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The map label for this gene is bioA [H]

Identifier: 119945616

GI number: 119945616

Start: 2351178

End: 2352461

Strand: Direct

Name: bioA [H]

Synonym: Ping_1925

Alternate gene names: 119945616

Gene position: 2351178-2352461 (Clockwise)

Preceding gene: 119945608

Following gene: 119945617

Centisome position: 51.57

GC content: 44.24

Gene sequence:

>1284_bases
ATGAGCCTTGACCTGCAATATGATAATAAACATTTATGGCATCCCTATACCTCAATGATTAATCCACTGCCCTGTTACGC
GGTTGTTTCGGCAGATAAATGCTTATTGACCCTGGATAATGGCAAGCAATTAATTGATGGTATGTCATCCTGGTGGGCCT
GTTTATTTGGTTATAATGTGCCGGAATTAAACACTGCCGCAAAACAGCAAATTGATAAAATGTCGCACGTTATGTTTGGC
GGCTTAACCCATCAACCTGCTATTGATCTAGCTAAAAAATTAGTGGCAATTACCCCCGCAGGATTGGAGAAAGTTTTTTT
ATCGGATTCGGGCAGCGTCAGTGTCGAAGTGGCTTTGAAAATGGCCTTGCAATATTGGCACGCATTAGAAAAACCTAAAA
GCCAATTTTTAACTGTGCGCAATGGTTATCATGGTGATACTTTTGGCGCAATGAGTGTGACTGACCCCGAAGGCTCTATG
CATGAGCTTTATCATGACTTTTTAGCCAAACAGTTATTTGCCCCTCAACCAGGGATTGCCTTTGACCAGCCTTGGGATGC
TACTGCACTTGATGAAATCACCCTGCTGGTTGAAAATAATCAAGCCAATATTGCGGCTATTATTCTCGAACCTATAGTGC
AGGGCGCGGGTGGGATGTATTTTTACCACAGTGAGTATTTAAAAGGCGTTCGGGCGCTGTGTGATAAATATGAGCTGTTA
TTGATTGCCGATGAAATTGCAACGGGTTTTGGCCGTACCGGTAAACTCTTTGCCTGTGAACATGCCGATATCAGTCCCGA
TATTATCTGTGTCGGTAAAGCCATTACCGGCGGTTATATGAGTTTAGCGGCGACTTTAGCCACTTCCGAAATAGCCGAAA
CCATCAGCCGCGGTAAAGCCGGAGTATTTATGCACGGGCCGACCTTTATGGGCAATCCGCTTGCCTGTGCCGTGGCCAAT
GCAAATATTGAGAAACTCTTAGCCTTCGACTGGCAAACAACCGTATTAAACATTGAGACAAGCTTAAAGCATTATCTGGC
TCCCTGCATCGAACTTGAGCAGGTGAAGTCTGTTCGTGTGCTGGGTGCAATCGGGGTTGTAGAACTTAAAAAAGCAGTCG
ATGTCGCCATAGTGCAGAAAAAATTTGTAGAGCTTGGAGTGTGGATACGGCCCTTTGGCAAGCTTATTTATATTATGCCC
CCCTATATTATTACCCCAGAGCAGTTACAACTATTGTGCCACGCCATTTACAGCATTATTAATGAAGAAGCAGTTGAGCT
GTAA

Upstream 100 bases:

>100_bases
CTTTAATTGCCCTTAAATTGTTTGGTTAGTTTAATGTGGAAAGATACACTGTCAACTTTTACGAGATTATATCTTTACAT
CTGACTAATAAGTGACCGTT

Downstream 100 bases:

>100_bases
AAAACGACTTCCCGTATTTTTAAAGCAGAAGATTAAGCAGGTGATCAGTAAAAATGAGGAGTAATTAACTGATTATTAAT
AAATTCTGTTTTTATCATTC

Product: adenosylmethionine-8-amino-7-oxononanoate aminotransferase

Products: NA

Alternate protein names: 7,8-diamino-pelargonic acid aminotransferase; DAPA AT; DAPA aminotransferase; Diaminopelargonic acid synthase [H]

Number of amino acids: Translated: 427; Mature: 426

Protein sequence:

>427_residues
MSLDLQYDNKHLWHPYTSMINPLPCYAVVSADKCLLTLDNGKQLIDGMSSWWACLFGYNVPELNTAAKQQIDKMSHVMFG
GLTHQPAIDLAKKLVAITPAGLEKVFLSDSGSVSVEVALKMALQYWHALEKPKSQFLTVRNGYHGDTFGAMSVTDPEGSM
HELYHDFLAKQLFAPQPGIAFDQPWDATALDEITLLVENNQANIAAIILEPIVQGAGGMYFYHSEYLKGVRALCDKYELL
LIADEIATGFGRTGKLFACEHADISPDIICVGKAITGGYMSLAATLATSEIAETISRGKAGVFMHGPTFMGNPLACAVAN
ANIEKLLAFDWQTTVLNIETSLKHYLAPCIELEQVKSVRVLGAIGVVELKKAVDVAIVQKKFVELGVWIRPFGKLIYIMP
PYIITPEQLQLLCHAIYSIINEEAVEL

Sequences:

>Translated_427_residues
MSLDLQYDNKHLWHPYTSMINPLPCYAVVSADKCLLTLDNGKQLIDGMSSWWACLFGYNVPELNTAAKQQIDKMSHVMFG
GLTHQPAIDLAKKLVAITPAGLEKVFLSDSGSVSVEVALKMALQYWHALEKPKSQFLTVRNGYHGDTFGAMSVTDPEGSM
HELYHDFLAKQLFAPQPGIAFDQPWDATALDEITLLVENNQANIAAIILEPIVQGAGGMYFYHSEYLKGVRALCDKYELL
LIADEIATGFGRTGKLFACEHADISPDIICVGKAITGGYMSLAATLATSEIAETISRGKAGVFMHGPTFMGNPLACAVAN
ANIEKLLAFDWQTTVLNIETSLKHYLAPCIELEQVKSVRVLGAIGVVELKKAVDVAIVQKKFVELGVWIRPFGKLIYIMP
PYIITPEQLQLLCHAIYSIINEEAVEL
>Mature_426_residues
SLDLQYDNKHLWHPYTSMINPLPCYAVVSADKCLLTLDNGKQLIDGMSSWWACLFGYNVPELNTAAKQQIDKMSHVMFGG
LTHQPAIDLAKKLVAITPAGLEKVFLSDSGSVSVEVALKMALQYWHALEKPKSQFLTVRNGYHGDTFGAMSVTDPEGSMH
ELYHDFLAKQLFAPQPGIAFDQPWDATALDEITLLVENNQANIAAIILEPIVQGAGGMYFYHSEYLKGVRALCDKYELLL
IADEIATGFGRTGKLFACEHADISPDIICVGKAITGGYMSLAATLATSEIAETISRGKAGVFMHGPTFMGNPLACAVANA
NIEKLLAFDWQTTVLNIETSLKHYLAPCIELEQVKSVRVLGAIGVVELKKAVDVAIVQKKFVELGVWIRPFGKLIYIMPP
YIITPEQLQLLCHAIYSIINEEAVEL

Specific function: Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor [H]

COG id: COG0161

COG function: function code H; Adenosylmethionine-8-amino-7-oxononanoate aminotransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily [H]

Homologues:

Organism=Homo sapiens, GI4557809, Length=380, Percent_Identity=28.9473684210526, Blast_Score=130, Evalue=3e-30,
Organism=Homo sapiens, GI284507298, Length=309, Percent_Identity=30.42071197411, Blast_Score=119, Evalue=5e-27,
Organism=Homo sapiens, GI13994255, Length=361, Percent_Identity=26.8698060941828, Blast_Score=104, Evalue=2e-22,
Organism=Homo sapiens, GI37574042, Length=431, Percent_Identity=25.9860788863109, Blast_Score=93, Evalue=5e-19,
Organism=Homo sapiens, GI226442705, Length=434, Percent_Identity=25.3456221198157, Blast_Score=88, Evalue=2e-17,
Organism=Homo sapiens, GI226442709, Length=375, Percent_Identity=26.9333333333333, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI188536080, Length=281, Percent_Identity=24.1992882562278, Blast_Score=69, Evalue=8e-12,
Organism=Homo sapiens, GI38679950, Length=281, Percent_Identity=24.1992882562278, Blast_Score=69, Evalue=8e-12,
Organism=Homo sapiens, GI38679946, Length=281, Percent_Identity=24.1992882562278, Blast_Score=69, Evalue=8e-12,
Organism=Escherichia coli, GI1786991, Length=420, Percent_Identity=62.6190476190476, Blast_Score=543, Evalue=1e-156,
Organism=Escherichia coli, GI145693181, Length=292, Percent_Identity=37.3287671232877, Blast_Score=166, Evalue=2e-42,
Organism=Escherichia coli, GI1789759, Length=400, Percent_Identity=29.5, Blast_Score=142, Evalue=3e-35,
Organism=Escherichia coli, GI1788044, Length=308, Percent_Identity=33.7662337662338, Blast_Score=141, Evalue=9e-35,
Organism=Escherichia coli, GI1789016, Length=350, Percent_Identity=30.5714285714286, Blast_Score=132, Evalue=6e-32,
Organism=Escherichia coli, GI1787560, Length=295, Percent_Identity=29.1525423728814, Blast_Score=119, Evalue=5e-28,
Organism=Escherichia coli, GI1786349, Length=331, Percent_Identity=25.3776435045317, Blast_Score=80, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI25144271, Length=414, Percent_Identity=28.5024154589372, Blast_Score=122, Evalue=3e-28,
Organism=Caenorhabditis elegans, GI25144274, Length=225, Percent_Identity=34.6666666666667, Blast_Score=115, Evalue=5e-26,
Organism=Caenorhabditis elegans, GI32564660, Length=433, Percent_Identity=27.0207852193995, Blast_Score=103, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI17541228, Length=279, Percent_Identity=26.1648745519713, Blast_Score=76, Evalue=4e-14,
Organism=Saccharomyces cerevisiae, GI6324386, Length=459, Percent_Identity=45.7516339869281, Blast_Score=395, Evalue=1e-111,
Organism=Saccharomyces cerevisiae, GI6323470, Length=440, Percent_Identity=30, Blast_Score=132, Evalue=1e-31,
Organism=Saccharomyces cerevisiae, GI6324432, Length=384, Percent_Identity=28.90625, Blast_Score=120, Evalue=4e-28,
Organism=Saccharomyces cerevisiae, GI6321456, Length=333, Percent_Identity=26.1261261261261, Blast_Score=78, Evalue=3e-15,
Organism=Drosophila melanogaster, GI21357415, Length=412, Percent_Identity=29.126213592233, Blast_Score=140, Evalue=1e-33,
Organism=Drosophila melanogaster, GI28574759, Length=415, Percent_Identity=28.433734939759, Blast_Score=100, Evalue=4e-21,
Organism=Drosophila melanogaster, GI161085790, Length=367, Percent_Identity=29.1553133514986, Blast_Score=99, Evalue=6e-21,
Organism=Drosophila melanogaster, GI21356575, Length=346, Percent_Identity=26.3005780346821, Blast_Score=81, Evalue=2e-15,
Organism=Drosophila melanogaster, GI281366494, Length=278, Percent_Identity=26.2589928057554, Blast_Score=78, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24667139, Length=278, Percent_Identity=26.2589928057554, Blast_Score=78, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24667143, Length=278, Percent_Identity=26.2589928057554, Blast_Score=78, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005814
- InterPro:   IPR005815
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =2.6.1.62 [H]

Molecular weight: Translated: 46925; Mature: 46794

Theoretical pI: Translated: 5.38; Mature: 5.38

Prosite motif: PS00600 AA_TRANSFER_CLASS_3 ; PS00142 ZINC_PROTEASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLDLQYDNKHLWHPYTSMINPLPCYAVVSADKCLLTLDNGKQLIDGMSSWWACLFGYNV
CCCEEEECCCCCCCCHHHHCCCCCCEEEEECCEEEEEECCCHHHHHHHHHHHHHHHCCCC
PELNTAAKQQIDKMSHVMFGGLTHQPAIDLAKKLVAITPAGLEKVFLSDSGSVSVEVALK
CCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCEEEEECCCCCEEHHHHHH
MALQYWHALEKPKSQFLTVRNGYHGDTFGAMSVTDPEGSMHELYHDFLAKQLFAPQPGIA
HHHHHHHHHCCCHHHEEEEECCCCCCCCCCEEEECCCCHHHHHHHHHHHHHHCCCCCCCC
FDQPWDATALDEITLLVENNQANIAAIILEPIVQGAGGMYFYHSEYLKGVRALCDKYELL
CCCCCCCCCCCEEEEEEECCCCCEEEHHHHHHHCCCCCEEEEHHHHHHHHHHHHCCCEEE
LIADEIATGFGRTGKLFACEHADISPDIICVGKAITGGYMSLAATLATSEIAETISRGKA
EEEHHHHHCCCCCCCEEEEECCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCC
GVFMHGPTFMGNPLACAVANANIEKLLAFDWQTTVLNIETSLKHYLAPCIELEQVKSVRV
EEEEECCCCCCCCEEEEEECCCHHHHEEECCCEEEEEHHHHHHHHHHHHHHHHHHHHHHH
LGAIGVVELKKAVDVAIVQKKFVELGVWIRPFGKLIYIMPPYIITPEQLQLLCHAIYSII
HHHHHHHHHHHHHHHHHHHHHHHHHCCHHCCCCCEEEECCCEEECHHHHHHHHHHHHHHH
NEEAVEL
HHHHHCC
>Mature Secondary Structure 
SLDLQYDNKHLWHPYTSMINPLPCYAVVSADKCLLTLDNGKQLIDGMSSWWACLFGYNV
CCEEEECCCCCCCCHHHHCCCCCCEEEEECCEEEEEECCCHHHHHHHHHHHHHHHCCCC
PELNTAAKQQIDKMSHVMFGGLTHQPAIDLAKKLVAITPAGLEKVFLSDSGSVSVEVALK
CCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCEEEEECCCCCEEHHHHHH
MALQYWHALEKPKSQFLTVRNGYHGDTFGAMSVTDPEGSMHELYHDFLAKQLFAPQPGIA
HHHHHHHHHCCCHHHEEEEECCCCCCCCCCEEEECCCCHHHHHHHHHHHHHHCCCCCCCC
FDQPWDATALDEITLLVENNQANIAAIILEPIVQGAGGMYFYHSEYLKGVRALCDKYELL
CCCCCCCCCCCEEEEEEECCCCCEEEHHHHHHHCCCCCEEEEHHHHHHHHHHHHCCCEEE
LIADEIATGFGRTGKLFACEHADISPDIICVGKAITGGYMSLAATLATSEIAETISRGKA
EEEHHHHHCCCCCCCEEEEECCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCC
GVFMHGPTFMGNPLACAVANANIEKLLAFDWQTTVLNIETSLKHYLAPCIELEQVKSVRV
EEEEECCCCCCCCEEEEEECCCHHHHEEECCCEEEEEHHHHHHHHHHHHHHHHHHHHHHH
LGAIGVVELKKAVDVAIVQKKFVELGVWIRPFGKLIYIMPPYIITPEQLQLLCHAIYSII
HHHHHHHHHHHHHHHHHHHHHHHHHCCHHCCCCCEEEECCCEEECHHHHHHHHHHHHHHH
NEEAVEL
HHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8890743 [H]