Click here to switch to the map view.

The map label for this gene is adhC [H]

Identifier: 119899912

GI number: 119899912

Start: 3973580

End: 3974692

Strand: Direct

Name: adhC [H]

Synonym: azo3623

Alternate gene names: 119899912

Gene position: 3973580-3974692 (Clockwise)

Preceding gene: 119899908

Following gene: 119899913

Centisome position: 90.8

GC content: 66.13

Gene sequence:

>1113_bases
ATGATCAAATCCCGCGCTGCCGTCGCCTGGGGCCCCAACCAGCCGCTCGAAATCACCGAGGTGGACGTCGCCCCGCCCAA
GGCCGGCGAGGTGCGGGTGCGCATCGTCGCTACCGGCGTCTGTCACACCGACGCCTTCACGCTGTCCGGCGCCGATCCGG
AAGGCATCTTCCCGTCCATCCTCGGCCACGAGGGTGGCGGCATCGTCGAGGCGATCGGCGAAGGCGTGACCTCGGTCGCA
GTCGGCGACCACGTGATCCCGCTGTACACGCCGGAATGCGGCAAGTGCAAATTCTGCCTGTCGGGCAAGACCAACCTCTG
CCAGGCGATCCGCGCAACCCAGGGCAAGGGCCTGATGCCGGACGGCACCAGCCGCTTCTCCAAGGACGGCAAGCCCATCT
TCCACTACATGGGCACCTCCACCTTCTCCGAATACACCGTGCTGCCGGAAATCTCGGTCGCCAAGATCCAGAAGGACGCG
CCGCTCGACAAGGTCTGCCTGCTCGGTTGCGGCGTCACCACCGGCATCGGCGCGGTGCTCAACACCGCCAAGGTCGAACC
CGGTGCCACCGTGGCGGTGTTCGGGCTGGGCGGCATCGGCCTGTCGGCGATCATCGGCGCGGTGATGGCCAAGGCCTCGC
GCATCGTCGCGGTCGACATCAACCCGGACAAGTTCGAGATCGCCAGACAGCTCGGCGCCACCGATTTCATCAACCCCAAG
GACTACGACCGGCCGATCCAGGAGGTCATCGTCGAACTCACCGACGGCGGCGTGGATTACTCCTTCGAGTGCATCGGCAA
CACCAACGTGATGCGCTCGGCGCTGGAGTGCTGCCACAAGGGCTGGGGCGAATCCATCATCATCGGCGTCGCCGGCGCCG
GCCAGGAAATCTCCACCCGCCCCTTCCAGCTCGTCACCGGCAGGGTGTGGCGCGGCTCGGCCTTCGGCGGGGTGCGCGGC
CGCACCGAGTTGCCCAGCTACGTGGCGAAGGCGCAGACGGGCGAGATTCCGCTCGACACCTTCATCACCCACCGCATGGG
GCTGGAAGACATCAACAAGGCCTTCGACCTGATGCACGAAGGCAAGAGCATCCGCTCGGTCATCATCTACTGA

Upstream 100 bases:

>100_bases
ATATTGCTCATCAGCAAGAATGTTTTGCCAAAGCACGCATTATCCCCATGCAGCCGTTTTCTAGAATAGTTGCCCTGCGC
ATCCAACCGAGAACATCGAC

Downstream 100 bases:

>100_bases
TACAGGTAAACGGGCGTCCGCGCCCGGCACCGCCATCCTCATGAACACACTCGAACAGATCGCTGCCAACCGCAGCTTCG
GCGGCTGGCACAAGCGCTTC

Product: alcohol dehydrogenase classIII

Products: NA

Alternate protein names: Alcohol dehydrogenase class-3; Alcohol dehydrogenase class-III; Glutathione-dependent formaldehyde dehydrogenase; FALDH; FDH; GSH-FDH [H]

Number of amino acids: Translated: 370; Mature: 370

Protein sequence:

>370_residues
MIKSRAAVAWGPNQPLEITEVDVAPPKAGEVRVRIVATGVCHTDAFTLSGADPEGIFPSILGHEGGGIVEAIGEGVTSVA
VGDHVIPLYTPECGKCKFCLSGKTNLCQAIRATQGKGLMPDGTSRFSKDGKPIFHYMGTSTFSEYTVLPEISVAKIQKDA
PLDKVCLLGCGVTTGIGAVLNTAKVEPGATVAVFGLGGIGLSAIIGAVMAKASRIVAVDINPDKFEIARQLGATDFINPK
DYDRPIQEVIVELTDGGVDYSFECIGNTNVMRSALECCHKGWGESIIIGVAGAGQEISTRPFQLVTGRVWRGSAFGGVRG
RTELPSYVAKAQTGEIPLDTFITHRMGLEDINKAFDLMHEGKSIRSVIIY

Sequences:

>Translated_370_residues
MIKSRAAVAWGPNQPLEITEVDVAPPKAGEVRVRIVATGVCHTDAFTLSGADPEGIFPSILGHEGGGIVEAIGEGVTSVA
VGDHVIPLYTPECGKCKFCLSGKTNLCQAIRATQGKGLMPDGTSRFSKDGKPIFHYMGTSTFSEYTVLPEISVAKIQKDA
PLDKVCLLGCGVTTGIGAVLNTAKVEPGATVAVFGLGGIGLSAIIGAVMAKASRIVAVDINPDKFEIARQLGATDFINPK
DYDRPIQEVIVELTDGGVDYSFECIGNTNVMRSALECCHKGWGESIIIGVAGAGQEISTRPFQLVTGRVWRGSAFGGVRG
RTELPSYVAKAQTGEIPLDTFITHRMGLEDINKAFDLMHEGKSIRSVIIY
>Mature_370_residues
MIKSRAAVAWGPNQPLEITEVDVAPPKAGEVRVRIVATGVCHTDAFTLSGADPEGIFPSILGHEGGGIVEAIGEGVTSVA
VGDHVIPLYTPECGKCKFCLSGKTNLCQAIRATQGKGLMPDGTSRFSKDGKPIFHYMGTSTFSEYTVLPEISVAKIQKDA
PLDKVCLLGCGVTTGIGAVLNTAKVEPGATVAVFGLGGIGLSAIIGAVMAKASRIVAVDINPDKFEIARQLGATDFINPK
DYDRPIQEVIVELTDGGVDYSFECIGNTNVMRSALECCHKGWGESIIIGVAGAGQEISTRPFQLVTGRVWRGSAFGGVRG
RTELPSYVAKAQTGEIPLDTFITHRMGLEDINKAFDLMHEGKSIRSVIIY

Specific function: Has High Formaldehyde Dehydrogenase Activity In The Presence Of Glutathione And Catalyzes The Oxidation Of Normal Alcohols In A Reaction That Is Not Gsh-Dependent. In Addition, Hemithiolacetals Other Than Those Formed From Gsh, Including Omega-Thiol Fatty

COG id: COG1062

COG function: function code C; Zn-dependent alcohol dehydrogenases, class III

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily [H]

Homologues:

Organism=Homo sapiens, GI71565154, Length=368, Percent_Identity=66.304347826087, Blast_Score=514, Evalue=1e-146,
Organism=Homo sapiens, GI34577061, Length=370, Percent_Identity=52.972972972973, Blast_Score=412, Evalue=1e-115,
Organism=Homo sapiens, GI4501929, Length=370, Percent_Identity=52.1621621621622, Blast_Score=402, Evalue=1e-112,
Organism=Homo sapiens, GI71565152, Length=375, Percent_Identity=52, Blast_Score=399, Evalue=1e-111,
Organism=Homo sapiens, GI4501933, Length=370, Percent_Identity=51.3513513513513, Blast_Score=398, Evalue=1e-111,
Organism=Homo sapiens, GI156523966, Length=369, Percent_Identity=48.5094850948509, Blast_Score=379, Evalue=1e-105,
Organism=Homo sapiens, GI4501939, Length=362, Percent_Identity=48.8950276243094, Blast_Score=372, Evalue=1e-103,
Organism=Homo sapiens, GI262073058, Length=371, Percent_Identity=48.5175202156334, Blast_Score=367, Evalue=1e-102,
Organism=Homo sapiens, GI71743840, Length=371, Percent_Identity=48.5175202156334, Blast_Score=367, Evalue=1e-101,
Organism=Escherichia coli, GI1786552, Length=369, Percent_Identity=68.8346883468835, Blast_Score=525, Evalue=1e-150,
Organism=Escherichia coli, GI87082125, Length=380, Percent_Identity=25, Blast_Score=100, Evalue=3e-22,
Organism=Escherichia coli, GI1790045, Length=365, Percent_Identity=27.3972602739726, Blast_Score=98, Evalue=8e-22,
Organism=Escherichia coli, GI1787863, Length=355, Percent_Identity=26.4788732394366, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI1788073, Length=361, Percent_Identity=25.7617728531856, Blast_Score=85, Evalue=8e-18,
Organism=Escherichia coli, GI87081918, Length=353, Percent_Identity=26.628895184136, Blast_Score=81, Evalue=1e-16,
Organism=Escherichia coli, GI1786825, Length=274, Percent_Identity=29.1970802919708, Blast_Score=78, Evalue=7e-16,
Organism=Escherichia coli, GI1788075, Length=373, Percent_Identity=24.9329758713137, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI226510992, Length=368, Percent_Identity=22.2826086956522, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1786518, Length=343, Percent_Identity=27.6967930029155, Blast_Score=67, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI25146526, Length=374, Percent_Identity=58.8235294117647, Blast_Score=467, Evalue=1e-132,
Organism=Caenorhabditis elegans, GI71997431, Length=376, Percent_Identity=58.5106382978723, Blast_Score=462, Evalue=1e-130,
Organism=Caenorhabditis elegans, GI17565904, Length=340, Percent_Identity=57.9411764705882, Blast_Score=421, Evalue=1e-118,
Organism=Caenorhabditis elegans, GI17562584, Length=359, Percent_Identity=28.9693593314763, Blast_Score=100, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI17562582, Length=373, Percent_Identity=28.9544235924933, Blast_Score=91, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI71988145, Length=370, Percent_Identity=26.7567567567568, Blast_Score=87, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI17562878, Length=278, Percent_Identity=29.4964028776978, Blast_Score=80, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6320033, Length=371, Percent_Identity=60.377358490566, Blast_Score=473, Evalue=1e-134,
Organism=Saccharomyces cerevisiae, GI6319621, Length=374, Percent_Identity=27.807486631016, Blast_Score=96, Evalue=1e-20,
Organism=Saccharomyces cerevisiae, GI6323099, Length=373, Percent_Identity=29.2225201072386, Blast_Score=94, Evalue=3e-20,
Organism=Saccharomyces cerevisiae, GI6323729, Length=377, Percent_Identity=25.9946949602122, Blast_Score=85, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6323961, Length=324, Percent_Identity=26.5432098765432, Blast_Score=84, Evalue=3e-17,
Organism=Saccharomyces cerevisiae, GI6324486, Length=360, Percent_Identity=24.4444444444444, Blast_Score=82, Evalue=1e-16,
Organism=Saccharomyces cerevisiae, GI6319258, Length=236, Percent_Identity=27.9661016949153, Blast_Score=71, Evalue=3e-13,
Organism=Drosophila melanogaster, GI17737895, Length=372, Percent_Identity=63.9784946236559, Blast_Score=506, Evalue=1e-144,
Organism=Drosophila melanogaster, GI17137530, Length=337, Percent_Identity=25.8160237388724, Blast_Score=81, Evalue=1e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014183
- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.284; =1.1.1.1 [H]

Molecular weight: Translated: 39110; Mature: 39110

Theoretical pI: Translated: 6.17; Mature: 6.17

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.7 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
2.7 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIKSRAAVAWGPNQPLEITEVDVAPPKAGEVRVRIVATGVCHTDAFTLSGADPEGIFPSI
CCCCCEEEEECCCCCCEEEEEECCCCCCCCEEEEEEEEEEEECCEEEECCCCCCCCCHHH
LGHEGGGIVEAIGEGVTSVAVGDHVIPLYTPECGKCKFCLSGKTNLCQAIRATQGKGLMP
HCCCCCCHHHHHHCCCEEEEECCEEEEEECCCCCCEEEEECCCHHHHHHHHHCCCCCCCC
DGTSRFSKDGKPIFHYMGTSTFSEYTVLPEISVAKIQKDAPLDKVCLLGCGVTTGIGAVL
CCCHHHCCCCCEEEEECCCCCCCCEEECCCCHHHHHCCCCCCCHHHEECCCHHHHHHHHH
NTAKVEPGATVAVFGLGGIGLSAIIGAVMAKASRIVAVDINPDKFEIARQLGATDFINPK
HHCCCCCCCEEEEEECCCCCHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHCCCCCCCCC
DYDRPIQEVIVELTDGGVDYSFECIGNTNVMRSALECCHKGWGESIIIGVAGAGQEISTR
CCCHHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCC
PFQLVTGRVWRGSAFGGVRGRTELPSYVAKAQTGEIPLDTFITHRMGLEDINKAFDLMHE
CEEEEECEEECCCCCCCCCCCCHHHHHHHHCCCCCCCHHHHHHHHCCHHHHHHHHHHHHC
GKSIRSVIIY
CCCCEEEEEC
>Mature Secondary Structure
MIKSRAAVAWGPNQPLEITEVDVAPPKAGEVRVRIVATGVCHTDAFTLSGADPEGIFPSI
CCCCCEEEEECCCCCCEEEEEECCCCCCCCEEEEEEEEEEEECCEEEECCCCCCCCCHHH
LGHEGGGIVEAIGEGVTSVAVGDHVIPLYTPECGKCKFCLSGKTNLCQAIRATQGKGLMP
HCCCCCCHHHHHHCCCEEEEECCEEEEEECCCCCCEEEEECCCHHHHHHHHHCCCCCCCC
DGTSRFSKDGKPIFHYMGTSTFSEYTVLPEISVAKIQKDAPLDKVCLLGCGVTTGIGAVL
CCCHHHCCCCCEEEEECCCCCCCCEEECCCCHHHHHCCCCCCCHHHEECCCHHHHHHHHH
NTAKVEPGATVAVFGLGGIGLSAIIGAVMAKASRIVAVDINPDKFEIARQLGATDFINPK
HHCCCCCCCEEEEEECCCCCHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHCCCCCCCCC
DYDRPIQEVIVELTDGGVDYSFECIGNTNVMRSALECCHKGWGESIIIGVAGAGQEISTR
CCCHHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCC
PFQLVTGRVWRGSAFGGVRGRTELPSYVAKAQTGEIPLDTFITHRMGLEDINKAFDLMHE
CEEEEECEEECCCCCCCCCCCCHHHHHHHHCCCCCCCHHHHHHHHCCHHHHHHHHHHHHC
GKSIRSVIIY
CCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]