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The map label for this gene is yngE [H]

Identifier: 119899360

GI number: 119899360

Start: 3380677

End: 3382284

Strand: Reverse

Name: yngE [H]

Synonym: azo3070

Alternate gene names: 119899360

Gene position: 3382284-3380677 (Counterclockwise)

Preceding gene: 119899361

Following gene: 119899359

Centisome position: 77.29

GC content: 67.04

Gene sequence:

>1608_bases
ATGAGCACCATCAAGTCCAGCATCAACACCCGCGCGGCGGATTTCCAGGCCAATGCCGCCAGCTTGCGCGGGCTGGTCGA
GGATCTGCGCGCCAAGGCGGCCGAGGTGTCGCTTGGCGGCGGCGAGGCGGCGCGGGCCAAGCACACCGCGCGCGGCAAGC
TGCTGCCGCGTGATCGCGTCGATCATCTGCTCGATCCGGGCACGCCTTTCCTCGAAGTCGGCCAGCTTGCCGCGCACGGC
ATGTACGACAACGAGGCGCCGTCGGCGGGTGTCATTACCGGCATCGGCCGGGTGCAGGGCGTGGAGTGCATGATCGTGGC
CAACGATGCCACGGTGAAGGGCGGCACCTATTACCCGATGACGGTGAAGAAGCACCTGCGCGCGCAGGAGATCGCCGAGC
AGAACAACCTGCCCTGCGTCTATCTGGTGGATTCGGGCGGGGCCTTCCTGCCGCGCCAGGACGAGGTGTTTCCGGACCGC
GACCACTTCGGCCGCATCTTCTACAACCAGGCCAACATGTCGGCCAAGGGCATTCCGCAGATCGCGGTGGTGATGGGTTC
CTGCACCGCCGGCGGTGCCTACGTGCCGGCGATGTCGGACGAGACGGTCATCGTCAAGAACCAGGGCACCATCTTCCTGG
GCGGCCCGCCGCTGGTAAAGGCGGCCACTGGCGAGGTGGTGAGCGCGGAAGACCTGGGCGGCGGCGACGTGCATACGCGC
CTCTCCGGCGTGGCGGATCACCTGGCAGAAAATGATGCCCACGCGCTGTATCTGGCGCGGCGGATCGTCTCCAACCTCAA
CCGCACGAAGCCCGTGAATCTGGCGCTGGGGCAGGGCGAAGAGCCGCTGTACGACCCGGAAGAGATCTACGGGATCATCC
CCACCGACACCCGCAAGCCCTTCGACGTGCGCGAGATCATCGCCCGCGTGGTCGATGGCTCGCGCTTCGACGAGTTCAAG
GCGCGCTACGGCACCACCCTGGTGTGCGGCTTCGCCCAGCTCTACGGCTACCCGGTGGGCATCGTCGCCAACAACGGCAT
CCTGTTCGGCGAATCGGCGCAGAAGGGCGCGCACTTCATCGAGCTGTGCGGCCAGCGCGGCATTCCGCTGCTGTTCCTGC
AGAACATCACCGGCTTCATGGTCGGCCGCAAGTACGAGAACGGCGGCATCGCCAAGGACGGCGCCAAGATGGTGACGGCG
GTCGCCACCGTGCAGGTGCCCAAGATCACCACGCTGATCGGCGGCAGCTTCGGCGCCGGCAACTACGGCATGTGCGGCCG
CGCCTATTCGCCGCGCTTTTTGTGGATGTGGCCCAACGCGCGCATTTCCGTGATGGGCGGCGAACAGGCCGCCAGCGTGC
TCGCCACCGTGCGCCGCGACGGCATCGAGGCCAAGGGCGGCAGCTGGAGCAAGGAAGACGAAGACGCCTTCAAGTCGCCG
ATTCGCGAGCAGTACGAAGTGCAGGGCCACCCCTACTACGCCACGGCGCGCATGTGGGACGACGGCGTGGTCGATCCGGC
GCAGACGCGCCGCATCCTCGGCTTGAGCCTGTCCGCGGCCTTGAACGCGCCCATCCAGCCGACCAGGTTCGGCGTGTTCC
GGATGTAA

Upstream 100 bases:

>100_bases
CCCCCATCCGTAAGCGGATGCGCACACCCGCATCCGCCAGCGGCGGAACCCGCACCCTCACGCGGGTTCCGCCGCGCAAA
CCAACAAGGGACGGGGAGAC

Downstream 100 bases:

>100_bases
GGGGAGGCGACATGTACGAAACCCTGGAAATCCTGCGCGACGGCGGCGTCGCCACCGTGTGGATGAACCGCCCCGAGGTG
CACAACGCCTTCAACGCGCA

Product: carboxyltransferase subunit of acetyl-CoA carboxylase

Products: ADP; phosphate; (S)-methylmalonyl-CoA

Alternate protein names: NA

Number of amino acids: Translated: 535; Mature: 534

Protein sequence:

>535_residues
MSTIKSSINTRAADFQANAASLRGLVEDLRAKAAEVSLGGGEAARAKHTARGKLLPRDRVDHLLDPGTPFLEVGQLAAHG
MYDNEAPSAGVITGIGRVQGVECMIVANDATVKGGTYYPMTVKKHLRAQEIAEQNNLPCVYLVDSGGAFLPRQDEVFPDR
DHFGRIFYNQANMSAKGIPQIAVVMGSCTAGGAYVPAMSDETVIVKNQGTIFLGGPPLVKAATGEVVSAEDLGGGDVHTR
LSGVADHLAENDAHALYLARRIVSNLNRTKPVNLALGQGEEPLYDPEEIYGIIPTDTRKPFDVREIIARVVDGSRFDEFK
ARYGTTLVCGFAQLYGYPVGIVANNGILFGESAQKGAHFIELCGQRGIPLLFLQNITGFMVGRKYENGGIAKDGAKMVTA
VATVQVPKITTLIGGSFGAGNYGMCGRAYSPRFLWMWPNARISVMGGEQAASVLATVRRDGIEAKGGSWSKEDEDAFKSP
IREQYEVQGHPYYATARMWDDGVVDPAQTRRILGLSLSAALNAPIQPTRFGVFRM

Sequences:

>Translated_535_residues
MSTIKSSINTRAADFQANAASLRGLVEDLRAKAAEVSLGGGEAARAKHTARGKLLPRDRVDHLLDPGTPFLEVGQLAAHG
MYDNEAPSAGVITGIGRVQGVECMIVANDATVKGGTYYPMTVKKHLRAQEIAEQNNLPCVYLVDSGGAFLPRQDEVFPDR
DHFGRIFYNQANMSAKGIPQIAVVMGSCTAGGAYVPAMSDETVIVKNQGTIFLGGPPLVKAATGEVVSAEDLGGGDVHTR
LSGVADHLAENDAHALYLARRIVSNLNRTKPVNLALGQGEEPLYDPEEIYGIIPTDTRKPFDVREIIARVVDGSRFDEFK
ARYGTTLVCGFAQLYGYPVGIVANNGILFGESAQKGAHFIELCGQRGIPLLFLQNITGFMVGRKYENGGIAKDGAKMVTA
VATVQVPKITTLIGGSFGAGNYGMCGRAYSPRFLWMWPNARISVMGGEQAASVLATVRRDGIEAKGGSWSKEDEDAFKSP
IREQYEVQGHPYYATARMWDDGVVDPAQTRRILGLSLSAALNAPIQPTRFGVFRM
>Mature_534_residues
STIKSSINTRAADFQANAASLRGLVEDLRAKAAEVSLGGGEAARAKHTARGKLLPRDRVDHLLDPGTPFLEVGQLAAHGM
YDNEAPSAGVITGIGRVQGVECMIVANDATVKGGTYYPMTVKKHLRAQEIAEQNNLPCVYLVDSGGAFLPRQDEVFPDRD
HFGRIFYNQANMSAKGIPQIAVVMGSCTAGGAYVPAMSDETVIVKNQGTIFLGGPPLVKAATGEVVSAEDLGGGDVHTRL
SGVADHLAENDAHALYLARRIVSNLNRTKPVNLALGQGEEPLYDPEEIYGIIPTDTRKPFDVREIIARVVDGSRFDEFKA
RYGTTLVCGFAQLYGYPVGIVANNGILFGESAQKGAHFIELCGQRGIPLLFLQNITGFMVGRKYENGGIAKDGAKMVTAV
ATVQVPKITTLIGGSFGAGNYGMCGRAYSPRFLWMWPNARISVMGGEQAASVLATVRRDGIEAKGGSWSKEDEDAFKSPI
REQYEVQGHPYYATARMWDDGVVDPAQTRRILGLSLSAALNAPIQPTRFGVFRM

Specific function: Unknown

COG id: COG4799

COG function: function code I; Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 carboxyltransferase domain [H]

Homologues:

Organism=Homo sapiens, GI11545863, Length=525, Percent_Identity=68, Blast_Score=747, Evalue=0.0,
Organism=Homo sapiens, GI119943100, Length=544, Percent_Identity=31.25, Blast_Score=233, Evalue=4e-61,
Organism=Homo sapiens, GI295821216, Length=564, Percent_Identity=30.3191489361702, Blast_Score=224, Evalue=2e-58,
Organism=Homo sapiens, GI310133460, Length=135, Percent_Identity=62.2222222222222, Blast_Score=165, Evalue=1e-40,
Organism=Caenorhabditis elegans, GI17552936, Length=533, Percent_Identity=63.0393996247655, Blast_Score=718, Evalue=0.0,
Organism=Caenorhabditis elegans, GI25147362, Length=522, Percent_Identity=32.7586206896552, Blast_Score=242, Evalue=4e-64,
Organism=Caenorhabditis elegans, GI25147359, Length=516, Percent_Identity=32.7519379844961, Blast_Score=240, Evalue=2e-63,
Organism=Drosophila melanogaster, GI24586065, Length=551, Percent_Identity=64.6098003629764, Blast_Score=739, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000022
- InterPro:   IPR011763
- InterPro:   IPR011762 [H]

Pfam domain/function: PF01039 Carboxyl_trans [H]

EC number: 6.4.1.3

Molecular weight: Translated: 57470; Mature: 57339

Theoretical pI: Translated: 7.29; Mature: 7.29

Prosite motif: PS50980 COA_CT_NTER ; PS50989 COA_CT_CTER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTIKSSINTRAADFQANAASLRGLVEDLRAKAAEVSLGGGEAARAKHTARGKLLPRDRV
CCCHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHEEECCCCCHHHHHHHHCCCCCCHHHH
DHLLDPGTPFLEVGQLAAHGMYDNEAPSAGVITGIGRVQGVECMIVANDATVKGGTYYPM
HHHHCCCCCHHHHHHHHHCCCCCCCCCCCCEEEECCCCCCEEEEEEECCCEECCCEECCH
TVKKHLRAQEIAEQNNLPCVYLVDSGGAFLPRQDEVFPDRDHFGRIFYNQANMSAKGIPQ
HHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCE
IAVVMGSCTAGGAYVPAMSDETVIVKNQGTIFLGGPPLVKAATGEVVSAEDLGGGDVHTR
EEEEEECCCCCCEEECCCCCCEEEEECCCEEEECCCCEEEECCCCEEECCCCCCCHHHHH
LSGVADHLAENDAHALYLARRIVSNLNRTKPVNLALGQGEEPLYDPEEIYGIIPTDTRKP
HHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCHHHEEEECCCCCCCC
FDVREIIARVVDGSRFDEFKARYGTTLVCGFAQLYGYPVGIVANNGILFGESAQKGAHFI
CCHHHHHHHHHCCCCHHHHHHHHCCCCEEEHHHHHCCCEEEEECCCEEECCCCCCCHHHH
ELCGQRGIPLLFLQNITGFMVGRKYENGGIAKDGAKMVTAVATVQVPKITTLIGGSFGAG
HHHCCCCCCEEEECCCHHHHEEEEECCCCCCCCCHHHEEEEEEEECCCEEEEECCCCCCC
NYGMCGRAYSPRFLWMWPNARISVMGGEQAASVLATVRRDGIEAKGGSWSKEDEDAFKSP
CCCCCCCCCCCEEEEECCCCEEEEECCHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHH
IREQYEVQGHPYYATARMWDDGVVDPAQTRRILGLSLSAALNAPIQPTRFGVFRM
HHHHHCCCCCCEEEEEEECCCCCCCHHHHHEEHEEEEHHHHCCCCCCCCCCEECC
>Mature Secondary Structure 
STIKSSINTRAADFQANAASLRGLVEDLRAKAAEVSLGGGEAARAKHTARGKLLPRDRV
CCHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHEEECCCCCHHHHHHHHCCCCCCHHHH
DHLLDPGTPFLEVGQLAAHGMYDNEAPSAGVITGIGRVQGVECMIVANDATVKGGTYYPM
HHHHCCCCCHHHHHHHHHCCCCCCCCCCCCEEEECCCCCCEEEEEEECCCEECCCEECCH
TVKKHLRAQEIAEQNNLPCVYLVDSGGAFLPRQDEVFPDRDHFGRIFYNQANMSAKGIPQ
HHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCE
IAVVMGSCTAGGAYVPAMSDETVIVKNQGTIFLGGPPLVKAATGEVVSAEDLGGGDVHTR
EEEEEECCCCCCEEECCCCCCEEEEECCCEEEECCCCEEEECCCCEEECCCCCCCHHHHH
LSGVADHLAENDAHALYLARRIVSNLNRTKPVNLALGQGEEPLYDPEEIYGIIPTDTRKP
HHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCHHHEEEECCCCCCCC
FDVREIIARVVDGSRFDEFKARYGTTLVCGFAQLYGYPVGIVANNGILFGESAQKGAHFI
CCHHHHHHHHHCCCCHHHHHHHHCCCCEEEHHHHHCCCEEEEECCCEEECCCCCCCHHHH
ELCGQRGIPLLFLQNITGFMVGRKYENGGIAKDGAKMVTAVATVQVPKITTLIGGSFGAG
HHHCCCCCCEEEECCCHHHHEEEEECCCCCCCCCHHHEEEEEEEECCCEEEEECCCCCCC
NYGMCGRAYSPRFLWMWPNARISVMGGEQAASVLATVRRDGIEAKGGSWSKEDEDAFKSP
CCCCCCCCCCCEEEEECCCCEEEEECCHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHH
IREQYEVQGHPYYATARMWDDGVVDPAQTRRILGLSLSAALNAPIQPTRFGVFRM
HHHHHCCCCCCEEEEEEECCCCCCCHHHHHEEHEEEEHHHHCCCCCCCCCCEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; propanoyl-CoA; HCO3-

Specific reaction: ATP + propanoyl-CoA + HCO3- = ADP + phosphate + (S)-methylmalonyl-CoA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377; 9387222 [H]