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The map label for this gene is trpE [H]

Identifier: 119944818

GI number: 119944818

Start: 1334018

End: 1335682

Strand: Reverse

Name: trpE [H]

Synonym: Ping_1060

Alternate gene names: 119944818

Gene position: 1335682-1334018 (Counterclockwise)

Preceding gene: 119944823

Following gene: 119944817

Centisome position: 29.29

GC content: 41.68

Gene sequence:

>1665_bases
ATGAATACTAATCATCCCATCGGCGTATTAAAAAGCCTTTCAGCAGACTGTCAATATATCAGTGACTCGCTTGGTTTATT
TCAAACTTTTAGTGCCAATACAGACAATCATCTATTATTTGATTCTGCCGAAATTGAAAGTAAAAACCATCTTAAAAGCT
TAATGCTGATTGATGCCTGTATGAAAATCACCTGTCATGGTCTAACCGTCACACTCGATGCCTTAACTGATAACGGTAAA
GACCTGCTTACTTTTATTACACCGCAATTTTCCACACAAATAATCAGCCAACATTCCGCCCATCAACTACAGCTTGTTTT
CCCAGCATCAGACGCCACTGGCGATGAAGATCAGCGTTTAAAATCATTATCACCAGTAGATGCTTTGCGTTTTATTGTTA
AAGGTATTAAAACGCCATCATCTCATCAGCAGGCATTGTTTTTGGGCGGTATCTTTGCCTATGACTTTATCGCTACCTTT
GAAGATTTAATGGCAGTGCCTGAGAGTGATAACATCTGTCCTGATTTTATGTTTTATGTCGCTGAAACATTAATGATTCA
AAATCATCAAACTCAGAAAGGGGAATTAATCGCTTCGGTATTTGGCGGATTATACTCCGATGAGAATGAGCAGCGCCTGA
ATGCGCGTTTAGCAGAAATACAACAACAATGTATTAATTTTGAAACAACCGAAAACCCTGTTACTCCCTTAACCGGAAAA
GTCAGTACGGATGTTTCAGATCAAGAATATTGCGCTATTGTTGAAGAGCTTAAAAAATACATCGTAAAAGGAGATATTTT
TCAGGTAGTGCCTTCACGTAGTTTTTCGCTTTCTTGCCCTAATCCGATTGCCGCTTATGCAAAACTTAAACAAACAAATC
CAAGTCCTTATATGTTTTATTTAAAAGACAGTGATTTCACTCTGTTTGGCGCATCTCCGGAAAGTGCACTTAAATACACC
CAAGCCTCAAATGATGTTGAGATTTATCCCATTGCAGGGACTCGCAGACGAGGATTTAATCCCGATGGCAGCATTAACAA
AGATTTAGACAGTCGTTTAGAGTTGGAATTACGTTTAGACCAAAAAGAAACATCTGAGCATTTAATGCTGGTTGATTTAG
CCCGTAATGACGTGGCGCGCATTAGCGAACCAGGTACCAGGCATGTGGCAGACCTATTAAAAGTAGACCGTTACAGTCAC
GTTATGCACTTAGTTTCTCGCGTTATCGGCAAATTACGCACGGATTTAGATGCACTGCACGCCTACCAGGCATGTATGAA
TATGGGCACTCTCGTAGGTGCGCCTAAAATCAGTGCATCGAATCTGGTCCGTCAAGTAGAAAAAAAACGCCGTGGCAGTT
ACGGTGGTGCAGTCGGTTATATCAACGGCTGTGGTGATATGGATAGCTGTATTGTTATCCGCTCGGCATTTGTAAAAAAT
GGTATCGCACAAGCGCAAGCAGGTGCAGGGGTTGTATTTGATTCAATACCACAGGCAGAGGCTGATGAAACCCGTACTAA
AGCCGCGGCGGTATTAAATGCGATTGCATTAGCCCATGGCACAACACTTGCGGAAGTATCTCGACCTGATGTGTCTTTAC
CTGATACCTCTTTACCTGAAACGCCCTCAACAGGCGCTTCCTCAACCTTAGCTAATGGAGAGTAA

Upstream 100 bases:

>100_bases
AAAAAACATGAATAATACCAATAAAATCCTTAAACAATCTTGGCGATGGTGGTGAACACAATCCATAACCCATTAACAGA
TATAATTTTAAAGGATAAAA

Downstream 100 bases:

>100_bases
AAAGATGGAGATAACTAAAAAACAAACACTCTTTTTCCTGGATAACTTTGACTCTTTTACTTATAACCTGGTTGATCAAT
TTAAGGCATTGGGTTATCCG

Product: anthranilate synthase component I

Products: NA

Alternate protein names: Anthranilate synthase component I [H]

Number of amino acids: Translated: 554; Mature: 554

Protein sequence:

>554_residues
MNTNHPIGVLKSLSADCQYISDSLGLFQTFSANTDNHLLFDSAEIESKNHLKSLMLIDACMKITCHGLTVTLDALTDNGK
DLLTFITPQFSTQIISQHSAHQLQLVFPASDATGDEDQRLKSLSPVDALRFIVKGIKTPSSHQQALFLGGIFAYDFIATF
EDLMAVPESDNICPDFMFYVAETLMIQNHQTQKGELIASVFGGLYSDENEQRLNARLAEIQQQCINFETTENPVTPLTGK
VSTDVSDQEYCAIVEELKKYIVKGDIFQVVPSRSFSLSCPNPIAAYAKLKQTNPSPYMFYLKDSDFTLFGASPESALKYT
QASNDVEIYPIAGTRRRGFNPDGSINKDLDSRLELELRLDQKETSEHLMLVDLARNDVARISEPGTRHVADLLKVDRYSH
VMHLVSRVIGKLRTDLDALHAYQACMNMGTLVGAPKISASNLVRQVEKKRRGSYGGAVGYINGCGDMDSCIVIRSAFVKN
GIAQAQAGAGVVFDSIPQAEADETRTKAAAVLNAIALAHGTTLAEVSRPDVSLPDTSLPETPSTGASSTLANGE

Sequences:

>Translated_554_residues
MNTNHPIGVLKSLSADCQYISDSLGLFQTFSANTDNHLLFDSAEIESKNHLKSLMLIDACMKITCHGLTVTLDALTDNGK
DLLTFITPQFSTQIISQHSAHQLQLVFPASDATGDEDQRLKSLSPVDALRFIVKGIKTPSSHQQALFLGGIFAYDFIATF
EDLMAVPESDNICPDFMFYVAETLMIQNHQTQKGELIASVFGGLYSDENEQRLNARLAEIQQQCINFETTENPVTPLTGK
VSTDVSDQEYCAIVEELKKYIVKGDIFQVVPSRSFSLSCPNPIAAYAKLKQTNPSPYMFYLKDSDFTLFGASPESALKYT
QASNDVEIYPIAGTRRRGFNPDGSINKDLDSRLELELRLDQKETSEHLMLVDLARNDVARISEPGTRHVADLLKVDRYSH
VMHLVSRVIGKLRTDLDALHAYQACMNMGTLVGAPKISASNLVRQVEKKRRGSYGGAVGYINGCGDMDSCIVIRSAFVKN
GIAQAQAGAGVVFDSIPQAEADETRTKAAAVLNAIALAHGTTLAEVSRPDVSLPDTSLPETPSTGASSTLANGE
>Mature_554_residues
MNTNHPIGVLKSLSADCQYISDSLGLFQTFSANTDNHLLFDSAEIESKNHLKSLMLIDACMKITCHGLTVTLDALTDNGK
DLLTFITPQFSTQIISQHSAHQLQLVFPASDATGDEDQRLKSLSPVDALRFIVKGIKTPSSHQQALFLGGIFAYDFIATF
EDLMAVPESDNICPDFMFYVAETLMIQNHQTQKGELIASVFGGLYSDENEQRLNARLAEIQQQCINFETTENPVTPLTGK
VSTDVSDQEYCAIVEELKKYIVKGDIFQVVPSRSFSLSCPNPIAAYAKLKQTNPSPYMFYLKDSDFTLFGASPESALKYT
QASNDVEIYPIAGTRRRGFNPDGSINKDLDSRLELELRLDQKETSEHLMLVDLARNDVARISEPGTRHVADLLKVDRYSH
VMHLVSRVIGKLRTDLDALHAYQACMNMGTLVGAPKISASNLVRQVEKKRRGSYGGAVGYINGCGDMDSCIVIRSAFVKN
GIAQAQAGAGVVFDSIPQAEADETRTKAAAVLNAIALAHGTTLAEVSRPDVSLPDTSLPETPSTGASSTLANGE

Specific function: Tryptophan biosynthesis; first step. [C]

COG id: COG0147

COG function: function code EH; Anthranilate/para-aminobenzoate synthases component I

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the anthranilate synthase component I family [H]

Homologues:

Organism=Escherichia coli, GI1787518, Length=523, Percent_Identity=54.302103250478, Blast_Score=552, Evalue=1e-158,
Organism=Escherichia coli, GI1788114, Length=397, Percent_Identity=28.7153652392947, Blast_Score=165, Evalue=7e-42,
Organism=Escherichia coli, GI1786809, Length=236, Percent_Identity=30.0847457627119, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI87082077, Length=303, Percent_Identity=26.4026402640264, Blast_Score=71, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6320935, Length=377, Percent_Identity=35.8090185676393, Blast_Score=206, Evalue=9e-54,
Organism=Saccharomyces cerevisiae, GI6324361, Length=392, Percent_Identity=23.9795918367347, Blast_Score=78, Evalue=3e-15,

Paralogues:

None

Copy number: 700 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005801
- InterPro:   IPR019999
- InterPro:   IPR006805
- InterPro:   IPR005257
- InterPro:   IPR015890 [H]

Pfam domain/function: PF04715 Anth_synt_I_N; PF00425 Chorismate_bind [H]

EC number: =4.1.3.27 [H]

Molecular weight: Translated: 60476; Mature: 60476

Theoretical pI: Translated: 5.05; Mature: 5.05

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNTNHPIGVLKSLSADCQYISDSLGLFQTFSANTDNHLLFDSAEIESKNHLKSLMLIDAC
CCCCCCHHHHHHHHHHHHHHHHHHHHHEEECCCCCCEEEECCHHCCCHHHHHHHHHHHHH
MKITCHGLTVTLDALTDNGKDLLTFITPQFSTQIISQHSAHQLQLVFPASDATGDEDQRL
HHHEECCEEEEEEEECCCCCEEEEEECCHHHHHHHHCCCCCEEEEEEECCCCCCCHHHHH
KSLSPVDALRFIVKGIKTPSSHQQALFLGGIFAYDFIATFEDLMAVPESDNICPDFMFYV
HHCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHH
AETLMIQNHQTQKGELIASVFGGLYSDENEQRLNARLAEIQQQCINFETTENPVTPLTGK
HHHHHHCCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
VSTDVSDQEYCAIVEELKKYIVKGDIFQVVPSRSFSLSCPNPIAAYAKLKQTNPSPYMFY
CCCCCCCHHHHHHHHHHHHHHHCCCHHEECCCCCEECCCCCHHHHHHHHHCCCCCCEEEE
LKDSDFTLFGASPESALKYTQASNDVEIYPIAGTRRRGFNPDGSINKDLDSRLELELRLD
EECCCEEEECCCHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCEEEEEEEC
QKETSEHLMLVDLARNDVARISEPGTRHVADLLKVDRYSHVMHLVSRVIGKLRTDLDALH
CCCCCCCEEEEEECCCCHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AYQACMNMGTLVGAPKISASNLVRQVEKKRRGSYGGAVGYINGCGDMDSCIVIRSAFVKN
HHHHHHHCCHHCCCCCCCHHHHHHHHHHHHCCCCCCCEEEEECCCCCHHHHHHHHHHHHC
GIAQAQAGAGVVFDSIPQAEADETRTKAAAVLNAIALAHGTTLAEVSRPDVSLPDTSLPE
CHHHHCCCCCCEECCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHCCCCCCCCCCCCCCC
TPSTGASSTLANGE
CCCCCCCCCCCCCC
>Mature Secondary Structure
MNTNHPIGVLKSLSADCQYISDSLGLFQTFSANTDNHLLFDSAEIESKNHLKSLMLIDAC
CCCCCCHHHHHHHHHHHHHHHHHHHHHEEECCCCCCEEEECCHHCCCHHHHHHHHHHHHH
MKITCHGLTVTLDALTDNGKDLLTFITPQFSTQIISQHSAHQLQLVFPASDATGDEDQRL
HHHEECCEEEEEEEECCCCCEEEEEECCHHHHHHHHCCCCCEEEEEEECCCCCCCHHHHH
KSLSPVDALRFIVKGIKTPSSHQQALFLGGIFAYDFIATFEDLMAVPESDNICPDFMFYV
HHCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHH
AETLMIQNHQTQKGELIASVFGGLYSDENEQRLNARLAEIQQQCINFETTENPVTPLTGK
HHHHHHCCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
VSTDVSDQEYCAIVEELKKYIVKGDIFQVVPSRSFSLSCPNPIAAYAKLKQTNPSPYMFY
CCCCCCCHHHHHHHHHHHHHHHCCCHHEECCCCCEECCCCCHHHHHHHHHCCCCCCEEEE
LKDSDFTLFGASPESALKYTQASNDVEIYPIAGTRRRGFNPDGSINKDLDSRLELELRLD
EECCCEEEECCCHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCEEEEEEEC
QKETSEHLMLVDLARNDVARISEPGTRHVADLLKVDRYSHVMHLVSRVIGKLRTDLDALH
CCCCCCCEEEEEECCCCHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AYQACMNMGTLVGAPKISASNLVRQVEKKRRGSYGGAVGYINGCGDMDSCIVIRSAFVKN
HHHHHHHCCHHCCCCCCCHHHHHHHHHHHHCCCCCCCEEEEECCCCCHHHHHHHHHHHHC
GIAQAQAGAGVVFDSIPQAEADETRTKAAAVLNAIALAHGTTLAEVSRPDVSLPDTSLPE
CHHHHCCCCCCEECCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHCCCCCCCCCCCCCCC
TPSTGASSTLANGE
CCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1773058; 12620739 [H]