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The map label for this gene is fumC [H]

Identifier: 119945441

GI number: 119945441

Start: 2116645

End: 2118015

Strand: Direct

Name: fumC [H]

Synonym: Ping_1738

Alternate gene names: 119945441

Gene position: 2116645-2118015 (Clockwise)

Preceding gene: 119945439

Following gene: 119945443

Centisome position: 46.42

GC content: 45.0

Gene sequence:

>1371_bases
ATGAAGAATTTTAGAATCGAAAGCGACAGTCTGGGGGATATTGATGTTCCTGTGGACGCTATTTACGGACCACAAACCCA
ACGAGCAATAAACAACTTCCCGATCAGTGGACTAACCCTCCCCAAACGCTTTATTCAGGCATTGGCTTTACTCAAAAAAT
CAGCTGCACAGGCTAATTTAGAATTAGGTTTGCTCGACCAGAAGAGAGCCGAGGGTATTATCCACAGCGCAAACTTGATT
GCCTCAGGCAAACATCTGGATCAGTTTCCTGTTGATGTATTTCAAACGGGCTCGGGTACCAGTACCAATATGAATATGAA
TGAGGTGATCGCGATGCTTGCGGGCAACACCGTCGATGCCAATGATCACGTTAATATGGGACAGAGCAGCAACGATGTTA
TTCCAAGTACTATCCATATTAGTGCCGCTATTGCTCTCAGTAATCACCTTTTACCTGCCTTAAAGCACTTGCATAAAACC
ATATCAAACAAAGCCGTTAGTGTAAGTGAACATATTAAAACCGGGCGTACTCATCTGATGGATGCTATGCCGATTAGTAT
GGGTCAGGAACTGTCCGGTTGGGCGGGGCAAATTGAGCAAGGCATAGAAGGACTGGAATCGGTGCGCAATCGCTTACATC
GTTTAGCCCTGGGCGGCACTGCAGTGGGAACCGGCATAAATACTCATTCGGACTTTGCGCAAACTTTTTGCGCTGCGTTA
ACGAAAGATACTGGGCTTGAATTTGAGCCGAGTGATAATTTTTTTGCAAGTTTAGCCGGTCAAGATGTGGCTGTGGCATT
GTCCGGGCAATTAAAAGTGGTTGCGGTGAGTTTAATGAAGATAGCCAATGATTTACGCTGGATGAACTCGGGCCCGTTAA
GCGGCATCGGGGAAATTGAACTTGAAGCATTGCAGCCGGGGTCATCTATTATGCCGGGTAAGGTAAATCCGGTTATACCT
GAAGCGGTCGCGATGGTATCTGCACAGGTGATAGGCAATGATGCAACGATAACTATTGCGGGACAATCGGGTAATTTTGA
GCTTAACGTCATGTTGCCTGTGATTGCCTATAATCTTTTGGAAAGTGTAGAAATACTGGCGAATTCAGCGAGCTTGTTGG
CTGATAAAGCGATCGCAGATTTTATTATCAAAACTGATAAGCTGCAACAGTCGTTGGCCCGCAATCCTATATTAGTGACC
GCCCTTAACCCTATTATTGGTTATGCAAAAGCCGCTGAAATTGCCAAAAAGGCTTATCATAGTGGCCGAAATATTATTGA
CGTGGCAGAAGAGGAAACGGATCTCAGTCATGAGCAATTAATTAAAATTTTGGATCCTATTGCGCTAACCACAGGCGGTA
TTCGTACATAA

Upstream 100 bases:

>100_bases
ATGCATTCTTTCAATAAAATAAAAAACATCCTGTGGAGTGATGGTTTAATAAACAAAGCACTTTTTAATAACGTTTTATA
TTCAAGTAAGGGAGGGCACT

Downstream 100 bases:

>100_bases
TTGAGTCGTTGCCGCTAAAGGATATGCTTGCTGTGTGACTTAATATTTTTGAGCAAAAAAGTTGTGTATTAAAAGTTCGT
ATCGCTTCAATTTCAGGGTT

Product: fumarate hydratase

Products: NA

Alternate protein names: Fumarase C 1 [H]

Number of amino acids: Translated: 456; Mature: 456

Protein sequence:

>456_residues
MKNFRIESDSLGDIDVPVDAIYGPQTQRAINNFPISGLTLPKRFIQALALLKKSAAQANLELGLLDQKRAEGIIHSANLI
ASGKHLDQFPVDVFQTGSGTSTNMNMNEVIAMLAGNTVDANDHVNMGQSSNDVIPSTIHISAAIALSNHLLPALKHLHKT
ISNKAVSVSEHIKTGRTHLMDAMPISMGQELSGWAGQIEQGIEGLESVRNRLHRLALGGTAVGTGINTHSDFAQTFCAAL
TKDTGLEFEPSDNFFASLAGQDVAVALSGQLKVVAVSLMKIANDLRWMNSGPLSGIGEIELEALQPGSSIMPGKVNPVIP
EAVAMVSAQVIGNDATITIAGQSGNFELNVMLPVIAYNLLESVEILANSASLLADKAIADFIIKTDKLQQSLARNPILVT
ALNPIIGYAKAAEIAKKAYHSGRNIIDVAEEETDLSHEQLIKILDPIALTTGGIRT

Sequences:

>Translated_456_residues
MKNFRIESDSLGDIDVPVDAIYGPQTQRAINNFPISGLTLPKRFIQALALLKKSAAQANLELGLLDQKRAEGIIHSANLI
ASGKHLDQFPVDVFQTGSGTSTNMNMNEVIAMLAGNTVDANDHVNMGQSSNDVIPSTIHISAAIALSNHLLPALKHLHKT
ISNKAVSVSEHIKTGRTHLMDAMPISMGQELSGWAGQIEQGIEGLESVRNRLHRLALGGTAVGTGINTHSDFAQTFCAAL
TKDTGLEFEPSDNFFASLAGQDVAVALSGQLKVVAVSLMKIANDLRWMNSGPLSGIGEIELEALQPGSSIMPGKVNPVIP
EAVAMVSAQVIGNDATITIAGQSGNFELNVMLPVIAYNLLESVEILANSASLLADKAIADFIIKTDKLQQSLARNPILVT
ALNPIIGYAKAAEIAKKAYHSGRNIIDVAEEETDLSHEQLIKILDPIALTTGGIRT
>Mature_456_residues
MKNFRIESDSLGDIDVPVDAIYGPQTQRAINNFPISGLTLPKRFIQALALLKKSAAQANLELGLLDQKRAEGIIHSANLI
ASGKHLDQFPVDVFQTGSGTSTNMNMNEVIAMLAGNTVDANDHVNMGQSSNDVIPSTIHISAAIALSNHLLPALKHLHKT
ISNKAVSVSEHIKTGRTHLMDAMPISMGQELSGWAGQIEQGIEGLESVRNRLHRLALGGTAVGTGINTHSDFAQTFCAAL
TKDTGLEFEPSDNFFASLAGQDVAVALSGQLKVVAVSLMKIANDLRWMNSGPLSGIGEIELEALQPGSSIMPGKVNPVIP
EAVAMVSAQVIGNDATITIAGQSGNFELNVMLPVIAYNLLESVEILANSASLLADKAIADFIIKTDKLQQSLARNPILVT
ALNPIIGYAKAAEIAKKAYHSGRNIIDVAEEETDLSHEQLIKILDPIALTTGGIRT

Specific function: Tricarboxylic acid cycle [C]

COG id: COG0114

COG function: function code C; Fumarase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II fumarase/aspartase family. Fumarase subfamily [H]

Homologues:

Organism=Homo sapiens, GI19743875, Length=456, Percent_Identity=44.5175438596491, Blast_Score=371, Evalue=1e-103,
Organism=Escherichia coli, GI1787896, Length=432, Percent_Identity=46.5277777777778, Blast_Score=385, Evalue=1e-108,
Organism=Escherichia coli, GI87082375, Length=456, Percent_Identity=38.8157894736842, Blast_Score=281, Evalue=4e-77,
Organism=Caenorhabditis elegans, GI17553882, Length=458, Percent_Identity=44.1048034934498, Blast_Score=375, Evalue=1e-104,
Organism=Caenorhabditis elegans, GI32565146, Length=321, Percent_Identity=44.5482866043614, Blast_Score=281, Evalue=6e-76,
Organism=Saccharomyces cerevisiae, GI6324993, Length=455, Percent_Identity=42.6373626373626, Blast_Score=356, Evalue=4e-99,
Organism=Drosophila melanogaster, GI24640179, Length=458, Percent_Identity=44.9781659388646, Blast_Score=384, Evalue=1e-107,
Organism=Drosophila melanogaster, GI24640177, Length=458, Percent_Identity=44.9781659388646, Blast_Score=384, Evalue=1e-106,
Organism=Drosophila melanogaster, GI78710009, Length=459, Percent_Identity=43.1372549019608, Blast_Score=369, Evalue=1e-102,
Organism=Drosophila melanogaster, GI24662684, Length=432, Percent_Identity=45.6018518518519, Blast_Score=367, Evalue=1e-101,
Organism=Drosophila melanogaster, GI24583245, Length=461, Percent_Identity=39.2624728850325, Blast_Score=338, Evalue=4e-93,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003031
- InterPro:   IPR005677
- InterPro:   IPR018951
- InterPro:   IPR000362
- InterPro:   IPR020557
- InterPro:   IPR008948
- InterPro:   IPR022761 [H]

Pfam domain/function: PF10415 FumaraseC_C; PF00206 Lyase_1 [H]

EC number: =4.2.1.2 [H]

Molecular weight: Translated: 48431; Mature: 48431

Theoretical pI: Translated: 5.55; Mature: 5.55

Prosite motif: PS00163 FUMARATE_LYASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNFRIESDSLGDIDVPVDAIYGPQTQRAINNFPISGLTLPKRFIQALALLKKSAAQANL
CCCCCCCCCCCCCCCCCHHHHCCCHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCC
ELGLLDQKRAEGIIHSANLIASGKHLDQFPVDVFQTGSGTSTNMNMNEVIAMLAGNTVDA
EEECCCHHHHCCCEECCHHEECCCCCCCCCHHHEECCCCCCCCCCHHHHHHHHCCCCCCC
NDHVNMGQSSNDVIPSTIHISAAIALSNHLLPALKHLHKTISNKAVSVSEHIKTGRTHLM
CCCCCCCCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHCCCEEHHHHHHCCHHHHH
DAMPISMGQELSGWAGQIEQGIEGLESVRNRLHRLALGGTAVGTGINTHSDFAQTFCAAL
HCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEECCCCCCHHHHHHHHHHHH
TKDTGLEFEPSDNFFASLAGQDVAVALSGQLKVVAVSLMKIANDLRWMNSGPLSGIGEIE
HHCCCCEECCCCCHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCEE
LEALQPGSSIMPGKVNPVIPEAVAMVSAQVIGNDATITIAGQSGNFELNVMLPVIAYNLL
EEEECCCCCCCCCCCCCCCHHHHHHHHHHHCCCCEEEEEEECCCCEEEEEEHHHHHHHHH
ESVEILANSASLLADKAIADFIIKTDKLQQSLARNPILVTALNPIIGYAKAAEIAKKAYH
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHHHHHHH
SGRNIIDVAEEETDLSHEQLIKILDPIALTTGGIRT
CCCCEEECCCCCCCCCHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MKNFRIESDSLGDIDVPVDAIYGPQTQRAINNFPISGLTLPKRFIQALALLKKSAAQANL
CCCCCCCCCCCCCCCCCHHHHCCCHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCC
ELGLLDQKRAEGIIHSANLIASGKHLDQFPVDVFQTGSGTSTNMNMNEVIAMLAGNTVDA
EEECCCHHHHCCCEECCHHEECCCCCCCCCHHHEECCCCCCCCCCHHHHHHHHCCCCCCC
NDHVNMGQSSNDVIPSTIHISAAIALSNHLLPALKHLHKTISNKAVSVSEHIKTGRTHLM
CCCCCCCCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHCCCEEHHHHHHCCHHHHH
DAMPISMGQELSGWAGQIEQGIEGLESVRNRLHRLALGGTAVGTGINTHSDFAQTFCAAL
HCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEECCCCCCHHHHHHHHHHHH
TKDTGLEFEPSDNFFASLAGQDVAVALSGQLKVVAVSLMKIANDLRWMNSGPLSGIGEIE
HHCCCCEECCCCCHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCEE
LEALQPGSSIMPGKVNPVIPEAVAMVSAQVIGNDATITIAGQSGNFELNVMLPVIAYNLL
EEEECCCCCCCCCCCCCCCHHHHHHHHHHHCCCCEEEEEEECCCCEEEEEEHHHHHHHHH
ESVEILANSASLLADKAIADFIIKTDKLQQSLARNPILVTALNPIIGYAKAAEIAKKAYH
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHHHHHHH
SGRNIIDVAEEETDLSHEQLIKILDPIALTTGGIRT
CCCCEEECCCCCCCCCHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8806672; 10984043 [H]