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The map label for this gene is hisB [H]

Identifier: 119899636

GI number: 119899636

Start: 3684561

End: 3685190

Strand: Reverse

Name: hisB [H]

Synonym: azo3347

Alternate gene names: 119899636

Gene position: 3685190-3684561 (Counterclockwise)

Preceding gene: 119899638

Following gene: 119899635

Centisome position: 84.21

GC content: 63.81

Gene sequence:

>630_bases
ATGGTATCATGGGCCTCGATTTTCTCTGCAGCCTGTCCAGCCATGCGGCACGCCGACGTAACCCGCGACACCCTCGAAAC
CCGTATTTCGGTCCGCATCGACCTGGATGGCACCGGCAAGTCCGTGCTCGCCACCGGGGTGCCGTTCTTCGATCACATGC
TCGACCAGATTGCCCGTCACGGCGCCATCGACCTCGAGGTGCGCGCGGAGGGTGATACCCATATCGACGACCACCATACG
GTGGAGGACGTGGGCATCACCCTGGGTCAGGCGTTTGCGAAGGCGCTGGGCGACAAGAAGGGCATCCTGCGCTACGGCCA
CGCCTACGTGCCGCTCGACGAGGCGCTGTCGCGCGTGGTGGTCGATTTTTCCGGCCGGCCGGGCCTGCATTATTTCGTCG
ATTACACGCGCGCACGTATCGGCAATTTCGATGTGGATCTGGCGCGCGAGTTCTTCCAGGGCTTTGTCAATCACGCCGGG
GTGACGCTGCACGTGGATAACCTGCGCGGCGACAACGCGCACCACCAGTGCGAGACGATCTTCAAGGCCTTTGGCCGCGC
GCTCCGCATGGCGGCTACCCGCGACGAACGCCTGGCCGGTGCCATTCCCTCCACGAAGGGTGCGCTTTAA

Upstream 100 bases:

>100_bases
CCGTGAACGACGGCGCTCCAGTAGCGGCTCATGCTTGCAGTATCGGCTGGCAACGGGGGATTTGCGGGGGCGGCGCGGCT
TGCGGCCGGATCGTGCGGCG

Downstream 100 bases:

>100_bases
CGCGCATCCACCCGCGCCCCTTTCTTCACTCATCTCCTCAGCGAGCGCTCCCAGATGACCGACGTGGCCATCATCGACTA
CGGAATGGGCAACCTCCGTT

Product: imidazoleglycerol-phosphate dehydratase

Products: NA

Alternate protein names: IGPD [H]

Number of amino acids: Translated: 209; Mature: 209

Protein sequence:

>209_residues
MVSWASIFSAACPAMRHADVTRDTLETRISVRIDLDGTGKSVLATGVPFFDHMLDQIARHGAIDLEVRAEGDTHIDDHHT
VEDVGITLGQAFAKALGDKKGILRYGHAYVPLDEALSRVVVDFSGRPGLHYFVDYTRARIGNFDVDLAREFFQGFVNHAG
VTLHVDNLRGDNAHHQCETIFKAFGRALRMAATRDERLAGAIPSTKGAL

Sequences:

>Translated_209_residues
MVSWASIFSAACPAMRHADVTRDTLETRISVRIDLDGTGKSVLATGVPFFDHMLDQIARHGAIDLEVRAEGDTHIDDHHT
VEDVGITLGQAFAKALGDKKGILRYGHAYVPLDEALSRVVVDFSGRPGLHYFVDYTRARIGNFDVDLAREFFQGFVNHAG
VTLHVDNLRGDNAHHQCETIFKAFGRALRMAATRDERLAGAIPSTKGAL
>Mature_209_residues
MVSWASIFSAACPAMRHADVTRDTLETRISVRIDLDGTGKSVLATGVPFFDHMLDQIARHGAIDLEVRAEGDTHIDDHHT
VEDVGITLGQAFAKALGDKKGILRYGHAYVPLDEALSRVVVDFSGRPGLHYFVDYTRARIGNFDVDLAREFFQGFVNHAG
VTLHVDNLRGDNAHHQCETIFKAFGRALRMAATRDERLAGAIPSTKGAL

Specific function: Histidine biosynthesis; sixth step. Histidine biosynthesis; eighth step. [C]

COG id: COG0131

COG function: function code E; Imidazoleglycerol-phosphate dehydratase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the imidazoleglycerol-phosphate dehydratase family [H]

Homologues:

Organism=Escherichia coli, GI87082027, Length=209, Percent_Identity=46.88995215311, Blast_Score=188, Evalue=3e-49,
Organism=Saccharomyces cerevisiae, GI6324776, Length=218, Percent_Identity=40.3669724770642, Blast_Score=153, Evalue=2e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000807
- InterPro:   IPR020565
- InterPro:   IPR020568 [H]

Pfam domain/function: PF00475 IGPD [H]

EC number: =4.2.1.19 [H]

Molecular weight: Translated: 22939; Mature: 22939

Theoretical pI: Translated: 6.65; Mature: 6.65

Prosite motif: PS00954 IGP_DEHYDRATASE_1 ; PS00955 IGP_DEHYDRATASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVSWASIFSAACPAMRHADVTRDTLETRISVRIDLDGTGKSVLATGVPFFDHMLDQIARH
CCCHHHHHHHHCHHHHHCCCHHHHHHCEEEEEEEECCCCCHHHHCCCCHHHHHHHHHHHC
GAIDLEVRAEGDTHIDDHHTVEDVGITLGQAFAKALGDKKGILRYGHAYVPLDEALSRVV
CCEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHCCCEECCHHHHHHHHH
VDFSGRPGLHYFVDYTRARIGNFDVDLAREFFQGFVNHAGVTLHVDNLRGDNAHHQCETI
HHCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHH
FKAFGRALRMAATRDERLAGAIPSTKGAL
HHHHHHHHHHHHCCHHHHHCCCCCCCCCC
>Mature Secondary Structure
MVSWASIFSAACPAMRHADVTRDTLETRISVRIDLDGTGKSVLATGVPFFDHMLDQIARH
CCCHHHHHHHHCHHHHHCCCHHHHHHCEEEEEEEECCCCCHHHHCCCCHHHHHHHHHHHC
GAIDLEVRAEGDTHIDDHHTVEDVGITLGQAFAKALGDKKGILRYGHAYVPLDEALSRVV
CCEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHCCCEECCHHHHHHHHH
VDFSGRPGLHYFVDYTRARIGNFDVDLAREFFQGFVNHAGVTLHVDNLRGDNAHHQCETI
HHCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHH
FKAFGRALRMAATRDERLAGAIPSTKGAL
HHHHHHHHHHHHCCHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA