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The map label for this gene is flcA [H]

Identifier: 119899725

GI number: 119899725

Start: 3768050

End: 3768676

Strand: Reverse

Name: flcA [H]

Synonym: azo3436

Alternate gene names: 119899725

Gene position: 3768676-3768050 (Counterclockwise)

Preceding gene: 119899729

Following gene: 119899720

Centisome position: 86.12

GC content: 66.67

Gene sequence:

>627_bases
GTGACAAAGATCCTCATCGTTGAAGACCATGCCCTCGTGCGCGAGGCCATGGCGCAAACGCTGTCCCGTCTCGAACCCGG
TATCGATTGTGTGGAGGCAAAGGGCGCAGACGATGCGCTGGCCAAGCTGGAGGGCGCGGCCGACTGGGACCTGGCGATCA
TCGACCTGATGCTGCCGGACATGAACGGGTTTTCGCTGCTGGCGGTACTGGCCAAGCGCTTCCCCGACATCCCGGCCATC
GTGGTGTCGGCAATGGATGACGAAGCCTCGGTGCGGCGGGCAATCAAGGGCGGCGCCTCGGGCTTCGTTTCCAAGGCCAG
TTCGGGAGATACGCTGCTGCAGGCGGTGCGGGTGGTCCTCGATGGCGGCGTGTGCACGCCTGAGGCCGCGACCCAGTCCG
GCCGTCGCAGCGCCGCCCCGGTGTCCGAACGTTTCGGCCTTACCGCCGCGCAGACCCGGGTTCTGGAGTTGCTGGCGCAG
GGCAAGACCAACCGGGAGATCGCCGATCTGCTGGGTTTGTCGGAAGGCACGGTCAAGGTGCACATGTCCGCGATCTTCCG
CGCGCTTGGCGTCTCCAACCGCGCTCAGGCCCTGGTGGTGATCGCGCGCCACGGCGCGCGTCTGTAG

Upstream 100 bases:

>100_bases
GTTTTTTCCGCGCTCGATAGGGGGGAGGGGCGCCCCGGCGATCGTGCTATGCTTCACGCATGCGTGGGAAGCCGCGCAAT
ATAAAAGCACGGAGTGAGCA

Downstream 100 bases:

>100_bases
GCGAACCGTTCCCGGCGTCACTGCCGGGGCGGTTTTTCCCCTGTTCTGTTTCTAGTGCGAGCGACTCTGTCCCAGCCGCA
TCGGCATGTCGGCCGGCGAC

Product: LuxR family DNA-binding response regulator

Products: NA

Alternate protein names: Protease production enhancer protein [H]

Number of amino acids: Translated: 208; Mature: 207

Protein sequence:

>208_residues
MTKILIVEDHALVREAMAQTLSRLEPGIDCVEAKGADDALAKLEGAADWDLAIIDLMLPDMNGFSLLAVLAKRFPDIPAI
VVSAMDDEASVRRAIKGGASGFVSKASSGDTLLQAVRVVLDGGVCTPEAATQSGRRSAAPVSERFGLTAAQTRVLELLAQ
GKTNREIADLLGLSEGTVKVHMSAIFRALGVSNRAQALVVIARHGARL

Sequences:

>Translated_208_residues
MTKILIVEDHALVREAMAQTLSRLEPGIDCVEAKGADDALAKLEGAADWDLAIIDLMLPDMNGFSLLAVLAKRFPDIPAI
VVSAMDDEASVRRAIKGGASGFVSKASSGDTLLQAVRVVLDGGVCTPEAATQSGRRSAAPVSERFGLTAAQTRVLELLAQ
GKTNREIADLLGLSEGTVKVHMSAIFRALGVSNRAQALVVIARHGARL
>Mature_207_residues
TKILIVEDHALVREAMAQTLSRLEPGIDCVEAKGADDALAKLEGAADWDLAIIDLMLPDMNGFSLLAVLAKRFPDIPAIV
VSAMDDEASVRRAIKGGASGFVSKASSGDTLLQAVRVVLDGGVCTPEAATQSGRRSAAPVSERFGLTAAQTRVLELLAQG
KTNREIADLLGLSEGTVKVHMSAIFRALGVSNRAQALVVIARHGARL

Specific function: Regulating factor for the production of extracellular proteases. The N-terminal region acts as an inhibitor, whereas the C-terminal region carries enhancing activity [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1790102, Length=197, Percent_Identity=39.0862944162437, Blast_Score=100, Evalue=1e-22,
Organism=Escherichia coli, GI1788521, Length=210, Percent_Identity=31.4285714285714, Blast_Score=90, Evalue=1e-19,
Organism=Escherichia coli, GI1786747, Length=195, Percent_Identity=28.2051282051282, Blast_Score=78, Evalue=4e-16,
Organism=Escherichia coli, GI1789937, Length=205, Percent_Identity=25.8536585365854, Blast_Score=68, Evalue=4e-13,
Organism=Escherichia coli, GI1787473, Length=211, Percent_Identity=31.2796208530806, Blast_Score=65, Evalue=4e-12,
Organism=Escherichia coli, GI1788222, Length=210, Percent_Identity=24.2857142857143, Blast_Score=64, Evalue=7e-12,
Organism=Escherichia coli, GI1788712, Length=185, Percent_Identity=25.9459459459459, Blast_Score=61, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR016032
- InterPro:   IPR001789
- InterPro:   IPR000792
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00196 GerE; PF00072 Response_reg [H]

EC number: NA

Molecular weight: Translated: 21841; Mature: 21709

Theoretical pI: Translated: 6.27; Mature: 6.27

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS50043 HTH_LUXR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKILIVEDHALVREAMAQTLSRLEPGIDCVEAKGADDALAKLEGAADWDLAIIDLMLPD
CCEEEEECCHHHHHHHHHHHHHHCCCCCCEECCCCCHHHHHHHCCCCCCHHHHEEHHCCC
MNGFSLLAVLAKRFPDIPAIVVSAMDDEASVRRAIKGGASGFVSKASSGDTLLQAVRVVL
CCCHHHHHHHHHHCCCCCHHHHHHCCCHHHHHHHHHCCCCHHHHCCCCCHHHHHHHHHHH
DGGVCTPEAATQSGRRSAAPVSERFGLTAAQTRVLELLAQGKTNREIADLLGLSEGTVKV
CCCCCCCHHHHHCCCCCCCCHHHHHCCHHHHHHHHHHHHCCCCCHHHHHHHCCCCCHHHH
HMSAIFRALGVSNRAQALVVIARHGARL
HHHHHHHHHCCCCCHHEEEEEECCCCCC
>Mature Secondary Structure 
TKILIVEDHALVREAMAQTLSRLEPGIDCVEAKGADDALAKLEGAADWDLAIIDLMLPD
CEEEEECCHHHHHHHHHHHHHHCCCCCCEECCCCCHHHHHHHCCCCCCHHHHEEHHCCC
MNGFSLLAVLAKRFPDIPAIVVSAMDDEASVRRAIKGGASGFVSKASSGDTLLQAVRVVL
CCCHHHHHHHHHHCCCCCHHHHHHCCCHHHHHHHHHCCCCHHHHCCCCCHHHHHHHHHHH
DGGVCTPEAATQSGRRSAAPVSERFGLTAAQTRVLELLAQGKTNREIADLLGLSEGTVKV
CCCCCCCHHHHHCCCCCCCCHHHHHCCHHHHHHHHHHHHCCCCCHHHHHHHCCCCCHHHH
HMSAIFRALGVSNRAQALVVIARHGARL
HHHHHHHHHCCCCCHHEEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3136143; 3141378; 3141377; 9384377 [H]