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The map label for this gene is cry [H]

Identifier: 119945273

GI number: 119945273

Start: 1896177

End: 1897523

Strand: Direct

Name: cry [H]

Synonym: Ping_1548

Alternate gene names: 119945273

Gene position: 1896177-1897523 (Clockwise)

Preceding gene: 119945272

Following gene: 119945274

Centisome position: 41.59

GC content: 40.98

Gene sequence:

>1347_bases
ATGAAACGTACCTTATACTGGGTGAATAAAGATCTTCGTATCAATGACAACGCCGCGCTTAACTTAGCCAGTAAAAGTGA
TCGTCTGCTTTGTGTATATGTTGTTGATAAACAGTCCTTTGAAGCAAATAATTTTCAGTCAAAACCTTTAGGCGATATCA
GGTGGCAATTTTTACAAGGCTGTTTAGAGGATTTTAATGAGAGCTTATCAAAGCTTGGGCAAGCGATGCATATTGTTTAT
GGCGATACCTTATCCACCTTAATGCGGCTCTGTGAAAGCTACCAGATTACTGATGTAATCACTACGAAATTACCAGGCAC
TTATGAAAATAGGCTTATTACTCAGCTTAACGAGCGCCTGCCTGAATTGACCATTGATCAAGTAGACCAATTTACTTTAT
TTACCAAAAAATCATTGCCTTTTGAGCTTGATGAATTACCAATTAGTTATTCTAAATTTCGAAAAAAAATGGCTGAAGTC
ATTATTCCCGAGCCAGTGTCAACTGTGCAATCTCTGCCTAGCATGTTTGACACCCTACCGGCGCCAACTCGCTTTAAGCC
TGAATGGCTACCCACCGTAAGTGCTATCAAGGCCAAGCAGGGTTTTGAGTTTGAAGGGGGTGAACAACAGGGCTTAAAGC
ATCTTAGGCAATATTTTTCATCAAATTCCCCCGCAGAGTATAAGCAAGTCAGAAATAATTTAGACGGTTGGAAAAATAGC
AGCAAGCTATCGCCGTGGTTAAATTCCGGCTGTATTTCTGTGCGCCAAGTGATGAATAACCTTGCTGAATTTGAACAGCA
GCATGGCAAAAATAGTTCAACCGAATGCCTGTATTTAGAATTACTGTGGCGAGAATACTATCAATGGGTACATTATAAAG
TTGGCGCTAAAACCTACCAATTTAAAGGTCTTGCTAAACATCGCCCCCTAACAACATTCTATCCTGAACGCTTTAATAAA
TGGTGTTTAGGCAATACCCCTTATTCCTTGGTTAATGCCTTTATGCATGAGTTAAGACAAACCGGGTATTTAAGTAACCG
AGGTCGCCAAATTGTTGCAAGTTGCCTAGTTAATGAACTCAGTGTTGATTGGCGCTATGGTGCTGCCTGGTTTGAAGAGC
AGTTAATTGATTATGACGCTGCAGTTAATTGGGGTAATTGGCAATACATCGCTGGCGTAGGTGTTGACCCTAGAGGTGGC
AGACATTTCAATATTGAGAAACAAACTACACTTTATGACCCTAATGGTGATTACCAAGCACAATGGATAGATCTAAGTCA
GCAAAGCACTCAAGCCAATCAAGCACTAGACTCTGTCGATGCTGCAGATTGGCCGGTGCTGCAGTAA

Upstream 100 bases:

>100_bases
AATTCAATGGCGGTAAGTTAAAGCAGGTGATAACTGAATTATTTTGATCTAAGTGCTAGCTTTATGCGTATAACTTTTTT
TAACTAATTGAATTATATCC

Downstream 100 bases:

>100_bases
GCTAGAATGGCAGCTAATATCGCGGCAACTAATATCCGGGCAGATAGTGTTGTCAATATTGTTTGGTTAAAGCGTGACCT
GCGGCTTAGCGATCATCAGC

Product: DNA photolyase FAD-binding subunit

Products: 2 pyrimidine residues (in DNA) [C]

Alternate protein names: NA

Number of amino acids: Translated: 448; Mature: 448

Protein sequence:

>448_residues
MKRTLYWVNKDLRINDNAALNLASKSDRLLCVYVVDKQSFEANNFQSKPLGDIRWQFLQGCLEDFNESLSKLGQAMHIVY
GDTLSTLMRLCESYQITDVITTKLPGTYENRLITQLNERLPELTIDQVDQFTLFTKKSLPFELDELPISYSKFRKKMAEV
IIPEPVSTVQSLPSMFDTLPAPTRFKPEWLPTVSAIKAKQGFEFEGGEQQGLKHLRQYFSSNSPAEYKQVRNNLDGWKNS
SKLSPWLNSGCISVRQVMNNLAEFEQQHGKNSSTECLYLELLWREYYQWVHYKVGAKTYQFKGLAKHRPLTTFYPERFNK
WCLGNTPYSLVNAFMHELRQTGYLSNRGRQIVASCLVNELSVDWRYGAAWFEEQLIDYDAAVNWGNWQYIAGVGVDPRGG
RHFNIEKQTTLYDPNGDYQAQWIDLSQQSTQANQALDSVDAADWPVLQ

Sequences:

>Translated_448_residues
MKRTLYWVNKDLRINDNAALNLASKSDRLLCVYVVDKQSFEANNFQSKPLGDIRWQFLQGCLEDFNESLSKLGQAMHIVY
GDTLSTLMRLCESYQITDVITTKLPGTYENRLITQLNERLPELTIDQVDQFTLFTKKSLPFELDELPISYSKFRKKMAEV
IIPEPVSTVQSLPSMFDTLPAPTRFKPEWLPTVSAIKAKQGFEFEGGEQQGLKHLRQYFSSNSPAEYKQVRNNLDGWKNS
SKLSPWLNSGCISVRQVMNNLAEFEQQHGKNSSTECLYLELLWREYYQWVHYKVGAKTYQFKGLAKHRPLTTFYPERFNK
WCLGNTPYSLVNAFMHELRQTGYLSNRGRQIVASCLVNELSVDWRYGAAWFEEQLIDYDAAVNWGNWQYIAGVGVDPRGG
RHFNIEKQTTLYDPNGDYQAQWIDLSQQSTQANQALDSVDAADWPVLQ
>Mature_448_residues
MKRTLYWVNKDLRINDNAALNLASKSDRLLCVYVVDKQSFEANNFQSKPLGDIRWQFLQGCLEDFNESLSKLGQAMHIVY
GDTLSTLMRLCESYQITDVITTKLPGTYENRLITQLNERLPELTIDQVDQFTLFTKKSLPFELDELPISYSKFRKKMAEV
IIPEPVSTVQSLPSMFDTLPAPTRFKPEWLPTVSAIKAKQGFEFEGGEQQGLKHLRQYFSSNSPAEYKQVRNNLDGWKNS
SKLSPWLNSGCISVRQVMNNLAEFEQQHGKNSSTECLYLELLWREYYQWVHYKVGAKTYQFKGLAKHRPLTTFYPERFNK
WCLGNTPYSLVNAFMHELRQTGYLSNRGRQIVASCLVNELSVDWRYGAAWFEEQLIDYDAAVNWGNWQYIAGVGVDPRGG
RHFNIEKQTTLYDPNGDYQAQWIDLSQQSTQANQALDSVDAADWPVLQ

Specific function: May have a photoreceptor function. Binds DNA; probably functions as a transcriptional repressor [H]

COG id: COG0415

COG function: function code L; Deoxyribodipyrimidine photolyase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 DNA photolyase domain [H]

Homologues:

Organism=Homo sapiens, GI4758072, Length=445, Percent_Identity=25.8426966292135, Blast_Score=130, Evalue=3e-30,
Organism=Homo sapiens, GI188536100, Length=443, Percent_Identity=26.410835214447, Blast_Score=121, Evalue=1e-27,
Organism=Homo sapiens, GI188536103, Length=397, Percent_Identity=24.9370277078086, Blast_Score=94, Evalue=3e-19,
Organism=Escherichia coli, GI1786926, Length=451, Percent_Identity=26.3858093126386, Blast_Score=132, Evalue=4e-32,
Organism=Saccharomyces cerevisiae, GI6324962, Length=489, Percent_Identity=26.1758691206544, Blast_Score=118, Evalue=2e-27,
Organism=Drosophila melanogaster, GI17137248, Length=464, Percent_Identity=24.3534482758621, Blast_Score=120, Evalue=2e-27,
Organism=Drosophila melanogaster, GI24585455, Length=464, Percent_Identity=24.3534482758621, Blast_Score=120, Evalue=2e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002081
- InterPro:   IPR014133
- InterPro:   IPR006050
- InterPro:   IPR005101
- InterPro:   IPR014729 [H]

Pfam domain/function: PF00875 DNA_photolyase; PF03441 FAD_binding_7 [H]

EC number: 4.1.99.3 [C]

Molecular weight: Translated: 51771; Mature: 51771

Theoretical pI: Translated: 6.63; Mature: 6.63

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRTLYWVNKDLRINDNAALNLASKSDRLLCVYVVDKQSFEANNFQSKPLGDIRWQFLQG
CCCEEEEECCCEEECCCCEEEEECCCCCEEEEEEECCCCCCCCCCCCCCCHHHHHHHHHH
CLEDFNESLSKLGQAMHIVYGDTLSTLMRLCESYQITDVITTKLPGTYENRLITQLNERL
HHHHHHHHHHHHHHHHEEEECCHHHHHHHHHHCCCHHHHHHHCCCCCHHHHHHHHHHHHC
PELTIDQVDQFTLFTKKSLPFELDELPISYSKFRKKMAEVIIPEPVSTVQSLPSMFDTLP
CCCCHHHHHHEEEEECCCCCCCHHHCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCC
APTRFKPEWLPTVSAIKAKQGFEFEGGEQQGLKHLRQYFSSNSPAEYKQVRNNLDGWKNS
CCCCCCCCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCC
SKLSPWLNSGCISVRQVMNNLAEFEQQHGKNSSTECLYLELLWREYYQWVHYKVGAKTYQ
CCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCCEEE
FKGLAKHRPLTTFYPERFNKWCLGNTPYSLVNAFMHELRQTGYLSNRGRQIVASCLVNEL
ECCCCCCCCCCCCCHHHCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHH
SVDWRYGAAWFEEQLIDYDAAVNWGNWQYIAGVGVDPRGGRHFNIEKQTTLYDPNGDYQA
CCCCHHHHHHHHHHHHHHHHEECCCCEEEEEEECCCCCCCCEEECCCCEEEECCCCCCEE
QWIDLSQQSTQANQALDSVDAADWPVLQ
EEEECCHHHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure
MKRTLYWVNKDLRINDNAALNLASKSDRLLCVYVVDKQSFEANNFQSKPLGDIRWQFLQG
CCCEEEEECCCEEECCCCEEEEECCCCCEEEEEEECCCCCCCCCCCCCCCHHHHHHHHHH
CLEDFNESLSKLGQAMHIVYGDTLSTLMRLCESYQITDVITTKLPGTYENRLITQLNERL
HHHHHHHHHHHHHHHHEEEECCHHHHHHHHHHCCCHHHHHHHCCCCCHHHHHHHHHHHHC
PELTIDQVDQFTLFTKKSLPFELDELPISYSKFRKKMAEVIIPEPVSTVQSLPSMFDTLP
CCCCHHHHHHEEEEECCCCCCCHHHCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCC
APTRFKPEWLPTVSAIKAKQGFEFEGGEQQGLKHLRQYFSSNSPAEYKQVRNNLDGWKNS
CCCCCCCCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCC
SKLSPWLNSGCISVRQVMNNLAEFEQQHGKNSSTECLYLELLWREYYQWVHYKVGAKTYQ
CCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCCEEE
FKGLAKHRPLTTFYPERFNKWCLGNTPYSLVNAFMHELRQTGYLSNRGRQIVASCLVNEL
ECCCCCCCCCCCCCHHHCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHH
SVDWRYGAAWFEEQLIDYDAAVNWGNWQYIAGVGVDPRGGRHFNIEKQTTLYDPNGDYQA
CCCCHHHHHHHHHHHHHHHHEECCCCEEEEEEECCCCCCCCEEECCCCEEEECCCCCCEE
QWIDLSQQSTQANQALDSVDAADWPVLQ
EEEECCHHHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: ATP; FADH2; Flavin; pterin [C]

Metal ions: NA

Kcat value (1/min): 2.4 [C]

Specific activity: NA

Km value (mM): NA

Substrates: cyclobutadipyrimidine (in DNA) [C]

Specific reaction: cyclobutadipyrimidine (in DNA) = 2 pyrimidine residues (in DNA) [C]

General reaction: C-C-bond cleavage [C]

Inhibitor: yeast DNA [C]

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA