Click here to switch to the map view.

The map label for this gene is cobT

Identifier: 119899849

GI number: 119899849

Start: 3906932

End: 3907978

Strand: Direct

Name: cobT

Synonym: azo3560

Alternate gene names: 119899849

Gene position: 3906932-3907978 (Clockwise)

Preceding gene: 119899846

Following gene: 119899850

Centisome position: 89.28

GC content: 72.59

Gene sequence:

>1047_bases
ATGAAGACCACCCTCGCCGCCCCCGACGAGCGCCTGCGCGCCGCCCTGCAACACCGCATCGACCGCAAGACCAAGCCGCT
CGGCGCGCTCGGCCGGCTGGAGGCGCTGGCGCTGCAGGTGGGCCTGGTGCAGCAGACCGAAACGCCGCAACTGCGCCAGC
CGCACATCCTGGTCTTTGCCGGCGACCACGGCGCCGCCCGCGCAGGCGTTTCCGCTTACCCGCAGGACGTGACCTGGCAG
ATGGTGGAGAACTTCCTCGCCGGCGGCGCCGCGATCAACGTCTTCTGCCGCCAGATGGACCTCGGCCTCAGCGTGGTCGA
TGCCGGCGTCAACCACGACTTCGGCAAACGGCCCGGGCTGGTGGATGCAAAGATCGGCCCTGGCACCGCCAACTACCTGG
AAGCGCCGGCGATGACGGCCGCCCAACGCGACGCCGCGCTGGAACGCGGGCGCGGCCTCGCCCACGCGCTTGCGGCCAAC
GGCTGCAACGCGGTCGGCTTCGGCGAAATGGGCATCGGCAACACCGCCTCGGCGTCGCTGATCACCCATTGCCTTGTCGG
CGAGGCGCGCGGCGCCGACCTTGCCACCATCACCGGCCGCGGCACCGGGCTCGACGACGCCGGGCTGGAACGCAAACGCG
CGCTGCTGGCGCGCGCGCTGGCCCGCGGCGGCCGCCCCGCGGACCCGCGGGCGGTGCTGGCCGAGTACGGCGGCTTCGAG
ATCGCGATGATGGCGGGTGCCATGCTGGGCGCGGCCGAGAAGGGCATGCTGGTGCTGGTGGATGGCTTCATCGTCACCTC
GGCGCTGCTCGTCGCGCACGCGCTCGCGCCGCAGATCCTGCCCTACTGCGTGTTCGCCCACCGCTCGCGTGAGCCGGGCC
ACCGCGTGCAGCTGGACGCCCTCGGCGCCGAGCCGCTGATGGATCTCGACCTGCGCCTGGGCGAAGGCACCGGCGCCGCG
CTGGCGTGGCCGCTGGTGCAGGCCGCGGTGAACTTCCTCGCCGAGATGGCGAGCTTCGAATCGGCCGGCGTCAGCGACAA
GACCTGA

Upstream 100 bases:

>100_bases
GCGCCCGCCGCGGCGGCGGATGCAGGCGCGGATTCGATCTGCTACCGTTCGCCCCCTGCCGGCGCGCCGCGCGCGCCCTC
CTTTCCAGCCCGACCCGCCG

Downstream 100 bases:

>100_bases
CCGCGGCGCCGATGCGGTCCCAGCTCGAACTCTTCTTCACCGCACTCGGTTACTTCAGCCGTCTGCCGGTGCCGGCCTGG
GTGGCGTGGTCGCCGCAGCG

Product: nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase

Products: NA

Alternate protein names: NN:DBI PRT; N(1)-alpha-phosphoribosyltransferase

Number of amino acids: Translated: 348; Mature: 348

Protein sequence:

>348_residues
MKTTLAAPDERLRAALQHRIDRKTKPLGALGRLEALALQVGLVQQTETPQLRQPHILVFAGDHGAARAGVSAYPQDVTWQ
MVENFLAGGAAINVFCRQMDLGLSVVDAGVNHDFGKRPGLVDAKIGPGTANYLEAPAMTAAQRDAALERGRGLAHALAAN
GCNAVGFGEMGIGNTASASLITHCLVGEARGADLATITGRGTGLDDAGLERKRALLARALARGGRPADPRAVLAEYGGFE
IAMMAGAMLGAAEKGMLVLVDGFIVTSALLVAHALAPQILPYCVFAHRSREPGHRVQLDALGAEPLMDLDLRLGEGTGAA
LAWPLVQAAVNFLAEMASFESAGVSDKT

Sequences:

>Translated_348_residues
MKTTLAAPDERLRAALQHRIDRKTKPLGALGRLEALALQVGLVQQTETPQLRQPHILVFAGDHGAARAGVSAYPQDVTWQ
MVENFLAGGAAINVFCRQMDLGLSVVDAGVNHDFGKRPGLVDAKIGPGTANYLEAPAMTAAQRDAALERGRGLAHALAAN
GCNAVGFGEMGIGNTASASLITHCLVGEARGADLATITGRGTGLDDAGLERKRALLARALARGGRPADPRAVLAEYGGFE
IAMMAGAMLGAAEKGMLVLVDGFIVTSALLVAHALAPQILPYCVFAHRSREPGHRVQLDALGAEPLMDLDLRLGEGTGAA
LAWPLVQAAVNFLAEMASFESAGVSDKT
>Mature_348_residues
MKTTLAAPDERLRAALQHRIDRKTKPLGALGRLEALALQVGLVQQTETPQLRQPHILVFAGDHGAARAGVSAYPQDVTWQ
MVENFLAGGAAINVFCRQMDLGLSVVDAGVNHDFGKRPGLVDAKIGPGTANYLEAPAMTAAQRDAALERGRGLAHALAAN
GCNAVGFGEMGIGNTASASLITHCLVGEARGADLATITGRGTGLDDAGLERKRALLARALARGGRPADPRAVLAEYGGFE
IAMMAGAMLGAAEKGMLVLVDGFIVTSALLVAHALAPQILPYCVFAHRSREPGHRVQLDALGAEPLMDLDLRLGEGTGAA
LAWPLVQAAVNFLAEMASFESAGVSDKT

Specific function: Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB)

COG id: COG2038

COG function: function code H; NaMN:DMB phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the CobT family

Homologues:

Organism=Escherichia coli, GI1788300, Length=344, Percent_Identity=34.8837209302326, Blast_Score=189, Evalue=2e-49,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): COBT_AZOSB (A1KBH0)

Other databases:

- EMBL:   AM406670
- RefSeq:   YP_935062.1
- ProteinModelPortal:   A1KBH0
- SMR:   A1KBH0
- STRING:   A1KBH0
- GeneID:   4608008
- GenomeReviews:   AM406670_GR
- KEGG:   azo:azo3560
- eggNOG:   COG2038
- HOGENOM:   HBG634399
- OMA:   NEMATFS
- PhylomeDB:   A1KBH0
- ProtClustDB:   PRK00105
- BioCyc:   ASP62928:AZO3560-MONOMER
- HAMAP:   MF_00230
- InterPro:   IPR003200
- InterPro:   IPR023195
- InterPro:   IPR017846
- Gene3D:   G3DSA:1.10.1610.10
- TIGRFAMs:   TIGR03160

Pfam domain/function: PF02277 DBI_PRT; SSF52733 NN:DBI_PRT

EC number: =2.4.2.21

Molecular weight: Translated: 36219; Mature: 36219

Theoretical pI: Translated: 6.79; Mature: 6.79

Prosite motif: NA

Important sites: ACT_SITE 315-315

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTTLAAPDERLRAALQHRIDRKTKPLGALGRLEALALQVGLVQQTETPQLRQPHILVFA
CCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEE
GDHGAARAGVSAYPQDVTWQMVENFLAGGAAINVFCRQMDLGLSVVDAGVNHDFGKRPGL
CCCCCHHCCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHCCCEEEECCCCCCCCCCCCE
VDAKIGPGTANYLEAPAMTAAQRDAALERGRGLAHALAANGCNAVGFGEMGIGNTASASL
EECCCCCCCHHHHCCCHHHHHHHHHHHHHCCCHHHHHHHCCCCCCCCCCCCCCCCHHHHH
ITHCLVGEARGADLATITGRGTGLDDAGLERKRALLARALARGGRPADPRAVLAEYGGFE
HHHHHHCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHCCCCH
IAMMAGAMLGAAEKGMLVLVDGFIVTSALLVAHALAPQILPYCVFAHRSREPGHRVQLDA
HHHHHHHHHCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEC
LGAEPLMDLDLRLGEGTGAALAWPLVQAAVNFLAEMASFESAGVSDKT
CCCCCCEECEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MKTTLAAPDERLRAALQHRIDRKTKPLGALGRLEALALQVGLVQQTETPQLRQPHILVFA
CCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEE
GDHGAARAGVSAYPQDVTWQMVENFLAGGAAINVFCRQMDLGLSVVDAGVNHDFGKRPGL
CCCCCHHCCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHCCCEEEECCCCCCCCCCCCE
VDAKIGPGTANYLEAPAMTAAQRDAALERGRGLAHALAANGCNAVGFGEMGIGNTASASL
EECCCCCCCHHHHCCCHHHHHHHHHHHHHCCCHHHHHHHCCCCCCCCCCCCCCCCHHHHH
ITHCLVGEARGADLATITGRGTGLDDAGLERKRALLARALARGGRPADPRAVLAEYGGFE
HHHHHHCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHCCCCH
IAMMAGAMLGAAEKGMLVLVDGFIVTSALLVAHALAPQILPYCVFAHRSREPGHRVQLDA
HHHHHHHHHCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEC
LGAEPLMDLDLRLGEGTGAALAWPLVQAAVNFLAEMASFESAGVSDKT
CCCCCCEECEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA