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The map label for this gene is hldD

Identifier: 119944120

GI number: 119944120

Start: 435349

End: 436284

Strand: Reverse

Name: hldD

Synonym: Ping_0335

Alternate gene names: 119944120

Gene position: 436284-435349 (Counterclockwise)

Preceding gene: 119944131

Following gene: 119944119

Centisome position: 9.57

GC content: 39.21

Gene sequence:

>936_bases
ATGTTTATAGTTACAGGTGGTGCAGGTTTTATCGGCAGCAGTATAGTTAAATCCCTTAATGAACGTGGTATCACCGACAT
TCTGGTTGTTGATGACCTAACTGACGGTGCCAAATTTGTTAATCTGGTTGATTTGCAAATCATGGATTATATGGATAAAG
ATGAATTCATCACCCAAATTGTCTCCGGTCAGGATTTTGGTGATATTGAAGCGATTTTCCATGAAGGTGCCTGCTCGGCA
ACCACTGAATGGAACGGCAAATTCATGATGGAAAATAATTATGAATATTCTAAAGATCTGCTGCATTACTGTATTGAGCG
TGATATTCCATTTTTATACGCTTCATCTGCGGCAACCTATGGCGGTAACGATACTTTTAAAGAAGAATTAAAATATGAAA
AGCCATTAAATGTTTACGGCTACTCTAAATTCCAGTTTGACCAGTATGTGCGACGTATCTGGGAAGATGCTGCAGCCCAT
GATGAAACACTGCCGCAAATTGTAGGTTTTCGTTATTTTAATGTCTACGGCCCACGCGAACAGCATAAAGGCAGTATGGC
AAGTGTTGCCTTCCATTTAAATAACCAGCTTAATGCCGGTGAAAATGCTAAATTATTTGAAGGTGAACATAAACGTGATT
TCGTTTATATTGGAGATGTCTGCAAAGTAAATCTATGGTTTTTTGATAATAATGTTTCAGGTATTTATAATCTGGGCACA
GGGCAAGCAGAATCTTTCCTTGAAGTAGGTCAAGCCGTTGTTGCTTATCACCAGAAGGGCGAAGTTGAACGCATCCCTTT
TCCTGAACATTTAAAAGGTCGCTACCAGAGTTTCACCGAAGCTGATTTAACAAATTTGCGGGCAGCGGGTTATAAAGATA
CTTTCAAATCTGTTGCACAAGGTACTGCTGAATATATGGCTTGGCTAAACAGATAA

Upstream 100 bases:

>100_bases
ATGAACTTACAGGTCTAAGTTGAGATCCCACTTTAAATAATTGCATGGTATAATGACAACAATTTTTATATTAAATTAGA
TTCCATGCGGAGGTGAGAAC

Downstream 100 bases:

>100_bases
GTTGAATAAATAAAATGAAAATATTAGTTATCGGTCCTTCTTGGGTCGGCGATATGGTGATGTCGCAATGTTTATATAAA
TTATTAAAACAGCAATATCC

Product: ADP-L-glycero-D-manno-heptose-6-epimerase

Products: NA

Alternate protein names: ADP-L-glycero-beta-D-manno-heptose-6-epimerase; ADP-glyceromanno-heptose 6-epimerase; ADP-hep 6-epimerase; AGME

Number of amino acids: Translated: 311; Mature: 311

Protein sequence:

>311_residues
MFIVTGGAGFIGSSIVKSLNERGITDILVVDDLTDGAKFVNLVDLQIMDYMDKDEFITQIVSGQDFGDIEAIFHEGACSA
TTEWNGKFMMENNYEYSKDLLHYCIERDIPFLYASSAATYGGNDTFKEELKYEKPLNVYGYSKFQFDQYVRRIWEDAAAH
DETLPQIVGFRYFNVYGPREQHKGSMASVAFHLNNQLNAGENAKLFEGEHKRDFVYIGDVCKVNLWFFDNNVSGIYNLGT
GQAESFLEVGQAVVAYHQKGEVERIPFPEHLKGRYQSFTEADLTNLRAAGYKDTFKSVAQGTAEYMAWLNR

Sequences:

>Translated_311_residues
MFIVTGGAGFIGSSIVKSLNERGITDILVVDDLTDGAKFVNLVDLQIMDYMDKDEFITQIVSGQDFGDIEAIFHEGACSA
TTEWNGKFMMENNYEYSKDLLHYCIERDIPFLYASSAATYGGNDTFKEELKYEKPLNVYGYSKFQFDQYVRRIWEDAAAH
DETLPQIVGFRYFNVYGPREQHKGSMASVAFHLNNQLNAGENAKLFEGEHKRDFVYIGDVCKVNLWFFDNNVSGIYNLGT
GQAESFLEVGQAVVAYHQKGEVERIPFPEHLKGRYQSFTEADLTNLRAAGYKDTFKSVAQGTAEYMAWLNR
>Mature_311_residues
MFIVTGGAGFIGSSIVKSLNERGITDILVVDDLTDGAKFVNLVDLQIMDYMDKDEFITQIVSGQDFGDIEAIFHEGACSA
TTEWNGKFMMENNYEYSKDLLHYCIERDIPFLYASSAATYGGNDTFKEELKYEKPLNVYGYSKFQFDQYVRRIWEDAAAH
DETLPQIVGFRYFNVYGPREQHKGSMASVAFHLNNQLNAGENAKLFEGEHKRDFVYIGDVCKVNLWFFDNNVSGIYNLGT
GQAESFLEVGQAVVAYHQKGEVERIPFPEHLKGRYQSFTEADLTNLRAAGYKDTFKSVAQGTAEYMAWLNR

Specific function: Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose

COG id: COG0451

COG function: function code MG; Nucleoside-diphosphate-sugar epimerases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sugar epimerase family. HldD subfamily

Homologues:

Organism=Escherichia coli, GI1790049, Length=314, Percent_Identity=72.2929936305732, Blast_Score=475, Evalue=1e-135,

Paralogues:

None

Copy number: 220 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): HLDD_PSYIN (A1SRT6)

Other databases:

- EMBL:   CP000510
- RefSeq:   YP_941800.1
- ProteinModelPortal:   A1SRT6
- SMR:   A1SRT6
- STRING:   A1SRT6
- GeneID:   4624973
- GenomeReviews:   CP000510_GR
- KEGG:   pin:Ping_0335
- eggNOG:   COG0451
- HOGENOM:   HBG755066
- OMA:   GFIGSAM
- PhylomeDB:   A1SRT6
- BioCyc:   PING357804:PING_0335-MONOMER
- HAMAP:   MF_01601
- InterPro:   IPR001509
- InterPro:   IPR011912
- InterPro:   IPR016040
- Gene3D:   G3DSA:3.40.50.720
- PANTHER:   PTHR10366:SF29
- TIGRFAMs:   TIGR02197

Pfam domain/function: PF01370 Epimerase

EC number: =5.1.3.20

Molecular weight: Translated: 35328; Mature: 35328

Theoretical pI: Translated: 4.61; Mature: 4.61

Prosite motif: NA

Important sites: ACT_SITE 139-139 ACT_SITE 183-183 BINDING 38-38 BINDING 53-53 BINDING 92-92 BINDING 143-143 BINDING 174-174 BINDING 175-175 BINDING 183-183 BINDING 185-185 BINDING 192-192 BINDING 212-212 BINDING 275-275

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFIVTGGAGFIGSSIVKSLNERGITDILVVDDLTDGAKFVNLVDLQIMDYMDKDEFITQI
CEEEECCCHHHHHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHHHHHHHCCHHHHHHHH
VSGQDFGDIEAIFHEGACSATTEWNGKFMMENNYEYSKDLLHYCIERDIPFLYASSAATY
HCCCCCCHHHHHHHCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHCCCCEEEECCCCCC
GGNDTFKEELKYEKPLNVYGYSKFQFDQYVRRIWEDAAAHDETLPQIVGFRYFNVYGPRE
CCCCHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHCEEEEEECCCHH
QHKGSMASVAFHLNNQLNAGENAKLFEGEHKRDFVYIGDVCKVNLWFFDNNVSGIYNLGT
HHCCCCEEEEEEECCCCCCCCCCCEECCCCCCCEEEECCEEEEEEEEEECCCCCEEECCC
GQAESFLEVGQAVVAYHQKGEVERIPFPEHLKGRYQSFTEADLTNLRAAGYKDTFKSVAQ
CCHHHHHHHHHHHHHHHHCCCEECCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
GTAEYMAWLNR
HHHHHHHHHCC
>Mature Secondary Structure
MFIVTGGAGFIGSSIVKSLNERGITDILVVDDLTDGAKFVNLVDLQIMDYMDKDEFITQI
CEEEECCCHHHHHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHHHHHHHCCHHHHHHHH
VSGQDFGDIEAIFHEGACSATTEWNGKFMMENNYEYSKDLLHYCIERDIPFLYASSAATY
HCCCCCCHHHHHHHCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHCCCCEEEECCCCCC
GGNDTFKEELKYEKPLNVYGYSKFQFDQYVRRIWEDAAAHDETLPQIVGFRYFNVYGPRE
CCCCHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHCEEEEEECCCHH
QHKGSMASVAFHLNNQLNAGENAKLFEGEHKRDFVYIGDVCKVNLWFFDNNVSGIYNLGT
HHCCCCEEEEEEECCCCCCCCCCCEECCCCCCCEEEECCEEEEEEEEEECCCCCEEECCC
GQAESFLEVGQAVVAYHQKGEVERIPFPEHLKGRYQSFTEADLTNLRAAGYKDTFKSVAQ
CCHHHHHHHHHHHHHHHHCCCEECCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
GTAEYMAWLNR
HHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA