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The map label for this gene is galK [H]

Identifier: 119945700

GI number: 119945700

Start: 2455103

End: 2456266

Strand: Direct

Name: galK [H]

Synonym: Ping_2017

Alternate gene names: 119945700

Gene position: 2455103-2456266 (Clockwise)

Preceding gene: 119945699

Following gene: 119945701

Centisome position: 53.84

GC content: 43.21

Gene sequence:

>1164_bases
ATGATGATTAGTTTAATTGAAAATGTAAAAAATGCTTTTATTAAGCAGTTTAATTACTTAGCAACGGACATTATTCAAGC
ACCGGGCCGGGTTAATTTAATCGGTGAGCACACGGATTATAATGACGGATTTGTTTTACCCTGCGCCATTAACTATCAAA
CTATGGTGGCTGCCGCTAAGCGTGAAGACAATATAGTGCGCGTTATTTCTGTTGATTACGGCAATGCGATCGATAGCTTT
GATATAACACAACCGATTGAATTTAATAAAGATAAAATGTGGGCTAATTATGTGCGGGGCGTGGTTAAATTTTTGCTCTC
CAGAGGATTTAAATTTCAAGGTGCGGATATTGTGGTCAGCGGCAATGTCCCTCAGGGTGCGGGCTTAAGCTCATCGGCTT
CATTAGAAGTGGTGATTGGGCAAACATTTAAAACACTCTATGACCTTGATATTAGTCAGGCAGAAGTCGCATTAAACGGT
CAGCAGGCAGAAAATGAATTTGTAGGCTGTAATTGCGGCATTATGGATCAGCTTATTTCCGCGCAGGGCAAAAAAAATCA
CGCGCTGTTAATTGATTGTCGTTCACTGCAGACAAAAGCGGTTTCTATGCCGGAAAATTTATCGATAGTGATTATTAACT
CCAATAAAAGACGCGGTCTAGTGGACAGTGAATACAATACACGACGACTTCAATGTGAAGAAGCTGCACGCGTATTCGGC
GTGAAGGCGTTACGCGATCTGAGTATTGAGCAGTTTAATGCGCGTATTGCAGAATTAGATGAAGTTGTCGCAAAACGTGC
GCGTCATGTTATCACCGAAAATGCACGTACATTACAGGCAGCACAAGCTTTAAGTGAAAATAATATTAGCCTAATGGGCA
AGTTAATGGCGGAATCCCATGCCTCTATGCGCGATGATTTCGCCATTACAGTCGCCGAAATCGATAAACTGGTTGATATT
GTGAAAACAGAAATTGGGGATCAAGGTGGTGTCCGTATGACCGGGGGCGGGTTTGGTGGCTGCATTGTGGCCTTGATCCC
AAGTGAACTGGTTGATGGTGTGAAAGCGGCCGTGGTTAGTCAGTACTCTGCAGCGACAGGATTAGACGCGTCTATTTATG
TTTGCAATGCAAGTGTGGGCGCGGGCATTGTCTTAGAAAAATGA

Upstream 100 bases:

>100_bases
CTCAAAAATTACGTGATGTAAGTGATATTCATTACCTGGAAAGTTAGTACAAAAATAATAACAAAAAACGTGTTTTTGAA
GCCTTTATAATTGAGAGAAA

Downstream 100 bases:

>100_bases
CAAATGAAGAGTGAAAAGTAATTTAACAAAAAAAGTAATATGACAGAGAAACAATATGACCCTAAGTCGAGCAGAACAGT
TACAGAAAAGCATGAGTATT

Product: galactokinase

Products: NA

Alternate protein names: Galactose kinase [H]

Number of amino acids: Translated: 387; Mature: 387

Protein sequence:

>387_residues
MMISLIENVKNAFIKQFNYLATDIIQAPGRVNLIGEHTDYNDGFVLPCAINYQTMVAAAKREDNIVRVISVDYGNAIDSF
DITQPIEFNKDKMWANYVRGVVKFLLSRGFKFQGADIVVSGNVPQGAGLSSSASLEVVIGQTFKTLYDLDISQAEVALNG
QQAENEFVGCNCGIMDQLISAQGKKNHALLIDCRSLQTKAVSMPENLSIVIINSNKRRGLVDSEYNTRRLQCEEAARVFG
VKALRDLSIEQFNARIAELDEVVAKRARHVITENARTLQAAQALSENNISLMGKLMAESHASMRDDFAITVAEIDKLVDI
VKTEIGDQGGVRMTGGGFGGCIVALIPSELVDGVKAAVVSQYSAATGLDASIYVCNASVGAGIVLEK

Sequences:

>Translated_387_residues
MMISLIENVKNAFIKQFNYLATDIIQAPGRVNLIGEHTDYNDGFVLPCAINYQTMVAAAKREDNIVRVISVDYGNAIDSF
DITQPIEFNKDKMWANYVRGVVKFLLSRGFKFQGADIVVSGNVPQGAGLSSSASLEVVIGQTFKTLYDLDISQAEVALNG
QQAENEFVGCNCGIMDQLISAQGKKNHALLIDCRSLQTKAVSMPENLSIVIINSNKRRGLVDSEYNTRRLQCEEAARVFG
VKALRDLSIEQFNARIAELDEVVAKRARHVITENARTLQAAQALSENNISLMGKLMAESHASMRDDFAITVAEIDKLVDI
VKTEIGDQGGVRMTGGGFGGCIVALIPSELVDGVKAAVVSQYSAATGLDASIYVCNASVGAGIVLEK
>Mature_387_residues
MMISLIENVKNAFIKQFNYLATDIIQAPGRVNLIGEHTDYNDGFVLPCAINYQTMVAAAKREDNIVRVISVDYGNAIDSF
DITQPIEFNKDKMWANYVRGVVKFLLSRGFKFQGADIVVSGNVPQGAGLSSSASLEVVIGQTFKTLYDLDISQAEVALNG
QQAENEFVGCNCGIMDQLISAQGKKNHALLIDCRSLQTKAVSMPENLSIVIINSNKRRGLVDSEYNTRRLQCEEAARVFG
VKALRDLSIEQFNARIAELDEVVAKRARHVITENARTLQAAQALSENNISLMGKLMAESHASMRDDFAITVAEIDKLVDI
VKTEIGDQGGVRMTGGGFGGCIVALIPSELVDGVKAAVVSQYSAATGLDASIYVCNASVGAGIVLEK

Specific function: Galactose metabolism; first step. [C]

COG id: COG0153

COG function: function code G; Galactokinase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GHMP kinase family. GalK subfamily [H]

Homologues:

Organism=Homo sapiens, GI4503895, Length=390, Percent_Identity=40.2564102564103, Blast_Score=273, Evalue=1e-73,
Organism=Homo sapiens, GI48527957, Length=421, Percent_Identity=28.2660332541568, Blast_Score=134, Evalue=2e-31,
Organism=Homo sapiens, GI4503897, Length=421, Percent_Identity=28.2660332541568, Blast_Score=134, Evalue=2e-31,
Organism=Escherichia coli, GI1786972, Length=380, Percent_Identity=65, Blast_Score=514, Evalue=1e-147,
Organism=Caenorhabditis elegans, GI71989053, Length=416, Percent_Identity=27.8846153846154, Blast_Score=120, Evalue=2e-27,
Organism=Saccharomyces cerevisiae, GI6320212, Length=267, Percent_Identity=27.7153558052434, Blast_Score=81, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6319494, Length=265, Percent_Identity=27.5471698113208, Blast_Score=79, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24661292, Length=413, Percent_Identity=25.90799031477, Blast_Score=98, Evalue=1e-20,
Organism=Drosophila melanogaster, GI21355577, Length=413, Percent_Identity=25.90799031477, Blast_Score=98, Evalue=1e-20,
Organism=Drosophila melanogaster, GI24661285, Length=413, Percent_Identity=25.90799031477, Blast_Score=98, Evalue=1e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000705
- InterPro:   IPR022963
- InterPro:   IPR019741
- InterPro:   IPR019539
- InterPro:   IPR006204
- InterPro:   IPR013750
- InterPro:   IPR006203
- InterPro:   IPR006206
- InterPro:   IPR020568
- InterPro:   IPR014721 [H]

Pfam domain/function: PF10509 GalKase_gal_bdg; PF08544 GHMP_kinases_C; PF00288 GHMP_kinases_N [H]

EC number: =2.7.1.6 [H]

Molecular weight: Translated: 41908; Mature: 41908

Theoretical pI: Translated: 5.01; Mature: 5.01

Prosite motif: PS00106 GALACTOKINASE ; PS00627 GHMP_KINASES_ATP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMISLIENVKNAFIKQFNYLATDIIQAPGRVNLIGEHTDYNDGFVLPCAINYQTMVAAAK
CCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCEEEEEEECHHHHHHHHH
REDNIVRVISVDYGNAIDSFDITQPIEFNKDKMWANYVRGVVKFLLSRGFKFQGADIVVS
CCCCEEEEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCEECCCEEEEE
GNVPQGAGLSSSASLEVVIGQTFKTLYDLDISQAEVALNGQQAENEFVGCNCGIMDQLIS
CCCCCCCCCCCCCCEEEEECHHHHHHHHCCCCCEEEEECCCCCCCCEECCCCCHHHHHHH
AQGKKNHALLIDCRSLQTKAVSMPENLSIVIINSNKRRGLVDSEYNTRRLQCEEAARVFG
CCCCCCCEEEEEECCCCHHHCCCCCCCEEEEEECCCCCCCCCCCCCCCCEEHHHHHHHHH
VKALRDLSIEQFNARIAELDEVVAKRARHVITENARTLQAAQALSENNISLMGKLMAESH
HHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCHHHHHHHHHHHH
ASMRDDFAITVAEIDKLVDIVKTEIGDQGGVRMTGGGFGGCIVALIPSELVDGVKAAVVS
CCCCCCCEEEHHHHHHHHHHHHHHCCCCCCEEEECCCCCCHHEEECCHHHHHHHHHHHHH
QYSAATGLDASIYVCNASVGAGIVLEK
HHHHHCCCCCEEEEEECCCCCCEEEEC
>Mature Secondary Structure
MMISLIENVKNAFIKQFNYLATDIIQAPGRVNLIGEHTDYNDGFVLPCAINYQTMVAAAK
CCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCEEEEEEECHHHHHHHHH
REDNIVRVISVDYGNAIDSFDITQPIEFNKDKMWANYVRGVVKFLLSRGFKFQGADIVVS
CCCCEEEEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCEECCCEEEEE
GNVPQGAGLSSSASLEVVIGQTFKTLYDLDISQAEVALNGQQAENEFVGCNCGIMDQLIS
CCCCCCCCCCCCCCEEEEECHHHHHHHHCCCCCEEEEECCCCCCCCEECCCCCHHHHHHH
AQGKKNHALLIDCRSLQTKAVSMPENLSIVIINSNKRRGLVDSEYNTRRLQCEEAARVFG
CCCCCCCEEEEEECCCCHHHCCCCCCCEEEEEECCCCCCCCCCCCCCCCEEHHHHHHHHH
VKALRDLSIEQFNARIAELDEVVAKRARHVITENARTLQAAQALSENNISLMGKLMAESH
HHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCHHHHHHHHHHHH
ASMRDDFAITVAEIDKLVDIVKTEIGDQGGVRMTGGGFGGCIVALIPSELVDGVKAAVVS
CCCCCCCEEEHHHHHHHHHHHHHHCCCCCCEEEECCCCCCHHEEECCHHHHHHHHHHHHH
QYSAATGLDASIYVCNASVGAGIVLEK
HHHHHCCCCCEEEEEECCCCCCEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA