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The map label for this gene is yxnA [H]

Identifier: 119944711

GI number: 119944711

Start: 1188000

End: 1188806

Strand: Reverse

Name: yxnA [H]

Synonym: Ping_0951

Alternate gene names: 119944711

Gene position: 1188806-1188000 (Counterclockwise)

Preceding gene: 119944712

Following gene: 119944710

Centisome position: 26.07

GC content: 42.87

Gene sequence:

>807_bases
ATGAAGCTTAAAGATAAACGCGTGTTATTAACGGGGGCAACAGGCGGTATTGGTCGCGCTCTTTCCCTGGCATTGGTTGA
GGCTGGTTGCCACTTAATCTTAGTCGGCCGAGAACAGGCTAAACTTGATCAACTCATTGATGACTTGCCGCACAGCAGTA
ATTATTTATCTATCGCAGCAGATATCGGCTGCGCAGAAGGTATTAAAGCCGTTGATAAGGAGTGCCAGTTATATATACAA
GAAGGCATCCCTATTGATATCGTCATTAACAATGCAGGCTGTAATACTTTTGATTATCTCACGCAACGGACCTTAACCTC
TATTGAGCAAGAGATTGCGGTTAATATCAGCGCGCCAATGCAATTGACTAAACTCTCTCTGACCTGGTTAAGTTATCCGG
GCATTATTTTAAATATTGGATCCACCTTTGCCGCTATCGGTTATCCGGGTTATGCCACTTACTGCGCAACAAAAGCGGCT
TTACATCGTTTTAGTGAAGCAATGCAACGCGAATTAAAGGATACCGGGCGACAAGTATTATTCGTCGCACCACGTGCCAC
GGACACCGATTTAAATGATCAACGCGTGACTGCGCTTAATAAAAAATTAGGTAACAGCACCGATAGCCCCAAGGCCGTCG
CCAAGCAGATATTAAAAACGCTGCAAACAGAGCAAAAAGTGTGCTGGATTGGCTGGCCTGAAAAATTATTTGTACGAATT
AATCAACTATTTCCAAGCTTAGTCGCTTCCTCTATCCACAAACAAAAAAAACATCTGAACAAAAGTCTTTCTGACATTAA
TGAATAA

Upstream 100 bases:

>100_bases
ATTATTGACGGTGCAAATATGGTCTTCAAACTTTACGGTGAAATGTTAAACGATCTCTCATCGAATGCTATTGAACAGAT
TCAGCAAAGCGAGTTCTGCC

Downstream 100 bases:

>100_bases
AGGAAAATAGGATGAAAACTACAAATTTTACAATATCACTACTGGGCTTCGCACTGTTATTAGGCAGCAGTTTTACAGCA
GCACAAACAGTAGCGGGTAC

Product: short chain dehydrogenase

Products: (3R)-hydroxyacyl-[acyl-carrier-protein]; NADP; NADPH; Proton; beta-ketoacyl-ACP [C]

Alternate protein names: NA

Number of amino acids: Translated: 268; Mature: 268

Protein sequence:

>268_residues
MKLKDKRVLLTGATGGIGRALSLALVEAGCHLILVGREQAKLDQLIDDLPHSSNYLSIAADIGCAEGIKAVDKECQLYIQ
EGIPIDIVINNAGCNTFDYLTQRTLTSIEQEIAVNISAPMQLTKLSLTWLSYPGIILNIGSTFAAIGYPGYATYCATKAA
LHRFSEAMQRELKDTGRQVLFVAPRATDTDLNDQRVTALNKKLGNSTDSPKAVAKQILKTLQTEQKVCWIGWPEKLFVRI
NQLFPSLVASSIHKQKKHLNKSLSDINE

Sequences:

>Translated_268_residues
MKLKDKRVLLTGATGGIGRALSLALVEAGCHLILVGREQAKLDQLIDDLPHSSNYLSIAADIGCAEGIKAVDKECQLYIQ
EGIPIDIVINNAGCNTFDYLTQRTLTSIEQEIAVNISAPMQLTKLSLTWLSYPGIILNIGSTFAAIGYPGYATYCATKAA
LHRFSEAMQRELKDTGRQVLFVAPRATDTDLNDQRVTALNKKLGNSTDSPKAVAKQILKTLQTEQKVCWIGWPEKLFVRI
NQLFPSLVASSIHKQKKHLNKSLSDINE
>Mature_268_residues
MKLKDKRVLLTGATGGIGRALSLALVEAGCHLILVGREQAKLDQLIDDLPHSSNYLSIAADIGCAEGIKAVDKECQLYIQ
EGIPIDIVINNAGCNTFDYLTQRTLTSIEQEIAVNISAPMQLTKLSLTWLSYPGIILNIGSTFAAIGYPGYATYCATKAA
LHRFSEAMQRELKDTGRQVLFVAPRATDTDLNDQRVTALNKKLGNSTDSPKAVAKQILKTLQTEQKVCWIGWPEKLFVRI
NQLFPSLVASSIHKQKKHLNKSLSDINE

Specific function: Fatty acid biosynthesis pathway; first reduction step. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI7705925, Length=193, Percent_Identity=27.979274611399, Blast_Score=75, Evalue=8e-14,
Organism=Homo sapiens, GI20149619, Length=282, Percent_Identity=27.3049645390071, Blast_Score=73, Evalue=3e-13,
Organism=Homo sapiens, GI4503817, Length=231, Percent_Identity=25.5411255411255, Blast_Score=69, Evalue=5e-12,
Organism=Homo sapiens, GI4557649, Length=191, Percent_Identity=28.2722513089005, Blast_Score=66, Evalue=3e-11,
Organism=Escherichia coli, GI1787335, Length=225, Percent_Identity=28.8888888888889, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1786812, Length=235, Percent_Identity=27.2340425531915, Blast_Score=66, Evalue=2e-12,
Organism=Escherichia coli, GI1786701, Length=266, Percent_Identity=25.5639097744361, Blast_Score=65, Evalue=4e-12,
Organism=Escherichia coli, GI1787820, Length=259, Percent_Identity=25.4826254826255, Blast_Score=64, Evalue=9e-12,
Organism=Escherichia coli, GI87082160, Length=197, Percent_Identity=26.3959390862944, Blast_Score=61, Evalue=7e-11,
Organism=Caenorhabditis elegans, GI115534694, Length=196, Percent_Identity=32.1428571428571, Blast_Score=82, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI71994604, Length=190, Percent_Identity=27.3684210526316, Blast_Score=67, Evalue=8e-12,
Organism=Caenorhabditis elegans, GI17563726, Length=246, Percent_Identity=26.0162601626016, Blast_Score=65, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6323882, Length=201, Percent_Identity=32.8358208955224, Blast_Score=84, Evalue=2e-17,
Organism=Drosophila melanogaster, GI21357041, Length=203, Percent_Identity=28.0788177339901, Blast_Score=75, Evalue=7e-14,
Organism=Drosophila melanogaster, GI28571526, Length=199, Percent_Identity=27.6381909547739, Blast_Score=72, Evalue=3e-13,
Organism=Drosophila melanogaster, GI23397609, Length=193, Percent_Identity=29.0155440414508, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI161076933, Length=194, Percent_Identity=26.8041237113402, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24584748, Length=194, Percent_Identity=26.8041237113402, Blast_Score=66, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24640442, Length=223, Percent_Identity=26.0089686098655, Blast_Score=64, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: 1.1.1.100 [C]

Molecular weight: Translated: 29424; Mature: 29424

Theoretical pI: Translated: 8.57; Mature: 8.57

Prosite motif: PS00061 ADH_SHORT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLKDKRVLLTGATGGIGRALSLALVEAGCHLILVGREQAKLDQLIDDLPHSSNYLSIAA
CCCCCCEEEEEECCCCHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHCCCCCCEEEEEE
DIGCAEGIKAVDKECQLYIQEGIPIDIVINNAGCNTFDYLTQRTLTSIEQEIAVNISAPM
CCCHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHEEECCCCC
QLTKLSLTWLSYPGIILNIGSTFAAIGYPGYATYCATKAALHRFSEAMQRELKDTGRQVL
EEEHEEEHEECCCCEEEECCCHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEE
FVAPRATDTDLNDQRVTALNKKLGNSTDSPKAVAKQILKTLQTEQKVCWIGWPEKLFVRI
EEECCCCCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCEEEECCHHHHHHHH
NQLFPSLVASSIHKQKKHLNKSLSDINE
HHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKLKDKRVLLTGATGGIGRALSLALVEAGCHLILVGREQAKLDQLIDDLPHSSNYLSIAA
CCCCCCEEEEEECCCCHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHCCCCCCEEEEEE
DIGCAEGIKAVDKECQLYIQEGIPIDIVINNAGCNTFDYLTQRTLTSIEQEIAVNISAPM
CCCHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHEEECCCCC
QLTKLSLTWLSYPGIILNIGSTFAAIGYPGYATYCATKAALHRFSEAMQRELKDTGRQVL
EEEHEEEHEECCCCEEEECCCHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEE
FVAPRATDTDLNDQRVTALNKKLGNSTDSPKAVAKQILKTLQTEQKVCWIGWPEKLFVRI
EEECCCCCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCEEEECCHHHHHHHH
NQLFPSLVASSIHKQKKHLNKSLSDINE
HHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NADPH [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Oxoacyl-[acyl-carrier-protein]; NADPH; D-3-hydroxy-acyl-ACP; NADP [C]

Specific reaction: Oxoacyl-[acyl-carrier-protein] + NADPH = (3R)-hydroxyacyl-[acyl-carrier-protein] + NADP+ D-3-hydroxy-acyl-ACP + NADP = NADPH + Proton + beta-ketoacyl-ACP [C]

General reaction: Redox reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]