Click here to switch to the map view.

The map label for this gene is envZ3 [H]

Identifier: 119899905

GI number: 119899905

Start: 3967591

End: 3968691

Strand: Direct

Name: envZ3 [H]

Synonym: azo3616

Alternate gene names: 119899905

Gene position: 3967591-3968691 (Clockwise)

Preceding gene: 119899904

Following gene: 119899906

Centisome position: 90.67

GC content: 72.75

Gene sequence:

>1101_bases
ATGCGGGTACTCCGCCGGCTGCGCCCGCTGCTGCCGGATTCGCTGTTCGGCCGCCTGTTCGGCATGGTGGTGGTGGCGGT
GCTCGCCAGCCACCTGGTCACCACGCTGCTGTTCCTGCTGGTGATCGACGATCGCCACTTCGCCCCCCCGCCGCCACCGC
GCATGGCCCCGCCGGCGCCGACGCCGGACGGCACGCTGCCGCTCCCGCGGCCGCGCCACGATGGGCCGCGGCTGCCGCCG
CCGCTCGGGCTGTGGCTGGGACTGGCAACCCAGATCGCGGCGCTGACGCTCGCCGCGTGGTATGGCGCCCGCCTGCTCGC
GCGCCCCATCCAGCAACTGGCCGACGCCGCCGAGCGCCTCGGCGACAACCTCAACAGCCCGCCGATCGACGAGCGCGGCC
CACGCGAGGCGCGGCTCGCCGCGCGCGTGTTCAACCGCATGCAGGACCGCATCCGCGCCCAGCTGGAAGAACGCGATCGC
TTCCTGGCCGCGGTATCGCACGACCTGCGCACCCCGCTGACACGCATGAAGCTGCGCGTGGAAACCCTCGCCGCGAGCGG
CGAGGGCGAAGCCCACCGGCGCCTGCGGGAGGACATCGGCGAGATGGCGAGCATGCTCGACGCGACACTGAACTACCTGC
GCGGCGAGGCGCACAGCGAAGCCTGGCAACGGCTGGACATCCAGGCGCTGGTCGACTCGGTGGCGGAGGATGCACGCGAA
AAGGGCGGTGAAGTCGCGGTGAGCGGCAGCGCGCAAGCGATCGAAGGGCTGCCGCATGCCCTGCGCCGCTGCCTCGACAA
TCTGGTGGACAACGCCGTGCGCTACGGCGAGCGGGCGACGATCACGCTGTGCGACAGCCCGACCGCGCTGCTCATCGAAA
TCCGCGACGCCGGACCCGGCATTCCGGAAAACCGCCTCGCCCAGGTGATGGAGCCCTTCGTGCGGCTGGAGCCGTCGCGC
AATCGCGATTCGGGCGGCGTTGGCCTCGGGCTGTCGATCGCGCGCGATACGGCACGGCGCAACGGCGGCGAACTCAGCCT
GCGCAATGCGCCCAGCGGCGGGCTCGTGGCCCGCCTGACGCTGCCGCGGCGCGAGGCCTGA

Upstream 100 bases:

>100_bases
CCCGGCTGCGGCAAAAGCTGCAGGAAGACCCCCGTCTGCCCAAGCTGCTGAAGACGATCCGCGGCGAGGGCTACCTGTTC
GATACCGAGGTGGTGCGCTG

Downstream 100 bases:

>100_bases
AGCCCTGTATCGGAACCGTTACCAAGCGGACAAACCGCGGCGACATGCACGGCCTAGATTGACGCCACTGCCGCCCCGCC
CGGGCGGGAATCCGTCGCAA

Product: putative sensor histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 366; Mature: 366

Protein sequence:

>366_residues
MRVLRRLRPLLPDSLFGRLFGMVVVAVLASHLVTTLLFLLVIDDRHFAPPPPPRMAPPAPTPDGTLPLPRPRHDGPRLPP
PLGLWLGLATQIAALTLAAWYGARLLARPIQQLADAAERLGDNLNSPPIDERGPREARLAARVFNRMQDRIRAQLEERDR
FLAAVSHDLRTPLTRMKLRVETLAASGEGEAHRRLREDIGEMASMLDATLNYLRGEAHSEAWQRLDIQALVDSVAEDARE
KGGEVAVSGSAQAIEGLPHALRRCLDNLVDNAVRYGERATITLCDSPTALLIEIRDAGPGIPENRLAQVMEPFVRLEPSR
NRDSGGVGLGLSIARDTARRNGGELSLRNAPSGGLVARLTLPRREA

Sequences:

>Translated_366_residues
MRVLRRLRPLLPDSLFGRLFGMVVVAVLASHLVTTLLFLLVIDDRHFAPPPPPRMAPPAPTPDGTLPLPRPRHDGPRLPP
PLGLWLGLATQIAALTLAAWYGARLLARPIQQLADAAERLGDNLNSPPIDERGPREARLAARVFNRMQDRIRAQLEERDR
FLAAVSHDLRTPLTRMKLRVETLAASGEGEAHRRLREDIGEMASMLDATLNYLRGEAHSEAWQRLDIQALVDSVAEDARE
KGGEVAVSGSAQAIEGLPHALRRCLDNLVDNAVRYGERATITLCDSPTALLIEIRDAGPGIPENRLAQVMEPFVRLEPSR
NRDSGGVGLGLSIARDTARRNGGELSLRNAPSGGLVARLTLPRREA
>Mature_366_residues
MRVLRRLRPLLPDSLFGRLFGMVVVAVLASHLVTTLLFLLVIDDRHFAPPPPPRMAPPAPTPDGTLPLPRPRHDGPRLPP
PLGLWLGLATQIAALTLAAWYGARLLARPIQQLADAAERLGDNLNSPPIDERGPREARLAARVFNRMQDRIRAQLEERDR
FLAAVSHDLRTPLTRMKLRVETLAASGEGEAHRRLREDIGEMASMLDATLNYLRGEAHSEAWQRLDIQALVDSVAEDARE
KGGEVAVSGSAQAIEGLPHALRRCLDNLVDNAVRYGERATITLCDSPTALLIEIRDAGPGIPENRLAQVMEPFVRLEPSR
NRDSGGVGLGLSIARDTARRNGGELSLRNAPSGGLVARLTLPRREA

Specific function: Member of the two-component regulatory system envZ/ompR involved in the regulation of osmoregulation (genes ompF and ompC). EnvZ functions as a membrane-associated protein kinase that phosphorylates ompR in response to environmental signals [H]

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1789808, Length=267, Percent_Identity=31.4606741573034, Blast_Score=127, Evalue=8e-31,
Organism=Escherichia coli, GI1790346, Length=266, Percent_Identity=31.203007518797, Blast_Score=112, Evalue=3e-26,
Organism=Escherichia coli, GI1787894, Length=292, Percent_Identity=33.5616438356164, Blast_Score=112, Evalue=4e-26,
Organism=Escherichia coli, GI87082128, Length=298, Percent_Identity=29.8657718120805, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI1788393, Length=272, Percent_Identity=25, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI1790861, Length=344, Percent_Identity=27.0348837209302, Blast_Score=83, Evalue=3e-17,
Organism=Escherichia coli, GI87081816, Length=337, Percent_Identity=28.7833827893175, Blast_Score=82, Evalue=5e-17,
Organism=Escherichia coli, GI1790551, Length=275, Percent_Identity=28.3636363636364, Blast_Score=81, Evalue=1e-16,
Organism=Escherichia coli, GI1789149, Length=219, Percent_Identity=26.027397260274, Blast_Score=79, Evalue=3e-16,
Organism=Escherichia coli, GI1786912, Length=239, Percent_Identity=32.2175732217573, Blast_Score=79, Evalue=5e-16,
Organism=Escherichia coli, GI1786783, Length=271, Percent_Identity=26.9372693726937, Blast_Score=76, Evalue=3e-15,
Organism=Escherichia coli, GI1786600, Length=226, Percent_Identity=26.9911504424779, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1789403, Length=266, Percent_Identity=28.1954887218045, Blast_Score=73, Evalue=4e-14,
Organism=Escherichia coli, GI1788713, Length=228, Percent_Identity=24.1228070175439, Blast_Score=66, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 40100; Mature: 40100

Theoretical pI: Translated: 9.75; Mature: 9.75

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRVLRRLRPLLPDSLFGRLFGMVVVAVLASHLVTTLLFLLVIDDRHFAPPPPPRMAPPAP
CCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC
TPDGTLPLPRPRHDGPRLPPPLGLWLGLATQIAALTLAAWYGARLLARPIQQLADAAERL
CCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GDNLNSPPIDERGPREARLAARVFNRMQDRIRAQLEERDRFLAAVSHDLRTPLTRMKLRV
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHH
ETLAASGEGEAHRRLREDIGEMASMLDATLNYLRGEAHSEAWQRLDIQALVDSVAEDARE
HHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHH
KGGEVAVSGSAQAIEGLPHALRRCLDNLVDNAVRYGERATITLCDSPTALLIEIRDAGPG
CCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCEEEEEEECCCCC
IPENRLAQVMEPFVRLEPSRNRDSGGVGLGLSIARDTARRNGGELSLRNAPSGGLVARLT
CCHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHCCCCCEEECCCCCCCEEEEEE
LPRREA
CCCCCC
>Mature Secondary Structure
MRVLRRLRPLLPDSLFGRLFGMVVVAVLASHLVTTLLFLLVIDDRHFAPPPPPRMAPPAP
CCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC
TPDGTLPLPRPRHDGPRLPPPLGLWLGLATQIAALTLAAWYGARLLARPIQQLADAAERL
CCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GDNLNSPPIDERGPREARLAARVFNRMQDRIRAQLEERDRFLAAVSHDLRTPLTRMKLRV
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHH
ETLAASGEGEAHRRLREDIGEMASMLDATLNYLRGEAHSEAWQRLDIQALVDSVAEDARE
HHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHH
KGGEVAVSGSAQAIEGLPHALRRCLDNLVDNAVRYGERATITLCDSPTALLIEIRDAGPG
CCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCEEEEEEECCCCC
IPENRLAQVMEPFVRLEPSRNRDSGGVGLGLSIARDTARRNGGELSLRNAPSGGLVARLT
CCHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHCCCCCEEECCCCCCCEEEEEE
LPRREA
CCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 6292200; 2997120; 9278503; 8132603; 2277041; 2824492; 1323560; 9817206; 10426948 [H]