Click here to switch to the map view.

The map label for this gene is catF [H]

Identifier: 119899349

GI number: 119899349

Start: 3365275

End: 3366483

Strand: Direct

Name: catF [H]

Synonym: azo3059

Alternate gene names: 119899349

Gene position: 3365275-3366483 (Clockwise)

Preceding gene: 119899348

Following gene: 119899350

Centisome position: 76.9

GC content: 71.71

Gene sequence:

>1209_bases
ATGACCCACACCGTCTATCTCTGCGACGCCATCCGCACCCCCTTCGGCCGCTACGGCGGGCTGCTTTCCTCCGTGCGTGC
CGACGACCTCGCGGCGCTGCCGATCAGGGCCTTGATCGCGCGCAACCCCGGCGTCGACTGGAACCTGGTCGACGACGTCA
TCTACGGCTGCGCCAACCAGGCGGGCGAGGACAACCGCAATGTCGCCCGCATGGCGGCGCTGCTGGCCGGGCTGCCGGTG
GAAGTGCCGGGCAGCACGGTCAACCGCCTGTGCGGCTCCAGCCTGGACGCCATCGGCAGCGCCGCGCGCGCGATCGCCGC
CGGCGAGGCCGAGCTGATGATCGCCGGCGGGGTCGAGAGCATGAGCCGCGCGCCCTTCGTCCTGGGCAAGGCCGACAGCG
CCTTTTCGCGCAGCGCGAAGATCGAGGACACCACCATCGGCTGGCGCTTCGTCAATCCGCTGATGAAGGCGCAGTACGGC
GTGGACTCCATGCCCGAAACCGCCGAGAACGTCGCCACCGACTTCAACGTGAGCCGCGCCGACCAGGACGCGCTCGCGCT
GCGTAGCCAGCAGCGCTGGGCGAGCGCCAACGAACGCGGCTTCTTCGCGCGCGAGATCGTGCCGGTCGACATCCCGAGGA
AGAAGGGCGATCCGGTGCGCATGACCACGGACGAACACCCCCGCCCCGACACCACGCTGGACATGCTGGCCAAGCTGAAA
GGCGTGGTGCGCCCGGACGGCACCGTGACCGCCGGCAACGCCTCTGGCGTGAACGACGGCGCCGCCGCGGTGCTGCTCGC
CTCCGAAGCCGCGGTGAAGCGCCACGGCCTGACCCCGCGCGCGCGCATCCTCGGCTCGGCCGCAGCCGGCGTGGCGCCGC
GCATCATGGGCATCGGCCCGGCCCCGGCGAGCGAAAAGCTGCTGGCGCGCCTGGGCATGGGCATCGCCCGGTTCGACGTC
ATCGAACTCAACGAGGCCTTCGCCGCGCAGGCGCTGGCGGTCACCCGCCGGCTGGGGCTGGCGGACGACGACGCGCGGGT
CAATCCCAACGGCGGCGCCATCTCCATCGGCCACCCGCTGGGGGCCTCGGGCGCGCGCCTGGTGACCACCGCGCTCAACC
AGCTCGAAACCAGCGGCGGGCGCTACGGCCTGGCGACGATGTGCATCGGCGTCGGCCAGGGCATCGCGCTCGCGATCGAA
CGGATTTAA

Upstream 100 bases:

>100_bases
GTTTCTCCAGAGGGTTGTCTCCAACTCTCTTCTCTTGGGTGGGCGTGGCGACACGCCCACTTTTTTCTCAAACCATCCGC
ATCGCGCACGGCAGGACACC

Downstream 100 bases:

>100_bases
GTTGACCTGGGTCATTGATCGCGCCGGCCATCGGCGCCACCTTTGGCCCTGAGCAATCGTCGCGGGACCGCCCCGCGCCG
GTTGCCCGGCTTGCCCGGGG

Product: beta-ketoadipyl CoA thiolase

Products: NA

Alternate protein names: 3-oxoadipyl-CoA thiolase [H]

Number of amino acids: Translated: 402; Mature: 401

Protein sequence:

>402_residues
MTHTVYLCDAIRTPFGRYGGLLSSVRADDLAALPIRALIARNPGVDWNLVDDVIYGCANQAGEDNRNVARMAALLAGLPV
EVPGSTVNRLCGSSLDAIGSAARAIAAGEAELMIAGGVESMSRAPFVLGKADSAFSRSAKIEDTTIGWRFVNPLMKAQYG
VDSMPETAENVATDFNVSRADQDALALRSQQRWASANERGFFAREIVPVDIPRKKGDPVRMTTDEHPRPDTTLDMLAKLK
GVVRPDGTVTAGNASGVNDGAAAVLLASEAAVKRHGLTPRARILGSAAAGVAPRIMGIGPAPASEKLLARLGMGIARFDV
IELNEAFAAQALAVTRRLGLADDDARVNPNGGAISIGHPLGASGARLVTTALNQLETSGGRYGLATMCIGVGQGIALAIE
RI

Sequences:

>Translated_402_residues
MTHTVYLCDAIRTPFGRYGGLLSSVRADDLAALPIRALIARNPGVDWNLVDDVIYGCANQAGEDNRNVARMAALLAGLPV
EVPGSTVNRLCGSSLDAIGSAARAIAAGEAELMIAGGVESMSRAPFVLGKADSAFSRSAKIEDTTIGWRFVNPLMKAQYG
VDSMPETAENVATDFNVSRADQDALALRSQQRWASANERGFFAREIVPVDIPRKKGDPVRMTTDEHPRPDTTLDMLAKLK
GVVRPDGTVTAGNASGVNDGAAAVLLASEAAVKRHGLTPRARILGSAAAGVAPRIMGIGPAPASEKLLARLGMGIARFDV
IELNEAFAAQALAVTRRLGLADDDARVNPNGGAISIGHPLGASGARLVTTALNQLETSGGRYGLATMCIGVGQGIALAIE
RI
>Mature_401_residues
THTVYLCDAIRTPFGRYGGLLSSVRADDLAALPIRALIARNPGVDWNLVDDVIYGCANQAGEDNRNVARMAALLAGLPVE
VPGSTVNRLCGSSLDAIGSAARAIAAGEAELMIAGGVESMSRAPFVLGKADSAFSRSAKIEDTTIGWRFVNPLMKAQYGV
DSMPETAENVATDFNVSRADQDALALRSQQRWASANERGFFAREIVPVDIPRKKGDPVRMTTDEHPRPDTTLDMLAKLKG
VVRPDGTVTAGNASGVNDGAAAVLLASEAAVKRHGLTPRARILGSAAAGVAPRIMGIGPAPASEKLLARLGMGIARFDVI
ELNEAFAAQALAVTRRLGLADDDARVNPNGGAISIGHPLGASGARLVTTALNQLETSGGRYGLATMCIGVGQGIALAIER
I

Specific function: Catalyzes thiolytic cleavage of beta-ketoadipyl-CoA to succinyl-CoA and acetyl-CoA [H]

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI167614485, Length=398, Percent_Identity=44.7236180904523, Blast_Score=322, Evalue=3e-88,
Organism=Homo sapiens, GI148539872, Length=399, Percent_Identity=39.3483709273183, Blast_Score=263, Evalue=3e-70,
Organism=Homo sapiens, GI4501853, Length=338, Percent_Identity=43.491124260355, Blast_Score=223, Evalue=2e-58,
Organism=Homo sapiens, GI4557237, Length=403, Percent_Identity=37.2208436724566, Blast_Score=221, Evalue=6e-58,
Organism=Homo sapiens, GI4504327, Length=428, Percent_Identity=33.6448598130841, Blast_Score=187, Evalue=1e-47,
Organism=Homo sapiens, GI194353979, Length=334, Percent_Identity=30.8383233532934, Blast_Score=123, Evalue=3e-28,
Organism=Escherichia coli, GI1787663, Length=397, Percent_Identity=65.9949622166247, Blast_Score=527, Evalue=1e-151,
Organism=Escherichia coli, GI48994986, Length=402, Percent_Identity=44.0298507462687, Blast_Score=296, Evalue=2e-81,
Organism=Escherichia coli, GI1788554, Length=398, Percent_Identity=46.4824120603015, Blast_Score=288, Evalue=3e-79,
Organism=Escherichia coli, GI87082165, Length=398, Percent_Identity=44.2211055276382, Blast_Score=279, Evalue=3e-76,
Organism=Escherichia coli, GI1788683, Length=411, Percent_Identity=31.8734793187348, Blast_Score=167, Evalue=1e-42,
Organism=Caenorhabditis elegans, GI133906874, Length=401, Percent_Identity=42.14463840399, Blast_Score=293, Evalue=1e-79,
Organism=Caenorhabditis elegans, GI25147385, Length=403, Percent_Identity=35.9801488833747, Blast_Score=224, Evalue=5e-59,
Organism=Caenorhabditis elegans, GI17535921, Length=406, Percent_Identity=33.2512315270936, Blast_Score=187, Evalue=8e-48,
Organism=Caenorhabditis elegans, GI17551802, Length=428, Percent_Identity=33.6448598130841, Blast_Score=186, Evalue=2e-47,
Organism=Caenorhabditis elegans, GI17535917, Length=411, Percent_Identity=31.3868613138686, Blast_Score=158, Evalue=4e-39,
Organism=Saccharomyces cerevisiae, GI6325229, Length=407, Percent_Identity=36.6093366093366, Blast_Score=222, Evalue=9e-59,
Organism=Saccharomyces cerevisiae, GI6322031, Length=408, Percent_Identity=35.7843137254902, Blast_Score=213, Evalue=5e-56,
Organism=Drosophila melanogaster, GI24655093, Length=398, Percent_Identity=44.2211055276382, Blast_Score=315, Evalue=3e-86,
Organism=Drosophila melanogaster, GI17648125, Length=407, Percent_Identity=39.3120393120393, Blast_Score=272, Evalue=4e-73,
Organism=Drosophila melanogaster, GI24640423, Length=402, Percent_Identity=36.318407960199, Blast_Score=206, Evalue=2e-53,
Organism=Drosophila melanogaster, GI17137578, Length=434, Percent_Identity=33.6405529953917, Blast_Score=188, Evalue=7e-48,
Organism=Drosophila melanogaster, GI19921506, Length=310, Percent_Identity=27.0967741935484, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24585051, Length=315, Percent_Identity=27.3015873015873, Blast_Score=70, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012793
- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: =2.3.1.174 [H]

Molecular weight: Translated: 41899; Mature: 41768

Theoretical pI: Translated: 7.45; Mature: 7.45

Prosite motif: PS00098 THIOLASE_1 ; PS00737 THIOLASE_2 ; PS00099 THIOLASE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTHTVYLCDAIRTPFGRYGGLLSSVRADDLAALPIRALIARNPGVDWNLVDDVIYGCANQ
CCEEEEEHHHHCCCHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCC
AGEDNRNVARMAALLAGLPVEVPGSTVNRLCGSSLDAIGSAARAIAAGEAELMIAGGVES
CCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHCCCHHHHHHHHHHHHCCCCEEEEECCHHH
MSRAPFVLGKADSAFSRSAKIEDTTIGWRFVNPLMKAQYGVDSMPETAENVATDFNVSRA
HCCCCEEEECCCCHHHCCCCCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCCCC
DQDALALRSQQRWASANERGFFAREIVPVDIPRKKGDPVRMTTDEHPRPDTTLDMLAKLK
CHHHHHHHHHHHHCCCCCCCCEEHEEEEECCCCCCCCCEEECCCCCCCCCHHHHHHHHHH
GVVRPDGTVTAGNASGVNDGAAAVLLASEAAVKRHGLTPRARILGSAAAGVAPRIMGIGP
CCCCCCCCEECCCCCCCCCCCEEEEEEHHHHHHHCCCCHHHHHHHHHHHCCCCCEEECCC
APASEKLLARLGMGIARFDVIELNEAFAAQALAVTRRLGLADDDARVNPNGGAISIGHPL
CCHHHHHHHHHCCCHHHEEEEEHHHHHHHHHHHHHHHCCCCCCCCEECCCCCEEEECCCC
GASGARLVTTALNQLETSGGRYGLATMCIGVGQGIALAIERI
CCCCHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCEEEEECC
>Mature Secondary Structure 
THTVYLCDAIRTPFGRYGGLLSSVRADDLAALPIRALIARNPGVDWNLVDDVIYGCANQ
CEEEEEHHHHCCCHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCC
AGEDNRNVARMAALLAGLPVEVPGSTVNRLCGSSLDAIGSAARAIAAGEAELMIAGGVES
CCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHCCCHHHHHHHHHHHHCCCCEEEEECCHHH
MSRAPFVLGKADSAFSRSAKIEDTTIGWRFVNPLMKAQYGVDSMPETAENVATDFNVSRA
HCCCCEEEECCCCHHHCCCCCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCCCC
DQDALALRSQQRWASANERGFFAREIVPVDIPRKKGDPVRMTTDEHPRPDTTLDMLAKLK
CHHHHHHHHHHHHCCCCCCCCEEHEEEEECCCCCCCCCEEECCCCCCCCCHHHHHHHHHH
GVVRPDGTVTAGNASGVNDGAAAVLLASEAAVKRHGLTPRARILGSAAAGVAPRIMGIGP
CCCCCCCCEECCCCCCCCCCCEEEEEEHHHHHHHCCCCHHHHHHHHHHHCCCCCEEECCC
APASEKLLARLGMGIARFDVIELNEAFAAQALAVTRRLGLADDDARVNPNGGAISIGHPL
CCHHHHHHHHHCCCHHHEEEEEHHHHHHHHHHHHHHHCCCCCCCCEECCCCCEEEECCCC
GASGARLVTTALNQLETSGGRYGLATMCIGVGQGIALAIERI
CCCCHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8125318 [H]