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The map label for this gene is ribA

Identifier: 119944292

GI number: 119944292

Start: 661190

End: 661792

Strand: Direct

Name: ribA

Synonym: Ping_0518

Alternate gene names: 119944292

Gene position: 661190-661792 (Clockwise)

Preceding gene: 119944291

Following gene: 119944293

Centisome position: 14.5

GC content: 40.63

Gene sequence:

>603_bases
ATGACCAAAGTAAGAACCAAAATTTCGCTAAAAATAGGTGCTAATAGCCGAATTCCAGCTCAGATAGCATCGTTTAATGG
CTTAACGTCCGATAAAGAGCATATCGCTATTATTTTTGGAAAAGCAGACGAGTGCTCAAGCTCGCCGATCGTGCGCATAC
ATTCCGAATGTTTAACGGGAGATGTTTTTCATTCATCACGTTGTGATTGCGGTGAACAATTAGATGAAGCCATCGAGCTA
ATGGAAAAAGAAGGCGGCATTATTATTTATCTGCGTCAGGAAGGTCGGGGAATTGGCCTATATAACAAAATTGATGCTTA
TAAACTTCAATCTGAAGGTATGGACACCTATCAAGCTAATAACCAGTTAGGTTTTGAAGACGACCTTAGAGATTTCACCG
AAGCGGGACAAATGCTCGCGGCGTTAAATATTAGGAAACTACAGCTATTAACCAATAACCCGCTAAAAGTGAAGGCGTTG
CGGGAGTATGGGATAACGGTTGATAAGGTGATCAGTACTTCAACATTTATTAAAGACGATAACGAATCCTATTTAAGGAC
TAAGGCAAAAAATGCCGGTCATGCTATCCGCTTTCCGTTTTAG

Upstream 100 bases:

>100_bases
AAACGTCACCAATGCGTCATTGATACTGGCCGATCAAGTGGCTTAATTGGACTCATCCTGTGTAACTAAAATAATAGTAG
AAGATATAAGGTTAAATATT

Downstream 100 bases:

>100_bases
GTTCGAAGCACTCAAGTTTAGCGTCGGAAAATAAAATACGATTTTTTCAAGTTTAGATTTAAATAATCACTGCGTTGCTT
GTATTAAGTCACAATAGAAT

Product: GTP cyclohydrolase II

Products: NA

Alternate protein names: GTP cyclohydrolase II

Number of amino acids: Translated: 200; Mature: 199

Protein sequence:

>200_residues
MTKVRTKISLKIGANSRIPAQIASFNGLTSDKEHIAIIFGKADECSSSPIVRIHSECLTGDVFHSSRCDCGEQLDEAIEL
MEKEGGIIIYLRQEGRGIGLYNKIDAYKLQSEGMDTYQANNQLGFEDDLRDFTEAGQMLAALNIRKLQLLTNNPLKVKAL
REYGITVDKVISTSTFIKDDNESYLRTKAKNAGHAIRFPF

Sequences:

>Translated_200_residues
MTKVRTKISLKIGANSRIPAQIASFNGLTSDKEHIAIIFGKADECSSSPIVRIHSECLTGDVFHSSRCDCGEQLDEAIEL
MEKEGGIIIYLRQEGRGIGLYNKIDAYKLQSEGMDTYQANNQLGFEDDLRDFTEAGQMLAALNIRKLQLLTNNPLKVKAL
REYGITVDKVISTSTFIKDDNESYLRTKAKNAGHAIRFPF
>Mature_199_residues
TKVRTKISLKIGANSRIPAQIASFNGLTSDKEHIAIIFGKADECSSSPIVRIHSECLTGDVFHSSRCDCGEQLDEAIELM
EKEGGIIIYLRQEGRGIGLYNKIDAYKLQSEGMDTYQANNQLGFEDDLRDFTEAGQMLAALNIRKLQLLTNNPLKVKALR
EYGITVDKVISTSTFIKDDNESYLRTKAKNAGHAIRFPF

Specific function: Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate

COG id: COG0807

COG function: function code H; GTP cyclohydrolase II

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP cyclohydrolase II family

Homologues:

Organism=Escherichia coli, GI1787533, Length=196, Percent_Identity=43.8775510204082, Blast_Score=160, Evalue=7e-41,
Organism=Saccharomyces cerevisiae, GI6319438, Length=173, Percent_Identity=42.1965317919075, Blast_Score=117, Evalue=1e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): RIBA_PSYIN (A1SSA8)

Other databases:

- EMBL:   CP000510
- RefSeq:   YP_941972.1
- ProteinModelPortal:   A1SSA8
- SMR:   A1SSA8
- STRING:   A1SSA8
- GeneID:   4623444
- GenomeReviews:   CP000510_GR
- KEGG:   pin:Ping_0518
- eggNOG:   COG0807
- HOGENOM:   HBG735778
- OMA:   ESINIMK
- PhylomeDB:   A1SSA8
- ProtClustDB:   PRK00393
- BioCyc:   PING357804:PING_0518-MONOMER
- HAMAP:   MF_00179
- InterPro:   IPR000926

Pfam domain/function: PF00925 GTP_cyclohydro2

EC number: =3.5.4.25

Molecular weight: Translated: 22308; Mature: 22177

Theoretical pI: Translated: 6.92; Mature: 6.92

Prosite motif: NA

Important sites: ACT_SITE 128-128 ACT_SITE 130-130 BINDING 73-73 BINDING 116-116 BINDING 151-151 BINDING 156-156

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKVRTKISLKIGANSRIPAQIASFNGLTSDKEHIAIIFGKADECSSSPIVRIHSECLTG
CCCEEEEEEEEECCCCCCCHHHHCCCCCCCCCCEEEEEEECCCCCCCCCEEEEEHHHHCC
DVFHSSRCDCGEQLDEAIELMEKEGGIIIYLRQEGRGIGLYNKIDAYKLQSEGMDTYQAN
CCCCCCCCCHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCEEECCCCCCCEECC
NQLGFEDDLRDFTEAGQMLAALNIRKLQLLTNNPLKVKALREYGITVDKVISTSTFIKDD
CCCCCHHHHHHHHHHHHHHHHHCCEEEEEECCCCEEEEEHHHHCCCHHHHHCCHHEEECC
NESYLRTKAKNAGHAIRFPF
CHHHHHHHCCCCCCEEECCC
>Mature Secondary Structure 
TKVRTKISLKIGANSRIPAQIASFNGLTSDKEHIAIIFGKADECSSSPIVRIHSECLTG
CCEEEEEEEEECCCCCCCHHHHCCCCCCCCCCEEEEEEECCCCCCCCCEEEEEHHHHCC
DVFHSSRCDCGEQLDEAIELMEKEGGIIIYLRQEGRGIGLYNKIDAYKLQSEGMDTYQAN
CCCCCCCCCHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCEEECCCCCCCEECC
NQLGFEDDLRDFTEAGQMLAALNIRKLQLLTNNPLKVKALREYGITVDKVISTSTFIKDD
CCCCCHHHHHHHHHHHHHHHHHCCEEEEEECCCCEEEEEHHHHCCCHHHHHCCHHEEECC
NESYLRTKAKNAGHAIRFPF
CHHHHHHHCCCCCCEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA