596, Blast_Score=99, Evalue=4e-21,
Organism=Caenorhabditis elegans, GI71990932, Length=376, Percent_Identity=26.8617021276596, Blast_Score=98, Evalue=9e-21,
Organism=Caenorhabditis elegans, GI71980847, Length=295, Percent_Identity=26.7796610169492, Blast_Score=96, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI71987535, Length=343, Percent_Identity=25.3644314868805, Blast_Score=94, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI71987537, Length=343, Percent_Identity=25.3644314868805, Blast_Score=94, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI71992107, Length=283, Percent_Identity=23.6749116607774, Blast_Score=72, Evalue=8e-13,
Organism=Caenorhabditis elegans, GI71992101, Length=283, Percent_Identity=23.6749116607774, Blast_Score=72, Evalue=8e-13,
Organism=Caenorhabditis elegans, GI25147678, Length=290, Percent_Identity=25.8620689655172, Blast_Score=70, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6320663, Length=340, Percent_Identity=25.2941176470588, Blast_Score=69, Evalue=1e-12,
Organism=Drosophila melanogaster, GI221510740, Length=330, Percent_Identity=25.7575757575758, Blast_Score=97, Evalue=2e-20,
Organism=Drosophila melanogaster, GI24585580, Length=330, Percent_Identity=25.7575757575758, Blast_Score=97, Evalue=2e-20,
Organism=Drosophila melanogaster, GI24585578, Length=330, Percent_Identity=25.7575757575758, Blast_Score=97, Evalue=2e-20,
Organism=Drosophila melanogaster, GI281360447, Length=411, Percent_Identity=24.330900243309, Blast_Score=81, Evalue=2e-15,
Organism=Drosophila melanogaster, GI221510734, Length=305, Percent_Identity=25.9016393442623, Blast_Score=80, Evalue=3e-15,
Organism=Drosophila melanogaster, GI281364513, Length=400, Percent_Identity=25.5, Blast_Score=79, Evalue=4e-15,
Organism=Drosophila melanogaster, GI221473222, Length=400, Percent_Identity=25.5, Blast_Score=79, Evalue=5e-15,
Organism=Drosophila melanogaster, GI221473212, Length=360, Percent_Identity=26.1111111111111, Blast_Score=79, Evalue=6e-15,
Organism=Drosophila melanogaster, GI221473215, Length=400, Percent_Identity=25.5, Blast_Score=79, Evalue=6e-15,
Organism=Drosophila melanogaster, GI221510738, Length=347, Percent_Identity=25.6484149855908, Blast_Score=78, Evalue=9e-15,
Organism=Drosophila melanogaster, GI221510736, Length=342, Percent_Identity=25.7309941520468, Blast_Score=71, Evalue=1e-12,
Organism=Drosophila melanogaster, GI221510732, Length=342, Percent_Identity=25.7309941520468, Blast_Score=71, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006153
- InterPro:   IPR018422
- InterPro:   IPR018417
- InterPro:   IPR004705 [H]

Pfam domain/function: PF00999 Na_H_Exchanger [H]

EC number: NA

Molecular weight: Translated: 46714; Mature: 46583

Theoretical pI: Translated: 7.04; Mature: 7.04

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTVYATLCFLAAAAMLITFLNSKIGKMQSTIAITAGSLILSLLIVIAGKNGFSPLQEIAS
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHH
EQLAKIDFNSFLLNGILGFLLFAGGLGIKLGNIKDQKWEIAVLALGATLFSTFFIGYVLF
HHHHHCCHHHHHHHHHHHHHHHHCCCCEEECCCCCCCEEEEEEHHHHHHHHHHHHHHHHH
YICQFLDFQFDLIYCLLFGALISPTDPIAVLAIVKKLNAPKRISTQIEGESLFNDGFGLV
HHHHHHCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCHHHCCCCCCHHHCCCCHHH
IFVTLYSIAFSDTQPTALSITELFLHEAIGGIIYGLALGLLFHYLISATNDHSMELLLTL
HHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEE
GIPSAGYVFAPIIGVSGPLAMVVSGIMIGNWTRINGFSKESIKLLDHFWELIDEFLNGIL
CCCCCCHHHHHHHCCCCCHHHHHHHHHCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHH
FLLIGLSMLEYSFHREDWVLMVIAVPLTLTARYLSIKFSYVAFKRFREYNPYSVSVLTWG
HHHHHHHHHHHHHCCCCEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEC
GLRGGLALAMAMAIPAGVIIIPSKQIDVREIILVMTYSAVFFSILVQGSTITPLINKAKA
CCHHHHHHHHHHHCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHH
WQEKQK
HHHCCC
>Mature Secondary Structure 
TVYATLCFLAAAAMLITFLNSKIGKMQSTIAITAGSLILSLLIVIAGKNGFSPLQEIAS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHH
EQLAKIDFNSFLLNGILGFLLFAGGLGIKLGNIKDQKWEIAVLALGATLFSTFFIGYVLF
HHHHHCCHHHHHHHHHHHHHHHHCCCCEEECCCCCCCEEEEEEHHHHHHHHHHHHHHHHH
YICQFLDFQFDLIYCLLFGALISPTDPIAVLAIVKKLNAPKRISTQIEGESLFNDGFGLV
HHHHHHCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCHHHCCCCCCHHHCCCCHHH
IFVTLYSIAFSDTQPTALSITELFLHEAIGGIIYGLALGLLFHYLISATNDHSMELLLTL
HHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEE
GIPSAGYVFAPIIGVSGPLAMVVSGIMIGNWTRINGFSKESIKLLDHFWELIDEFLNGIL
CCCCCCHHHHHHHCCCCCHHHHHHHHHCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHH
FLLIGLSMLEYSFHREDWVLMVIAVPLTLTARYLSIKFSYVAFKRFREYNPYSVSVLTWG
HHHHHHHHHHHHHCCCCEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEC
GLRGGLALAMAMAIPAGVIIIPSKQIDVREIILVMTYSAVFFSILVQGSTITPLINKAKA
CCHHHHHHHHHHHCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHH
WQEKQK
HHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA