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The map label for this gene is polC [H]

Identifier: 119944051

GI number: 119944051

Start: 347145

End: 347831

Strand: Direct

Name: polC [H]

Synonym: Ping_0265

Alternate gene names: 119944051

Gene position: 347145-347831 (Clockwise)

Preceding gene: 119944050

Following gene: 119944053

Centisome position: 7.61

GC content: 36.39

Gene sequence:

>687_bases
ATGTTTAAACAATGGTGGTTACAGTACAAATTAAAACGGCTGATTAAAAATAGCAAACTCGCCGCGCTAAAAGCACATTA
TCAGTATCTGTTAACACAGCTTAATCGGCCGATTGCTGAAGCTACGTTATTAGCATTAGATATTGAAATGACAGGCTTAG
ATCCTAAAAAAGATCAGATGGTCAGTATTGGAATTATCCCTATTATCAATGCTAAGATTCAACCTGAATTTGCACAGCAT
AAATTAATAAAAATACAGGGTAGTGTTGGACAAAGTGCTGTTATACACGGTGTTTTAGATAAAGATCTGGCTGATGCATT
ACCACTAGAAGAAGCCCTGCAATGGTTGTTCGAGCAATGTAAAGATAAAGTATTAGTCGCGCATCATGCTCAATTAGATT
TACAATTTCTGCAACAATCATTATCAAAATCCGGAGCACATTCCTTTTCTATGTTAGCCATAGATACCTTAATCATTGAG
AAGGAGCGGGAACTGCGCAAGCACCAGGTTTTAAAAACAGGGAGTTTACGTTTGAACGCATGTAGAGATCGTTATAATTT
ACCTATTTATAATGCACATAATGCATTAACCGATGCATTAGCTTGCGCTGAATTATTATTAGCGCAATTAAATCAGATGG
GTGGCTTAGATAATATCACTTTAGTGCAATTGCTCACTAAGCGATAA

Upstream 100 bases:

>100_bases
ACAGCCTCTCTTCATTGGTGCGTCATCAGCTAAAGGATGCCTTTAAAGTTATCCATGAAGCACAAGACACCGTTAGGCTA
AAATTCTTAAGGCAATTTTG

Downstream 100 bases:

>100_bases
TAGTAATGCTAAGGAAATTTAGACTGTGAAAAATGGGTGGCATGATTGTTTTTTGTGGAATGGTTGTTTTTTGAAAACAG
TCATACATCTAAGGTTACTG

Product: exonuclease, RNase T and DNA polymerase III

Products: NA

Alternate protein names: PolIII [H]

Number of amino acids: Translated: 228; Mature: 228

Protein sequence:

>228_residues
MFKQWWLQYKLKRLIKNSKLAALKAHYQYLLTQLNRPIAEATLLALDIEMTGLDPKKDQMVSIGIIPIINAKIQPEFAQH
KLIKIQGSVGQSAVIHGVLDKDLADALPLEEALQWLFEQCKDKVLVAHHAQLDLQFLQQSLSKSGAHSFSMLAIDTLIIE
KERELRKHQVLKTGSLRLNACRDRYNLPIYNAHNALTDALACAELLLAQLNQMGGLDNITLVQLLTKR

Sequences:

>Translated_228_residues
MFKQWWLQYKLKRLIKNSKLAALKAHYQYLLTQLNRPIAEATLLALDIEMTGLDPKKDQMVSIGIIPIINAKIQPEFAQH
KLIKIQGSVGQSAVIHGVLDKDLADALPLEEALQWLFEQCKDKVLVAHHAQLDLQFLQQSLSKSGAHSFSMLAIDTLIIE
KERELRKHQVLKTGSLRLNACRDRYNLPIYNAHNALTDALACAELLLAQLNQMGGLDNITLVQLLTKR
>Mature_228_residues
MFKQWWLQYKLKRLIKNSKLAALKAHYQYLLTQLNRPIAEATLLALDIEMTGLDPKKDQMVSIGIIPIINAKIQPEFAQH
KLIKIQGSVGQSAVIHGVLDKDLADALPLEEALQWLFEQCKDKVLVAHHAQLDLQFLQQSLSKSGAHSFSMLAIDTLIIE
KERELRKHQVLKTGSLRLNACRDRYNLPIYNAHNALTDALACAELLLAQLNQMGGLDNITLVQLLTKR

Specific function: Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity [H]

COG id: COG0847

COG function: function code L; DNA polymerase III, epsilon subunit and related 3'-5' exonucleases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 exonuclease domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011708
- InterPro:   IPR006054
- InterPro:   IPR006055
- InterPro:   IPR013520
- InterPro:   IPR023223
- InterPro:   IPR004013
- InterPro:   IPR003141
- InterPro:   IPR006308
- InterPro:   IPR012337 [H]

Pfam domain/function: PF07733 DNA_pol3_alpha; PF00929 Exonuc_X-T; PF02811 PHP [H]

EC number: =2.7.7.7 [H]

Molecular weight: Translated: 25777; Mature: 25777

Theoretical pI: Translated: 9.38; Mature: 9.38

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFKQWWLQYKLKRLIKNSKLAALKAHYQYLLTQLNRPIAEATLLALDIEMTGLDPKKDQM
CCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCHHHHHHHEEEEEECCCCCCCCCE
VSIGIIPIINAKIQPEFAQHKLIKIQGSVGQSAVIHGVLDKDLADALPLEEALQWLFEQC
EEEEEEEEECCCCCCCHHHCEEEEEECCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
KDKVLVAHHAQLDLQFLQQSLSKSGAHSFSMLAIDTLIIEKERELRKHQVLKTGSLRLNA
HCCEEEHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEE
CRDRYNLPIYNAHNALTDALACAELLLAQLNQMGGLDNITLVQLLTKR
HHHHCCCCEECCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCC
>Mature Secondary Structure
MFKQWWLQYKLKRLIKNSKLAALKAHYQYLLTQLNRPIAEATLLALDIEMTGLDPKKDQM
CCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCHHHHHHHEEEEEECCCCCCCCCE
VSIGIIPIINAKIQPEFAQHKLIKIQGSVGQSAVIHGVLDKDLADALPLEEALQWLFEQC
EEEEEEEEECCCCCCCHHHCEEEEEECCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
KDKVLVAHHAQLDLQFLQQSLSKSGAHSFSMLAIDTLIIEKERELRKHQVLKTGSLRLNA
HCCEEEHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEE
CRDRYNLPIYNAHNALTDALACAELLLAQLNQMGGLDNITLVQLLTKR
HHHHCCCCEECCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9826752; 10360571 [H]