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The map label for this gene is thiD2 [H]

Identifier: 119899740

GI number: 119899740

Start: 3785441

End: 3786283

Strand: Reverse

Name: thiD2 [H]

Synonym: azo3451

Alternate gene names: 119899740

Gene position: 3786283-3785441 (Counterclockwise)

Preceding gene: 119899747

Following gene: 119899739

Centisome position: 86.52

GC content: 69.87

Gene sequence:

>843_bases
ATGCCTATTGCCATACCTGAAACGCCTCCTGTCGTGCTTTGTTTCGCCGCCGGAGATGCGACCGGCGGCGGCGGTCTGCC
GTCCGACGTGCTGACCCTCGGCAGCATGGGCTGCCATCCCCTTGCGGTCCAGACCGCCGCCGTGGTGCGCGATACCCGCG
GGGCCGATGAAATCTGGCCGCAGGATGCCGACGTAGTGGTGGCCCAGGCCCGCGCTGTGCTCGAGGACATTCCGGTGCAT
GCGTTCAAGCTCGGCTACTGCGGCAGCGTGGAGAACATCGCCGCGATCGCCGAGATCCTGTCCGACTACCCGGACGTACC
GCTCGTCGTCGAACCCGCGCTGTTTCCGGGCGTGGACGACTCCCCGACCGAGGACGTGATCGCTGCGCTCGCCGAACTCA
TCCTGCCGCAGACCACCTTGCTGGTTGCGGGGGCGCACGAGGTCCTGCGGCTGGCGGGACTCGATGCCGATGACGAAGAC
GACACCACCCTGCTGTCGGCCGAGGAGGCTGTGGCGCGGCTGGTGGACCTGGGTGTCGCGCATGTGCTGCTGACCGGCGG
CGGAAGCCACGGGCCGCAGGTCGTCAACCTGCTGATCGGCGAGGGCGGCGTGGTGCGGACCGACGCGTGGGAGCGCCTGC
CCGGGCGTTTCCTCGGCGCCGGTTCCACCTTGGCGGCGGCGGCTGCGGCCGCCCTGGCGCATGGCATGGACATGGACGAA
GCCGTGGCCGAAGCCCAGGATTTCGCCCAGCAGGCGCTCAAGCATGCCTACCGCGCGGGGATGGGGCTGGCGCTGCCCGA
CCGCTTCTTCTGGGCGCGCGGAAAGGGCGTGGGCGATGGGTGA

Upstream 100 bases:

>100_bases
GGAATCCGGCATAAATCTGCCGTCGCGATTGACGGTAGAATCCGGGCCATCTTACCCCATTTCGAGGGCGTTCCAGAAGC
GTCCCGGCCTCTCGCTTGTC

Downstream 100 bases:

>100_bases
GCGCATCCGCGGGCTTTATCTGGTGACGCCGGACGCCGCCGACAGCGCGACGCTGCTGGCGAGTGTGGAACGCGTGCTGC
CGGCCAGGCCGGCCTTGCTG

Product: phosphomethylpyrimidine kinase

Products: NA

Alternate protein names: Hydroxymethylpyrimidine kinase; HMP kinase; Hydroxymethylpyrimidine phosphate kinase; HMP-P kinase; HMP-phosphate kinase; HMPP kinase [H]

Number of amino acids: Translated: 280; Mature: 279

Protein sequence:

>280_residues
MPIAIPETPPVVLCFAAGDATGGGGLPSDVLTLGSMGCHPLAVQTAAVVRDTRGADEIWPQDADVVVAQARAVLEDIPVH
AFKLGYCGSVENIAAIAEILSDYPDVPLVVEPALFPGVDDSPTEDVIAALAELILPQTTLLVAGAHEVLRLAGLDADDED
DTTLLSAEEAVARLVDLGVAHVLLTGGGSHGPQVVNLLIGEGGVVRTDAWERLPGRFLGAGSTLAAAAAAALAHGMDMDE
AVAEAQDFAQQALKHAYRAGMGLALPDRFFWARGKGVGDG

Sequences:

>Translated_280_residues
MPIAIPETPPVVLCFAAGDATGGGGLPSDVLTLGSMGCHPLAVQTAAVVRDTRGADEIWPQDADVVVAQARAVLEDIPVH
AFKLGYCGSVENIAAIAEILSDYPDVPLVVEPALFPGVDDSPTEDVIAALAELILPQTTLLVAGAHEVLRLAGLDADDED
DTTLLSAEEAVARLVDLGVAHVLLTGGGSHGPQVVNLLIGEGGVVRTDAWERLPGRFLGAGSTLAAAAAAALAHGMDMDE
AVAEAQDFAQQALKHAYRAGMGLALPDRFFWARGKGVGDG
>Mature_279_residues
PIAIPETPPVVLCFAAGDATGGGGLPSDVLTLGSMGCHPLAVQTAAVVRDTRGADEIWPQDADVVVAQARAVLEDIPVHA
FKLGYCGSVENIAAIAEILSDYPDVPLVVEPALFPGVDDSPTEDVIAALAELILPQTTLLVAGAHEVLRLAGLDADDEDD
TTLLSAEEAVARLVDLGVAHVLLTGGGSHGPQVVNLLIGEGGVVRTDAWERLPGRFLGAGSTLAAAAAAALAHGMDMDEA
VAEAQDFAQQALKHAYRAGMGLALPDRFFWARGKGVGDG

Specific function: Catalyzes the phosphorylation of hydroxymethylpyrimidine phosphate (HMP-P) to HMP-PP, and of HMP to HMP-P [H]

COG id: COG0351

COG function: function code H; Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiD family [H]

Homologues:

Organism=Escherichia coli, GI1788420, Length=248, Percent_Identity=28.6290322580645, Blast_Score=79, Evalue=3e-16,
Organism=Saccharomyces cerevisiae, GI6325378, Length=276, Percent_Identity=25.7246376811594, Blast_Score=65, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013749
- InterPro:   IPR004399 [H]

Pfam domain/function: PF08543 Phos_pyr_kin [H]

EC number: =2.7.1.49; =2.7.4.7 [H]

Molecular weight: Translated: 28718; Mature: 28587

Theoretical pI: Translated: 4.03; Mature: 4.03

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPIAIPETPPVVLCFAAGDATGGGGLPSDVLTLGSMGCHPLAVQTAAVVRDTRGADEIWP
CCCCCCCCCCEEEEEECCCCCCCCCCCHHHHHHCCCCCCHHHHHHHHHHHCCCCCHHCCC
QDADVVVAQARAVLEDIPVHAFKLGYCGSVENIAAIAEILSDYPDVPLVVEPALFPGVDD
CCHHHHHHHHHHHHHHCCHHEEEECCCCCHHHHHHHHHHHHCCCCCCEEECCCCCCCCCC
SPTEDVIAALAELILPQTTLLVAGAHEVLRLAGLDADDEDDTTLLSAEEAVARLVDLGVA
CCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHH
HVLLTGGGSHGPQVVNLLIGEGGVVRTDAWERLPGRFLGAGSTLAAAAAAALAHGMDMDE
HEEEECCCCCCCCEEEEEECCCCEEECCHHHHCCCHHCCCCHHHHHHHHHHHHHCCCHHH
AVAEAQDFAQQALKHAYRAGMGLALPDRFFWARGKGVGDG
HHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHCCCCCCCCC
>Mature Secondary Structure 
PIAIPETPPVVLCFAAGDATGGGGLPSDVLTLGSMGCHPLAVQTAAVVRDTRGADEIWP
CCCCCCCCCEEEEEECCCCCCCCCCCHHHHHHCCCCCCHHHHHHHHHHHCCCCCHHCCC
QDADVVVAQARAVLEDIPVHAFKLGYCGSVENIAAIAEILSDYPDVPLVVEPALFPGVDD
CCHHHHHHHHHHHHHHCCHHEEEECCCCCHHHHHHHHHHHHCCCCCCEEECCCCCCCCCC
SPTEDVIAALAELILPQTTLLVAGAHEVLRLAGLDADDEDDTTLLSAEEAVARLVDLGVA
CCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHH
HVLLTGGGSHGPQVVNLLIGEGGVVRTDAWERLPGRFLGAGSTLAAAAAAALAHGMDMDE
HEEEECCCCCCCCEEEEEECCCCEEECCHHHHCCCHHCCCCHHHHHHHHHHHHHCCCHHH
AVAEAQDFAQQALKHAYRAGMGLALPDRFFWARGKGVGDG
HHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11418146 [H]