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The map label for this gene is yieO [C]

Identifier: 119946256

GI number: 119946256

Start: 3210868

End: 3212322

Strand: Reverse

Name: yieO [C]

Synonym: Ping_2618

Alternate gene names: 119946256

Gene position: 3212322-3210868 (Counterclockwise)

Preceding gene: 119946257

Following gene: 119946255

Centisome position: 70.45

GC content: 39.45

Gene sequence:

>1455_bases
ATGATTAATTCTTCATCCAGCACGGCCTCACTATTAGTTTCAAAAAAGAACTTTCTGCATATTTTTTCGATTGTTTTTTT
ACCCATGTTCTTGGCTGCCGTTGATCAAACATTATTAGCCACGGCAACACCCACTATTGTCAATGAATTAGGGGGGATGC
ATTTGGCATCTTGGATTATTATTGGTTATTTATTGGCCACGGCAGCTTCAGTGCCGATTTATGGTTGGTTAGGGGACCGT
TTTAATCGTCGTAATATGCTGATTGTCGCTTTAGTTATTTTCACGCTTGGTTCAATTGTTTCTGCATTGGCACCATCAAT
GCCTATATTGGTTGTCGGGCGAGTAATACAAGGTCTCGGTGGTGGGGGATTGATGAGTTTATCTCAGGCATTAATTGGTG
AATTTGTACCTCCTCGCCAACGCGCCAGATTTCAGGGGTATTTTGCTTCATTATTTGCTATTGCAAGTATTGGTGGTCCC
GTGATCGGCGGTTTCGTTGTTACTTACCTTTCGTGGCAGTGGCTATTTTGGGTAAACATTCCGATTATCATTTTTGCTAT
TTCTCGTTTAATGTCTTTAACCACAACAAAATCAACACTGCATAAAGGAAAAATTGATTGGACTGGTTTGATCTTATTTC
CCATTATAATGACCACCCTTATTTATTGGTTAACCTCTGGTGGTCATGGATTTGGATGGCTATCTTTAGAAAGTGTCATG
ATTATTGGCGCTTGTGTATTGCTGACTATCGTCTTTATAATCCAACAAAAAAAAGCGCTGCATTCTTTTTTACCGTTAAC
ATTGTTATATAAAAAAGAAATCTATATTCCATTAACCTCCACTTTTTTATTTGCAGCCTGTTTATTTGCATTAATATTCT
TTTTACCCATTTATCTGCAAATTGGCTTTGGTGCAAATGCATCAACGTCTGGTTTATTATTATTACCTTTAACCATAGGC
ACGATTACAGGCGCTTATACTACAGGTAAAATAATTTCCCAAACGGGGGTGCCAAAGTGGATTCCTGTGGTGGGTATGAG
CATTACTACGATAGCATTTTTGCTATTAGGCTTATTACCTCCGGTTCCCGAGTTAATCGCCGGATTAGGGTTTTTCTGCG
GTATCGGACTGGGAACGGTCATGCCTTCTACCCAGCTATTAATTCAATCGCTCGCAGGTAAGGAAAATTTAGGGCGAATA
ATTTCTATGGCCTCATTGTCCCGATCGCTTGGTGCGTCAATGGGTACTGCTCTATTTGGTGCGTTGATTTATGCGTTAAT
TCCAAATTTCAATCGTAATTCGGGCATAGAATTTTTATTAAATAGCCCACGGGAAAATATTATTAATGCTTTTCAAACAG
GATTTCTTGTTGCTGCAATAATTGCTTTTTGCTGTGCTGTTAATGCCGCTCGAGCACCCAGAATCTCTTTGGATGATTTA
GGAGATGAGTGGTAG

Upstream 100 bases:

>100_bases
TGAAGTAACATAGGTATATATAAACAGTTGAGTATCTCTTTATTGAGCATTCATTTAAACTTATCTCTATTTTGTTGTTA
ACTTGGTTGTCCATTTTTCT

Downstream 100 bases:

>100_bases
TCTTTATGGTATGTATTAATATCGCGGTGCACTGTGTCCAATAGGTTATAGCCTCTGTAAAAGACCTTCGCCTTTTTCTT
TGTTAGTTAGCTGCCGCTGG

Product: major facilitator transporter

Products: Proton [Cytoplasm]; drug [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 484; Mature: 484

Protein sequence:

>484_residues
MINSSSSTASLLVSKKNFLHIFSIVFLPMFLAAVDQTLLATATPTIVNELGGMHLASWIIIGYLLATAASVPIYGWLGDR
FNRRNMLIVALVIFTLGSIVSALAPSMPILVVGRVIQGLGGGGLMSLSQALIGEFVPPRQRARFQGYFASLFAIASIGGP
VIGGFVVTYLSWQWLFWVNIPIIIFAISRLMSLTTTKSTLHKGKIDWTGLILFPIIMTTLIYWLTSGGHGFGWLSLESVM
IIGACVLLTIVFIIQQKKALHSFLPLTLLYKKEIYIPLTSTFLFAACLFALIFFLPIYLQIGFGANASTSGLLLLPLTIG
TITGAYTTGKIISQTGVPKWIPVVGMSITTIAFLLLGLLPPVPELIAGLGFFCGIGLGTVMPSTQLLIQSLAGKENLGRI
ISMASLSRSLGASMGTALFGALIYALIPNFNRNSGIEFLLNSPRENIINAFQTGFLVAAIIAFCCAVNAARAPRISLDDL
GDEW

Sequences:

>Translated_484_residues
MINSSSSTASLLVSKKNFLHIFSIVFLPMFLAAVDQTLLATATPTIVNELGGMHLASWIIIGYLLATAASVPIYGWLGDR
FNRRNMLIVALVIFTLGSIVSALAPSMPILVVGRVIQGLGGGGLMSLSQALIGEFVPPRQRARFQGYFASLFAIASIGGP
VIGGFVVTYLSWQWLFWVNIPIIIFAISRLMSLTTTKSTLHKGKIDWTGLILFPIIMTTLIYWLTSGGHGFGWLSLESVM
IIGACVLLTIVFIIQQKKALHSFLPLTLLYKKEIYIPLTSTFLFAACLFALIFFLPIYLQIGFGANASTSGLLLLPLTIG
TITGAYTTGKIISQTGVPKWIPVVGMSITTIAFLLLGLLPPVPELIAGLGFFCGIGLGTVMPSTQLLIQSLAGKENLGRI
ISMASLSRSLGASMGTALFGALIYALIPNFNRNSGIEFLLNSPRENIINAFQTGFLVAAIIAFCCAVNAARAPRISLDDL
GDEW
>Mature_484_residues
MINSSSSTASLLVSKKNFLHIFSIVFLPMFLAAVDQTLLATATPTIVNELGGMHLASWIIIGYLLATAASVPIYGWLGDR
FNRRNMLIVALVIFTLGSIVSALAPSMPILVVGRVIQGLGGGGLMSLSQALIGEFVPPRQRARFQGYFASLFAIASIGGP
VIGGFVVTYLSWQWLFWVNIPIIIFAISRLMSLTTTKSTLHKGKIDWTGLILFPIIMTTLIYWLTSGGHGFGWLSLESVM
IIGACVLLTIVFIIQQKKALHSFLPLTLLYKKEIYIPLTSTFLFAACLFALIFFLPIYLQIGFGANASTSGLLLLPLTIG
TITGAYTTGKIISQTGVPKWIPVVGMSITTIAFLLLGLLPPVPELIAGLGFFCGIGLGTVMPSTQLLIQSLAGKENLGRI
ISMASLSRSLGASMGTALFGALIYALIPNFNRNSGIEFLLNSPRENIINAFQTGFLVAAIIAFCCAVNAARAPRISLDDL
GDEW

Specific function: Unknown

COG id: COG0477

COG function: function code GEPR; Permeases of the major facilitator superfamily

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. TCR/tet family [H]

Homologues:

Organism=Escherichia coli, GI1790195, Length=327, Percent_Identity=30.8868501529052, Blast_Score=137, Evalue=1e-33,
Organism=Escherichia coli, GI87081983, Length=401, Percent_Identity=30.6733167082294, Blast_Score=132, Evalue=4e-32,
Organism=Escherichia coli, GI1788392, Length=343, Percent_Identity=27.6967930029155, Blast_Score=117, Evalue=2e-27,
Organism=Escherichia coli, GI1789042, Length=411, Percent_Identity=24.8175182481752, Blast_Score=114, Evalue=1e-26,
Organism=Escherichia coli, GI1788710, Length=311, Percent_Identity=27.0096463022508, Blast_Score=102, Evalue=6e-23,
Organism=Saccharomyces cerevisiae, GI6322958, Length=451, Percent_Identity=26.6075388026608, Blast_Score=115, Evalue=1e-26,
Organism=Saccharomyces cerevisiae, GI6323735, Length=320, Percent_Identity=26.5625, Blast_Score=98, Evalue=2e-21,
Organism=Saccharomyces cerevisiae, GI6321663, Length=148, Percent_Identity=35.8108108108108, Blast_Score=97, Evalue=7e-21,
Organism=Saccharomyces cerevisiae, GI6319770, Length=389, Percent_Identity=24.6786632390745, Blast_Score=94, Evalue=7e-20,
Organism=Saccharomyces cerevisiae, GI6325455, Length=210, Percent_Identity=30, Blast_Score=90, Evalue=7e-19,
Organism=Saccharomyces cerevisiae, GI6319783, Length=371, Percent_Identity=25.8760107816712, Blast_Score=77, Evalue=4e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR005829
- InterPro:   IPR001958
- InterPro:   IPR011991 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 52005; Mature: 52005

Theoretical pI: Translated: 9.90; Mature: 9.90

Prosite motif: PS50850 MFS ; PS00217 SUGAR_TRANSPORT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MINSSSSTASLLVSKKNFLHIFSIVFLPMFLAAVDQTLLATATPTIVNELGGMHLASWII
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCHHHHHHHH
IGYLLATAASVPIYGWLGDRFNRRNMLIVALVIFTLGSIVSALAPSMPILVVGRVIQGLG
HHHHHHHHHCCCEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCC
GGGLMSLSQALIGEFVPPRQRARFQGYFASLFAIASIGGPVIGGFVVTYLSWQWLFWVNI
CCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHH
PIIIFAISRLMSLTTTKSTLHKGKIDWTGLILFPIIMTTLIYWLTSGGHGFGWLSLESVM
HHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEHHHHHHHH
IIGACVLLTIVFIIQQKKALHSFLPLTLLYKKEIYIPLTSTFLFAACLFALIFFLPIYLQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEEHHHHHHHHHHHHHHHHHHHHHHH
IGFGANASTSGLLLLPLTIGTITGAYTTGKIISQTGVPKWIPVVGMSITTIAFLLLGLLP
HCCCCCCCCCCEEEEEEHHHHHHCCCCCCHHHHHCCCCCHHHHHCHHHHHHHHHHHHHCC
PVPELIAGLGFFCGIGLGTVMPSTQLLIQSLAGKENLGRIISMASLSRSLGASMGTALFG
CHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHH
ALIYALIPNFNRNSGIEFLLNSPRENIINAFQTGFLVAAIIAFCCAVNAARAPRISLDDL
HHHHHHCCCCCCCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHC
GDEW
CCCC
>Mature Secondary Structure
MINSSSSTASLLVSKKNFLHIFSIVFLPMFLAAVDQTLLATATPTIVNELGGMHLASWII
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCHHHHHHHH
IGYLLATAASVPIYGWLGDRFNRRNMLIVALVIFTLGSIVSALAPSMPILVVGRVIQGLG
HHHHHHHHHCCCEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCC
GGGLMSLSQALIGEFVPPRQRARFQGYFASLFAIASIGGPVIGGFVVTYLSWQWLFWVNI
CCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHH
PIIIFAISRLMSLTTTKSTLHKGKIDWTGLILFPIIMTTLIYWLTSGGHGFGWLSLESVM
HHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEHHHHHHHH
IIGACVLLTIVFIIQQKKALHSFLPLTLLYKKEIYIPLTSTFLFAACLFALIFFLPIYLQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEEHHHHHHHHHHHHHHHHHHHHHHH
IGFGANASTSGLLLLPLTIGTITGAYTTGKIISQTGVPKWIPVVGMSITTIAFLLLGLLP
HCCCCCCCCCCEEEEEEHHHHHHCCCCCCHHHHHCCCCCHHHHHCHHHHHHHHHHHHHCC
PVPELIAGLGFFCGIGLGTVMPSTQLLIQSLAGKENLGRIISMASLSRSLGASMGTALFG
CHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHH
ALIYALIPNFNRNSGIEFLLNSPRENIINAFQTGFLVAAIIAFCCAVNAARAPRISLDDL
HHHHHHCCCCCCCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHC
GDEW
CCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; drug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + drug [Cytoplasm] = Proton [Cytoplasm] + drug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]