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The map label for this gene is fabB [H]

Identifier: 119945679

GI number: 119945679

Start: 2424993

End: 2426207

Strand: Reverse

Name: fabB [H]

Synonym: Ping_1995

Alternate gene names: 119945679

Gene position: 2426207-2424993 (Counterclockwise)

Preceding gene: 119945686

Following gene: 119945678

Centisome position: 53.21

GC content: 42.8

Gene sequence:

>1215_bases
ATGAAAAGAGCAGTAATTACAGGTATTGGTATTGTTTCTAGTATTGGTAACAACAAAGAAGAAGTTTTAGCGTCACTTAA
AAGCGGCAAATCAGGCATCAGCTTCTCGGAGCAATTTGCTGAGATGAAAATGCGCAGTCAGGTTTGGGGCGATCTAAAAA
TTGAGCCTAAAGATCATATTGACCGTAAAATCATGCGTTTTATGGGTGATGCTGCTGCTTATGCTTATCTTTCTATGGAA
CAAGCTATTGCCGATGCGCAGTTAACCGATGACCTGGTGTCTAATGAACGTACTGGTTTAGTGGCTGGATCCGGCGGTGG
TTCTTCTAAAAATCAGGTTGAAGCCTGCAAACTGATGGTTGAAAAAGGCGTACGTCGTGTCGGTCCTTATATGGTCCCTC
GTACGATGGCGAGCACAACATCTGCCTGTCTCGCAACCCCGTTCAAAATTAAAGGTATTAACTATTCAATGAGCAGCGCT
TGTGCAACCAGCTCTCACTGTATTGGTAATGCACTGGAACAAATTCAATTAGGTAAACAGGATATTGTGTTTGCTGGTGG
TGGTGAAGAATTAGACTGGACTATGGCATGCGAATTTGATGCGATGGGTGCACTATCAAGCAAATTTAATGACACACCTT
CTAGCGCATCGCGAACTTATGATGCAAAGCGCGATGGTTTTGTTATTTCTGGCGGTGGCGGTATGGTTGTGGTTGAAGAG
CTTGAGCATGCTTTAGCGCGTGGCGCAAAAATTTATGCGGAGATTGTGGGCTACGGCGCAACATCTGATGGCTATGATAT
GGTTGCACCCTCGGGTGAAGGTGCTGTGCGCTGTATGCGTCAAGCACTTGCAACCGTTGATGGTGAGGTTGATTACTTAA
ATACACACGGTACTTCGACCCCCGTTGGTGATACTAAAGAATTAGAAGCTATTAATATTGTATTTCCTGATAAAGCGCCA
AAAATCAGTGCAACTAAATCTCAAACAGGTCATTCACTTGGCGCCGCGGGTGTTCATGAAACAATCTATAGTTTGCTAAT
GATGGAAAATGATTTTATTTCACCTTCTATTAATATTGATGAGATAGATGAAAAAGCGGTGAATCTACCGATCGTGGCCA
ATAAGGCTGTTGATGCAAAACTAAACATTGTAATGTCCAATAGTTTTGGTTTTGGTGGCACTAACGCAACATTAGTTTTC
AAACGTTTCTCTTAG

Upstream 100 bases:

>100_bases
TTAATGCGATAATTTAGTTTAATTTATTAGAGTTTAATTGATCTATTACACTCCTTAGATCCATCATATAATTAGTCCCT
CTAGCAATAAAGGCTTAAAA

Downstream 100 bases:

>100_bases
TTAGTAGTTTAAGACTGATAAAAATAATAGTTTAATACTGATAAAAAACAAAAAAAGGAGCTTTTAGCTCCTTTTTTTGT
CGCAATTTATTCTGCTATCT

Product: beta-ketoacyl synthase

Products: NA

Alternate protein names: 3-oxoacyl-[acyl-carrier-protein] synthase I; Beta-ketoacyl-ACP synthase I; KAS I [H]

Number of amino acids: Translated: 404; Mature: 404

Protein sequence:

>404_residues
MKRAVITGIGIVSSIGNNKEEVLASLKSGKSGISFSEQFAEMKMRSQVWGDLKIEPKDHIDRKIMRFMGDAAAYAYLSME
QAIADAQLTDDLVSNERTGLVAGSGGGSSKNQVEACKLMVEKGVRRVGPYMVPRTMASTTSACLATPFKIKGINYSMSSA
CATSSHCIGNALEQIQLGKQDIVFAGGGEELDWTMACEFDAMGALSSKFNDTPSSASRTYDAKRDGFVISGGGGMVVVEE
LEHALARGAKIYAEIVGYGATSDGYDMVAPSGEGAVRCMRQALATVDGEVDYLNTHGTSTPVGDTKELEAINIVFPDKAP
KISATKSQTGHSLGAAGVHETIYSLLMMENDFISPSINIDEIDEKAVNLPIVANKAVDAKLNIVMSNSFGFGGTNATLVF
KRFS

Sequences:

>Translated_404_residues
MKRAVITGIGIVSSIGNNKEEVLASLKSGKSGISFSEQFAEMKMRSQVWGDLKIEPKDHIDRKIMRFMGDAAAYAYLSME
QAIADAQLTDDLVSNERTGLVAGSGGGSSKNQVEACKLMVEKGVRRVGPYMVPRTMASTTSACLATPFKIKGINYSMSSA
CATSSHCIGNALEQIQLGKQDIVFAGGGEELDWTMACEFDAMGALSSKFNDTPSSASRTYDAKRDGFVISGGGGMVVVEE
LEHALARGAKIYAEIVGYGATSDGYDMVAPSGEGAVRCMRQALATVDGEVDYLNTHGTSTPVGDTKELEAINIVFPDKAP
KISATKSQTGHSLGAAGVHETIYSLLMMENDFISPSINIDEIDEKAVNLPIVANKAVDAKLNIVMSNSFGFGGTNATLVF
KRFS
>Mature_404_residues
MKRAVITGIGIVSSIGNNKEEVLASLKSGKSGISFSEQFAEMKMRSQVWGDLKIEPKDHIDRKIMRFMGDAAAYAYLSME
QAIADAQLTDDLVSNERTGLVAGSGGGSSKNQVEACKLMVEKGVRRVGPYMVPRTMASTTSACLATPFKIKGINYSMSSA
CATSSHCIGNALEQIQLGKQDIVFAGGGEELDWTMACEFDAMGALSSKFNDTPSSASRTYDAKRDGFVISGGGGMVVVEE
LEHALARGAKIYAEIVGYGATSDGYDMVAPSGEGAVRCMRQALATVDGEVDYLNTHGTSTPVGDTKELEAINIVFPDKAP
KISATKSQTGHSLGAAGVHETIYSLLMMENDFISPSINIDEIDEKAVNLPIVANKAVDAKLNIVMSNSFGFGGTNATLVF
KRFS

Specific function: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Specific for elongation from C-10 to unsaturated C-16 and C-18 fatty acids [H]

COG id: COG0304

COG function: function code IQ; 3-oxoacyl-(acyl-carrier-protein) synthase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the beta-ketoacyl-ACP synthases family [H]

Homologues:

Organism=Homo sapiens, GI8923559, Length=420, Percent_Identity=34.2857142857143, Blast_Score=208, Evalue=8e-54,
Organism=Homo sapiens, GI223972627, Length=138, Percent_Identity=44.2028985507246, Blast_Score=99, Evalue=6e-21,
Organism=Homo sapiens, GI41872631, Length=339, Percent_Identity=25.9587020648968, Blast_Score=91, Evalue=2e-18,
Organism=Escherichia coli, GI1788663, Length=405, Percent_Identity=70.6172839506173, Blast_Score=583, Evalue=1e-168,
Organism=Escherichia coli, GI1787337, Length=412, Percent_Identity=38.1067961165049, Blast_Score=248, Evalue=3e-67,
Organism=Caenorhabditis elegans, GI71983541, Length=413, Percent_Identity=36.8038740920097, Blast_Score=219, Evalue=3e-57,
Organism=Caenorhabditis elegans, GI71983535, Length=258, Percent_Identity=43.4108527131783, Blast_Score=178, Evalue=6e-45,
Organism=Caenorhabditis elegans, GI212642053, Length=342, Percent_Identity=25.7309941520468, Blast_Score=96, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI17550940, Length=360, Percent_Identity=25.8333333333333, Blast_Score=92, Evalue=5e-19,
Organism=Saccharomyces cerevisiae, GI6320904, Length=445, Percent_Identity=31.0112359550562, Blast_Score=193, Evalue=3e-50,
Organism=Drosophila melanogaster, GI24644341, Length=416, Percent_Identity=35.5769230769231, Blast_Score=246, Evalue=2e-65,
Organism=Drosophila melanogaster, GI19920632, Length=336, Percent_Identity=27.6785714285714, Blast_Score=101, Evalue=1e-21,
Organism=Drosophila melanogaster, GI221330659, Length=336, Percent_Identity=27.6785714285714, Blast_Score=100, Evalue=1e-21,
Organism=Drosophila melanogaster, GI24581345, Length=269, Percent_Identity=26.3940520446097, Blast_Score=80, Evalue=2e-15,

Paralogues:

None

Copy number: 24024 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 30,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000794
- InterPro:   IPR018201
- InterPro:   IPR014031
- InterPro:   IPR014030
- InterPro:   IPR016039
- InterPro:   IPR016038 [H]

Pfam domain/function: PF00109 ketoacyl-synt; PF02801 Ketoacyl-synt_C [H]

EC number: =2.3.1.41 [H]

Molecular weight: Translated: 42902; Mature: 42902

Theoretical pI: Translated: 5.15; Mature: 5.15

Prosite motif: PS00606 B_KETOACYL_SYNTHASE ; PS00639 THIOL_PROTEASE_HIS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
4.5 %Met     (Translated Protein)
5.9 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
4.5 %Met     (Mature Protein)
5.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRAVITGIGIVSSIGNNKEEVLASLKSGKSGISFSEQFAEMKMRSQVWGDLKIEPKDHI
CCCEEEEHHHHHHHCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCEEECCHHHH
DRKIMRFMGDAAAYAYLSMEQAIADAQLTDDLVSNERTGLVAGSGGGSSKNQVEACKLMV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCHHHHHHHHHH
EKGVRRVGPYMVPRTMASTTSACLATPFKIKGINYSMSSACATSSHCIGNALEQIQLGKQ
HHHHHHHCCCCCCHHHHHHHHHHHCCCEEEECCCCCHHHHHCCCHHHHHHHHHHHHCCCC
DIVFAGGGEELDWTMACEFDAMGALSSKFNDTPSSASRTYDAKRDGFVISGGGGMVVVEE
EEEEECCCCCCCEEEEECCHHHHHHHHHCCCCCCCHHHCCCCCCCCEEEECCCCEEEHHH
LEHALARGAKIYAEIVGYGATSDGYDMVAPSGEGAVRCMRQALATVDGEVDYLNTHGTST
HHHHHHCCHHEEEHHHCCCCCCCCCEEECCCCCHHHHHHHHHHHHCCCCEEEEECCCCCC
PVGDTKELEAINIVFPDKAPKISATKSQTGHSLGAAGVHETIYSLLMMENDFISPSINID
CCCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCHH
EIDEKAVNLPIVANKAVDAKLNIVMSNSFGFGGTNATLVFKRFS
HHHHHHCCCCEEECCCCCEEEEEEEECCCCCCCCCEEEEEEECC
>Mature Secondary Structure
MKRAVITGIGIVSSIGNNKEEVLASLKSGKSGISFSEQFAEMKMRSQVWGDLKIEPKDHI
CCCEEEEHHHHHHHCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCEEECCHHHH
DRKIMRFMGDAAAYAYLSMEQAIADAQLTDDLVSNERTGLVAGSGGGSSKNQVEACKLMV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCHHHHHHHHHH
EKGVRRVGPYMVPRTMASTTSACLATPFKIKGINYSMSSACATSSHCIGNALEQIQLGKQ
HHHHHHHCCCCCCHHHHHHHHHHHCCCEEEECCCCCHHHHHCCCHHHHHHHHHHHHCCCC
DIVFAGGGEELDWTMACEFDAMGALSSKFNDTPSSASRTYDAKRDGFVISGGGGMVVVEE
EEEEECCCCCCCEEEEECCHHHHHHHHHCCCCCCCHHHCCCCCCCCEEEECCCCEEEHHH
LEHALARGAKIYAEIVGYGATSDGYDMVAPSGEGAVRCMRQALATVDGEVDYLNTHGTST
HHHHHHCCHHEEEHHHCCCCCCCCCEEECCCCCHHHHHHHHHHHHCCCCEEEEECCCCCC
PVGDTKELEAINIVFPDKAPKISATKSQTGHSLGAAGVHETIYSLLMMENDFISPSINID
CCCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCHH
EIDEKAVNLPIVANKAVDAKLNIVMSNSFGFGGTNATLVFKRFS
HHHHHHCCCCEEECCCCCEEEEEEEECCCCCCCCCEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]