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The map label for this gene is qacE [H]

Identifier: 119945522

GI number: 119945522

Start: 2215108

End: 2215437

Strand: Direct

Name: qacE [H]

Synonym: Ping_1826

Alternate gene names: 119945522

Gene position: 2215108-2215437 (Clockwise)

Preceding gene: 119945521

Following gene: 119945524

Centisome position: 48.58

GC content: 38.48

Gene sequence:

>330_bases
ATGGGTTACTGGTATTTGGCAATTGCTATTGTAGCTGAGGTAATGGCAACATTAGCACTTAAAGCATCAAATGGTTTTTC
TGATTTAACCTTCAGTGCTGTTTGTGTTATTGGTTATGCAGTTGCATTTTATTTCTTATCCTTAGTGCTTAAAACGGTAC
CCGTTGGTATCGCTTATGCTATCTGGGCAGGCATGGGAATAGTATTAATTGCATCAATAAGTGCTGTGGTCTATAAACAA
CTGCCTGATCTTGCGGCGGTGATAGGAATGTTGTTAATTTTGGTGGGTGTCATGGTTATTAATGTGTTTTCAAAAACAGT
GAGCCATTAG

Upstream 100 bases:

>100_bases
TCTAGTAACGTTATGAAATCATTGGCAGTGTCGGTGTTTCTTGTGGGAAGGTGGAATTATTCCGTCTAAAAAATATTATA
TTTTTATTGGGAAATGAAGT

Downstream 100 bases:

>100_bases
AAGTCGAGCGGTAAGTGTGTGGGTCACGGCTTAACCCAATTGTTGGACAAGACCTGGCATTTATCGCTGTTATTTAACGA
GAATAAAAAACCACGACTAA

Product: small multidrug resistance protein

Products: Proton [Cytoplasm]; multidrug [Periplasm] [C]

Alternate protein names: Quaternary ammonium determinant E [H]

Number of amino acids: Translated: 109; Mature: 108

Protein sequence:

>109_residues
MGYWYLAIAIVAEVMATLALKASNGFSDLTFSAVCVIGYAVAFYFLSLVLKTVPVGIAYAIWAGMGIVLIASISAVVYKQ
LPDLAAVIGMLLILVGVMVINVFSKTVSH

Sequences:

>Translated_109_residues
MGYWYLAIAIVAEVMATLALKASNGFSDLTFSAVCVIGYAVAFYFLSLVLKTVPVGIAYAIWAGMGIVLIASISAVVYKQ
LPDLAAVIGMLLILVGVMVINVFSKTVSH
>Mature_108_residues
GYWYLAIAIVAEVMATLALKASNGFSDLTFSAVCVIGYAVAFYFLSLVLKTVPVGIAYAIWAGMGIVLIASISAVVYKQL
PDLAAVIGMLLILVGVMVINVFSKTVSH

Specific function: Multidrug exporter. Is implicated for the resistance to bacteriocidal quaternary ammonium compounds [H]

COG id: COG2076

COG function: function code P; Membrane transporters of cations and cationic drugs

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the small multidrug resistance (SMR) protein family [H]

Homologues:

Organism=Escherichia coli, GI1786755, Length=107, Percent_Identity=46.7289719626168, Blast_Score=94, Evalue=2e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000390 [H]

Pfam domain/function: PF00893 Multi_Drug_Res [H]

EC number: NA

Molecular weight: Translated: 11520; Mature: 11389

Theoretical pI: Translated: 8.43; Mature: 8.43

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
4.6 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGYWYLAIAIVAEVMATLALKASNGFSDLTFSAVCVIGYAVAFYFLSLVLKTVPVGIAYA
CCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IWAGMGIVLIASISAVVYKQLPDLAAVIGMLLILVGVMVINVFSKTVSH
HHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
GYWYLAIAIVAEVMATLALKASNGFSDLTFSAVCVIGYAVAFYFLSLVLKTVPVGIAYA
CHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IWAGMGIVLIASISAVVYKQLPDLAAVIGMLLILVGVMVINVFSKTVSH
HHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; multidrug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + multidrug [Cytoplasm] = Proton [Cytoplasm] + multidrug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 8494372 [H]