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The map label for this gene is epd

Identifier: 119945473

GI number: 119945473

Start: 2152573

End: 2153688

Strand: Direct

Name: epd

Synonym: Ping_1771

Alternate gene names: 119945473

Gene position: 2152573-2153688 (Clockwise)

Preceding gene: 119945469

Following gene: 119945474

Centisome position: 47.21

GC content: 41.22

Gene sequence:

>1116_bases
ATGTCAATTAGAATTGCTATTAATGGTTATGGACGAATAGGGCGCAGTGTAGTGCGTGCATTATATGAAAATAACCGTCA
AGATGAAATGAAAGTCGTGGTCATTAATGAACTTGCTGAGCCGTCAGCGATCGCACATTTAACCCAGTATGACTCAACCC
ACGGACGTTTCCCCTTTCCCGTTAATTTACAGAATAACCTTCTAAAAATTAAAAATGATGATATTCATTTGGTGCGTTTT
TCTGAACTTGCTGATTTACCATGGCATGAACACGATATAGATATAGTCTTAGATTGTACCGGTATTTACGGCTCTAGAGC
CGATGCCGATGCGCATATAGCTGCCGGGGCTAAAAAAGTGATTTTTTCTCATCCAGCAGATCCAGATGTAGATGCAACGG
TTGTTTACGGTATAAACCATCAACAACTCACCGGTGACGAAACGTTTATTTCGGGTGCTTCCTGTACCACTAACTGCATG
GTGCCGGTGATAGATACTCTAGATAAACACTTTGCTATTAAATGTGGGACTATTACGACTATTCATTCTGCCATGAATGA
TCAGCCGGTGATCGATGCCTACCATTCAGATCTGCGACGTACCCGCGCCGCCAGTCAGTCTATTATTCCCGTTGATACTA
AATTAGCCGCAGGAATAGAACGTATTCTGCCTAAATTTGCCAATAAATTTGAGGCGATTGCAGTGCGCGTTCCAACCATT
AACGTGACCGCAATGGATCTCAGTATTACCGTCAGTAAAGATGTCACTATTCAGGAGATTAACGATTGTCTGCTAAAGGC
CTCTGAGACCAACTTAAAAGATATTTTGGGTTACACCGAAGCGCCGCTGGTTTCAATTGACTTTAATCACGATCCTCGCT
CTTGTATTATTGATGGAACCCAAACCCGGGTCAGTGATGGGAATTTAGTTAAACTATTAGTCTGGTGTGATAACGAATGG
GGATTTGCTAATCGTTTGTTAGATACCAGTTTTTATCTTGCTAATTTGGCAGAACAAAAAAGACTACAATCTACAGAGAC
AGTCAAATCACTTGAAGATACAGGCATCAGTAACGAAATAAAGGATGAACTTCAGGATAGAAGGAAAATCATCTAG

Upstream 100 bases:

>100_bases
TATTGCCTTTCCTGGCAATTAAACCCTTTAATATATTCGCTTATGCGCTAATTTATCCTACAATGGTGCTTGTTTTTTTA
TTGGGTGTTTTACAGTTATT

Downstream 100 bases:

>100_bases
TTATTCCAAATCAAAAAGTGGTAATACTTGAAAAGGGAATAACCGTTTTCATTATGTGACCCTTGTACCAGTATTCAGGC
GCACCGCTGCATCTTCAATC

Product: D-erythrose-4-phosphate dehydrogenase

Products: NA

Alternate protein names: E4PDH

Number of amino acids: Translated: 371; Mature: 370

Protein sequence:

>371_residues
MSIRIAINGYGRIGRSVVRALYENNRQDEMKVVVINELAEPSAIAHLTQYDSTHGRFPFPVNLQNNLLKIKNDDIHLVRF
SELADLPWHEHDIDIVLDCTGIYGSRADADAHIAAGAKKVIFSHPADPDVDATVVYGINHQQLTGDETFISGASCTTNCM
VPVIDTLDKHFAIKCGTITTIHSAMNDQPVIDAYHSDLRRTRAASQSIIPVDTKLAAGIERILPKFANKFEAIAVRVPTI
NVTAMDLSITVSKDVTIQEINDCLLKASETNLKDILGYTEAPLVSIDFNHDPRSCIIDGTQTRVSDGNLVKLLVWCDNEW
GFANRLLDTSFYLANLAEQKRLQSTETVKSLEDTGISNEIKDELQDRRKII

Sequences:

>Translated_371_residues
MSIRIAINGYGRIGRSVVRALYENNRQDEMKVVVINELAEPSAIAHLTQYDSTHGRFPFPVNLQNNLLKIKNDDIHLVRF
SELADLPWHEHDIDIVLDCTGIYGSRADADAHIAAGAKKVIFSHPADPDVDATVVYGINHQQLTGDETFISGASCTTNCM
VPVIDTLDKHFAIKCGTITTIHSAMNDQPVIDAYHSDLRRTRAASQSIIPVDTKLAAGIERILPKFANKFEAIAVRVPTI
NVTAMDLSITVSKDVTIQEINDCLLKASETNLKDILGYTEAPLVSIDFNHDPRSCIIDGTQTRVSDGNLVKLLVWCDNEW
GFANRLLDTSFYLANLAEQKRLQSTETVKSLEDTGISNEIKDELQDRRKII
>Mature_370_residues
SIRIAINGYGRIGRSVVRALYENNRQDEMKVVVINELAEPSAIAHLTQYDSTHGRFPFPVNLQNNLLKIKNDDIHLVRFS
ELADLPWHEHDIDIVLDCTGIYGSRADADAHIAAGAKKVIFSHPADPDVDATVVYGINHQQLTGDETFISGASCTTNCMV
PVIDTLDKHFAIKCGTITTIHSAMNDQPVIDAYHSDLRRTRAASQSIIPVDTKLAAGIERILPKFANKFEAIAVRVPTIN
VTAMDLSITVSKDVTIQEINDCLLKASETNLKDILGYTEAPLVSIDFNHDPRSCIIDGTQTRVSDGNLVKLLVWCDNEWG
FANRLLDTSFYLANLAEQKRLQSTETVKSLEDTGISNEIKDELQDRRKII

Specific function: Catalyzes the NAD-dependent conversion of D-erythrose 4- phosphate to 4-phosphoerythronate

COG id: COG0057

COG function: function code G; Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. Epd subfamily

Homologues:

Organism=Homo sapiens, GI7669492, Length=336, Percent_Identity=35.4166666666667, Blast_Score=219, Evalue=3e-57,
Organism=Homo sapiens, GI7657116, Length=334, Percent_Identity=34.7305389221557, Blast_Score=208, Evalue=6e-54,
Organism=Escherichia coli, GI1789295, Length=337, Percent_Identity=62.0178041543027, Blast_Score=449, Evalue=1e-127,
Organism=Escherichia coli, GI1788079, Length=329, Percent_Identity=37.0820668693009, Blast_Score=234, Evalue=5e-63,
Organism=Caenorhabditis elegans, GI17534677, Length=339, Percent_Identity=35.3982300884956, Blast_Score=214, Evalue=5e-56,
Organism=Caenorhabditis elegans, GI17534679, Length=339, Percent_Identity=35.693215339233, Blast_Score=214, Evalue=7e-56,
Organism=Caenorhabditis elegans, GI32566163, Length=342, Percent_Identity=35.3801169590643, Blast_Score=208, Evalue=4e-54,
Organism=Caenorhabditis elegans, GI17568413, Length=342, Percent_Identity=35.3801169590643, Blast_Score=208, Evalue=5e-54,
Organism=Saccharomyces cerevisiae, GI6322409, Length=334, Percent_Identity=37.125748502994, Blast_Score=228, Evalue=2e-60,
Organism=Saccharomyces cerevisiae, GI6322468, Length=329, Percent_Identity=37.6899696048632, Blast_Score=226, Evalue=5e-60,
Organism=Saccharomyces cerevisiae, GI6321631, Length=329, Percent_Identity=37.3860182370821, Blast_Score=226, Evalue=6e-60,
Organism=Drosophila melanogaster, GI19922412, Length=339, Percent_Identity=36.283185840708, Blast_Score=211, Evalue=5e-55,
Organism=Drosophila melanogaster, GI85725000, Length=333, Percent_Identity=35.1351351351351, Blast_Score=206, Evalue=2e-53,
Organism=Drosophila melanogaster, GI22023983, Length=333, Percent_Identity=35.1351351351351, Blast_Score=206, Evalue=2e-53,
Organism=Drosophila melanogaster, GI17933600, Length=333, Percent_Identity=34.2342342342342, Blast_Score=202, Evalue=3e-52,
Organism=Drosophila melanogaster, GI18110149, Length=333, Percent_Identity=34.2342342342342, Blast_Score=202, Evalue=3e-52,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): E4PD_PSYIN (A1SVN9)

Other databases:

- EMBL:   CP000510
- RefSeq:   YP_943153.1
- ProteinModelPortal:   A1SVN9
- SMR:   A1SVN9
- STRING:   A1SVN9
- GeneID:   4626104
- GenomeReviews:   CP000510_GR
- KEGG:   pin:Ping_1771
- eggNOG:   COG0057
- HOGENOM:   HBG571736
- OMA:   IQAKAVR
- PhylomeDB:   A1SVN9
- BioCyc:   PING357804:PING_1771-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01640
- InterPro:   IPR006422
- InterPro:   IPR020831
- InterPro:   IPR020830
- InterPro:   IPR020829
- InterPro:   IPR020828
- InterPro:   IPR016040
- Gene3D:   G3DSA:3.40.50.720
- PANTHER:   PTHR10836
- PIRSF:   PIRSF000149
- PRINTS:   PR00078
- SMART:   SM00846
- TIGRFAMs:   TIGR01532

Pfam domain/function: PF02800 Gp_dh_C; PF00044 Gp_dh_N

EC number: =1.2.1.72

Molecular weight: Translated: 41195; Mature: 41064

Theoretical pI: Translated: 5.25; Mature: 5.25

Prosite motif: PS00071 GAPDH

Important sites: ACT_SITE 155-155 BINDING 200-200 BINDING 236-236 BINDING 318-318

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSIRIAINGYGRIGRSVVRALYENNRQDEMKVVVINELAEPSAIAHLTQYDSTHGRFPFP
CEEEEEECCCCHHHHHHHHHHHHCCCCCCEEEEEEECCCCCHHHHHHHHCCCCCCCCCCE
VNLQNNLLKIKNDDIHLVRFSELADLPWHEHDIDIVLDCTGIYGSRADADAHIAAGAKKV
ECCCCCEEEEECCCEEEEEEHHHCCCCCCCCCCEEEEEECCCCCCCCCCCCEECCCCEEE
IFSHPADPDVDATVVYGINHQQLTGDETFISGASCTTNCMVPVIDTLDKHFAIKCGTITT
EEECCCCCCCCEEEEEECCCCEECCCCCEECCCCCCCCCCHHHHHCCCCCEEEEECCHHH
IHSAMNDQPVIDAYHSDLRRTRAASQSIIPVDTKLAAGIERILPKFANKFEAIAVRVPTI
HHHHCCCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCEEEEEEEECEE
NVTAMDLSITVSKDVTIQEINDCLLKASETNLKDILGYTEAPLVSIDFNHDPRSCIIDGT
EEEEEEEEEEEECCCCHHHHHHHHHCCCCCCHHHHHCCCCCCEEEEECCCCCCEEEECCC
QTRVSDGNLVKLLVWCDNEWGFANRLLDTSFYLANLAEQKRLQSTETVKSLEDTGISNEI
CEEECCCCEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHH
KDELQDRRKII
HHHHHHHHCCC
>Mature Secondary Structure 
SIRIAINGYGRIGRSVVRALYENNRQDEMKVVVINELAEPSAIAHLTQYDSTHGRFPFP
EEEEEECCCCHHHHHHHHHHHHCCCCCCEEEEEEECCCCCHHHHHHHHCCCCCCCCCCE
VNLQNNLLKIKNDDIHLVRFSELADLPWHEHDIDIVLDCTGIYGSRADADAHIAAGAKKV
ECCCCCEEEEECCCEEEEEEHHHCCCCCCCCCCEEEEEECCCCCCCCCCCCEECCCCEEE
IFSHPADPDVDATVVYGINHQQLTGDETFISGASCTTNCMVPVIDTLDKHFAIKCGTITT
EEECCCCCCCCEEEEEECCCCEECCCCCEECCCCCCCCCCHHHHHCCCCCEEEEECCHHH
IHSAMNDQPVIDAYHSDLRRTRAASQSIIPVDTKLAAGIERILPKFANKFEAIAVRVPTI
HHHHCCCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCEEEEEEEECEE
NVTAMDLSITVSKDVTIQEINDCLLKASETNLKDILGYTEAPLVSIDFNHDPRSCIIDGT
EEEEEEEEEEEECCCCHHHHHHHHHCCCCCCHHHHHCCCCCCEEEEECCCCCCEEEECCC
QTRVSDGNLVKLLVWCDNEWGFANRLLDTSFYLANLAEQKRLQSTETVKSLEDTGISNEI
CEEECCCCEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHH
KDELQDRRKII
HHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA