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The map label for this gene is mutY [H]

Identifier: 119944156

GI number: 119944156

Start: 481833

End: 482909

Strand: Reverse

Name: mutY [H]

Synonym: Ping_0376

Alternate gene names: 119944156

Gene position: 482909-481833 (Counterclockwise)

Preceding gene: 119944159

Following gene: 119944155

Centisome position: 10.59

GC content: 42.15

Gene sequence:

>1077_bases
GTGAATCACGAAGATTTTAGTCAACGCATCATCGCATGGCATCAAAAATTTGGCCGTAAAACATTACCCTGGCAACAGGA
TAAAAGTCTTTATCGAACATGGGTGAGCGAAGTCATGCTGCAACAAACACAAGTTGCCACTGTGATCCCCTATTTTAATA
AGTTTATGCGTGCTTTTCCAACTATCTCATACCTTGCCAATGCGCCTTTAGATGAAGTATTGCATCACTGGACTGGACTC
GGCTACTACGCCAGAGCGCGTAATTTACATAAAAGTGCGCAATTTATTCGTGATAATTATGCAGGGGATTTTCCGGAAGA
GTTTCAACAAGTGCTGGATTTACCCGGGATTGGACGATCCACTGCAGGGGCTATTTTATCTCTGACCTTGAATCAAAACT
TTGCTATTTTAGATGGTAACGTCAAACGTGTCCTCACTCGCCATCAAACTATTGAAGGCTGGACAGGTGGAAAGTCCGTT
GAAAATACCCTATGGCAACTTGCTGAAAAACTAACACCGGCAAAACAGACCAACATATTTAATCAGGCCATGATGGATAT
GGGGGCAATGGTTTGCACGCGCAGTAAAGCAAATTGTGTAGAGTGCCCTGTTCAGGACGATTGTTTAGCGCTTGCTGACG
GGACAGTGAAAGCTTACCCGACACCCAAAGCTAAAAAGAAGATTCCAATAAAAACAGCTGTGATGCTGGTACTGTGCAAA
GACGGTAAAACACTGCACTTAAAAAAACGTCCACCGGTAGGTATCTGGGGTGGATTATGGTGTTTTCCCGAATATGAAAG
TGAAGCATTATGTCTGGCAGCTATTCAAGCACAGGGCATTGAACAGTTTAACAGCACCCTGTTACCCGCATTTCGTCATA
CTTTTAGCCATTTTCATTTTGATATAACCCCGCTAAAAATTGACGTTTCGATCATAGACACAAAACAAGTAATGGAAGAA
AATGACACTCTTTGGTATAACTTACACCACCCACAAAAAATTGGGTTAGCAGCAGCAACAACAAAAATTATAACCGCTGT
TAACAAAAACCTCTCAAAGGAGAAGATAGATGACTAG

Upstream 100 bases:

>100_bases
TTCCAAATAAGCACCTAATATTTGTGGCGTTATATTTTTAACGTAACTCTGTTATGCTCAACGCTCCTAAAAAAGTTCTC
AAAATATAAAAGAGTTTGTA

Downstream 100 bases:

>100_bases
AACCGTATTTTGCAGTTATTTAAAAAAAGAAGCCCCTGGTTTAGCCTTTCAATTAATTCCAGGCGCTTTGGGTAAACGTA
TCTTTGACAATATTAGCCAG

Product: A/G-specific adenine glycosylase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 358; Mature: 358

Protein sequence:

>358_residues
MNHEDFSQRIIAWHQKFGRKTLPWQQDKSLYRTWVSEVMLQQTQVATVIPYFNKFMRAFPTISYLANAPLDEVLHHWTGL
GYYARARNLHKSAQFIRDNYAGDFPEEFQQVLDLPGIGRSTAGAILSLTLNQNFAILDGNVKRVLTRHQTIEGWTGGKSV
ENTLWQLAEKLTPAKQTNIFNQAMMDMGAMVCTRSKANCVECPVQDDCLALADGTVKAYPTPKAKKKIPIKTAVMLVLCK
DGKTLHLKKRPPVGIWGGLWCFPEYESEALCLAAIQAQGIEQFNSTLLPAFRHTFSHFHFDITPLKIDVSIIDTKQVMEE
NDTLWYNLHHPQKIGLAAATTKIITAVNKNLSKEKIDD

Sequences:

>Translated_358_residues
MNHEDFSQRIIAWHQKFGRKTLPWQQDKSLYRTWVSEVMLQQTQVATVIPYFNKFMRAFPTISYLANAPLDEVLHHWTGL
GYYARARNLHKSAQFIRDNYAGDFPEEFQQVLDLPGIGRSTAGAILSLTLNQNFAILDGNVKRVLTRHQTIEGWTGGKSV
ENTLWQLAEKLTPAKQTNIFNQAMMDMGAMVCTRSKANCVECPVQDDCLALADGTVKAYPTPKAKKKIPIKTAVMLVLCK
DGKTLHLKKRPPVGIWGGLWCFPEYESEALCLAAIQAQGIEQFNSTLLPAFRHTFSHFHFDITPLKIDVSIIDTKQVMEE
NDTLWYNLHHPQKIGLAAATTKIITAVNKNLSKEKIDD
>Mature_358_residues
MNHEDFSQRIIAWHQKFGRKTLPWQQDKSLYRTWVSEVMLQQTQVATVIPYFNKFMRAFPTISYLANAPLDEVLHHWTGL
GYYARARNLHKSAQFIRDNYAGDFPEEFQQVLDLPGIGRSTAGAILSLTLNQNFAILDGNVKRVLTRHQTIEGWTGGKSV
ENTLWQLAEKLTPAKQTNIFNQAMMDMGAMVCTRSKANCVECPVQDDCLALADGTVKAYPTPKAKKKIPIKTAVMLVLCK
DGKTLHLKKRPPVGIWGGLWCFPEYESEALCLAAIQAQGIEQFNSTLLPAFRHTFSHFHFDITPLKIDVSIIDTKQVMEE
NDTLWYNLHHPQKIGLAAATTKIITAVNKNLSKEKIDD

Specific function: Adenine glycosylase active on G-A mispairs. MutY also corrects error-prone DNA synthesis past GO lesions which are due to the oxidatively damaged form of guanine:7,8-dihydro-8- oxoguanine (8-oxo-dGTP) [H]

COG id: COG1194

COG function: function code L; A/G-specific DNA glycosylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Nth/MutY family [H]

Homologues:

Organism=Homo sapiens, GI115298648, Length=360, Percent_Identity=33.6111111111111, Blast_Score=177, Evalue=2e-44,
Organism=Homo sapiens, GI115298650, Length=360, Percent_Identity=33.6111111111111, Blast_Score=177, Evalue=2e-44,
Organism=Homo sapiens, GI115298654, Length=360, Percent_Identity=33.6111111111111, Blast_Score=176, Evalue=2e-44,
Organism=Homo sapiens, GI115298652, Length=360, Percent_Identity=33.6111111111111, Blast_Score=176, Evalue=2e-44,
Organism=Homo sapiens, GI190358497, Length=360, Percent_Identity=33.8888888888889, Blast_Score=176, Evalue=2e-44,
Organism=Homo sapiens, GI6912520, Length=360, Percent_Identity=33.8888888888889, Blast_Score=176, Evalue=2e-44,
Organism=Escherichia coli, GI1789331, Length=344, Percent_Identity=54.9418604651163, Blast_Score=397, Evalue=1e-112,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011257
- InterPro:   IPR004036
- InterPro:   IPR004035
- InterPro:   IPR003651
- InterPro:   IPR003265
- InterPro:   IPR000445
- InterPro:   IPR003583
- InterPro:   IPR023170
- InterPro:   IPR005760
- InterPro:   IPR000086
- InterPro:   IPR015797 [H]

Pfam domain/function: PF10576 EndIII_4Fe-2S; PF00633 HHH; PF00730 HhH-GPD [H]

EC number: 3.2.2.-

Molecular weight: Translated: 40546; Mature: 40546

Theoretical pI: Translated: 8.81; Mature: 8.81

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNHEDFSQRIIAWHQKFGRKTLPWQQDKSLYRTWVSEVMLQQTQVATVIPYFNKFMRAFP
CCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
TISYLANAPLDEVLHHWTGLGYYARARNLHKSAQFIRDNYAGDFPEEFQQVLDLPGIGRS
HHHHHHCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCC
TAGAILSLTLNQNFAILDGNVKRVLTRHQTIEGWTGGKSVENTLWQLAEKLTPAKQTNIF
CCCEEEEEEECCCEEEECCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCHHHHHHH
NQAMMDMGAMVCTRSKANCVECPVQDDCLALADGTVKAYPTPKAKKKIPIKTAVMLVLCK
HHHHHHHHHHHHCCCCCCCEECCCCCCCEEECCCCEEECCCCCCCCCCCHHEEEEEEEEC
DGKTLHLKKRPPVGIWGGLWCFPEYESEALCLAAIQAQGIEQFNSTLLPAFRHTFSHFHF
CCCEEEEECCCCCCCCCCEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEE
DITPLKIDVSIIDTKQVMEENDTLWYNLHHPQKIGLAAATTKIITAVNKNLSKEKIDD
EEEEEEEEEEEECHHHHHCCCCCEEEEECCCHHHHHHHHHHHHHHHHHCCCCHHCCCC
>Mature Secondary Structure
MNHEDFSQRIIAWHQKFGRKTLPWQQDKSLYRTWVSEVMLQQTQVATVIPYFNKFMRAFP
CCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
TISYLANAPLDEVLHHWTGLGYYARARNLHKSAQFIRDNYAGDFPEEFQQVLDLPGIGRS
HHHHHHCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCC
TAGAILSLTLNQNFAILDGNVKRVLTRHQTIEGWTGGKSVENTLWQLAEKLTPAKQTNIF
CCCEEEEEEECCCEEEECCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCHHHHHHH
NQAMMDMGAMVCTRSKANCVECPVQDDCLALADGTVKAYPTPKAKKKIPIKTAVMLVLCK
HHHHHHHHHHHHCCCCCCCEECCCCCCCEEECCCCEEECCCCCCCCCCCHHEEEEEEEEC
DGKTLHLKKRPPVGIWGGLWCFPEYESEALCLAAIQAQGIEQFNSTLLPAFRHTFSHFHF
CCCEEEEECCCCCCCCCCEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEE
DITPLKIDVSIIDTKQVMEENDTLWYNLHHPQKIGLAAATTKIITAVNKNLSKEKIDD
EEEEEEEEEEEECHHHHHCCCCCEEEEECCCHHHHHHHHHHHHHHHHHCCCCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: 4Fe-4S Cluster [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Glycosylases; Hydrolysing N-glycosyl compounds [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2197596; 2001994; 9278503; 9846876 [H]