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The map label for this gene is apt

Identifier: 119945938

GI number: 119945938

Start: 2766447

End: 2766992

Strand: Reverse

Name: apt

Synonym: Ping_2278

Alternate gene names: 119945938

Gene position: 2766992-2766447 (Counterclockwise)

Preceding gene: 119945940

Following gene: 119945937

Centisome position: 60.68

GC content: 41.76

Gene sequence:

>546_bases
ATGACAGCACCGACATTAGAAGAGATCAAAAACTGTATTAAAAGTATTCCAGATTATCCTATTCCGGGCATTATGTTTCG
TGATATCACCAGTTTAATTGAAAATGGCGCTGCATTTTCAGCCACCATTAACTTATTAGTCGAACGTTATAAAGATCAAA
ATATTTCCAAAGTGGTGGGCACCGAAGCGCGCGGTTTTATTTTTGGCGCTCCCTTAGCGGCGGCGATTGGGGCTGGATTT
GTGCCTGTGCGTAAACCGGGTAAATTACCCCGAACAACCGTTCATGAAAATTATGAACTTGAATATGGCACTGATTCGTT
ACATATCCACAGCGATGCGATTAAAAAGAATGAAAGAGTGTTACTAGTGGATGATCTTTTAGCGACGGGCGGGACAGCCG
AAGCTTCTATCAAATTAATTCACCGCTCGGGGGGAATTGTTATTGAGTCAGCTTTTGTTATTGAATTGCCGGCCTTAAAA
GGGGCGCAAAAACTGCACGCACTTAATGTTCCGTATTTTTCCTTAATCAAATTTGAAGGTGAGTAA

Upstream 100 bases:

>100_bases
CTACATCTACAAGTAATTTGCGTATATATGTCAGCAATGCTTGCACATGGTCATGCAACTAATTATTCTTCACCTACAGG
TTTTTAAAAAGAGTTAAATA

Downstream 100 bases:

>100_bases
TTTTTGTGAGTTATCAAGTTTTAGCACGAAAATGGCGACCAGGTAATTTCCAGGAAGTGGTTGGCCAGCAACATGTGTTG
ACCGCTTTATCTAATAGTTT

Product: adenine phosphoribosyltransferase

Products: NA

Alternate protein names: APRT

Number of amino acids: Translated: 181; Mature: 180

Protein sequence:

>181_residues
MTAPTLEEIKNCIKSIPDYPIPGIMFRDITSLIENGAAFSATINLLVERYKDQNISKVVGTEARGFIFGAPLAAAIGAGF
VPVRKPGKLPRTTVHENYELEYGTDSLHIHSDAIKKNERVLLVDDLLATGGTAEASIKLIHRSGGIVIESAFVIELPALK
GAQKLHALNVPYFSLIKFEGE

Sequences:

>Translated_181_residues
MTAPTLEEIKNCIKSIPDYPIPGIMFRDITSLIENGAAFSATINLLVERYKDQNISKVVGTEARGFIFGAPLAAAIGAGF
VPVRKPGKLPRTTVHENYELEYGTDSLHIHSDAIKKNERVLLVDDLLATGGTAEASIKLIHRSGGIVIESAFVIELPALK
GAQKLHALNVPYFSLIKFEGE
>Mature_180_residues
TAPTLEEIKNCIKSIPDYPIPGIMFRDITSLIENGAAFSATINLLVERYKDQNISKVVGTEARGFIFGAPLAAAIGAGFV
PVRKPGKLPRTTVHENYELEYGTDSLHIHSDAIKKNERVLLVDDLLATGGTAEASIKLIHRSGGIVIESAFVIELPALKG
AQKLHALNVPYFSLIKFEGE

Specific function: Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis

COG id: COG0503

COG function: function code F; Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family

Homologues:

Organism=Homo sapiens, GI4502171, Length=182, Percent_Identity=42.8571428571429, Blast_Score=150, Evalue=6e-37,
Organism=Homo sapiens, GI71773201, Length=133, Percent_Identity=43.609022556391, Blast_Score=116, Evalue=8e-27,
Organism=Escherichia coli, GI1786675, Length=179, Percent_Identity=62.0111731843575, Blast_Score=228, Evalue=1e-61,
Organism=Caenorhabditis elegans, GI17509087, Length=176, Percent_Identity=40.3409090909091, Blast_Score=125, Evalue=1e-29,
Organism=Saccharomyces cerevisiae, GI6323619, Length=179, Percent_Identity=40.2234636871508, Blast_Score=117, Evalue=9e-28,
Organism=Saccharomyces cerevisiae, GI6320649, Length=174, Percent_Identity=36.7816091954023, Blast_Score=97, Evalue=2e-21,
Organism=Drosophila melanogaster, GI17136334, Length=175, Percent_Identity=38.8571428571429, Blast_Score=122, Evalue=2e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): APT_PSYIN (A1SX04)

Other databases:

- EMBL:   CP000510
- RefSeq:   YP_943618.1
- ProteinModelPortal:   A1SX04
- SMR:   A1SX04
- STRING:   A1SX04
- GeneID:   4626807
- GenomeReviews:   CP000510_GR
- KEGG:   pin:Ping_2278
- eggNOG:   COG0503
- HOGENOM:   HBG703830
- OMA:   GILFYDI
- PhylomeDB:   A1SX04
- BioCyc:   PING357804:PING_2278-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00004
- InterPro:   IPR005764
- InterPro:   IPR000836
- TIGRFAMs:   TIGR01090

Pfam domain/function: PF00156 Pribosyltran

EC number: =2.4.2.7

Molecular weight: Translated: 19628; Mature: 19497

Theoretical pI: Translated: 6.68; Mature: 6.68

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER; PS00572 GLYCOSYL_HYDROL_F1_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
1.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTAPTLEEIKNCIKSIPDYPIPGIMFRDITSLIENGAAFSATINLLVERYKDQNISKVVG
CCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCHHHHHC
TEARGFIFGAPLAAAIGAGFVPVRKPGKLPRTTVHENYELEYGTDSLHIHSDAIKKNERV
CCCCCEEEECHHHHHHCCCCCCCCCCCCCCCCCCCCCEEEEECCCEEEEEHHHHCCCCCE
LLVDDLLATGGTAEASIKLIHRSGGIVIESAFVIELPALKGAQKLHALNVPYFSLIKFEG
EEEEHHHHCCCCCCEEEEEEEECCCEEEEEEEEEEECCCCCCHHHEECCCCEEEEEEECC
E
C
>Mature Secondary Structure 
TAPTLEEIKNCIKSIPDYPIPGIMFRDITSLIENGAAFSATINLLVERYKDQNISKVVG
CCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCHHHHHC
TEARGFIFGAPLAAAIGAGFVPVRKPGKLPRTTVHENYELEYGTDSLHIHSDAIKKNERV
CCCCCEEEECHHHHHHCCCCCCCCCCCCCCCCCCCCCEEEEECCCEEEEEHHHHCCCCCE
LLVDDLLATGGTAEASIKLIHRSGGIVIESAFVIELPALKGAQKLHALNVPYFSLIKFEG
EEEEHHHHCCCCCCEEEEEEEECCCEEEEEEEEEEECCCCCCHHHEECCCCEEEEEEECC
E
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA