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The map label for this gene is mutH [H]

Identifier: 119944275

GI number: 119944275

Start: 635596

End: 636270

Strand: Reverse

Name: mutH [H]

Synonym: Ping_0501

Alternate gene names: 119944275

Gene position: 636270-635596 (Counterclockwise)

Preceding gene: 119944278

Following gene: 119944274

Centisome position: 13.95

GC content: 43.26

Gene sequence:

>675_bases
ATGGACTTTAATTCTCCCCGTTCAACCGCCGAACTGCTAAGTCGATGTGAGCAAATTGCTGGCCATTCTCTGGAGGAACT
GGCCGAGATGGCCGGCCAGCCTATGGCTAAGGATTTACGCAGCAATAAAGGCTGGGTGGGTCAACTTATAGAATGGCACC
TAGGCGCCACCGCCGGCAGCAAACCTGAGCAAGACTTTAAGCATCTCGGTATTGAACTAAAAACAATTCCAATTGATCAA
AATGGCAAAGTATTGGAAACTACCTTTGTCTGTAGCGCCCCTATTTTAAATACCCGTCAGCTAAATTGGGAAAACTCCAA
CGTGCGCAATAAGATCAGCAAGGTTTTATGGGTTCCGGTTCAGGGAGAGCGAACTGTCCCGCTTTGTGATCGCATCGTCG
GTAATAGTTTTTTATGGTCAGCTAATCAGCAACAAACCCAATTATTAAAATTGGACTGGAATGAAATAATGGAAAAAATT
GCGCTTGGCCAAATAGAATCAATCACAGCTCGGAATGGTCAAGTGATGCAACTCAGGCCAAAGGCGGCTAATGGGAAGTG
CTTAACCAATGCGGTTGGAGAAGACGGACAATTAATAAAAGTTCGCCCACGGGGTTTTTACTTAAAAAAGACATTTACAC
AATCAATTATTAGTCAATATTTCAATATAAAATAA

Upstream 100 bases:

>100_bases
CTAAGACTCAGTTATTCAACCGATAAAAGTGAATAACTCTGTGCAGCTAACAAAATAAACATAAATAGTCCGAATAGAGT
CAATAGATAGGGTAAATAGC

Downstream 100 bases:

>100_bases
GAAATAAAGATAATTTTTATAGAATTTAATCCGTTTTTACAGTAAATTTATTATTAATCTTAAGGAGTTAAAGATGCCCA
TAAAAAAACAATATTTGAAA

Product: DNA mismatch repair protein

Products: NA

Alternate protein names: Methyl-directed mismatch repair protein [H]

Number of amino acids: Translated: 224; Mature: 224

Protein sequence:

>224_residues
MDFNSPRSTAELLSRCEQIAGHSLEELAEMAGQPMAKDLRSNKGWVGQLIEWHLGATAGSKPEQDFKHLGIELKTIPIDQ
NGKVLETTFVCSAPILNTRQLNWENSNVRNKISKVLWVPVQGERTVPLCDRIVGNSFLWSANQQQTQLLKLDWNEIMEKI
ALGQIESITARNGQVMQLRPKAANGKCLTNAVGEDGQLIKVRPRGFYLKKTFTQSIISQYFNIK

Sequences:

>Translated_224_residues
MDFNSPRSTAELLSRCEQIAGHSLEELAEMAGQPMAKDLRSNKGWVGQLIEWHLGATAGSKPEQDFKHLGIELKTIPIDQ
NGKVLETTFVCSAPILNTRQLNWENSNVRNKISKVLWVPVQGERTVPLCDRIVGNSFLWSANQQQTQLLKLDWNEIMEKI
ALGQIESITARNGQVMQLRPKAANGKCLTNAVGEDGQLIKVRPRGFYLKKTFTQSIISQYFNIK
>Mature_224_residues
MDFNSPRSTAELLSRCEQIAGHSLEELAEMAGQPMAKDLRSNKGWVGQLIEWHLGATAGSKPEQDFKHLGIELKTIPIDQ
NGKVLETTFVCSAPILNTRQLNWENSNVRNKISKVLWVPVQGERTVPLCDRIVGNSFLWSANQQQTQLLKLDWNEIMEKI
ALGQIESITARNGQVMQLRPKAANGKCLTNAVGEDGQLIKVRPRGFYLKKTFTQSIISQYFNIK

Specific function: Sequence-specific endonuclease that cleaves unmethylated GATC sequences. It is involved in DNA mismatch repair [H]

COG id: COG3066

COG function: function code L; DNA mismatch repair protein

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mutH family [H]

Homologues:

Organism=Escherichia coli, GI1789196, Length=222, Percent_Identity=50.4504504504504, Blast_Score=252, Evalue=2e-68,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004230
- InterPro:   IPR011337
- InterPro:   IPR011335 [H]

Pfam domain/function: PF02976 MutH [H]

EC number: NA

Molecular weight: Translated: 25190; Mature: 25190

Theoretical pI: Translated: 9.28; Mature: 9.28

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDFNSPRSTAELLSRCEQIAGHSLEELAEMAGQPMAKDLRSNKGWVGQLIEWHLGATAGS
CCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHCCCHHHHHHCCCCHHHHHHHHHHCCCCCC
KPEQDFKHLGIELKTIPIDQNGKVLETTFVCSAPILNTRQLNWENSNVRNKISKVLWVPV
CCHHHHHHCCEEEEEEEECCCCCEEEEEEEECCCCCCCEECCCCCCHHHHHHHHEEEEEC
QGERTVPLCDRIVGNSFLWSANQQQTQLLKLDWNEIMEKIALGQIESITARNGQVMQLRP
CCCCCCHHHHHHHCCCEEECCCCHHHHHHCCCHHHHHHHHHHCCHHHHHCCCCEEEEEEC
KAANGKCLTNAVGEDGQLIKVRPRGFYLKKTFTQSIISQYFNIK
CCCCCCEEECCCCCCCCEEEECCCCEEHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MDFNSPRSTAELLSRCEQIAGHSLEELAEMAGQPMAKDLRSNKGWVGQLIEWHLGATAGS
CCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHCCCHHHHHHCCCCHHHHHHHHHHCCCCCC
KPEQDFKHLGIELKTIPIDQNGKVLETTFVCSAPILNTRQLNWENSNVRNKISKVLWVPV
CCHHHHHHCCEEEEEEEECCCCCEEEEEEEECCCCCCCEECCCCCCHHHHHHHHEEEEEC
QGERTVPLCDRIVGNSFLWSANQQQTQLLKLDWNEIMEKIALGQIESITARNGQVMQLRP
CCCCCCHHHHHHHCCCEEECCCCHHHHHHCCCHHHHHHHHHHCCHHHHHCCCCEEEEEEC
KAANGKCLTNAVGEDGQLIKVRPRGFYLKKTFTQSIISQYFNIK
CCCCCCEEECCCCCCCCEEEECCCCEEHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA