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The map label for this gene is hutU [H]

Identifier: 119944788

GI number: 119944788

Start: 1299488

End: 1301167

Strand: Reverse

Name: hutU [H]

Synonym: Ping_1030

Alternate gene names: 119944788

Gene position: 1301167-1299488 (Counterclockwise)

Preceding gene: 119944789

Following gene: 119944787

Centisome position: 28.54

GC content: 47.86

Gene sequence:

>1680_bases
ATGACTGATAAGCGTTTAGATACTTCGCGCACTATTATTGCACCACAAGGTACAAAATTGAATGCTAAATCTTGGCTAAC
GGAAGCGCCCCTTAGAATGTTAATGAATAATCTTCATCCTGACGTTGCTGAGCACCCGCATGCCTTAGTTGTCTATGGTG
GTATCGGCCGTGCTGCACGTGATTGGCAGTCCTATGACAAGATTGTCGAAGTACTGCAGCGTTTAGAAGATGACGAAACC
TTATTAGTCCAGTCAGGTAAACCCGTCGGTGTTTTTCAAACCCATAAAAATGCGCCACGGGTACTGATTGCCAATTCGAA
CCTCGTGCCCCATTGGGCAAACTGGGAACACTTCAATAAACTCGATAAGCAGGGTTTGATGATGTACGGACAAATGACCG
CGGGCTCTTGGATTTACATTGGCTCTCAGGGAATTGTGCAAGGTACTTATGAGACTTTTGTGGCCATGGCGAAAAAACAT
TTTTCCGGCAGCGCTAGCGGTCGCTGGATATTAACTGGCGGCTTAGGCGGAATGGGGGGGGCACAACCCCTTGCTGCCAC
GATGGCAGGCTTTTCAATGGTGGCCGTAGAATGTGATGAATCGCGTATTGATTACCGTTTACGGACAGGTTATGTGGATC
AAAAAGCCACTTCTTTGAATCAGGCATTAAGACTGCTTGAACAGGCAAAAGCGGATAATAAAACCACTTCAATTGCGCTG
CTTGCCAATACCGCGGATATTTTTACCGAGCTGGTTAAACGTCAAATAACCCCCGATGTGGTCACTGACCAGACCTCGGC
ACACGATCCCTTAAACGGTTACCTGCCTCAGAACTGGACTATGGAATACGTGGCAGAAATGCGTAAAACCGATGAAGCTG
CTGTTATTAAAGCCGCTAAAAAATCCATGGCAGTACAAGTTAAGGCGATGCTGGATCTCCAGTCTGCGGGCGCTGCAACC
GTTGATTATGGGAATAATATTCGGCAAATGGCCCTTGAGGAAGGAGTTAAAAATGCCTTTGATTTCCCGGGATTTGTACC
GGCTTATATCCGTCCGCTATTTTGTGAAGGTATTGGTCCTTTTCGCTGGGTTGCGCTGTCTGGCGATCCAGAAGATATTT
ACAAAACAGATCAGAAAGTAAAAGAGCTTATTCCCAATAATCCAGATCTGCACAACTGGCTGGATATGGCGCGGGAACAC
ATCCAATTCCAAGGTCTGCCGGCACGTATTTGCTGGGTTGGTTTAAAAGATCGTCAGCGTCTGGGACTGGCATTTAATGA
AATGGTTAAAAATGGCGAACTGAAAGCCCCTCTTGTTATTGGCCGTGATCACCTTGATTCAGGCTCGGTCGCAAGCCCAA
ACCGCGAGACTGAAGACATGCTGGATGGTTCCGATGCGGTGTCAGACTGGCCATTATTAAACGCGTTATTAAACACCGCC
AGTGGTGCAACATGGGTATCACTGCATCATGGTGGTGGTGTCGGTATGGGGTTTTCACAACATTCGGGCATGGTCGTGGT
CTGTGATGGGACAGATGATGCCCACCAGCGTATTAGCCGGGTATTAAGAAACGATCCGGCCACAGGTGTAATGCGTCATG
CCGATGCGGGTTACGAGATCGCTAAAAAATGTGCTCGCGAGCAGCACCTTGATTTGCCTATGCTCGATACCGAACAGTAA

Upstream 100 bases:

>100_bases
ATCTCCCATGCCATGTTCAAAACGCTATAACTATTTATAACAAGTATGATAACCCCGTCTGTTTTATGAAGGGATAAATT
ACTATTACGAGGAAATAAAA

Downstream 100 bases:

>100_bases
AAATATTAAATAATAGATATCGAATAGTAAAAATATTGAATAACAGATATCGCATAGCAAACCGCATTCAACTAAATATT
ATTGTCATGATAGGTAATCC

Product: urocanate hydratase

Products: NA

Alternate protein names: Urocanase; Imidazolonepropionate hydrolase [H]

Number of amino acids: Translated: 559; Mature: 558

Protein sequence:

>559_residues
MTDKRLDTSRTIIAPQGTKLNAKSWLTEAPLRMLMNNLHPDVAEHPHALVVYGGIGRAARDWQSYDKIVEVLQRLEDDET
LLVQSGKPVGVFQTHKNAPRVLIANSNLVPHWANWEHFNKLDKQGLMMYGQMTAGSWIYIGSQGIVQGTYETFVAMAKKH
FSGSASGRWILTGGLGGMGGAQPLAATMAGFSMVAVECDESRIDYRLRTGYVDQKATSLNQALRLLEQAKADNKTTSIAL
LANTADIFTELVKRQITPDVVTDQTSAHDPLNGYLPQNWTMEYVAEMRKTDEAAVIKAAKKSMAVQVKAMLDLQSAGAAT
VDYGNNIRQMALEEGVKNAFDFPGFVPAYIRPLFCEGIGPFRWVALSGDPEDIYKTDQKVKELIPNNPDLHNWLDMAREH
IQFQGLPARICWVGLKDRQRLGLAFNEMVKNGELKAPLVIGRDHLDSGSVASPNRETEDMLDGSDAVSDWPLLNALLNTA
SGATWVSLHHGGGVGMGFSQHSGMVVVCDGTDDAHQRISRVLRNDPATGVMRHADAGYEIAKKCAREQHLDLPMLDTEQ

Sequences:

>Translated_559_residues
MTDKRLDTSRTIIAPQGTKLNAKSWLTEAPLRMLMNNLHPDVAEHPHALVVYGGIGRAARDWQSYDKIVEVLQRLEDDET
LLVQSGKPVGVFQTHKNAPRVLIANSNLVPHWANWEHFNKLDKQGLMMYGQMTAGSWIYIGSQGIVQGTYETFVAMAKKH
FSGSASGRWILTGGLGGMGGAQPLAATMAGFSMVAVECDESRIDYRLRTGYVDQKATSLNQALRLLEQAKADNKTTSIAL
LANTADIFTELVKRQITPDVVTDQTSAHDPLNGYLPQNWTMEYVAEMRKTDEAAVIKAAKKSMAVQVKAMLDLQSAGAAT
VDYGNNIRQMALEEGVKNAFDFPGFVPAYIRPLFCEGIGPFRWVALSGDPEDIYKTDQKVKELIPNNPDLHNWLDMAREH
IQFQGLPARICWVGLKDRQRLGLAFNEMVKNGELKAPLVIGRDHLDSGSVASPNRETEDMLDGSDAVSDWPLLNALLNTA
SGATWVSLHHGGGVGMGFSQHSGMVVVCDGTDDAHQRISRVLRNDPATGVMRHADAGYEIAKKCAREQHLDLPMLDTEQ
>Mature_558_residues
TDKRLDTSRTIIAPQGTKLNAKSWLTEAPLRMLMNNLHPDVAEHPHALVVYGGIGRAARDWQSYDKIVEVLQRLEDDETL
LVQSGKPVGVFQTHKNAPRVLIANSNLVPHWANWEHFNKLDKQGLMMYGQMTAGSWIYIGSQGIVQGTYETFVAMAKKHF
SGSASGRWILTGGLGGMGGAQPLAATMAGFSMVAVECDESRIDYRLRTGYVDQKATSLNQALRLLEQAKADNKTTSIALL
ANTADIFTELVKRQITPDVVTDQTSAHDPLNGYLPQNWTMEYVAEMRKTDEAAVIKAAKKSMAVQVKAMLDLQSAGAATV
DYGNNIRQMALEEGVKNAFDFPGFVPAYIRPLFCEGIGPFRWVALSGDPEDIYKTDQKVKELIPNNPDLHNWLDMAREHI
QFQGLPARICWVGLKDRQRLGLAFNEMVKNGELKAPLVIGRDHLDSGSVASPNRETEDMLDGSDAVSDWPLLNALLNTAS
GATWVSLHHGGGVGMGFSQHSGMVVVCDGTDDAHQRISRVLRNDPATGVMRHADAGYEIAKKCAREQHLDLPMLDTEQ

Specific function: Unknown

COG id: COG2987

COG function: function code E; Urocanate hydratase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the urocanase family [H]

Homologues:

Organism=Homo sapiens, GI21389467, Length=558, Percent_Identity=32.7956989247312, Blast_Score=302, Evalue=6e-82,
Organism=Homo sapiens, GI260306182, Length=351, Percent_Identity=30.4843304843305, Blast_Score=155, Evalue=1e-37,
Organism=Caenorhabditis elegans, GI71997891, Length=550, Percent_Identity=32.9090909090909, Blast_Score=307, Evalue=9e-84,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000193 [H]

Pfam domain/function: PF01175 Urocanase [H]

EC number: =4.2.1.49 [H]

Molecular weight: Translated: 61562; Mature: 61431

Theoretical pI: Translated: 6.37; Mature: 6.37

Prosite motif: PS01233 UROCANASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDKRLDTSRTIIAPQGTKLNAKSWLTEAPLRMLMNNLHPDVAEHPHALVVYGGIGRAAR
CCCCCCCCCCEEECCCCCEECHHHHHHHHHHHHHHHHCCCCHHHCCCEEEEECCCCCHHH
DWQSYDKIVEVLQRLEDDETLLVQSGKPVGVFQTHKNAPRVLIANSNLVPHWANWEHFNK
HHHHHHHHHHHHHHCCCCCEEEEECCCCCEEEEECCCCCEEEEECCCCCCCCCCCHHHHH
LDKQGLMMYGQMTAGSWIYIGSQGIVQGTYETFVAMAKKHFSGSASGRWILTGGLGGMGG
HCCCCEEEEEEECCCCEEEECCCCCCCHHHHHHHHHHHHHCCCCCCCCEEEECCCCCCCC
AQPLAATMAGFSMVAVECDESRIDYRLRTGYVDQKATSLNQALRLLEQAKADNKTTSIAL
CCHHHHHHCCCEEEEEECCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHCCCCCCEEEEE
LANTADIFTELVKRQITPDVVTDQTSAHDPLNGYLPQNWTMEYVAEMRKTDEAAVIKAAK
EECCHHHHHHHHHHHCCCCHHCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCHHHHHHHHH
KSMAVQVKAMLDLQSAGAATVDYGNNIRQMALEEGVKNAFDFPGFVPAYIRPLFCEGIGP
HHHHEEHHHHHHHHCCCCEEECCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCC
FRWVALSGDPEDIYKTDQKVKELIPNNPDLHNWLDMAREHIQFQGLPARICWVGLKDRQR
EEEEEECCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCEEEEEECCCCHHH
LGLAFNEMVKNGELKAPLVIGRDHLDSGSVASPNRETEDMLDGSDAVSDWPLLNALLNTA
HHHHHHHHHCCCCCCCCEEECCCCCCCCCCCCCCCCHHHHCCCCCCCCCHHHHHHHHHCC
SGATWVSLHHGGGVGMGFSQHSGMVVVCDGTDDAHQRISRVLRNDPATGVMRHADAGYEI
CCCEEEEEECCCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHCCCCCHHHHHCCCCHHH
AKKCAREQHLDLPMLDTEQ
HHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure 
TDKRLDTSRTIIAPQGTKLNAKSWLTEAPLRMLMNNLHPDVAEHPHALVVYGGIGRAAR
CCCCCCCCCEEECCCCCEECHHHHHHHHHHHHHHHHCCCCHHHCCCEEEEECCCCCHHH
DWQSYDKIVEVLQRLEDDETLLVQSGKPVGVFQTHKNAPRVLIANSNLVPHWANWEHFNK
HHHHHHHHHHHHHHCCCCCEEEEECCCCCEEEEECCCCCEEEEECCCCCCCCCCCHHHHH
LDKQGLMMYGQMTAGSWIYIGSQGIVQGTYETFVAMAKKHFSGSASGRWILTGGLGGMGG
HCCCCEEEEEEECCCCEEEECCCCCCCHHHHHHHHHHHHHCCCCCCCCEEEECCCCCCCC
AQPLAATMAGFSMVAVECDESRIDYRLRTGYVDQKATSLNQALRLLEQAKADNKTTSIAL
CCHHHHHHCCCEEEEEECCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHCCCCCCEEEEE
LANTADIFTELVKRQITPDVVTDQTSAHDPLNGYLPQNWTMEYVAEMRKTDEAAVIKAAK
EECCHHHHHHHHHHHCCCCHHCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCHHHHHHHHH
KSMAVQVKAMLDLQSAGAATVDYGNNIRQMALEEGVKNAFDFPGFVPAYIRPLFCEGIGP
HHHHEEHHHHHHHHCCCCEEECCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCC
FRWVALSGDPEDIYKTDQKVKELIPNNPDLHNWLDMAREHIQFQGLPARICWVGLKDRQR
EEEEEECCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCEEEEEECCCCHHH
LGLAFNEMVKNGELKAPLVIGRDHLDSGSVASPNRETEDMLDGSDAVSDWPLLNALLNTA
HHHHHHHHHCCCCCCCCEEECCCCCCCCCCCCCCCCHHHHCCCCCCCCCHHHHHHHHHCC
SGATWVSLHHGGGVGMGFSQHSGMVVVCDGTDDAHQRISRVLRNDPATGVMRHADAGYEI
CCCEEEEEECCCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHCCCCCHHHHHCCCCHHH
AKKCAREQHLDLPMLDTEQ
HHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA