Click here to switch to the map view.

The map label for this gene is mutL [H]

Identifier: 119899416

GI number: 119899416

Start: 3433752

End: 3435617

Strand: Direct

Name: mutL [H]

Synonym: azo3126

Alternate gene names: 119899416

Gene position: 3433752-3435617 (Clockwise)

Preceding gene: 119899408

Following gene: 119899418

Centisome position: 78.47

GC content: 72.56

Gene sequence:

>1866_bases
ATGCCCCAGATCCAGCGCCTGCCCGACCTCCTCGTGAACCAGATCGCCGCCGGCGAGGTCGTCGAACGCCCCGCCTCGGT
ACTCAAGGAAGTGCTGGAAAACGCGGTGGACGCCGGGGCGCGCGCCGTCGAGGTTCAGCTCGAACAAGGCGGCGTACGCC
GCATCCGGATTACCGACGACGGCTGCGGCATCGCCCGGGACGAACTCGCGCTCGCGCTCGAACGGCACGCCACCAGCAAG
ATCGCCACGCTCGACGATCTCGAACGCGTGGGCACCATGGGCTTTCGCGGCGAGGCGCTCGCCGCGATCGCCGGCGTGGC
CCGCACCGTCATCACCAGCCGTGCCGAAGGCGCGGCGCACGCCTGGCGCATCGACGGCAGCGACCGCAGCCTGGCGCCGG
CGGCGCTCAACCAGGGCACCGTGGTGGACGTGGCCGACCTCTACTACAACACCCCCGCGCGGCGGAAATTCCTCAAGTCG
GAAGGCACCGAGTACGCCCACTGCGACGAGGTCTTCCGCCGCGTCGCGCTGGCGCGGCCGGACATCGCACTGCAGCTGTC
GCACAACGGCCGGGTGGCCCACCGCCTGCCGGTGGGCGAGCCGGTGCGCCGCATCGCCGCGCTGATGGGGGACGACTTCC
TTGCGCAGGCGCGCGCCGTGGTGGCCGAAGGCGGCCCGCTGCGCCTCACCGGCTACGCCTCGCTGCCCGCCTATTCCCGC
GCGAGCCGCGACGCGCAGTATTTCTTTGTGAACGGCCGCTTCGTGCGCGACAAGCTGCTGACCCACGCGCTGCGGCAGGC
CTACGCCGACATCCTGCACGGCGCCCGCCACCCGGCCTACGTGCTGTTCCTCGAGCTCGACCCCGCCGGCGTCGATGTGA
ACGTGCATCCGGCCAAGATCGAGGTCCGCTTCCGCGACTCGCGCGCGGTGCACCAGTTCGTGTTCCATGCCGTCAGCCGC
GCCCTGGCCGAGTCGGGCGCGGCGCTCGCCGGCGGCAACGGCGCGGGCGAGCCGGCCCCGCTGCCCTCCTCGGGGCAGCG
CGTCGCCGCCTCCCCGCCCGCCGCCGGTGCCGGACAGTGGCCGTCCGCGCAGGCGGTGCAGGGCCGCCTGGCAATGGACT
CCGGCGCGGCCAGTCACCGCTATTACGACTTCGTCGCCGCGGCCCGGCCGGACGGCACGGGCGGCGCAGCCGGCGCCGCC
GGCCTGGTCGCCGCGCCGCCGCGGATGGACGCCGCGGCCAGACCCTCCGGCTATGCCCCCGCGCCGCTGCCGAGCGCCGA
CAAGGCGCCCCCGCTCGGCTACGCGCTCGCGCAGTTGCACGGCATCTACGTGCTGGCCCAGAACGAATCCGGCTTGGTGC
TGGTGGACATGCATGCCGCGCACGAACGCATCCTGTACGAGAAGCTCAAGGTCGTGCTGGACGGCACGCCGTCCATCCAG
CGCCTGCTGATCCCGGCGGTGTTCTCGGTCAGCGCGCGCGACCTCGCGGTGGCGGAAGAGTGCGGCGAGGTGCTGGCGCG
GATGGGTTTCGAAGTCGGCGTCGCCGGCCCGCAGGAACTCGCCGTGCGGACGGTGCCGGCCCTGCTCGCGAGCGCACCGG
TGGCGGAACTGATGCGCAAGCTGCTCGAAGAACTGCGCGAATTCCCCGCCACCGAGGTGATCACCGCGCGCCGCAACGAA
CTGCTTGCCACGATGGCCTGCCACGGCGCAGTGCGCGCCAACCGGACGCTGACGCTGCCCGAGATGAACGCGCTGCTGCG
CGACATGGAAGCCACCGAGCGCGCGGACCAGTGCAATCACGGCCGGCCGACCTGGACGCAGCTCACGATGGCCGATCTCG
ACCGCTTCTTCATGCGCGGCCAGTAG

Upstream 100 bases:

>100_bases
CAACATGATAGCGCCCGCCTTCCGGACGCAGCGGCCGGCCGGCGGGGCCCGCGCCGTATAATCCACCGCCCGTGACACCC
GCCACGCCACGCCCGCCCCC

Downstream 100 bases:

>100_bases
GCCAGGCGGGGCCGGCGCTGGCGGGCGCCGTCAGCGGCGCGGGCCGGGCTCTTCCCCGCCGACCGGCCCCAGCCGGATCG
ACGCCCCCGGGCGCGGCGGC

Product: DNA mismatch repair protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 621; Mature: 620

Protein sequence:

>621_residues
MPQIQRLPDLLVNQIAAGEVVERPASVLKEVLENAVDAGARAVEVQLEQGGVRRIRITDDGCGIARDELALALERHATSK
IATLDDLERVGTMGFRGEALAAIAGVARTVITSRAEGAAHAWRIDGSDRSLAPAALNQGTVVDVADLYYNTPARRKFLKS
EGTEYAHCDEVFRRVALARPDIALQLSHNGRVAHRLPVGEPVRRIAALMGDDFLAQARAVVAEGGPLRLTGYASLPAYSR
ASRDAQYFFVNGRFVRDKLLTHALRQAYADILHGARHPAYVLFLELDPAGVDVNVHPAKIEVRFRDSRAVHQFVFHAVSR
ALAESGAALAGGNGAGEPAPLPSSGQRVAASPPAAGAGQWPSAQAVQGRLAMDSGAASHRYYDFVAAARPDGTGGAAGAA
GLVAAPPRMDAAARPSGYAPAPLPSADKAPPLGYALAQLHGIYVLAQNESGLVLVDMHAAHERILYEKLKVVLDGTPSIQ
RLLIPAVFSVSARDLAVAEECGEVLARMGFEVGVAGPQELAVRTVPALLASAPVAELMRKLLEELREFPATEVITARRNE
LLATMACHGAVRANRTLTLPEMNALLRDMEATERADQCNHGRPTWTQLTMADLDRFFMRGQ

Sequences:

>Translated_621_residues
MPQIQRLPDLLVNQIAAGEVVERPASVLKEVLENAVDAGARAVEVQLEQGGVRRIRITDDGCGIARDELALALERHATSK
IATLDDLERVGTMGFRGEALAAIAGVARTVITSRAEGAAHAWRIDGSDRSLAPAALNQGTVVDVADLYYNTPARRKFLKS
EGTEYAHCDEVFRRVALARPDIALQLSHNGRVAHRLPVGEPVRRIAALMGDDFLAQARAVVAEGGPLRLTGYASLPAYSR
ASRDAQYFFVNGRFVRDKLLTHALRQAYADILHGARHPAYVLFLELDPAGVDVNVHPAKIEVRFRDSRAVHQFVFHAVSR
ALAESGAALAGGNGAGEPAPLPSSGQRVAASPPAAGAGQWPSAQAVQGRLAMDSGAASHRYYDFVAAARPDGTGGAAGAA
GLVAAPPRMDAAARPSGYAPAPLPSADKAPPLGYALAQLHGIYVLAQNESGLVLVDMHAAHERILYEKLKVVLDGTPSIQ
RLLIPAVFSVSARDLAVAEECGEVLARMGFEVGVAGPQELAVRTVPALLASAPVAELMRKLLEELREFPATEVITARRNE
LLATMACHGAVRANRTLTLPEMNALLRDMEATERADQCNHGRPTWTQLTMADLDRFFMRGQ
>Mature_620_residues
PQIQRLPDLLVNQIAAGEVVERPASVLKEVLENAVDAGARAVEVQLEQGGVRRIRITDDGCGIARDELALALERHATSKI
ATLDDLERVGTMGFRGEALAAIAGVARTVITSRAEGAAHAWRIDGSDRSLAPAALNQGTVVDVADLYYNTPARRKFLKSE
GTEYAHCDEVFRRVALARPDIALQLSHNGRVAHRLPVGEPVRRIAALMGDDFLAQARAVVAEGGPLRLTGYASLPAYSRA
SRDAQYFFVNGRFVRDKLLTHALRQAYADILHGARHPAYVLFLELDPAGVDVNVHPAKIEVRFRDSRAVHQFVFHAVSRA
LAESGAALAGGNGAGEPAPLPSSGQRVAASPPAAGAGQWPSAQAVQGRLAMDSGAASHRYYDFVAAARPDGTGGAAGAAG
LVAAPPRMDAAARPSGYAPAPLPSADKAPPLGYALAQLHGIYVLAQNESGLVLVDMHAAHERILYEKLKVVLDGTPSIQR
LLIPAVFSVSARDLAVAEECGEVLARMGFEVGVAGPQELAVRTVPALLASAPVAELMRKLLEELREFPATEVITARRNEL
LATMACHGAVRANRTLTLPEMNALLRDMEATERADQCNHGRPTWTQLTMADLDRFFMRGQ

Specific function: This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a "molecular matchmaker", a protein that promotes the formation of a stable complex between two or more DNA-bindi

COG id: COG0323

COG function: function code L; DNA mismatch repair enzyme (predicted ATPase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DNA mismatch repair mutL/hexB family [H]

Homologues:

Organism=Homo sapiens, GI4557757, Length=334, Percent_Identity=35.9281437125749, Blast_Score=206, Evalue=7e-53,
Organism=Homo sapiens, GI4505911, Length=325, Percent_Identity=28.3076923076923, Blast_Score=136, Evalue=8e-32,
Organism=Homo sapiens, GI189458898, Length=325, Percent_Identity=28.3076923076923, Blast_Score=135, Evalue=1e-31,
Organism=Homo sapiens, GI189458896, Length=317, Percent_Identity=29.0220820189274, Blast_Score=127, Evalue=2e-29,
Organism=Homo sapiens, GI4505913, Length=328, Percent_Identity=27.1341463414634, Blast_Score=120, Evalue=5e-27,
Organism=Homo sapiens, GI310128478, Length=328, Percent_Identity=27.1341463414634, Blast_Score=119, Evalue=8e-27,
Organism=Homo sapiens, GI263191589, Length=248, Percent_Identity=32.6612903225806, Blast_Score=110, Evalue=4e-24,
Organism=Homo sapiens, GI91992160, Length=327, Percent_Identity=25.6880733944954, Blast_Score=91, Evalue=3e-18,
Organism=Homo sapiens, GI91992162, Length=327, Percent_Identity=25.6880733944954, Blast_Score=91, Evalue=3e-18,
Organism=Escherichia coli, GI1790612, Length=558, Percent_Identity=40.6810035842294, Blast_Score=353, Evalue=1e-98,
Organism=Caenorhabditis elegans, GI71991825, Length=323, Percent_Identity=35.9133126934984, Blast_Score=182, Evalue=3e-46,
Organism=Caenorhabditis elegans, GI17562796, Length=346, Percent_Identity=23.4104046242775, Blast_Score=108, Evalue=8e-24,
Organism=Saccharomyces cerevisiae, GI6323819, Length=354, Percent_Identity=32.7683615819209, Blast_Score=183, Evalue=6e-47,
Organism=Saccharomyces cerevisiae, GI6324247, Length=351, Percent_Identity=27.9202279202279, Blast_Score=134, Evalue=3e-32,
Organism=Saccharomyces cerevisiae, GI6325093, Length=703, Percent_Identity=21.6216216216216, Blast_Score=101, Evalue=4e-22,
Organism=Drosophila melanogaster, GI17136968, Length=313, Percent_Identity=36.741214057508, Blast_Score=188, Evalue=1e-47,
Organism=Drosophila melanogaster, GI17136970, Length=357, Percent_Identity=26.0504201680672, Blast_Score=103, Evalue=3e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR002099
- InterPro:   IPR013507
- InterPro:   IPR014762
- InterPro:   IPR020667
- InterPro:   IPR014763
- InterPro:   IPR014790
- InterPro:   IPR020568
- InterPro:   IPR014721 [H]

Pfam domain/function: PF01119 DNA_mis_repair; PF02518 HATPase_c; PF08676 MutL_C [H]

EC number: NA

Molecular weight: Translated: 66324; Mature: 66193

Theoretical pI: Translated: 7.13; Mature: 7.13

Prosite motif: PS00058 DNA_MISMATCH_REPAIR_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPQIQRLPDLLVNQIAAGEVVERPASVLKEVLENAVDAGARAVEVQLEQGGVRRIRITDD
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCEEEEEEECC
GCGIARDELALALERHATSKIATLDDLERVGTMGFRGEALAAIAGVARTVITSRAEGAAH
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCCCE
AWRIDGSDRSLAPAALNQGTVVDVADLYYNTPARRKFLKSEGTEYAHCDEVFRRVALARP
EEEECCCCCCCCHHHCCCCCEEEEHHHHHCCHHHHHHHHHCCCCCHHHHHHHHHHHHCCC
DIALQLSHNGRVAHRLPVGEPVRRIAALMGDDFLAQARAVVAEGGPLRLTGYASLPAYSR
CEEEEECCCCCEEEECCCCHHHHHHHHHHCCHHHHHHHHHHCCCCCEEEEEEECCCCHHH
ASRDAQYFFVNGRFVRDKLLTHALRQAYADILHGARHPAYVLFLELDPAGVDVNVHPAKI
CCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEECCCCCEEEECCEEE
EVRFRDSRAVHQFVFHAVSRALAESGAALAGGNGAGEPAPLPSSGQRVAASPPAAGAGQW
EEEECCHHHHHHHHHHHHHHHHHHCCCEEECCCCCCCCCCCCCCCCEEECCCCCCCCCCC
PSAQAVQGRLAMDSGAASHRYYDFVAAARPDGTGGAAGAAGLVAAPPRMDAAARPSGYAP
CCHHHHCCCCEECCCCCCCHHHHHHEECCCCCCCCCCCCCCCEECCCCCCCCCCCCCCCC
APLPSADKAPPLGYALAQLHGIYVLAQNESGLVLVDMHAAHERILYEKLKVVLDGTPSIQ
CCCCCCCCCCCHHHHHHHHCEEEEEEECCCCEEEEECHHHHHHHHHHHHHHHCCCCCHHH
RLLIPAVFSVSARDLAVAEECGEVLARMGFEVGVAGPQELAVRTVPALLASAPVAELMRK
HHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHH
LLEELREFPATEVITARRNELLATMACHGAVRANRTLTLPEMNALLRDMEATERADQCNH
HHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCEEECHHHHHHHHHHHHHHHHHHCCC
GRPTWTQLTMADLDRFFMRGQ
CCCCHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
PQIQRLPDLLVNQIAAGEVVERPASVLKEVLENAVDAGARAVEVQLEQGGVRRIRITDD
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCEEEEEEECC
GCGIARDELALALERHATSKIATLDDLERVGTMGFRGEALAAIAGVARTVITSRAEGAAH
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCCCE
AWRIDGSDRSLAPAALNQGTVVDVADLYYNTPARRKFLKSEGTEYAHCDEVFRRVALARP
EEEECCCCCCCCHHHCCCCCEEEEHHHHHCCHHHHHHHHHCCCCCHHHHHHHHHHHHCCC
DIALQLSHNGRVAHRLPVGEPVRRIAALMGDDFLAQARAVVAEGGPLRLTGYASLPAYSR
CEEEEECCCCCEEEECCCCHHHHHHHHHHCCHHHHHHHHHHCCCCCEEEEEEECCCCHHH
ASRDAQYFFVNGRFVRDKLLTHALRQAYADILHGARHPAYVLFLELDPAGVDVNVHPAKI
CCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEECCCCCEEEECCEEE
EVRFRDSRAVHQFVFHAVSRALAESGAALAGGNGAGEPAPLPSSGQRVAASPPAAGAGQW
EEEECCHHHHHHHHHHHHHHHHHHCCCEEECCCCCCCCCCCCCCCCEEECCCCCCCCCCC
PSAQAVQGRLAMDSGAASHRYYDFVAAARPDGTGGAAGAAGLVAAPPRMDAAARPSGYAP
CCHHHHCCCCEECCCCCCCHHHHHHEECCCCCCCCCCCCCCCEECCCCCCCCCCCCCCCC
APLPSADKAPPLGYALAQLHGIYVLAQNESGLVLVDMHAAHERILYEKLKVVLDGTPSIQ
CCCCCCCCCCCHHHHHHHHCEEEEEEECCCCEEEEECHHHHHHHHHHHHHHHCCCCCHHH
RLLIPAVFSVSARDLAVAEECGEVLARMGFEVGVAGPQELAVRTVPALLASAPVAELMRK
HHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHH
LLEELREFPATEVITARRNELLATMACHGAVRANRTLTLPEMNALLRDMEATERADQCNH
HHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCEEECHHHHHHHHHHHHHHHHHHCCC
GRPTWTQLTMADLDRFFMRGQ
CCCCHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA