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The map label for this gene is ispA [H]

Identifier: 119945899

GI number: 119945899

Start: 2721918

End: 2722808

Strand: Direct

Name: ispA [H]

Synonym: Ping_2239

Alternate gene names: 119945899

Gene position: 2721918-2722808 (Clockwise)

Preceding gene: 119945898

Following gene: 119945900

Centisome position: 59.7

GC content: 41.08

Gene sequence:

>891_bases
ATGACACAACTTGCAGAAACTCTGAATCAATATCAGCAACGTGTTGATAAAAATTTAAATAAATATATCAATATCACCCA
CCCTATCTCCCCTTTATTGAATGAAGCCATGGGATACGGAGCTTTATTAGGCGGCAAACGCGTCCGACCATTCTTGGTTT
ACGCCGTCGGTGATATGCTTGGTTGTTCATTGCAATCGTTAGATCCACTGGCGGCTGCCGTTGAATGTATTCATGCTTAT
TCATTGATTCATGACGATCTTCCGGCGATGGATGATGATGATCTTCGGCGCGGGCAGATGACTTGCCATAAAAAATTTGA
TGAAGCAACGGCGATTCTTGCAGGTGATGCATTACAAACCTTAGCGTTTGATATAATATCAATGCCAAACAAGGCAATAA
CAGCACAAGCACAATTAAAAATGGTCAATTTTTTAGCGAAAGCGGCAGGTGATCATGGTATGTGTGCCGGACAAGCGTTA
GACTTAGTCGCTGAAAATCAATCTGTCAATTTGGTTACCCTGCAAAAAATACACCAGGCAAAAACGGGTGCTTTGATAAA
AGTTGCGATTCAATTAGCAGCGATGACCAAAAGCGATTTACACGAAGATCATTTTCAGTTATTAAATACTTTTGCCGACG
CAATCGGTTTGGCATTTCAGGTACAGGATGATATTTTAGACATTATCGGTGATACACAAACTCTGGGTAAACCCCAAGGT
TCCGACCTTGCTCTGCATAAATCAACCTACCCGGCACTATTAGGTTTAGAAGAAGCACAAAATAAAGCACAAGCACTTTG
CCACGAGGCACAACTTGCTTTATCACAATTACCTTATAATACAGAATTGCTATCGAAATTTGCACAATACATCATCGCGC
GCGATAGATAG

Upstream 100 bases:

>100_bases
ATGAGTAAAGTATATTGTTTAAAAGTGCATTATTTTTGTAATAATTCACTTTTTCTGTTTTTATCCTATTAACGTTCAAT
TAACACAACTATAAAACCCT

Downstream 100 bases:

>100_bases
GCAATATCTACACTCATTAAAATTACCAATAAAAACATTTAGTAATTTTTTATTATTTTCTATATACACGACTGAAGCTT
ATGCCATTGGATTTAAAAAA

Product: geranyltranstransferase

Products: NA

Alternate protein names: FPP synthase; (2E,6E)-farnesyl diphosphate synthase; Geranyltranstransferase [H]

Number of amino acids: Translated: 296; Mature: 295

Protein sequence:

>296_residues
MTQLAETLNQYQQRVDKNLNKYINITHPISPLLNEAMGYGALLGGKRVRPFLVYAVGDMLGCSLQSLDPLAAAVECIHAY
SLIHDDLPAMDDDDLRRGQMTCHKKFDEATAILAGDALQTLAFDIISMPNKAITAQAQLKMVNFLAKAAGDHGMCAGQAL
DLVAENQSVNLVTLQKIHQAKTGALIKVAIQLAAMTKSDLHEDHFQLLNTFADAIGLAFQVQDDILDIIGDTQTLGKPQG
SDLALHKSTYPALLGLEEAQNKAQALCHEAQLALSQLPYNTELLSKFAQYIIARDR

Sequences:

>Translated_296_residues
MTQLAETLNQYQQRVDKNLNKYINITHPISPLLNEAMGYGALLGGKRVRPFLVYAVGDMLGCSLQSLDPLAAAVECIHAY
SLIHDDLPAMDDDDLRRGQMTCHKKFDEATAILAGDALQTLAFDIISMPNKAITAQAQLKMVNFLAKAAGDHGMCAGQAL
DLVAENQSVNLVTLQKIHQAKTGALIKVAIQLAAMTKSDLHEDHFQLLNTFADAIGLAFQVQDDILDIIGDTQTLGKPQG
SDLALHKSTYPALLGLEEAQNKAQALCHEAQLALSQLPYNTELLSKFAQYIIARDR
>Mature_295_residues
TQLAETLNQYQQRVDKNLNKYINITHPISPLLNEAMGYGALLGGKRVRPFLVYAVGDMLGCSLQSLDPLAAAVECIHAYS
LIHDDLPAMDDDDLRRGQMTCHKKFDEATAILAGDALQTLAFDIISMPNKAITAQAQLKMVNFLAKAAGDHGMCAGQALD
LVAENQSVNLVTLQKIHQAKTGALIKVAIQLAAMTKSDLHEDHFQLLNTFADAIGLAFQVQDDILDIIGDTQTLGKPQGS
DLALHKSTYPALLGLEEAQNKAQALCHEAQLALSQLPYNTELLSKFAQYIIARDR

Specific function: Unknown

COG id: COG0142

COG function: function code H; Geranylgeranyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FPP/GGPP synthase family [H]

Homologues:

Organism=Homo sapiens, GI50659086, Length=300, Percent_Identity=25.6666666666667, Blast_Score=75, Evalue=1e-13,
Organism=Escherichia coli, GI1786623, Length=268, Percent_Identity=59.3283582089552, Blast_Score=273, Evalue=1e-74,
Organism=Escherichia coli, GI1789578, Length=223, Percent_Identity=30.0448430493274, Blast_Score=92, Evalue=3e-20,
Organism=Drosophila melanogaster, GI24651612, Length=191, Percent_Identity=28.2722513089005, Blast_Score=66, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000092
- InterPro:   IPR017446
- InterPro:   IPR008949 [H]

Pfam domain/function: PF00348 polyprenyl_synt [H]

EC number: =2.5.1.10 [H]

Molecular weight: Translated: 32250; Mature: 32119

Theoretical pI: Translated: 5.51; Mature: 5.51

Prosite motif: PS00723 POLYPRENYL_SYNTHET_1 ; PS00444 POLYPRENYL_SYNTHET_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQLAETLNQYQQRVDKNLNKYINITHPISPLLNEAMGYGALLGGKRVRPFLVYAVGDML
CCHHHHHHHHHHHHHHHHHHHHEECCCCHHHHHHHHHCCHHHCCCCCCCHHHHHHHHHHH
GCSLQSLDPLAAAVECIHAYSLIHDDLPAMDDDDLRRGQMTCHKKFDEATAILAGDALQT
CCCHHHCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
LAFDIISMPNKAITAQAQLKMVNFLAKAAGDHGMCAGQALDLVAENQSVNLVTLQKIHQA
HHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCCCCHHHHHHHHHH
KTGALIKVAIQLAAMTKSDLHEDHFQLLNTFADAIGLAFQVQDDILDIIGDTQTLGKPQG
HCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEHHHHHHHHCCHHHCCCCCC
SDLALHKSTYPALLGLEEAQNKAQALCHEAQLALSQLPYNTELLSKFAQYIIARDR
CCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TQLAETLNQYQQRVDKNLNKYINITHPISPLLNEAMGYGALLGGKRVRPFLVYAVGDML
CHHHHHHHHHHHHHHHHHHHHEECCCCHHHHHHHHHCCHHHCCCCCCCHHHHHHHHHHH
GCSLQSLDPLAAAVECIHAYSLIHDDLPAMDDDDLRRGQMTCHKKFDEATAILAGDALQT
CCCHHHCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
LAFDIISMPNKAITAQAQLKMVNFLAKAAGDHGMCAGQALDLVAENQSVNLVTLQKIHQA
HHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCCCCHHHHHHHHHH
KTGALIKVAIQLAAMTKSDLHEDHFQLLNTFADAIGLAFQVQDDILDIIGDTQTLGKPQG
HCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEHHHHHHHHCCHHHCCCCCC
SDLALHKSTYPALLGLEEAQNKAQALCHEAQLALSQLPYNTELLSKFAQYIIARDR
CCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2089044; 9278503 [H]