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The map label for this gene is ilvD

Identifier: 119944131

GI number: 119944131

Start: 447662

End: 449500

Strand: Reverse

Name: ilvD

Synonym: Ping_0346

Alternate gene names: 119944131

Gene position: 449500-447662 (Counterclockwise)

Preceding gene: 119944132

Following gene: 119944120

Centisome position: 9.86

GC content: 46.66

Gene sequence:

>1839_bases
ATGCCACAGTATCGTTCAAAAACATCAACCCATGGCCGTAATATGGCGGGTGCTCGTGCACTATGGCGTGCAACTGGCGT
GAAAGATGATGATTTCGGAAAACCAATCATTGCCATTGCTAACTCATTTACCCAATTTGTTCCCGGCCATGTGCATTTAA
AGGACATGGGACAGCTTGTTGCAGGAGCCGTTGAAGCTGCAGGCGGTATCGCCAAAGAGTTTAATACTATTGCCATTGAT
GATGGTATTGCGATGGGTCACTCGGGCATGCTCTATAGTCTGCCCTCTCGTGATTTGATTGCTGATTCGATTGAATATAT
GGTCAATGCACACTGTGCCGATGCTATTGTTTGCATTTCCAACTGTGACAAAATCACGCCGGGAATGTTAATGGCGGCAT
TACGTTTAAATATTCCGGTTATTTTTGTTTCCGGTGGTCCGATGGAAGCGGGTAAAACCAAACTTTCAGATCAGATTATC
AAGCTCGACTTAGTTGATGCGATGGTGATGGGACCGGATAAAAATGTTTCCGATGAAGATCTGGCTAAAGTTGAACGCAG
TGCCTGCCCGACTTGTGGGTCATGCTCCGGTATGTTTACCGCCAATTCAATGAACTGTTTAACCGAAGCACTGGGGCTTT
CATTACCGGGTAACGGCTCAATGCTTGCGACCCATGCTGACCGTGAACAACTGTTTTTAGAGGCCGGTGAACGTATTGTT
GATATTACTAAACGTCATTATGAACAGGATGATTATTCAGTATTGCCGCGTGCAATTGCCTGCCGGGAAGCTTTTGAAAA
TGCAATGGCACTTGATATCGCCATGGGCGGCTCAACCAATACAATTTTACATCTGTTAGCCTGTGCTCAGGAAGCTGAAC
TGGACTACACAGTAGCCGACATGGATGAAATGTCCCGCCGTATCCCTCAGCTTTGTAAAGTTGCGCCTTCCACTCCTTTG
TACCATATGGAAGATGTACACCGTGCGGGTGGTGTGATGGCTATTTTAGGGGAATTGGACCGTGCGGGTTTATTAAACAG
TGATATTCCAACTATCCTTAGCCCGACCATGAAAGAGCAGTTGGCAAAATACGATATTATGCAAACTGACGATCCAAAAA
TCATTGATTTTTATCGTGCCGGGCCCGCTGGTATTCGTACGGTAAAACCCTTCAGTCAGTCTTGTCGCTGGGATACCGTT
GATAATGATCGCGCAGCAGGTTGCGTACGTTCACTGGAGCATGCTTTTAGTACTGAAGGTGGTCTTGCGGTGTTATTTGG
AAATATGGCCGTTGACGGTGCCGTGGTTAAAACTGCTGGCGTTGATAATGATAATCTTACCTTTACCGGTCCGGCTAAAA
TATACGAAAGCCAGGATACTGCGGTAGCCGCTATTTTAGGGGGTAAAGTCGTCGAAGGTGATGTAGTTGTTATCCGTTAT
GAAGGCCCTCAAGGTGGCCCGGGTATGCAGGAAATGCTTTATCCAACCAGTTACCTGAAATCCATGGGACTCGGCAAAAA
ATGTGCATTAGTTACCGATGGCCGTTTCTCCGGGGGTACCTCGGGACTGTCAATCGGTCACGCTTCACCAGAAGCCGCCG
CCGGTGGTGTTATTGGTCTGATTGAGGATGGCGATATTATCGATATCAATATTCCAACACGGACAATGGACTTAAAAGTA
TCTGACGAAATATTAGCTGAACGTCGTATCGCAATGGATATTCATGGCTGGAAACCCGTCAGCCGTGAACGCCACGTGTC
AACGGCACTAAAAGTTTATGCTTTAATGGCAACCTCTGCCGATAAAGGCGCAATACGCGATATAAGCAAGCTGAAATAG

Upstream 100 bases:

>100_bases
TCACTCCATAACAGACAGTTTCTGCGCTCGATTAAACAGCTTTTATTTTCTGTAAAGCAGTACTAAAGAGCCATTAGTTA
TCAACCAGTAAGGAATTTAA

Downstream 100 bases:

>100_bases
AAACTGACGGCTGTTGGCTGACGGCTATCGGCTGACAGCTGACAGCTGACAGCTGAATTTAACCTATCTGCTTTACACTG
TCCCGCTCAATTAATGTCGG

Product: dihydroxy-acid dehydratase

Products: NA

Alternate protein names: DAD

Number of amino acids: Translated: 612; Mature: 611

Protein sequence:

>612_residues
MPQYRSKTSTHGRNMAGARALWRATGVKDDDFGKPIIAIANSFTQFVPGHVHLKDMGQLVAGAVEAAGGIAKEFNTIAID
DGIAMGHSGMLYSLPSRDLIADSIEYMVNAHCADAIVCISNCDKITPGMLMAALRLNIPVIFVSGGPMEAGKTKLSDQII
KLDLVDAMVMGPDKNVSDEDLAKVERSACPTCGSCSGMFTANSMNCLTEALGLSLPGNGSMLATHADREQLFLEAGERIV
DITKRHYEQDDYSVLPRAIACREAFENAMALDIAMGGSTNTILHLLACAQEAELDYTVADMDEMSRRIPQLCKVAPSTPL
YHMEDVHRAGGVMAILGELDRAGLLNSDIPTILSPTMKEQLAKYDIMQTDDPKIIDFYRAGPAGIRTVKPFSQSCRWDTV
DNDRAAGCVRSLEHAFSTEGGLAVLFGNMAVDGAVVKTAGVDNDNLTFTGPAKIYESQDTAVAAILGGKVVEGDVVVIRY
EGPQGGPGMQEMLYPTSYLKSMGLGKKCALVTDGRFSGGTSGLSIGHASPEAAAGGVIGLIEDGDIIDINIPTRTMDLKV
SDEILAERRIAMDIHGWKPVSRERHVSTALKVYALMATSADKGAIRDISKLK

Sequences:

>Translated_612_residues
MPQYRSKTSTHGRNMAGARALWRATGVKDDDFGKPIIAIANSFTQFVPGHVHLKDMGQLVAGAVEAAGGIAKEFNTIAID
DGIAMGHSGMLYSLPSRDLIADSIEYMVNAHCADAIVCISNCDKITPGMLMAALRLNIPVIFVSGGPMEAGKTKLSDQII
KLDLVDAMVMGPDKNVSDEDLAKVERSACPTCGSCSGMFTANSMNCLTEALGLSLPGNGSMLATHADREQLFLEAGERIV
DITKRHYEQDDYSVLPRAIACREAFENAMALDIAMGGSTNTILHLLACAQEAELDYTVADMDEMSRRIPQLCKVAPSTPL
YHMEDVHRAGGVMAILGELDRAGLLNSDIPTILSPTMKEQLAKYDIMQTDDPKIIDFYRAGPAGIRTVKPFSQSCRWDTV
DNDRAAGCVRSLEHAFSTEGGLAVLFGNMAVDGAVVKTAGVDNDNLTFTGPAKIYESQDTAVAAILGGKVVEGDVVVIRY
EGPQGGPGMQEMLYPTSYLKSMGLGKKCALVTDGRFSGGTSGLSIGHASPEAAAGGVIGLIEDGDIIDINIPTRTMDLKV
SDEILAERRIAMDIHGWKPVSRERHVSTALKVYALMATSADKGAIRDISKLK
>Mature_611_residues
PQYRSKTSTHGRNMAGARALWRATGVKDDDFGKPIIAIANSFTQFVPGHVHLKDMGQLVAGAVEAAGGIAKEFNTIAIDD
GIAMGHSGMLYSLPSRDLIADSIEYMVNAHCADAIVCISNCDKITPGMLMAALRLNIPVIFVSGGPMEAGKTKLSDQIIK
LDLVDAMVMGPDKNVSDEDLAKVERSACPTCGSCSGMFTANSMNCLTEALGLSLPGNGSMLATHADREQLFLEAGERIVD
ITKRHYEQDDYSVLPRAIACREAFENAMALDIAMGGSTNTILHLLACAQEAELDYTVADMDEMSRRIPQLCKVAPSTPLY
HMEDVHRAGGVMAILGELDRAGLLNSDIPTILSPTMKEQLAKYDIMQTDDPKIIDFYRAGPAGIRTVKPFSQSCRWDTVD
NDRAAGCVRSLEHAFSTEGGLAVLFGNMAVDGAVVKTAGVDNDNLTFTGPAKIYESQDTAVAAILGGKVVEGDVVVIRYE
GPQGGPGMQEMLYPTSYLKSMGLGKKCALVTDGRFSGGTSGLSIGHASPEAAAGGVIGLIEDGDIIDINIPTRTMDLKVS
DEILAERRIAMDIHGWKPVSRERHVSTALKVYALMATSADKGAIRDISKLK

Specific function: Valine and isoleucine biosynthesis; fourth step. [C]

COG id: COG0129

COG function: function code EG; Dihydroxyacid dehydratase/phosphogluconate dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ilvD/edd family

Homologues:

Organism=Escherichia coli, GI48994964, Length=614, Percent_Identity=76.2214983713355, Blast_Score=987, Evalue=0.0,
Organism=Escherichia coli, GI1788157, Length=544, Percent_Identity=29.0441176470588, Blast_Score=185, Evalue=6e-48,
Organism=Escherichia coli, GI2367371, Length=530, Percent_Identity=29.4339622641509, Blast_Score=182, Evalue=5e-47,
Organism=Escherichia coli, GI1786464, Length=534, Percent_Identity=30.5243445692884, Blast_Score=171, Evalue=1e-43,
Organism=Saccharomyces cerevisiae, GI6322476, Length=605, Percent_Identity=35.3719008264463, Blast_Score=333, Evalue=3e-92,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ILVD_PSYIN (A1SRU7)

Other databases:

- EMBL:   CP000510
- RefSeq:   YP_941811.1
- STRING:   A1SRU7
- GeneID:   4626723
- GenomeReviews:   CP000510_GR
- KEGG:   pin:Ping_0346
- eggNOG:   COG0129
- HOGENOM:   HBG671001
- OMA:   KVPCLSK
- PhylomeDB:   A1SRU7
- BioCyc:   PING357804:PING_0346-MONOMER
- HAMAP:   MF_00012
- InterPro:   IPR015928
- InterPro:   IPR004404
- InterPro:   IPR000581
- InterPro:   IPR020558
- PANTHER:   PTHR21000
- TIGRFAMs:   TIGR00110

Pfam domain/function: PF00920 ILVD_EDD; SSF52016 Aconitase/3IPM_dehydase_swvl

EC number: =4.2.1.9

Molecular weight: Translated: 65383; Mature: 65252

Theoretical pI: Translated: 5.03; Mature: 5.03

Prosite motif: PS00886 ILVD_EDD_1; PS00887 ILVD_EDD_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
4.7 %Met     (Translated Protein)
6.9 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
4.6 %Met     (Mature Protein)
6.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPQYRSKTSTHGRNMAGARALWRATGVKDDDFGKPIIAIANSFTQFVPGHVHLKDMGQLV
CCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCEEHHHHHHHH
AGAVEAAGGIAKEFNTIAIDDGIAMGHSGMLYSLPSRDLIADSIEYMVNAHCADAIVCIS
HHHHHHHCCHHHHCCEEEEECCEEECCCCCEEECCCCHHHHHHHHHHHHCCHHHEEEEEC
NCDKITPGMLMAALRLNIPVIFVSGGPMEAGKTKLSDQIIKLDLVDAMVMGPDKNVSDED
CCCCCCHHHHHHHHHHCCCEEEEECCCCCCCCHHHHHHEEEEEEHHHHEECCCCCCCHHH
LAKVERSACPTCGSCSGMFTANSMNCLTEALGLSLPGNGSMLATHADREQLFLEAGERIV
HHHHHHHCCCCCCCCCCCEECCHHHHHHHHHCCCCCCCCCEEEECCCHHHHHHHHCHHHH
DITKRHYEQDDYSVLPRAIACREAFENAMALDIAMGGSTNTILHLLACAQEAELDYTVAD
HHHHHHCCCCCHHHHHHHHHHHHHHCCCEEEEEEECCCHHHHHHHHHHHHHCCCCEEECC
MDEMSRRIPQLCKVAPSTPLYHMEDVHRAGGVMAILGELDRAGLLNSDIPTILSPTMKEQ
HHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCEEEEHHHHHCCCCCCCCCHHCCHHHHHH
LAKYDIMQTDDPKIIDFYRAGPAGIRTVKPFSQSCRWDTVDNDRAAGCVRSLEHAFSTEG
HHHHCCCCCCCCCEEEEECCCCCCCCCCCCHHHCCCCCCCCCCHHHHHHHHHHHHHCCCC
GLAVLFGNMAVDGAVVKTAGVDNDNLTFTGPAKIYESQDTAVAAILGGKVVEGDVVVIRY
CEEEEEECEEECCEEEEECCCCCCCEEEECCHHEECCCCCEEEEECCCEEEECCEEEEEE
EGPQGGPGMQEMLYPTSYLKSMGLGKKCALVTDGRFSGGTSGLSIGHASPEAAAGGVIGL
CCCCCCCCHHHHHCCHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCCCCCCHHCCCEEEE
IEDGDIIDINIPTRTMDLKVSDEILAERRIAMDIHGWKPVSRERHVSTALKVYALMATSA
ECCCCEEEEECCCEEEEEEECHHHHHHHHHEEEECCCCCCCHHHHHHHHHHHHHHHHCCC
DKGAIRDISKLK
CCCHHHHHHHCC
>Mature Secondary Structure 
PQYRSKTSTHGRNMAGARALWRATGVKDDDFGKPIIAIANSFTQFVPGHVHLKDMGQLV
CCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCEEHHHHHHHH
AGAVEAAGGIAKEFNTIAIDDGIAMGHSGMLYSLPSRDLIADSIEYMVNAHCADAIVCIS
HHHHHHHCCHHHHCCEEEEECCEEECCCCCEEECCCCHHHHHHHHHHHHCCHHHEEEEEC
NCDKITPGMLMAALRLNIPVIFVSGGPMEAGKTKLSDQIIKLDLVDAMVMGPDKNVSDED
CCCCCCHHHHHHHHHHCCCEEEEECCCCCCCCHHHHHHEEEEEEHHHHEECCCCCCCHHH
LAKVERSACPTCGSCSGMFTANSMNCLTEALGLSLPGNGSMLATHADREQLFLEAGERIV
HHHHHHHCCCCCCCCCCCEECCHHHHHHHHHCCCCCCCCCEEEECCCHHHHHHHHCHHHH
DITKRHYEQDDYSVLPRAIACREAFENAMALDIAMGGSTNTILHLLACAQEAELDYTVAD
HHHHHHCCCCCHHHHHHHHHHHHHHCCCEEEEEEECCCHHHHHHHHHHHHHCCCCEEECC
MDEMSRRIPQLCKVAPSTPLYHMEDVHRAGGVMAILGELDRAGLLNSDIPTILSPTMKEQ
HHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCEEEEHHHHHCCCCCCCCCHHCCHHHHHH
LAKYDIMQTDDPKIIDFYRAGPAGIRTVKPFSQSCRWDTVDNDRAAGCVRSLEHAFSTEG
HHHHCCCCCCCCCEEEEECCCCCCCCCCCCHHHCCCCCCCCCCHHHHHHHHHHHHHCCCC
GLAVLFGNMAVDGAVVKTAGVDNDNLTFTGPAKIYESQDTAVAAILGGKVVEGDVVVIRY
CEEEEEECEEECCEEEEECCCCCCCEEEECCHHEECCCCCEEEEECCCEEEECCEEEEEE
EGPQGGPGMQEMLYPTSYLKSMGLGKKCALVTDGRFSGGTSGLSIGHASPEAAAGGVIGL
CCCCCCCCHHHHHCCHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCCCCCCHHCCCEEEE
IEDGDIIDINIPTRTMDLKVSDEILAERRIAMDIHGWKPVSRERHVSTALKVYALMATSA
ECCCCEEEEECCCEEEEEEECHHHHHHHHHEEEECCCCCCCHHHHHHHHHHHHHHHHCCC
DKGAIRDISKLK
CCCHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA