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The map label for this gene is hutH

Identifier: 119944787

GI number: 119944787

Start: 1297829

End: 1299361

Strand: Reverse

Name: hutH

Synonym: Ping_1029

Alternate gene names: 119944787

Gene position: 1299361-1297829 (Counterclockwise)

Preceding gene: 119944788

Following gene: 119944783

Centisome position: 28.5

GC content: 45.66

Gene sequence:

>1533_bases
ATGTACGAATTACATATTAAACCGGGACAATTAACACTTTCTCAACTGCGTAAAATCAGCCGTCATGCGCTTAAAGTCAG
CTTAGAATCAAGTTGTATTGAGGCCATTCATGCCAGTACACAAGTTGTCAATCAAGTGATTGCAGAAAATAGGGTTGCTT
ATGGTATTAATACCGGTTTTGGTTTGCTGGCTAATACTCGAATCGCCCCGGAAGACTTGGAAACACTGCAGCGCAGTATT
GTCCTTTCCCATGCGGCGGGTATCGGCGAATTGATGAATGATGAAACCGTGCGGATGATGATGGTATTAAAAATCAACAG
TCTGGCGCGGGGTTTTTCAGGGATTCGTTTATCTGTTATTGAAGCATTAATGACACTGGTAAATGCACAGATTTACCCTT
GTGTGCCCAAAAAAGGGTCAGTGGGTGCATCGGGTGATTTAGCACCATTAGCACACATGAGTACGGTGTTACTAGGTGAA
GGTGAAGCGCGTTATCAGGGAAACATAATTTCAGGTGCAAAAGCGTTAGAAATTGCCGGCATGCAGCCTATTACTTTGGC
TCCTAAAGAAGGACTCGCATTATTAAACGGTACTCAGGCATCCTGTGCTTTTGGCCTGGAAGGGCTATTTGCCGCTGAGG
ATCTGTTCGCTTCTGCCACTTTATGCGGCGCAATGACGGTCGATGCCGCATTAGGCAGCCGTCGTCCCTTTGATGACCGG
GTACATCAAGTACGCGGTCATCAATCACAAATAGATTCAGCTTTAATCTATCGTCATATACTCGATACACACAGTGAAGT
AAGTCATTCACATACAGCCTGTGAAAAAGTGCAGGATCCCTACTCTCTTCGCTGTCAGCCCCAGGTAATGGGGGCCTGTT
TACAGCAAATTCGTAATTCTGCCGCTATTTATGAAATTGAAGCAAATTCTGTCTCGGATAATCCGCTGGTCTTTGCCGAG
GATGGTGATATTATTTCTGCCGGTAATTTCCATGCTGAACCTATTGCTATGGCCAGTGATAATTTAGCCTTAGCCATTGC
TGAAATTGGCAGTTTATCTGAACGCCGTATGGCATTGTTAATTGACAACAGTTTAAGTAAATTACCGCCCTTTTTGGTCA
ATAACGGCGGCGTTAACTCCGGCTTTATGATTGCTCAGGTAACGGCAGCGGCGCTTGCCAGCGAAAATAAATCCCTCGCT
CACCCGGCCTGTGTGGACAGCCTGCCAACATCGGCCAATCAGGAAGATCACGTTTCAATGGCAACCTTTGCCGGTCGGCG
CTTAAAAGAGATGGCGGAAAACACCCGCGGTATTTTAGCGGTGGAGTTATTGGCCGCAGCCCAGGGGCTGGATTTTAGAT
CCCCGTTAAAATCCTCTGAATTAATAGAAACAGCCAAGGCTGAATTACGGGAGCGGGTTGATTTTTATGATAAAGACAGA
TATTTCGCACCCGATATTAAACAGGCAAATCAGTTGTTAATTGAAGCCATGCATAACAAACTGATCCCGGAAGGTTTACT
GCCGAGCCTTTAA

Upstream 100 bases:

>100_bases
GTAAAAATATTGAATAACAGATATCGCATAGCAAACCGCATTCAACTAAATATTATTGTCATGATAGGTAATCCAAGCTG
TCATGACTGTGGAGAAAAAG

Downstream 100 bases:

>100_bases
AAACAGAAATCAGTAAAACTTGCGAATATAATGCATAAAAAAACGCTGAATTATCAGCGTTTTTTATATTAGTCAGCTAG
CTGTCAGTCACGCACTAATC

Product: histidine ammonia-lyase

Products: NA

Alternate protein names: Histidase

Number of amino acids: Translated: 510; Mature: 510

Protein sequence:

>510_residues
MYELHIKPGQLTLSQLRKISRHALKVSLESSCIEAIHASTQVVNQVIAENRVAYGINTGFGLLANTRIAPEDLETLQRSI
VLSHAAGIGELMNDETVRMMMVLKINSLARGFSGIRLSVIEALMTLVNAQIYPCVPKKGSVGASGDLAPLAHMSTVLLGE
GEARYQGNIISGAKALEIAGMQPITLAPKEGLALLNGTQASCAFGLEGLFAAEDLFASATLCGAMTVDAALGSRRPFDDR
VHQVRGHQSQIDSALIYRHILDTHSEVSHSHTACEKVQDPYSLRCQPQVMGACLQQIRNSAAIYEIEANSVSDNPLVFAE
DGDIISAGNFHAEPIAMASDNLALAIAEIGSLSERRMALLIDNSLSKLPPFLVNNGGVNSGFMIAQVTAAALASENKSLA
HPACVDSLPTSANQEDHVSMATFAGRRLKEMAENTRGILAVELLAAAQGLDFRSPLKSSELIETAKAELRERVDFYDKDR
YFAPDIKQANQLLIEAMHNKLIPEGLLPSL

Sequences:

>Translated_510_residues
MYELHIKPGQLTLSQLRKISRHALKVSLESSCIEAIHASTQVVNQVIAENRVAYGINTGFGLLANTRIAPEDLETLQRSI
VLSHAAGIGELMNDETVRMMMVLKINSLARGFSGIRLSVIEALMTLVNAQIYPCVPKKGSVGASGDLAPLAHMSTVLLGE
GEARYQGNIISGAKALEIAGMQPITLAPKEGLALLNGTQASCAFGLEGLFAAEDLFASATLCGAMTVDAALGSRRPFDDR
VHQVRGHQSQIDSALIYRHILDTHSEVSHSHTACEKVQDPYSLRCQPQVMGACLQQIRNSAAIYEIEANSVSDNPLVFAE
DGDIISAGNFHAEPIAMASDNLALAIAEIGSLSERRMALLIDNSLSKLPPFLVNNGGVNSGFMIAQVTAAALASENKSLA
HPACVDSLPTSANQEDHVSMATFAGRRLKEMAENTRGILAVELLAAAQGLDFRSPLKSSELIETAKAELRERVDFYDKDR
YFAPDIKQANQLLIEAMHNKLIPEGLLPSL
>Mature_510_residues
MYELHIKPGQLTLSQLRKISRHALKVSLESSCIEAIHASTQVVNQVIAENRVAYGINTGFGLLANTRIAPEDLETLQRSI
VLSHAAGIGELMNDETVRMMMVLKINSLARGFSGIRLSVIEALMTLVNAQIYPCVPKKGSVGASGDLAPLAHMSTVLLGE
GEARYQGNIISGAKALEIAGMQPITLAPKEGLALLNGTQASCAFGLEGLFAAEDLFASATLCGAMTVDAALGSRRPFDDR
VHQVRGHQSQIDSALIYRHILDTHSEVSHSHTACEKVQDPYSLRCQPQVMGACLQQIRNSAAIYEIEANSVSDNPLVFAE
DGDIISAGNFHAEPIAMASDNLALAIAEIGSLSERRMALLIDNSLSKLPPFLVNNGGVNSGFMIAQVTAAALASENKSLA
HPACVDSLPTSANQEDHVSMATFAGRRLKEMAENTRGILAVELLAAAQGLDFRSPLKSSELIETAKAELRERVDFYDKDR
YFAPDIKQANQLLIEAMHNKLIPEGLLPSL

Specific function: Unknown

COG id: COG2986

COG function: function code E; Histidine ammonia-lyase

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PAL/histidase family

Homologues:

Organism=Homo sapiens, GI4504333, Length=490, Percent_Identity=44.2857142857143, Blast_Score=414, Evalue=1e-116,
Organism=Caenorhabditis elegans, GI17567831, Length=492, Percent_Identity=41.4634146341463, Blast_Score=355, Evalue=3e-98,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HUTH_PSYIN (A1STQ3)

Other databases:

- EMBL:   CP000510
- RefSeq:   YP_942467.1
- ProteinModelPortal:   A1STQ3
- SMR:   A1STQ3
- STRING:   A1STQ3
- GeneID:   4624172
- GenomeReviews:   CP000510_GR
- KEGG:   pin:Ping_1029
- eggNOG:   COG2986
- HOGENOM:   HBG510887
- OMA:   QKGQIDS
- ProtClustDB:   PRK09367
- BioCyc:   PING357804:PING_1029-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00229
- InterPro:   IPR005921
- InterPro:   IPR008948
- InterPro:   IPR001106
- InterPro:   IPR022313
- TIGRFAMs:   TIGR01225

Pfam domain/function: PF00221 PAL; SSF48557 L-Aspartase-like

EC number: =4.3.1.3

Molecular weight: Translated: 54784; Mature: 54784

Theoretical pI: Translated: 5.72; Mature: 5.72

Prosite motif: PS00488 PAL_HISTIDASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYELHIKPGQLTLSQLRKISRHALKVSLESSCIEAIHASTQVVNQVIAENRVAYGINTGF
CEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCC
GLLANTRIAPEDLETLQRSIVLSHAAGIGELMNDETVRMMMVLKINSLARGFSGIRLSVI
CHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCHHHHHH
EALMTLVNAQIYPCVPKKGSVGASGDLAPLAHMSTVLLGEGEARYQGNIISGAKALEIAG
HHHHHHHCCCEEECCCCCCCCCCCCCCHHHHHHHHHEECCCCCCCCCCEECCCHHEEECC
MQPITLAPKEGLALLNGTQASCAFGLEGLFAAEDLFASATLCGAMTVDAALGSRRPFDDR
CCCEEECCCCCCEEECCCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHH
VHQVRGHQSQIDSALIYRHILDTHSEVSHSHTACEKVQDPYSLRCQPQVMGACLQQIRNS
HHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCC
AAIYEIEANSVSDNPLVFAEDGDIISAGNFHAEPIAMASDNLALAIAEIGSLSERRMALL
CEEEEEECCCCCCCCEEEECCCCEEECCCCCCCCEEECCCCCEEEEHHHCCCCCCCEEEE
IDNSLSKLPPFLVNNGGVNSGFMIAQVTAAALASENKSLAHPACVDSLPTSANQEDHVSM
ECCCHHHCCCEEEECCCCCCCCHHHHHHHHHHHCCCCCCCCCHHHHCCCCCCCCCHHHHH
ATFAGRRLKEMAENTRGILAVELLAAAQGLDFRSPLKSSELIETAKAELRERVDFYDKDR
HHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHCHHCCCC
YFAPDIKQANQLLIEAMHNKLIPEGLLPSL
CCCCCHHHHHHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure
MYELHIKPGQLTLSQLRKISRHALKVSLESSCIEAIHASTQVVNQVIAENRVAYGINTGF
CEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCC
GLLANTRIAPEDLETLQRSIVLSHAAGIGELMNDETVRMMMVLKINSLARGFSGIRLSVI
CHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCHHHHHH
EALMTLVNAQIYPCVPKKGSVGASGDLAPLAHMSTVLLGEGEARYQGNIISGAKALEIAG
HHHHHHHCCCEEECCCCCCCCCCCCCCHHHHHHHHHEECCCCCCCCCCEECCCHHEEECC
MQPITLAPKEGLALLNGTQASCAFGLEGLFAAEDLFASATLCGAMTVDAALGSRRPFDDR
CCCEEECCCCCCEEECCCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHH
VHQVRGHQSQIDSALIYRHILDTHSEVSHSHTACEKVQDPYSLRCQPQVMGACLQQIRNS
HHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCC
AAIYEIEANSVSDNPLVFAEDGDIISAGNFHAEPIAMASDNLALAIAEIGSLSERRMALL
CEEEEEECCCCCCCCEEEECCCCEEECCCCCCCCEEECCCCCEEEEHHHCCCCCCCEEEE
IDNSLSKLPPFLVNNGGVNSGFMIAQVTAAALASENKSLAHPACVDSLPTSANQEDHVSM
ECCCHHHCCCEEEECCCCCCCCHHHHHHHHHHHCCCCCCCCCHHHHCCCCCCCCCHHHHH
ATFAGRRLKEMAENTRGILAVELLAAAQGLDFRSPLKSSELIETAKAELRERVDFYDKDR
HHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHCHHCCCC
YFAPDIKQANQLLIEAMHNKLIPEGLLPSL
CCCCCHHHHHHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA