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The map label for this gene is nhaA1

Identifier: 119944000

GI number: 119944000

Start: 267796

End: 269115

Strand: Reverse

Name: nhaA1

Synonym: Ping_0214

Alternate gene names: 119944000

Gene position: 269115-267796 (Counterclockwise)

Preceding gene: 119944001

Following gene: 119943999

Centisome position: 5.9

GC content: 42.8

Gene sequence:

>1320_bases
ATGAGTTCTCGCGGTAAATGGTCCTGGTTACACAGCCCCATAACAGGTGGTATTCTTTTAATTATTGCAGCAACGACTGC
ACTGTTCTGGGCAAATTTAGCCCCCTCTCTCTACCATCACGCTTGGCATGATGCTCTATTCTCGGTTTCTTCAGGATTTA
GCGCCACTATCTATTCGATTAGTCTCCATCAAATTGTAAATGAATTCTTGATGGCGATTTTCTTCTTTTTCATTGGCTTA
GAAATGAAACGTGAACTCTTAGATGATGACCTTTCTACCCTTAAAAAAGCCGCTTTACCATTATTTTCCGCCTTAGGGGG
AGTTGTTCTTCCCGCCAGCATCTATTATTTTTTCAATGCAGGGACTGATACGGTTAATGGCTGGGGTATCCCAATGGCAA
CGGATATTGCCTTTGCATTAGGTGTGCTGGCAATGGTCGGCAGTCGTGTCCCTCTTTCTTTAAAAATATTTCTATCGGCA
TTGGCGATCGGTGATGATTTAATGGCAGTATTGGTTATTGCCATCTTCTATACCGAGCAAATCTTTGTTAATGAATTGCT
GGTTGGTTTCTTAGGATTAATTGTCCTGGCAGTCGCCAATAAAATGGGTGTACGCAACCGCTTAGTTTATTACTCTATTG
GTTTAATCATTGTCTGGATCAGTTTTTTAGCTTCTGGGGTCCATGCGACTATTGCGGGCGTTGCTGTCGCGTTTACTATC
CCTTCTCGCCGGGAAATATCCATGGGAAATTATTTAATTACGGCTAAAGGGTTACTTAGCGGCTTGGACAAGGAACGCCA
CAATAAAGCCGATGTATTAACTAAAAATGCCATTTCATCTTTACGCGAAATCAGAGATTTAAGTTATCAGGCATCGAACC
CTTTACAACTTAAAGAAGAAGCACTGCACCCTATTTCAGCCCTGTTTATTGTGCCATTATTCGCACTGGGTAATGCCGGT
GTTATTGTGGATGACAGCATGCTGGCAGAGTTAACTAACCCTATTGTGTTAGGCATTGCAGCCGGCCTTATTATTGGTAA
ACCTCTGGGTATTTTTCTGTTCGCTAAGCTTCTGACCCTTTTAAAATTGGGCCAACTCCCGGAGGGTGTCACATGGAGGC
ATATTATCGGGACCGGTTTCTTAGCAGGTATGGGGTTTACTATGTCGCTCTTTATTAGCGACCTGGCCTTCTCTGAGCCA
GAGCAGAAGATTGTCGCTAAAGTTGCCGTGCTGTTAGCATCAATCATATCCGGTATTGTAGGTTATCTGATTTTGATCAG
CGCCCCGGTTATCAAAAAAGACAATAAATTAAATAGTTAG

Upstream 100 bases:

>100_bases
CCTGAAATAACACCGTAAAATCAATAACAAAAAAATGACGGTTAACAGGCTTGATTGGATATTTTTCTGGATTGGCAGCA
TTATTTTTTTAGGAGTAACA

Downstream 100 bases:

>100_bases
AGATTATCTAATGAGTCAAAACCTGCTATTTTTGCAGGCTTTTTTACAACAGGAATTATTTATGACCACAGATCCAAAAC
ACTTAAAAAGAATGAAAGCC

Product: Na+/H+ antiporter NhaA

Products: Na (I) [Periplasm]; Proton [Cytoplasm] [C]

Alternate protein names: Sodium/proton antiporter nhaA 1

Number of amino acids: Translated: 439; Mature: 438

Protein sequence:

>439_residues
MSSRGKWSWLHSPITGGILLIIAATTALFWANLAPSLYHHAWHDALFSVSSGFSATIYSISLHQIVNEFLMAIFFFFIGL
EMKRELLDDDLSTLKKAALPLFSALGGVVLPASIYYFFNAGTDTVNGWGIPMATDIAFALGVLAMVGSRVPLSLKIFLSA
LAIGDDLMAVLVIAIFYTEQIFVNELLVGFLGLIVLAVANKMGVRNRLVYYSIGLIIVWISFLASGVHATIAGVAVAFTI
PSRREISMGNYLITAKGLLSGLDKERHNKADVLTKNAISSLREIRDLSYQASNPLQLKEEALHPISALFIVPLFALGNAG
VIVDDSMLAELTNPIVLGIAAGLIIGKPLGIFLFAKLLTLLKLGQLPEGVTWRHIIGTGFLAGMGFTMSLFISDLAFSEP
EQKIVAKVAVLLASIISGIVGYLILISAPVIKKDNKLNS

Sequences:

>Translated_439_residues
MSSRGKWSWLHSPITGGILLIIAATTALFWANLAPSLYHHAWHDALFSVSSGFSATIYSISLHQIVNEFLMAIFFFFIGL
EMKRELLDDDLSTLKKAALPLFSALGGVVLPASIYYFFNAGTDTVNGWGIPMATDIAFALGVLAMVGSRVPLSLKIFLSA
LAIGDDLMAVLVIAIFYTEQIFVNELLVGFLGLIVLAVANKMGVRNRLVYYSIGLIIVWISFLASGVHATIAGVAVAFTI
PSRREISMGNYLITAKGLLSGLDKERHNKADVLTKNAISSLREIRDLSYQASNPLQLKEEALHPISALFIVPLFALGNAG
VIVDDSMLAELTNPIVLGIAAGLIIGKPLGIFLFAKLLTLLKLGQLPEGVTWRHIIGTGFLAGMGFTMSLFISDLAFSEP
EQKIVAKVAVLLASIISGIVGYLILISAPVIKKDNKLNS
>Mature_438_residues
SSRGKWSWLHSPITGGILLIIAATTALFWANLAPSLYHHAWHDALFSVSSGFSATIYSISLHQIVNEFLMAIFFFFIGLE
MKRELLDDDLSTLKKAALPLFSALGGVVLPASIYYFFNAGTDTVNGWGIPMATDIAFALGVLAMVGSRVPLSLKIFLSAL
AIGDDLMAVLVIAIFYTEQIFVNELLVGFLGLIVLAVANKMGVRNRLVYYSIGLIIVWISFLASGVHATIAGVAVAFTIP
SRREISMGNYLITAKGLLSGLDKERHNKADVLTKNAISSLREIRDLSYQASNPLQLKEEALHPISALFIVPLFALGNAGV
IVDDSMLAELTNPIVLGIAAGLIIGKPLGIFLFAKLLTLLKLGQLPEGVTWRHIIGTGFLAGMGFTMSLFISDLAFSEPE
QKIVAKVAVLLASIISGIVGYLILISAPVIKKDNKLNS

Specific function: Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons

COG id: COG3004

COG function: function code P; Na+/H+ antiporter

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nhaA Na(+)/H(+) (TC 2.A.33) antiporter family

Homologues:

Organism=Escherichia coli, GI1786201, Length=360, Percent_Identity=45.5555555555556, Blast_Score=260, Evalue=1e-70,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NHAA1_PSYIN (A1SRG6)

Other databases:

- EMBL:   CP000510
- RefSeq:   YP_941680.1
- ProteinModelPortal:   A1SRG6
- SMR:   A1SRG6
- STRING:   A1SRG6
- GeneID:   4627152
- GenomeReviews:   CP000510_GR
- KEGG:   pin:Ping_0214
- eggNOG:   COG3004
- HOGENOM:   HBG665619
- OMA:   QKAIFPA
- PhylomeDB:   A1SRG6
- BioCyc:   PING357804:PING_0214-MONOMER
- HAMAP:   MF_01844
- InterPro:   IPR023171
- InterPro:   IPR004670
- TIGRFAMs:   TIGR00773

Pfam domain/function: PF06965 Na_H_antiport_1

EC number: NA

Molecular weight: Translated: 47292; Mature: 47160

Theoretical pI: Translated: 8.68; Mature: 8.68

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x1404be68)-; HASH(0x14796f70)-; HASH(0x13f4d01c)-; HASH(0x1505cf80)-; HASH(0xc0af4fc)-; HASH(0x15b42048)-; HASH(0x15b41d24)-; HASH(0x142ec9e0)-; HASH(0x15b476d0)-; HASH(0x1521b918)-; HASH(0x15b3ea78)-;

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSRGKWSWLHSPITGGILLIIAATTALFWANLAPSLYHHAWHDALFSVSSGFSATIYSI
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHCCCCCHHHHHH
SLHQIVNEFLMAIFFFFIGLEMKRELLDDDLSTLKKAALPLFSALGGVVLPASIYYFFNA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHEEEEEC
GTDTVNGWGIPMATDIAFALGVLAMVGSRVPLSLKIFLSALAIGDDLMAVLVIAIFYTEQ
CCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCHHHHHHHHHHHHHHHH
IFVNELLVGFLGLIVLAVANKMGVRNRLVYYSIGLIIVWISFLASGVHATIAGVAVAFTI
HHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEC
PSRREISMGNYLITAKGLLSGLDKERHNKADVLTKNAISSLREIRDLSYQASNPLQLKEE
CCCCCCCCCCEEEEHHHHHHHCCHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHH
ALHPISALFIVPLFALGNAGVIVDDSMLAELTNPIVLGIAAGLIIGKPLGIFLFAKLLTL
HHHHHHHHHHHHHHHCCCCCEEECHHHHHHHHCHHHHHHHHHHHHCCHHHHHHHHHHHHH
LKLGQLPEGVTWRHIIGTGFLAGMGFTMSLFISDLAFSEPEQKIVAKVAVLLASIISGIV
HHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHH
GYLILISAPVIKKDNKLNS
HHHHHHCCCCCCCCCCCCH
>Mature Secondary Structure 
SSRGKWSWLHSPITGGILLIIAATTALFWANLAPSLYHHAWHDALFSVSSGFSATIYSI
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHCCCCCHHHHHH
SLHQIVNEFLMAIFFFFIGLEMKRELLDDDLSTLKKAALPLFSALGGVVLPASIYYFFNA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHEEEEEC
GTDTVNGWGIPMATDIAFALGVLAMVGSRVPLSLKIFLSALAIGDDLMAVLVIAIFYTEQ
CCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCHHHHHHHHHHHHHHHH
IFVNELLVGFLGLIVLAVANKMGVRNRLVYYSIGLIIVWISFLASGVHATIAGVAVAFTI
HHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEC
PSRREISMGNYLITAKGLLSGLDKERHNKADVLTKNAISSLREIRDLSYQASNPLQLKEE
CCCCCCCCCCEEEEHHHHHHHCCHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHH
ALHPISALFIVPLFALGNAGVIVDDSMLAELTNPIVLGIAAGLIIGKPLGIFLFAKLLTL
HHHHHHHHHHHHHHHCCCCCEEECHHHHHHHHCHHHHHHHHHHHHCCHHHHHHHHHHHHH
LKLGQLPEGVTWRHIIGTGFLAGMGFTMSLFISDLAFSEPEQKIVAKVAVLLASIISGIV
HHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHH
GYLILISAPVIKKDNKLNS
HHHHHHCCCCCCCCCCCCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Na (I) [Cytoplasm]; Proton [Periplasm] [C]

Specific reaction: Na (I) [Cytoplasm] + 2 Proton [Periplasm] = Na (I) [Periplasm] + 2 Proton [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA