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The map label for this gene is lolC [H]

Identifier: 119945863

GI number: 119945863

Start: 2680089

End: 2681315

Strand: Reverse

Name: lolC [H]

Synonym: Ping_2203

Alternate gene names: 119945863

Gene position: 2681315-2680089 (Counterclockwise)

Preceding gene: 119945866

Following gene: 119945862

Centisome position: 58.81

GC content: 41.48

Gene sequence:

>1227_bases
ATGTTCTACCCCCTTAGTGTATTTATCGGCTTGCGCTATACCAAATCAAAGCGTAATAATAAATTTATCTCATTTGTTTC
TTTGTTTTCAACGGGTGGCATTACCTTAGGTGTACTGGCACTGATCACTGTGTTATCTGTTATGAACGGTTTCGAAAATG
AACTGAAAGTAAGAATATTAGGCGCCATTCCGCACGCAATTATTAGTAACCAAGAACAAGTCATTGATGACTGGCAAAGC
CGGCTTCCTGCATTACAGAATATGCCATTAGTCAACACCGTCGAGCCTGTGGTGCGGAGCGAAGCCATTATTCAGAGTAA
TAGAGGCCTGCAGGGAGTGCAACTTGAAGGTATCATACCTGATTTATATGTCAGCAACGTGATTAAAAACAATCTTACTC
TGGGTCAGATGAGTGATTTAAAAGCCGGACAATACAATGTTATTATTGGTCAAAGTTTAGCCCAACAACTGGGTGTCACT
AAAGGTGATAAAATTCGAATTATCTCAGCCAGAGGCAGTCGTTTTACCCCTTTGGGGCGTATCCCCAGTCAGCGAAATTT
TACCGTAATGGGATTGTTTGCCGTTGGATCAGATGTTGATAAACAACTTGTTTTATTACATGCGCAAGACGCTGCACGTT
TAATCAGAATAGGCCTTGATCAGGTGACCGGCTTAAGGCTTTATTTTAATGATGCTTTTGATGTTGAAGATTGGTTGCCG
CCTGTTTTGAAAGAGGGGCAAACGCTGCAGGATTGGCGGCAAACACATGGTGAGTTATTTTCTGCCGTAAAAATGGAAAA
AAATATGATTTGGTTATTGTTATGTCTGATCATTGCAGTTGCCGCATTTAATATACTTTCAGCGTCTGTGATGGTGGTTA
ATGATAAAAATGCGGAAGTGGCCATTTTGAAGACTCTGGGTATTAAAGGCACAACCCTCAACCTTATCTTTATTATTCAA
GGTGCCTGGAGTGGCATTATCGGAGCGCTTGTTGGTACAGGATTGGGGCTGTTGGTGAGTGCATACATCAATGAAATATT
ATCCTTTTTGGGGCTGAACCTGCTCTCTAGTGCATCTGGTGGTACCCGCTTATTACCTGTTTTGTACGAACCAGTGCAGA
TATTTGCTATCATATTTGGTGCTATGTTATTAAGTTTAATGGCGACCTTGTACCCCGCTTATCAAGCCGGGAAAGTCAGC
CCTATAGAGGCATTAAGATATGAATAA

Upstream 100 bases:

>100_bases
ATAATTTTGAATCAAAGCGTTATTTGTCATTTCCTGATTTTTACCGCATTTAACTTTCATTGCCAATGGCAAAATAACAG
CTTAAATAATAAAGGCATTT

Downstream 100 bases:

>100_bases
AGAACTTTTGGTGTGTCGTAATTTAAGTAAAGTTTATGGTGAAGGAAAACTCTCAACCACAGTGTTACATGATGTTGATT
TGTCCGTTAACGCGGGGGAG

Product: lipoprotein releasing system, transmembrane protein, LolC/E family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 408; Mature: 408

Protein sequence:

>408_residues
MFYPLSVFIGLRYTKSKRNNKFISFVSLFSTGGITLGVLALITVLSVMNGFENELKVRILGAIPHAIISNQEQVIDDWQS
RLPALQNMPLVNTVEPVVRSEAIIQSNRGLQGVQLEGIIPDLYVSNVIKNNLTLGQMSDLKAGQYNVIIGQSLAQQLGVT
KGDKIRIISARGSRFTPLGRIPSQRNFTVMGLFAVGSDVDKQLVLLHAQDAARLIRIGLDQVTGLRLYFNDAFDVEDWLP
PVLKEGQTLQDWRQTHGELFSAVKMEKNMIWLLLCLIIAVAAFNILSASVMVVNDKNAEVAILKTLGIKGTTLNLIFIIQ
GAWSGIIGALVGTGLGLLVSAYINEILSFLGLNLLSSASGGTRLLPVLYEPVQIFAIIFGAMLLSLMATLYPAYQAGKVS
PIEALRYE

Sequences:

>Translated_408_residues
MFYPLSVFIGLRYTKSKRNNKFISFVSLFSTGGITLGVLALITVLSVMNGFENELKVRILGAIPHAIISNQEQVIDDWQS
RLPALQNMPLVNTVEPVVRSEAIIQSNRGLQGVQLEGIIPDLYVSNVIKNNLTLGQMSDLKAGQYNVIIGQSLAQQLGVT
KGDKIRIISARGSRFTPLGRIPSQRNFTVMGLFAVGSDVDKQLVLLHAQDAARLIRIGLDQVTGLRLYFNDAFDVEDWLP
PVLKEGQTLQDWRQTHGELFSAVKMEKNMIWLLLCLIIAVAAFNILSASVMVVNDKNAEVAILKTLGIKGTTLNLIFIIQ
GAWSGIIGALVGTGLGLLVSAYINEILSFLGLNLLSSASGGTRLLPVLYEPVQIFAIIFGAMLLSLMATLYPAYQAGKVS
PIEALRYE
>Mature_408_residues
MFYPLSVFIGLRYTKSKRNNKFISFVSLFSTGGITLGVLALITVLSVMNGFENELKVRILGAIPHAIISNQEQVIDDWQS
RLPALQNMPLVNTVEPVVRSEAIIQSNRGLQGVQLEGIIPDLYVSNVIKNNLTLGQMSDLKAGQYNVIIGQSLAQQLGVT
KGDKIRIISARGSRFTPLGRIPSQRNFTVMGLFAVGSDVDKQLVLLHAQDAARLIRIGLDQVTGLRLYFNDAFDVEDWLP
PVLKEGQTLQDWRQTHGELFSAVKMEKNMIWLLLCLIIAVAAFNILSASVMVVNDKNAEVAILKTLGIKGTTLNLIFIIQ
GAWSGIIGALVGTGLGLLVSAYINEILSFLGLNLLSSASGGTRLLPVLYEPVQIFAIIFGAMLLSLMATLYPAYQAGKVS
PIEALRYE

Specific function: Part of an ATP-dependent transport system lolCDE responsible for the release of lipoproteins targeted to the outer membrane from the inner membrane. Such a release is dependent of the sorting-signal (absence of an Asp at position 2 of the mature lipoprote

COG id: COG4591

COG function: function code M; ABC-type transport system, involved in lipoprotein release, permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ABC-4 integral membrane protein family. LolC/E subfamily [H]

Homologues:

Organism=Escherichia coli, GI1787360, Length=416, Percent_Identity=43.9903846153846, Blast_Score=309, Evalue=2e-85,
Organism=Escherichia coli, GI1787362, Length=413, Percent_Identity=30.7506053268765, Blast_Score=181, Evalue=6e-47,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003838
- InterPro:   IPR011925 [H]

Pfam domain/function: PF02687 FtsX [H]

EC number: NA

Molecular weight: Translated: 44586; Mature: 44586

Theoretical pI: Translated: 9.39; Mature: 9.39

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFYPLSVFIGLRYTKSKRNNKFISFVSLFSTGGITLGVLALITVLSVMNGFENELKVRIL
CCCEEEEEEEEEECCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCEEEEEE
GAIPHAIISNQEQVIDDWQSRLPALQNMPLVNTVEPVVRSEAIIQSNRGLQGVQLEGIIP
ECCHHHHHCCHHHHHHHHHHHCCHHHCCCCCHHHHHHHHHHHHHHCCCCCCCEEECCCCC
DLYVSNVIKNNLTLGQMSDLKAGQYNVIIGQSLAQQLGVTKGDKIRIISARGSRFTPLGR
HHHHHHHHHCCCCCCCCCCCCCCCEEEEECHHHHHHHCCCCCCEEEEEECCCCCCCCCCC
IPSQRNFTVMGLFAVGSDVDKQLVLLHAQDAARLIRIGLDQVTGLRLYFNDAFDVEDWLP
CCCCCCEEEEEEEEECCCCCCEEEEEECHHHHHHHHHHHHHHCCEEEEECCCCCHHHCCC
PVLKEGQTLQDWRQTHGELFSAVKMEKNMIWLLLCLIIAVAAFNILSASVMVVNDKNAEV
HHHHCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCEEEEEECCCCCE
AILKTLGIKGTTLNLIFIIQGAWSGIIGALVGTGLGLLVSAYINEILSFLGLNLLSSASG
EEEEECCCCCCEEEEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
GTRLLPVLYEPVQIFAIIFGAMLLSLMATLYPAYQAGKVSPIEALRYE
CCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHCCCCCCHHHHHCCC
>Mature Secondary Structure
MFYPLSVFIGLRYTKSKRNNKFISFVSLFSTGGITLGVLALITVLSVMNGFENELKVRIL
CCCEEEEEEEEEECCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCEEEEEE
GAIPHAIISNQEQVIDDWQSRLPALQNMPLVNTVEPVVRSEAIIQSNRGLQGVQLEGIIP
ECCHHHHHCCHHHHHHHHHHHCCHHHCCCCCHHHHHHHHHHHHHHCCCCCCCEEECCCCC
DLYVSNVIKNNLTLGQMSDLKAGQYNVIIGQSLAQQLGVTKGDKIRIISARGSRFTPLGR
HHHHHHHHHCCCCCCCCCCCCCCCEEEEECHHHHHHHCCCCCCEEEEEECCCCCCCCCCC
IPSQRNFTVMGLFAVGSDVDKQLVLLHAQDAARLIRIGLDQVTGLRLYFNDAFDVEDWLP
CCCCCCEEEEEEEEECCCCCCEEEEEECHHHHHHHHHHHHHHCCEEEEECCCCCHHHCCC
PVLKEGQTLQDWRQTHGELFSAVKMEKNMIWLLLCLIIAVAAFNILSASVMVVNDKNAEV
HHHHCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCEEEEEECCCCCE
AILKTLGIKGTTLNLIFIIQGAWSGIIGALVGTGLGLLVSAYINEILSFLGLNLLSSASG
EEEEECCCCCCEEEEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
GTRLLPVLYEPVQIFAIIFGAMLLSLMATLYPAYQAGKVSPIEALRYE
CCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHCCCCCCHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]