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The map label for this gene is hoxH [H]

Identifier: 119944966

GI number: 119944966

Start: 1516764

End: 1518263

Strand: Reverse

Name: hoxH [H]

Synonym: Ping_1215

Alternate gene names: 119944966

Gene position: 1518263-1516764 (Counterclockwise)

Preceding gene: 119944967

Following gene: 119944965

Centisome position: 33.3

GC content: 44.93

Gene sequence:

>1500_bases
ATGGACAACCCTATGGATCATTCATTAGACACAGCAGAAAACAGCGAAAACCTGAAAAGATTTGTGATTGAACCTGTATC
AAGAGTAGAGGGACACGGTAAAGTGACGCTGCTCGTTGATGATAATAATCAGATTCAGCAGTGTCGTCTGCATATTGCCG
AATTTCGGGGATTTGAACGTTTTATTCAAGGGCGTCCTTATTGGGAAATTCCTATTTTGGTTCAGCGACTTTGTGGCATC
TGCCCGGTTAGCCATCATATTGCCGCCGGCAAGGCGATTGATATGATTAGTGGCGTCACAGAGCTTACCGAATCCGCCTA
TAAATTAAGATTATTACTGCATTACGGGCAAACTTTACAGTCCCATGCGCTGCACTTTTTTCATCTCTGCTCACCGGACT
TCCTGTTTGGTTTTGAAAGTGAACTTGCCGGCAGAAATATCGTCGGCGTAATTCAAAAACACCCGGAGCTCGCGCTTCAG
GGAGTGAAACTCAGAAAGTATGGTCAGGAGGTGATCCGGGTTATTTGCGGTAAGCGCATCCATGGCACGGGTTGTATTCC
GGGCGGCATGAATAAACCTTTAAGCCGGGAGGATAAGCACTATCTTCTTGGTGACACTGAGCAGATCATCGCATGGGCAG
AGTGCGCGGTTAAAACAGCCCGAGATTGTTATCTCGCTAATGAGCCTTTCCACAAAAATTTCGCCGGTTTAAGGTCCAAT
TATTTAAGCTTAGTCGGCGATAAGGGTGAGCTTAATCTTTATCACGGTAAATTAAGATTAAAAGATGCCAGCGGTAATCT
ACTCTTTGATAAACAGGATTATTGCGATTATCAAAATCTGATTCAGGAAGAAGTTAAATCATGGACCTATATGAAATTTC
CTTTTATTAAAACAATGGGCAAAGAATCAGGTTGGTACCGTACAGGCCCATTAGCACGAGTCAATAATTGTGATTATATA
CCGACACCCCTGGCTGAAATGGCGCGTCAAGAATTTGTCGCCTATGGCGGTAAAGAGCCGGTGCATTCAACATTAGCCTA
CCATTGGGCGCGCATGATAGAAGTGCTTTTTTCTGCCGAAAAAATCAAGCAGTTACTCTTCGATCCCATGATTACCGGAA
AAGATCTTATTGTTCAGGGCAAGCGCCAGAGCGAAGGGATAGGCGTGGTTGAGGCACCACGGGGAACACTGATTCATCAT
TACCAGGTGGGTGAAGATGATCTGATCACTAAAGCCAATCTTATCGTCGCGACGACCCATAACAATACCGCATTAAATGA
ATCTATCCGCATCGTTTGCACTCAGCAAATTAACGGCCGGGAAATCAGCGAAAAGGTGTTAAATAATATAGAAGTTGCCA
TTCGTGCTTATGATCCCTGTTTATCCTGTGCAACGCACGCGATCGGCAGAATGCCGCTAAAAGTTGAAATGCGCCACCAG
CAAAGCGGAGAGCTTATCAGCCAACTGATTAAGGATATCGATGGCACTCTACACCGCTAA

Upstream 100 bases:

>100_bases
CCTGCTGATGCTTTTTGGAAAATACTCAATGATTTGCTGGACGGGAAAGAGCCAGAATTACCCTATGACCTATTACACTT
TGATTGATGGACAATGATTA

Downstream 100 bases:

>100_bases
GCGTGATATAAAAAACAGACCCCTTATTATTGAAAAGAGGTCGTGATAGAAAAACTCGGTCAGCAAGCTTTAAATCTGTT
TATCCAGTGTAATAAATGCA

Product: nickel-dependent hydrogenase, large subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 499; Mature: 499

Protein sequence:

>499_residues
MDNPMDHSLDTAENSENLKRFVIEPVSRVEGHGKVTLLVDDNNQIQQCRLHIAEFRGFERFIQGRPYWEIPILVQRLCGI
CPVSHHIAAGKAIDMISGVTELTESAYKLRLLLHYGQTLQSHALHFFHLCSPDFLFGFESELAGRNIVGVIQKHPELALQ
GVKLRKYGQEVIRVICGKRIHGTGCIPGGMNKPLSREDKHYLLGDTEQIIAWAECAVKTARDCYLANEPFHKNFAGLRSN
YLSLVGDKGELNLYHGKLRLKDASGNLLFDKQDYCDYQNLIQEEVKSWTYMKFPFIKTMGKESGWYRTGPLARVNNCDYI
PTPLAEMARQEFVAYGGKEPVHSTLAYHWARMIEVLFSAEKIKQLLFDPMITGKDLIVQGKRQSEGIGVVEAPRGTLIHH
YQVGEDDLITKANLIVATTHNNTALNESIRIVCTQQINGREISEKVLNNIEVAIRAYDPCLSCATHAIGRMPLKVEMRHQ
QSGELISQLIKDIDGTLHR

Sequences:

>Translated_499_residues
MDNPMDHSLDTAENSENLKRFVIEPVSRVEGHGKVTLLVDDNNQIQQCRLHIAEFRGFERFIQGRPYWEIPILVQRLCGI
CPVSHHIAAGKAIDMISGVTELTESAYKLRLLLHYGQTLQSHALHFFHLCSPDFLFGFESELAGRNIVGVIQKHPELALQ
GVKLRKYGQEVIRVICGKRIHGTGCIPGGMNKPLSREDKHYLLGDTEQIIAWAECAVKTARDCYLANEPFHKNFAGLRSN
YLSLVGDKGELNLYHGKLRLKDASGNLLFDKQDYCDYQNLIQEEVKSWTYMKFPFIKTMGKESGWYRTGPLARVNNCDYI
PTPLAEMARQEFVAYGGKEPVHSTLAYHWARMIEVLFSAEKIKQLLFDPMITGKDLIVQGKRQSEGIGVVEAPRGTLIHH
YQVGEDDLITKANLIVATTHNNTALNESIRIVCTQQINGREISEKVLNNIEVAIRAYDPCLSCATHAIGRMPLKVEMRHQ
QSGELISQLIKDIDGTLHR
>Mature_499_residues
MDNPMDHSLDTAENSENLKRFVIEPVSRVEGHGKVTLLVDDNNQIQQCRLHIAEFRGFERFIQGRPYWEIPILVQRLCGI
CPVSHHIAAGKAIDMISGVTELTESAYKLRLLLHYGQTLQSHALHFFHLCSPDFLFGFESELAGRNIVGVIQKHPELALQ
GVKLRKYGQEVIRVICGKRIHGTGCIPGGMNKPLSREDKHYLLGDTEQIIAWAECAVKTARDCYLANEPFHKNFAGLRSN
YLSLVGDKGELNLYHGKLRLKDASGNLLFDKQDYCDYQNLIQEEVKSWTYMKFPFIKTMGKESGWYRTGPLARVNNCDYI
PTPLAEMARQEFVAYGGKEPVHSTLAYHWARMIEVLFSAEKIKQLLFDPMITGKDLIVQGKRQSEGIGVVEAPRGTLIHH
YQVGEDDLITKANLIVATTHNNTALNESIRIVCTQQINGREISEKVLNNIEVAIRAYDPCLSCATHAIGRMPLKVEMRHQ
QSGELISQLIKDIDGTLHR

Specific function: This Is One Of Three E.Coli Hydrogenases Synthesized In Response To Different Physiological Conditions. Hyd1 Is Believed To Have A Role In Hydrogen Cycling During Fermentative Growth. [C]

COG id: COG3259

COG function: function code C; Coenzyme F420-reducing hydrogenase, alpha subunit

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family [H]

Homologues:

Organism=Escherichia coli, GI1787207, Length=117, Percent_Identity=29.0598290598291, Blast_Score=67, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001501
- InterPro:   IPR018194 [H]

Pfam domain/function: PF00374 NiFeSe_Hases [H]

EC number: =1.12.1.2 [H]

Molecular weight: Translated: 56429; Mature: 56429

Theoretical pI: Translated: 7.46; Mature: 7.46

Prosite motif: PS00507 NI_HGENASE_L_1 ; PS00508 NI_HGENASE_L_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDNPMDHSLDTAENSENLKRFVIEPVSRVEGHGKVTLLVDDNNQIQQCRLHIAEFRGFER
CCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHH
FIQGRPYWEIPILVQRLCGICPVSHHIAAGKAIDMISGVTELTESAYKLRLLLHYGQTLQ
HHCCCCCEEHHHHHHHHHCCCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SHALHFFHLCSPDFLFGFESELAGRNIVGVIQKHPELALQGVKLRKYGQEVIRVICGKRI
HHHHHHHCCCCCHHEECCHHHHCCCCEEHHHHCCCHHHHCCHHHHHHHHHHHHHHHCCCC
HGTGCIPGGMNKPLSREDKHYLLGDTEQIIAWAECAVKTARDCYLANEPFHKNFAGLRSN
CCCCCCCCCCCCCCCCCCCEEECCCHHHHHHHHHHHHHHHHHHEECCCCCHHHHHHHHHH
YLSLVGDKGELNLYHGKLRLKDASGNLLFDKQDYCDYQNLIQEEVKSWTYMKFPFIKTMG
HHHHCCCCCCEEEEEEEEEEEECCCCEEECCHHHCCHHHHHHHHHHHCEEEECHHHHHCC
KESGWYRTGPLARVNNCDYIPTPLAEMARQEFVAYGGKEPVHSTLAYHWARMIEVLFSAE
CCCCCEECCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHH
KIKQLLFDPMITGKDLIVQGKRQSEGIGVVEAPRGTLIHHYQVGEDDLITKANLIVATTH
HHHHHHHCCCCCCCCEEEECCCCCCCCCEEECCCCCEEEEEECCCCCCEEECCEEEEEEC
NNTALNESIRIVCTQQINGREISEKVLNNIEVAIRAYDPCLSCATHAIGRMPLKVEMRHQ
CCCCCCCCEEEEEECCCCCCHHHHHHHCCCEEEEEECCHHHHHHHHHHCCCCEEEEECCC
QSGELISQLIKDIDGTLHR
HHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MDNPMDHSLDTAENSENLKRFVIEPVSRVEGHGKVTLLVDDNNQIQQCRLHIAEFRGFER
CCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHH
FIQGRPYWEIPILVQRLCGICPVSHHIAAGKAIDMISGVTELTESAYKLRLLLHYGQTLQ
HHCCCCCEEHHHHHHHHHCCCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SHALHFFHLCSPDFLFGFESELAGRNIVGVIQKHPELALQGVKLRKYGQEVIRVICGKRI
HHHHHHHCCCCCHHEECCHHHHCCCCEEHHHHCCCHHHHCCHHHHHHHHHHHHHHHCCCC
HGTGCIPGGMNKPLSREDKHYLLGDTEQIIAWAECAVKTARDCYLANEPFHKNFAGLRSN
CCCCCCCCCCCCCCCCCCCEEECCCHHHHHHHHHHHHHHHHHHEECCCCCHHHHHHHHHH
YLSLVGDKGELNLYHGKLRLKDASGNLLFDKQDYCDYQNLIQEEVKSWTYMKFPFIKTMG
HHHHCCCCCCEEEEEEEEEEEECCCCEEECCHHHCCHHHHHHHHHHHCEEEECHHHHHCC
KESGWYRTGPLARVNNCDYIPTPLAEMARQEFVAYGGKEPVHSTLAYHWARMIEVLFSAE
CCCCCEECCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHH
KIKQLLFDPMITGKDLIVQGKRQSEGIGVVEAPRGTLIHHYQVGEDDLITKANLIVATTH
HHHHHHHCCCCCCCCEEEECCCCCCCCCEEECCCCCEEEEEECCCCCCEEECCEEEEEEC
NNTALNESIRIVCTQQINGREISEKVLNNIEVAIRAYDPCLSCATHAIGRMPLKVEMRHQ
CCCCCCCCEEEEEECCCCCCHHHHHHHCCCEEEEEECCHHHHHHHHHHCCCCEEEEECCC
QSGELISQLIKDIDGTLHR
HHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2188945; 12948488; 2496982 [H]