Click here to switch to the map view.

The map label for this gene is trxC [H]

Identifier: 119946270

GI number: 119946270

Start: 3229266

End: 3229700

Strand: Reverse

Name: trxC [H]

Synonym: Ping_2633

Alternate gene names: 119946270

Gene position: 3229700-3229266 (Counterclockwise)

Preceding gene: 119946271

Following gene: 119946269

Centisome position: 70.83

GC content: 38.39

Gene sequence:

>435_bases
ATGAATTCAATTGTCAGCCGATGCCCATTTTGTCAAGCGATGAACCGTTTACCCATTGAGAAAATCGAAGTTTCTCCTAC
CTGCGGTAGCTGCAAGCAACCATTATTGGAAGGAAAACCAATAGAGGGAAGCAGCAATAATTTAGCCGAATTAATCAATA
GTGAAAAGCCTGTTGTTATTGATTTTTGGGCTCCCTGGTGCAGCCCCTGTATTAATTTTGCACCTGTTTTTGAACAAGTT
GCCATGGAAGAAAAAGATAAATTACGCTTTGTTAAAGTAGATACAGAAGCGCAGCAAGAGATTGCTGCACAGTACAAAAT
TCGTAGTATTCCAACCTTAATGATGTTCAGAAAAGGGCGCTTAATTGACAGTTTAAATGGCGCATTACCAAAGTCACAAT
TTAAAGAATGGGTAGCGGAAACATTAAATAAATAA

Upstream 100 bases:

>100_bases
ATTCTGTGTGATATTTTAGATAATTAATTAGCGCTATCAACTGTTAATCGTACTTTTTTGTTATTAGAATAGGTAGTTTT
AAAACTAAAGGAACGTATCA

Downstream 100 bases:

>100_bases
ACTGCGAACAACAGATCTATAAAGTTCATTGATCTGTTGTTCTATTTTTTAAGTGTGTACCACTGCGCCTGAAGTCGCAC
TTCCTGAAATAGATTACAAA

Product: thioredoxin 2

Products: NA

Alternate protein names: Trx-2; Protein-disulfide reductase [H]

Number of amino acids: Translated: 144; Mature: 144

Protein sequence:

>144_residues
MNSIVSRCPFCQAMNRLPIEKIEVSPTCGSCKQPLLEGKPIEGSSNNLAELINSEKPVVIDFWAPWCSPCINFAPVFEQV
AMEEKDKLRFVKVDTEAQQEIAAQYKIRSIPTLMMFRKGRLIDSLNGALPKSQFKEWVAETLNK

Sequences:

>Translated_144_residues
MNSIVSRCPFCQAMNRLPIEKIEVSPTCGSCKQPLLEGKPIEGSSNNLAELINSEKPVVIDFWAPWCSPCINFAPVFEQV
AMEEKDKLRFVKVDTEAQQEIAAQYKIRSIPTLMMFRKGRLIDSLNGALPKSQFKEWVAETLNK
>Mature_144_residues
MNSIVSRCPFCQAMNRLPIEKIEVSPTCGSCKQPLLEGKPIEGSSNNLAELINSEKPVVIDFWAPWCSPCINFAPVFEQV
AMEEKDKLRFVKVDTEAQQEIAAQYKIRSIPTLMMFRKGRLIDSLNGALPKSQFKEWVAETLNK

Specific function: Efficient electron donor for the essential enzyme ribonucleotide reductase. Is also able to reduce the interchain disulfide bridges of insulin [H]

COG id: COG0526

COG function: function code OC; Thiol-disulfide isomerase and thioredoxins

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI21361403, Length=94, Percent_Identity=28.7234042553192, Blast_Score=71, Evalue=4e-13,
Organism=Homo sapiens, GI224493972, Length=136, Percent_Identity=30.8823529411765, Blast_Score=66, Evalue=9e-12,
Organism=Homo sapiens, GI42794771, Length=136, Percent_Identity=30.8823529411765, Blast_Score=66, Evalue=9e-12,
Organism=Homo sapiens, GI4758304, Length=100, Percent_Identity=32, Blast_Score=64, Evalue=5e-11,
Organism=Escherichia coli, GI1788936, Length=142, Percent_Identity=50, Blast_Score=165, Evalue=1e-42,
Organism=Escherichia coli, GI87082331, Length=93, Percent_Identity=35.4838709677419, Blast_Score=80, Evalue=4e-17,
Organism=Escherichia coli, GI87081747, Length=86, Percent_Identity=30.2325581395349, Blast_Score=63, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI212646193, Length=128, Percent_Identity=27.34375, Blast_Score=67, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17554386, Length=100, Percent_Identity=30, Blast_Score=67, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI115532378, Length=66, Percent_Identity=34.8484848484849, Blast_Score=65, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI71980565, Length=114, Percent_Identity=28.0701754385965, Blast_Score=64, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17507705, Length=83, Percent_Identity=32.5301204819277, Blast_Score=64, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI115532380, Length=66, Percent_Identity=34.8484848484849, Blast_Score=64, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17509965, Length=87, Percent_Identity=34.4827586206897, Blast_Score=62, Evalue=7e-11,
Organism=Saccharomyces cerevisiae, GI6321648, Length=92, Percent_Identity=31.5217391304348, Blast_Score=63, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6323072, Length=89, Percent_Identity=30.3370786516854, Blast_Score=61, Evalue=7e-11,
Organism=Drosophila melanogaster, GI28573567, Length=113, Percent_Identity=30.0884955752212, Blast_Score=81, Evalue=2e-16,
Organism=Drosophila melanogaster, GI17647799, Length=98, Percent_Identity=31.6326530612245, Blast_Score=64, Evalue=4e-11,
Organism=Drosophila melanogaster, GI24639826, Length=77, Percent_Identity=31.1688311688312, Blast_Score=63, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005746
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR017937
- InterPro:   IPR013766
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00085 Thioredoxin [H]

EC number: =1.8.1.8 [H]

Molecular weight: Translated: 16277; Mature: 16277

Theoretical pI: Translated: 7.73; Mature: 7.73

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

4.2 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
7.6 %Cys+Met (Translated Protein)
4.2 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
7.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNSIVSRCPFCQAMNRLPIEKIEVSPTCGSCKQPLLEGKPIEGSSNNLAELINSEKPVVI
CCCHHHHCCHHHHHHCCCHHHEECCCCCCCHHCCCCCCCCCCCCCCHHHHHHCCCCCEEE
DFWAPWCSPCINFAPVFEQVAMEEKDKLRFVKVDTEAQQEIAAQYKIRSIPTLMMFRKGR
EECCHHHHHHCCHHHHHHHHHHHHHHCEEEEEECCHHHHHHHHHHHHHCCHHHHHHHCCC
LIDSLNGALPKSQFKEWVAETLNK
HHHHHCCCCCHHHHHHHHHHHHCC
>Mature Secondary Structure
MNSIVSRCPFCQAMNRLPIEKIEVSPTCGSCKQPLLEGKPIEGSSNNLAELINSEKPVVI
CCCHHHHCCHHHHHHCCCHHHEECCCCCCCHHCCCCCCCCCCCCCCHHHHHHCCCCCEEE
DFWAPWCSPCINFAPVFEQVAMEEKDKLRFVKVDTEAQQEIAAQYKIRSIPTLMMFRKGR
EECCHHHHHHCCHHHHHHHHHHHHHHCEEEEEECCHHHHHHHHHHHHHCCHHHHHHHCCC
LIDSLNGALPKSQFKEWVAETLNK
HHHHHCCCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]