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The map label for this gene is ttcA

Identifier: 119945858

GI number: 119945858

Start: 2674590

End: 2675519

Strand: Direct

Name: ttcA

Synonym: Ping_2198

Alternate gene names: 119945858

Gene position: 2674590-2675519 (Clockwise)

Preceding gene: 119945857

Following gene: 119945859

Centisome position: 58.66

GC content: 39.14

Gene sequence:

>930_bases
ATGTCAGACGTACTTTCAAAAAAACAACAGTTCTCACTAAAAAAACTGAACAAATCTTTACGCAAATCAACAGGTCAAGC
TATTGCTGATTATAATATGATCGAAGAAGGTGACCGGGTGATGGTTTGCTTGTCGGGGGGTAAAGACAGTTTTACCATGC
TTGATATCTTACTTGAGTTACGCGCGGCTGCACCCATACATTTTGAGATTATTGCCGTCAACTTAGATCAAAAACAACCT
GATTTTCCCGAGCATATCCTCCCTGAATATTTACAAAAATTAGGCGTTGATTACAAAATAGTAGAAGAAGACACCTACAG
CATTGTGCAAGATAAAATTCCGGAAGGTAAAACAACCTGCAGTTTATGCTCACGTTTAAGACGCGGCATTTTATACCGGA
CGGCTAAAGAACTAGGCGCGACTAAAATCGCACTTGGACATCATCGAGATGATTTATTAGCGACGCTAATGTTAAATATG
TTTTTTGGCGGTAAATTAAAATCTATGCCGGCAAAACTGGTTTCTGATAATGGAGAACACGTTGTTATCCGCCCATTAGC
CTACTGTAAAGAAAAAGAGATTGAAGCCTACGCAAAACTCAAAGAGTACCCTATTATTCCCTGTAATTTATGTGGTTCAC
AACCCAATTTACAGCGCCAAGTCACCAAGAATATGTTGAACGAGTGGGATGTTAAATTCCCGGGCAGGCTAGAAACGATG
TTTACCGCCATGCAAAATGTTGTTCCTTCGCATCTTTCCGACACTGCTCTTTTTAATTTTAAAGAGATAGATAAAAGTTC
CGGAGTAATTGATGGTGGCGATCTCGCTTTTGATAAAGAACCGATAAAGCATCACACTGAAGACATTACCCCGATCGAAA
CACAATATTATCAACAGCATCAAGCCGTTAAAATAAAACAATTAACTTAG

Upstream 100 bases:

>100_bases
ACTAAATTGCCCGATGCTATGCAAGTCGGGCTTTGCATCTGAAAAATTATTTTTGTACAATGCCCCGCAAATCCTCTGCT
CTCTTTTTCAAGGTTTATTC

Downstream 100 bases:

>100_bases
CGTTAAAAGACGAACTTTCAATCTATTCGTTTTGTTATAGATCATAGTATTATCTCTTAGAAAGCATGATCTGATGTGTT
TCTAAAAAAAAGGTAGGCTT

Product: PP-loop domain-containing protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 309; Mature: 308

Protein sequence:

>309_residues
MSDVLSKKQQFSLKKLNKSLRKSTGQAIADYNMIEEGDRVMVCLSGGKDSFTMLDILLELRAAAPIHFEIIAVNLDQKQP
DFPEHILPEYLQKLGVDYKIVEEDTYSIVQDKIPEGKTTCSLCSRLRRGILYRTAKELGATKIALGHHRDDLLATLMLNM
FFGGKLKSMPAKLVSDNGEHVVIRPLAYCKEKEIEAYAKLKEYPIIPCNLCGSQPNLQRQVTKNMLNEWDVKFPGRLETM
FTAMQNVVPSHLSDTALFNFKEIDKSSGVIDGGDLAFDKEPIKHHTEDITPIETQYYQQHQAVKIKQLT

Sequences:

>Translated_309_residues
MSDVLSKKQQFSLKKLNKSLRKSTGQAIADYNMIEEGDRVMVCLSGGKDSFTMLDILLELRAAAPIHFEIIAVNLDQKQP
DFPEHILPEYLQKLGVDYKIVEEDTYSIVQDKIPEGKTTCSLCSRLRRGILYRTAKELGATKIALGHHRDDLLATLMLNM
FFGGKLKSMPAKLVSDNGEHVVIRPLAYCKEKEIEAYAKLKEYPIIPCNLCGSQPNLQRQVTKNMLNEWDVKFPGRLETM
FTAMQNVVPSHLSDTALFNFKEIDKSSGVIDGGDLAFDKEPIKHHTEDITPIETQYYQQHQAVKIKQLT
>Mature_308_residues
SDVLSKKQQFSLKKLNKSLRKSTGQAIADYNMIEEGDRVMVCLSGGKDSFTMLDILLELRAAAPIHFEIIAVNLDQKQPD
FPEHILPEYLQKLGVDYKIVEEDTYSIVQDKIPEGKTTCSLCSRLRRGILYRTAKELGATKIALGHHRDDLLATLMLNMF
FGGKLKSMPAKLVSDNGEHVVIRPLAYCKEKEIEAYAKLKEYPIIPCNLCGSQPNLQRQVTKNMLNEWDVKFPGRLETMF
TAMQNVVPSHLSDTALFNFKEIDKSSGVIDGGDLAFDKEPIKHHTEDITPIETQYYQQHQAVKIKQLT

Specific function: Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32)

COG id: COG0037

COG function: function code D; Predicted ATPase of the PP-loop superfamily implicated in cell cycle control

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the TtcA family

Homologues:

Organism=Escherichia coli, GI1787606, Length=278, Percent_Identity=72.6618705035971, Blast_Score=449, Evalue=1e-128,
Organism=Caenorhabditis elegans, GI193211090, Length=243, Percent_Identity=32.0987654320988, Blast_Score=130, Evalue=1e-30,
Organism=Caenorhabditis elegans, GI17540090, Length=219, Percent_Identity=25.5707762557078, Blast_Score=75, Evalue=6e-14,
Organism=Drosophila melanogaster, GI24651972, Length=221, Percent_Identity=28.0542986425339, Blast_Score=77, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): TTCA_PSYIN (A1SWS4)

Other databases:

- EMBL:   CP000510
- RefSeq:   YP_943538.1
- ProteinModelPortal:   A1SWS4
- SMR:   A1SWS4
- STRING:   A1SWS4
- GeneID:   4625232
- GenomeReviews:   CP000510_GR
- KEGG:   pin:Ping_2198
- eggNOG:   COG0037
- HOGENOM:   HBG347038
- OMA:   EHILPEY
- PhylomeDB:   A1SWS4
- BioCyc:   PING357804:PING_2198-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01850
- InterPro:   IPR012089
- InterPro:   IPR014729
- InterPro:   IPR011063
- Gene3D:   G3DSA:3.40.50.620
- PIRSF:   PIRSF004976

Pfam domain/function: PF01171 ATP_bind_3

EC number: NA

Molecular weight: Translated: 35004; Mature: 34873

Theoretical pI: Translated: 7.25; Mature: 7.25

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDVLSKKQQFSLKKLNKSLRKSTGQAIADYNMIEEGDRVMVCLSGGKDSFTMLDILLEL
CCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHH
RAAAPIHFEIIAVNLDQKQPDFPEHILPEYLQKLGVDYKIVEEDTYSIVQDKIPEGKTTC
HHCCCEEEEEEEEECCCCCCCCCHHHHHHHHHHHCCCEEEECCHHHHHHHHCCCCCCHHH
SLCSRLRRGILYRTAKELGATKIALGHHRDDLLATLMLNMFFGGKLKSMPAKLVSDNGEH
HHHHHHHHHHHHHHHHHHCCEEEEECCCHHHHHHHHHHHHHHCCCHHHCCHHHHCCCCCE
VVIRPLAYCKEKEIEAYAKLKEYPIIPCNLCGSQPNLQRQVTKNMLNEWDVKFPGRLETM
EEECCHHHHHHHHHHHHHHHHHCCCCCHHCCCCCCCHHHHHHHHHHHHCCCCCCCHHHHH
FTAMQNVVPSHLSDTALFNFKEIDKSSGVIDGGDLAFDKEPIKHHTEDITPIETQYYQQH
HHHHHHHHHHHCCHHHHCCHHHHHCCCCCCCCCCCCCCCCHHHHCCCCCCCCHHHHHHHH
QAVKIKQLT
HCEEEEECC
>Mature Secondary Structure 
SDVLSKKQQFSLKKLNKSLRKSTGQAIADYNMIEEGDRVMVCLSGGKDSFTMLDILLEL
CHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHH
RAAAPIHFEIIAVNLDQKQPDFPEHILPEYLQKLGVDYKIVEEDTYSIVQDKIPEGKTTC
HHCCCEEEEEEEEECCCCCCCCCHHHHHHHHHHHCCCEEEECCHHHHHHHHCCCCCCHHH
SLCSRLRRGILYRTAKELGATKIALGHHRDDLLATLMLNMFFGGKLKSMPAKLVSDNGEH
HHHHHHHHHHHHHHHHHHCCEEEEECCCHHHHHHHHHHHHHHCCCHHHCCHHHHCCCCCE
VVIRPLAYCKEKEIEAYAKLKEYPIIPCNLCGSQPNLQRQVTKNMLNEWDVKFPGRLETM
EEECCHHHHHHHHHHHHHHHHHCCCCCHHCCCCCCCHHHHHHHHHHHHCCCCCCCHHHHH
FTAMQNVVPSHLSDTALFNFKEIDKSSGVIDGGDLAFDKEPIKHHTEDITPIETQYYQQH
HHHHHHHHHHHCCHHHHCCHHHHHCCCCCCCCCCCCCCCCHHHHCCCCCCCCHHHHHHHH
QAVKIKQLT
HCEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA