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The map label for this gene is dxs

Identifier: 119945900

GI number: 119945900

Start: 2722889

End: 2724757

Strand: Direct

Name: dxs

Synonym: Ping_2240

Alternate gene names: 119945900

Gene position: 2722889-2724757 (Clockwise)

Preceding gene: 119945899

Following gene: 119945903

Centisome position: 59.72

GC content: 41.89

Gene sequence:

>1869_bases
ATGCCATTGGATTTAAAAAACTACCCATTGCTGACGAATATTAATTATCCAGAGGATTTGCGGTTATTAAAAAAAGAGCA
ATTACCGGCTTTTTGTAATGAATTACGTTCATTTCTTCTAAATACTGTCAGTCAAACGAGCGGTCATTTAGCATCCGGTT
TGGGTGTTGTTGAATTAACTGTTGCTCTGCATTATATTTACCGCACGCCTTTTGATAACCTTATTTTCGATGTTGGCCAT
CAAGCATACCCGCATAAAATTTTAACGGGTCGGCGAGATAAAATGGGCAGTATTCGTAACTTTAAAGGCTTACATCCCTT
TCCGTGGCGTGAAGAAAGTGAATATGATGTGTTAAGCGTTGGTCACTCCTCGACATCAATAGGGGCAGCATTAGGCATGT
CAATTGCTGCCGAAAAAGAACAACAAGGCCGCAAAGTAGTCGCTGTTATTGGTGATGGTGCCATTACCGCGGGCATGGCA
TTTGAAGCCTTAAATCACGCAGGTTCATTGCACAATGATATGCTGGTGGTGTTAAATGATAATGAAATGTCAATTTCTGA
AAATGTCGGGGCTTTAAATAACCATTTAGCAAAAATACTCTCCGGTGATATTTATACTCAGCTTAGAGAAGGCAGTAAAA
AAGTACTTTCTAATATCCCTCCCGTTAAAGAGCTGGCCAAAAGAACGGAAGAACACCTTAAAGGAATGATCTCACCTGCC
ACCATATTCGAAGAGTTTGGTTTTAACTATATCGGCCCGATGGACGGTCATAATGTTATCGATTTAGTGGATACGTTACG
CAATATGCGCTCCCATAGCGGACCGCAGTTTTTACATGTAATGACGAAAAAAGGCAAAGGTTATAAACAGGCAGAGCTTG
ATCCTATTAAGTACCATGCGGTACCAAAATTCACACCGGATCAGGACCTTCCAAAATCACCACCCAGCTCTGCTACTTTT
TCACAGGTATTTGGAGATTGGTTAAATGATATGGCCGATCAGGATAATAAACTGACGGCAATTACGCCAGCAATGCGCGA
AGGCTCCGGTATGGTGAGCTTTTCAAAACGACATGCTGACAAGTATTACGATGTGGCTATTGCTGAACAGCATGCTGTCA
CACTGGCGGCCGGCATGGCAATTGCTGGATTAAACCCTGTTGTTGCTATTTACTCAACTTTTTTGCAACGTGCCTATGAC
CAACTTATCCATGATATTGCTATCCAAAATCTAGGGGTGTTATTTGCCATAGACAGAGCCGGTATTGTGGGTGCGGATGG
TCCAACACATCAAGGTGTGTTTGATTTAAGTTTTTTACGCTGCGTTCCTAATATGATTGTAATGACCCCGTCCGATGAAC
AAGAGTGTCGGAATATGCTTTATACGGGTCATATGCTCAATCAGCCTGCCGCGGTCAGATATCCACGCGGCACCGGAACC
GGTATCGAGATAAACAAACAGATGAGCAGGTTAACTATTGGTAAAGCGAAGGTGGTAAAAGAAGGTAAAAATCTTGCCAT
ATTATGTTTTGGTACCTTTTTACAACAAGCCTATTCCGTCGCAGAAAAATTGAATGCGACCCTGGTTGATATGCGCTTTG
TTAAACCGCTTGATAAAGAGCTGCTTGATAATCTCGCCAGCACCCACAAAGAGTTTGTCACTATTGAGGAAAATAGTATT
GCCGGTGGCGCAGGCTCAGCAGTTAATGAATATTTTATGTCTCAGCAAATAAAGACAAGCGTTTTAAATATAGGCATACC
CGACAGGTTTATTGAACAGGGAACGCAGCAGGAAATATATACATTACTTGAGCTCGATAGTGCTGGAATAGAGAAGCAAA
TTGTCAGCTACTATAGCCATCTCAAATAA

Upstream 100 bases:

>100_bases
TCATCGCGCGCGATAGATAGGCAATATCTACACTCATTAAAATTACCAATAAAAACATTTAGTAATTTTTTATTATTTTC
TATATACACGACTGAAGCTT

Downstream 100 bases:

>100_bases
ACGAAAAAGGTTAATATTTCTGCAGGCCTATCTGTATTACGCATTTAAATCACGTAATAGCACAGGTTAGCCTGCAGCAG
ATAGCCTACTGATATTCATT

Product: deoxyxylulose-5-phosphate synthase

Products: NA

Alternate protein names: 1-deoxyxylulose-5-phosphate synthase; DXP synthase; DXPS

Number of amino acids: Translated: 622; Mature: 621

Protein sequence:

>622_residues
MPLDLKNYPLLTNINYPEDLRLLKKEQLPAFCNELRSFLLNTVSQTSGHLASGLGVVELTVALHYIYRTPFDNLIFDVGH
QAYPHKILTGRRDKMGSIRNFKGLHPFPWREESEYDVLSVGHSSTSIGAALGMSIAAEKEQQGRKVVAVIGDGAITAGMA
FEALNHAGSLHNDMLVVLNDNEMSISENVGALNNHLAKILSGDIYTQLREGSKKVLSNIPPVKELAKRTEEHLKGMISPA
TIFEEFGFNYIGPMDGHNVIDLVDTLRNMRSHSGPQFLHVMTKKGKGYKQAELDPIKYHAVPKFTPDQDLPKSPPSSATF
SQVFGDWLNDMADQDNKLTAITPAMREGSGMVSFSKRHADKYYDVAIAEQHAVTLAAGMAIAGLNPVVAIYSTFLQRAYD
QLIHDIAIQNLGVLFAIDRAGIVGADGPTHQGVFDLSFLRCVPNMIVMTPSDEQECRNMLYTGHMLNQPAAVRYPRGTGT
GIEINKQMSRLTIGKAKVVKEGKNLAILCFGTFLQQAYSVAEKLNATLVDMRFVKPLDKELLDNLASTHKEFVTIEENSI
AGGAGSAVNEYFMSQQIKTSVLNIGIPDRFIEQGTQQEIYTLLELDSAGIEKQIVSYYSHLK

Sequences:

>Translated_622_residues
MPLDLKNYPLLTNINYPEDLRLLKKEQLPAFCNELRSFLLNTVSQTSGHLASGLGVVELTVALHYIYRTPFDNLIFDVGH
QAYPHKILTGRRDKMGSIRNFKGLHPFPWREESEYDVLSVGHSSTSIGAALGMSIAAEKEQQGRKVVAVIGDGAITAGMA
FEALNHAGSLHNDMLVVLNDNEMSISENVGALNNHLAKILSGDIYTQLREGSKKVLSNIPPVKELAKRTEEHLKGMISPA
TIFEEFGFNYIGPMDGHNVIDLVDTLRNMRSHSGPQFLHVMTKKGKGYKQAELDPIKYHAVPKFTPDQDLPKSPPSSATF
SQVFGDWLNDMADQDNKLTAITPAMREGSGMVSFSKRHADKYYDVAIAEQHAVTLAAGMAIAGLNPVVAIYSTFLQRAYD
QLIHDIAIQNLGVLFAIDRAGIVGADGPTHQGVFDLSFLRCVPNMIVMTPSDEQECRNMLYTGHMLNQPAAVRYPRGTGT
GIEINKQMSRLTIGKAKVVKEGKNLAILCFGTFLQQAYSVAEKLNATLVDMRFVKPLDKELLDNLASTHKEFVTIEENSI
AGGAGSAVNEYFMSQQIKTSVLNIGIPDRFIEQGTQQEIYTLLELDSAGIEKQIVSYYSHLK
>Mature_621_residues
PLDLKNYPLLTNINYPEDLRLLKKEQLPAFCNELRSFLLNTVSQTSGHLASGLGVVELTVALHYIYRTPFDNLIFDVGHQ
AYPHKILTGRRDKMGSIRNFKGLHPFPWREESEYDVLSVGHSSTSIGAALGMSIAAEKEQQGRKVVAVIGDGAITAGMAF
EALNHAGSLHNDMLVVLNDNEMSISENVGALNNHLAKILSGDIYTQLREGSKKVLSNIPPVKELAKRTEEHLKGMISPAT
IFEEFGFNYIGPMDGHNVIDLVDTLRNMRSHSGPQFLHVMTKKGKGYKQAELDPIKYHAVPKFTPDQDLPKSPPSSATFS
QVFGDWLNDMADQDNKLTAITPAMREGSGMVSFSKRHADKYYDVAIAEQHAVTLAAGMAIAGLNPVVAIYSTFLQRAYDQ
LIHDIAIQNLGVLFAIDRAGIVGADGPTHQGVFDLSFLRCVPNMIVMTPSDEQECRNMLYTGHMLNQPAAVRYPRGTGTG
IEINKQMSRLTIGKAKVVKEGKNLAILCFGTFLQQAYSVAEKLNATLVDMRFVKPLDKELLDNLASTHKEFVTIEENSIA
GGAGSAVNEYFMSQQIKTSVLNIGIPDRFIEQGTQQEIYTLLELDSAGIEKQIVSYYSHLK

Specific function: Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)

COG id: COG1154

COG function: function code HI; Deoxyxylulose-5-phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family. DXPS subfamily

Homologues:

Organism=Homo sapiens, GI205277463, Length=661, Percent_Identity=22.9954614220877, Blast_Score=109, Evalue=9e-24,
Organism=Homo sapiens, GI4507521, Length=661, Percent_Identity=22.9954614220877, Blast_Score=109, Evalue=9e-24,
Organism=Homo sapiens, GI133778974, Length=604, Percent_Identity=22.1854304635762, Blast_Score=72, Evalue=2e-12,
Organism=Homo sapiens, GI225637459, Length=273, Percent_Identity=24.1758241758242, Blast_Score=70, Evalue=7e-12,
Organism=Homo sapiens, GI225637463, Length=273, Percent_Identity=24.1758241758242, Blast_Score=70, Evalue=8e-12,
Organism=Homo sapiens, GI225637461, Length=273, Percent_Identity=24.1758241758242, Blast_Score=70, Evalue=8e-12,
Organism=Escherichia coli, GI1786622, Length=621, Percent_Identity=65.8615136876006, Blast_Score=872, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17539652, Length=545, Percent_Identity=23.4862385321101, Blast_Score=85, Evalue=1e-16,
Organism=Drosophila melanogaster, GI45551847, Length=597, Percent_Identity=24.7906197654941, Blast_Score=91, Evalue=3e-18,
Organism=Drosophila melanogaster, GI45550715, Length=597, Percent_Identity=24.7906197654941, Blast_Score=91, Evalue=3e-18,
Organism=Drosophila melanogaster, GI24645119, Length=497, Percent_Identity=25.3521126760563, Blast_Score=90, Evalue=5e-18,
Organism=Drosophila melanogaster, GI24666278, Length=600, Percent_Identity=23.3333333333333, Blast_Score=89, Evalue=1e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DXS_PSYIN (A1SWW6)

Other databases:

- EMBL:   CP000510
- RefSeq:   YP_943580.1
- ProteinModelPortal:   A1SWW6
- SMR:   A1SWW6
- STRING:   A1SWW6
- GeneID:   4623448
- GenomeReviews:   CP000510_GR
- KEGG:   pin:Ping_2240
- eggNOG:   COG1154
- HOGENOM:   HBG571647
- OMA:   IMEYAYL
- PhylomeDB:   A1SWW6
- BioCyc:   PING357804:PING_2240-MONOMER
- HAMAP:   MF_00315
- InterPro:   IPR005477
- InterPro:   IPR011766
- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR020826
- InterPro:   IPR005476
- InterPro:   IPR005474
- Gene3D:   G3DSA:3.40.50.920
- SMART:   SM00861
- TIGRFAMs:   TIGR00204

Pfam domain/function: PF02775 TPP_enzyme_C; PF02779 Transket_pyr; PF02780 Transketolase_C; SSF52922 Transketo_C_like

EC number: =2.2.1.7

Molecular weight: Translated: 68644; Mature: 68512

Theoretical pI: Translated: 6.63; Mature: 6.63

Prosite motif: PS00801 TRANSKETOLASE_1; PS00802 TRANSKETOLASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPLDLKNYPLLTNINYPEDLRLLKKEQLPAFCNELRSFLLNTVSQTSGHLASGLGVVELT
CCCCCCCCCEEECCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCHHHHCCHHHHHH
VALHYIYRTPFDNLIFDVGHQAYPHKILTGRRDKMGSIRNFKGLHPFPWREESEYDVLSV
HHHHHHHHCCHHHHHHHCCCCCCCCHHHCCCCHHCCCHHCCCCCCCCCCCCCCCCCEEEE
GHSSTSIGAALGMSIAAEKEQQGRKVVAVIGDGAITAGMAFEALNHAGSLHNDMLVVLND
CCCCCHHHHHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHHCCCCCCCEEEEECC
NEMSISENVGALNNHLAKILSGDIYTQLREGSKKVLSNIPPVKELAKRTEEHLKGMISPA
CCCCHHHCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCHH
TIFEEFGFNYIGPMDGHNVIDLVDTLRNMRSHSGPQFLHVMTKKGKGYKQAELDPIKYHA
HHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCEEEEC
VPKFTPDQDLPKSPPSSATFSQVFGDWLNDMADQDNKLTAITPAMREGSGMVSFSKRHAD
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCEEEECCHHHCCCCCEEEHHHHCC
KYYDVAIAEQHAVTLAAGMAIAGLNPVVAIYSTFLQRAYDQLIHDIAIQNLGVLFAIDRA
HHHEEEEHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECC
GIVGADGPTHQGVFDLSFLRCVPNMIVMTPSDEQECRNMLYTGHMLNQPAAVRYPRGTGT
CEECCCCCCCCCHHHHHHHHHCCCEEEECCCCHHHHHHHHHHCHHCCCCCEEECCCCCCC
GIEINKQMSRLTIGKAKVVKEGKNLAILCFGTFLQQAYSVAEKLNATLVDMRFVKPLDKE
CEEEHHHHHHHHCCHHHHHHCCCCEEEEEHHHHHHHHHHHHHHHCCHHHHHHHHCHHHHH
LLDNLASTHKEFVTIEENSIAGGAGSAVNEYFMSQQIKTSVLNIGIPDRFIEQGTQQEIY
HHHHHHHHHHHEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHCCCHHHHH
TLLELDSAGIEKQIVSYYSHLK
HHHHHCCCCHHHHHHHHHHHCC
>Mature Secondary Structure 
PLDLKNYPLLTNINYPEDLRLLKKEQLPAFCNELRSFLLNTVSQTSGHLASGLGVVELT
CCCCCCCCEEECCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCHHHHCCHHHHHH
VALHYIYRTPFDNLIFDVGHQAYPHKILTGRRDKMGSIRNFKGLHPFPWREESEYDVLSV
HHHHHHHHCCHHHHHHHCCCCCCCCHHHCCCCHHCCCHHCCCCCCCCCCCCCCCCCEEEE
GHSSTSIGAALGMSIAAEKEQQGRKVVAVIGDGAITAGMAFEALNHAGSLHNDMLVVLND
CCCCCHHHHHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHHCCCCCCCEEEEECC
NEMSISENVGALNNHLAKILSGDIYTQLREGSKKVLSNIPPVKELAKRTEEHLKGMISPA
CCCCHHHCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCHH
TIFEEFGFNYIGPMDGHNVIDLVDTLRNMRSHSGPQFLHVMTKKGKGYKQAELDPIKYHA
HHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCEEEEC
VPKFTPDQDLPKSPPSSATFSQVFGDWLNDMADQDNKLTAITPAMREGSGMVSFSKRHAD
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCEEEECCHHHCCCCCEEEHHHHCC
KYYDVAIAEQHAVTLAAGMAIAGLNPVVAIYSTFLQRAYDQLIHDIAIQNLGVLFAIDRA
HHHEEEEHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECC
GIVGADGPTHQGVFDLSFLRCVPNMIVMTPSDEQECRNMLYTGHMLNQPAAVRYPRGTGT
CEECCCCCCCCCHHHHHHHHHCCCEEEECCCCHHHHHHHHHHCHHCCCCCEEECCCCCCC
GIEINKQMSRLTIGKAKVVKEGKNLAILCFGTFLQQAYSVAEKLNATLVDMRFVKPLDKE
CEEEHHHHHHHHCCHHHHHHCCCCEEEEEHHHHHHHHHHHHHHHCCHHHHHHHHCHHHHH
LLDNLASTHKEFVTIEENSIAGGAGSAVNEYFMSQQIKTSVLNIGIPDRFIEQGTQQEIY
HHHHHHHHHHHEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHCCCHHHHH
TLLELDSAGIEKQIVSYYSHLK
HHHHHCCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA