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The map label for this gene is paaH2 [H]

Identifier: 119899330

GI number: 119899330

Start: 3344244

End: 3345770

Strand: Reverse

Name: paaH2 [H]

Synonym: azo3040

Alternate gene names: 119899330

Gene position: 3345770-3344244 (Counterclockwise)

Preceding gene: 119899331

Following gene: 119899329

Centisome position: 76.46

GC content: 70.86

Gene sequence:

>1527_bases
ATGGCCGCACTCGCTCACTCCATCAAGGTCGCCGTGGTCGGCGCCGGCGCCATGGGTAGCGGCATCGCCCACGTCGCCGC
GCGCGCCGGGCACACCGTCTATCTGTACGACATGAACGCCGAGGCGGTTGCGCGCGGCAAGGCCGGCATCGAGAAGGACC
TGCGCTTTCTTGTCGGCAAGGGCAAGCTCTCCGAGGCCGATTGCGAGGCGACGCTGGCACGGGTGCAGCCGACCAGCCGC
ATCGAGGACCTGGCCGACGCCGGCCTGCTGATCGAGGCCATCGTCGAGAACCTCGAAATCAAGCAGAAGCTGTTCCGCCA
GCTGGAGGAAATGGTCGGCAGCGGCGCCATCCTCGCCACCAACACCTCGTCGCTGTCGATCACCGCGATGGGCTCAGCGC
TGGCGCGGCCCCAGCAACTGGCCGGCCTGCACTTCTTCAACCCGGCGCCGCGCATGGCGCTGGTGGAGATCGTCTCCGGC
CTGGCCACCGATCCGGCGGTCGCCGCCACGCTGTACGACACCGCCAAGGCCTGGGGCAAGGTGCCGGTGCACGCCACCTC
CACCCCCGGCTTCATCGTCAATCGCGTCGCGCGGCCCTACTACGCCGAAGCGCTGCGGGTGCTGGCCGAACGCGCCGCCA
CCCCGGCCACGCTGGACGCGATCATGCGCGAGGCCTGCAACTTCCCGATGGGCCCGTTCGAGCTGATGGACCTGATCGGC
CACGACGTGAATTACGCGGTGACGCGCTCGGTGTTCGACGCCTATTTCGGCGACAAGCGCTTCACCCCCAGCCTGATCCA
GCAGGAGCTGACCCTGGCCGGCCGCCTCGGCCGCAAGAGCGGGCAGGGCTTCTACGACTACCGCGACGGCGCCGACAAGC
CGCAGCCGGCGGTCGAGCCGCACGCGGCGCCGGCGAAGGCGGTGTCGGTCAGCGGCGACCTCGGCGTCGCCGCGCCGCTG
CTGGCCCGGCTGGAAGCCGCCGGCATTCCGATCGAACACTGCGCCGGCGCGCCTTCGCACGGGGGCGAACTGCTGATCGG
CGATGCCCGCCTGCTGATGTCCGACGGCCGCACCGCGACCCACCGCGCCGCCGAGGAAGGCACGCCCGACCTGGTGCTGT
TCGACCTCGCCCGCGACTACGCCACCACGCCGCGCATCGCCCTGGCGCGCGCCGACCAGTGCGGCGAGGAAGCCTGGCAA
CTGGTCGTCGGCACGCTGCAGGCGGCCGGCATCGCCGTCAGCCGGCTGGACGACGTCGCTGGCCTGGTGGCGCTGCGCAC
CGTCTGCATGCTGGCCAACGAAGCGGCGGACGGCGTGGTGCAGGGCATCGGCAGCGCGGCGGATATCGACACCGCGATGC
GCTACGGCACCAACTACCCGGAAGGCCCGCTGGCCTGGGCGGACCGGCTGGGTGTGGATTTCGTGGCGCGGGTGCTGACG
AATCTGCGCGCGCACTATGGCGAGGAGAGATATCGGCTGTCGCCGCTGATTCAGCGGCGGGCTTACGGGAGGCGGGGGTT
GCTTTGA

Upstream 100 bases:

>100_bases
CCGAAGTCCAACTGGATGCAATACAACCCGGAATAAATTGGCGGCGGCGCACTCCGGTGCGCGCTTCCGATCGATCCGAA
CCGCATAAGGAATCTTCCGC

Downstream 100 bases:

>100_bases
GGGGGACGGAGGTGAGGGGGGAGGGGCGCTCGCCCCGAGCGCGGTTTTTGTTCCTCCCCCTTCAAGGGGGAGGTTAGGAG
GGGGATGGGGTTGGAGCACG

Product: 3-hydroxy-acyl-CoA dehydrogenase

Products: NA

Alternate protein names: Beta-hydroxybutyryl-CoA dehydrogenase; BHBD [H]

Number of amino acids: Translated: 508; Mature: 507

Protein sequence:

>508_residues
MAALAHSIKVAVVGAGAMGSGIAHVAARAGHTVYLYDMNAEAVARGKAGIEKDLRFLVGKGKLSEADCEATLARVQPTSR
IEDLADAGLLIEAIVENLEIKQKLFRQLEEMVGSGAILATNTSSLSITAMGSALARPQQLAGLHFFNPAPRMALVEIVSG
LATDPAVAATLYDTAKAWGKVPVHATSTPGFIVNRVARPYYAEALRVLAERAATPATLDAIMREACNFPMGPFELMDLIG
HDVNYAVTRSVFDAYFGDKRFTPSLIQQELTLAGRLGRKSGQGFYDYRDGADKPQPAVEPHAAPAKAVSVSGDLGVAAPL
LARLEAAGIPIEHCAGAPSHGGELLIGDARLLMSDGRTATHRAAEEGTPDLVLFDLARDYATTPRIALARADQCGEEAWQ
LVVGTLQAAGIAVSRLDDVAGLVALRTVCMLANEAADGVVQGIGSAADIDTAMRYGTNYPEGPLAWADRLGVDFVARVLT
NLRAHYGEERYRLSPLIQRRAYGRRGLL

Sequences:

>Translated_508_residues
MAALAHSIKVAVVGAGAMGSGIAHVAARAGHTVYLYDMNAEAVARGKAGIEKDLRFLVGKGKLSEADCEATLARVQPTSR
IEDLADAGLLIEAIVENLEIKQKLFRQLEEMVGSGAILATNTSSLSITAMGSALARPQQLAGLHFFNPAPRMALVEIVSG
LATDPAVAATLYDTAKAWGKVPVHATSTPGFIVNRVARPYYAEALRVLAERAATPATLDAIMREACNFPMGPFELMDLIG
HDVNYAVTRSVFDAYFGDKRFTPSLIQQELTLAGRLGRKSGQGFYDYRDGADKPQPAVEPHAAPAKAVSVSGDLGVAAPL
LARLEAAGIPIEHCAGAPSHGGELLIGDARLLMSDGRTATHRAAEEGTPDLVLFDLARDYATTPRIALARADQCGEEAWQ
LVVGTLQAAGIAVSRLDDVAGLVALRTVCMLANEAADGVVQGIGSAADIDTAMRYGTNYPEGPLAWADRLGVDFVARVLT
NLRAHYGEERYRLSPLIQRRAYGRRGLL
>Mature_507_residues
AALAHSIKVAVVGAGAMGSGIAHVAARAGHTVYLYDMNAEAVARGKAGIEKDLRFLVGKGKLSEADCEATLARVQPTSRI
EDLADAGLLIEAIVENLEIKQKLFRQLEEMVGSGAILATNTSSLSITAMGSALARPQQLAGLHFFNPAPRMALVEIVSGL
ATDPAVAATLYDTAKAWGKVPVHATSTPGFIVNRVARPYYAEALRVLAERAATPATLDAIMREACNFPMGPFELMDLIGH
DVNYAVTRSVFDAYFGDKRFTPSLIQQELTLAGRLGRKSGQGFYDYRDGADKPQPAVEPHAAPAKAVSVSGDLGVAAPLL
ARLEAAGIPIEHCAGAPSHGGELLIGDARLLMSDGRTATHRAAEEGTPDLVLFDLARDYATTPRIALARADQCGEEAWQL
VVGTLQAAGIAVSRLDDVAGLVALRTVCMLANEAADGVVQGIGSAADIDTAMRYGTNYPEGPLAWADRLGVDFVARVLTN
LRAHYGEERYRLSPLIQRRAYGRRGLL

Specific function: Butyrate/butanol-producing pathway. Phenylacetic acid aerobic catabolism. [C]

COG id: COG1250

COG function: function code I; 3-hydroxyacyl-CoA dehydrogenase

Gene ontology:

Cell location: Mitochondria or Peroxisomes [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyacyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI296179429, Length=286, Percent_Identity=39.5104895104895, Blast_Score=209, Evalue=6e-54,
Organism=Homo sapiens, GI296179427, Length=304, Percent_Identity=38.1578947368421, Blast_Score=200, Evalue=3e-51,
Organism=Homo sapiens, GI20127408, Length=287, Percent_Identity=31.7073170731707, Blast_Score=149, Evalue=4e-36,
Organism=Homo sapiens, GI68989263, Length=296, Percent_Identity=32.0945945945946, Blast_Score=139, Evalue=6e-33,
Organism=Homo sapiens, GI261878539, Length=296, Percent_Identity=32.0945945945946, Blast_Score=139, Evalue=7e-33,
Organism=Homo sapiens, GI115430219, Length=235, Percent_Identity=28.5106382978723, Blast_Score=102, Evalue=8e-22,
Organism=Escherichia coli, GI1787661, Length=497, Percent_Identity=45.8752515090543, Blast_Score=403, Evalue=1e-113,
Organism=Escherichia coli, GI1788682, Length=297, Percent_Identity=31.986531986532, Blast_Score=154, Evalue=2e-38,
Organism=Escherichia coli, GI1790281, Length=287, Percent_Identity=31.0104529616725, Blast_Score=144, Evalue=1e-35,
Organism=Caenorhabditis elegans, GI17563036, Length=287, Percent_Identity=39.0243902439024, Blast_Score=201, Evalue=1e-51,
Organism=Caenorhabditis elegans, GI17549919, Length=293, Percent_Identity=38.9078498293515, Blast_Score=200, Evalue=1e-51,
Organism=Caenorhabditis elegans, GI17553560, Length=292, Percent_Identity=36.986301369863, Blast_Score=188, Evalue=7e-48,
Organism=Caenorhabditis elegans, GI25144276, Length=288, Percent_Identity=35.7638888888889, Blast_Score=159, Evalue=2e-39,
Organism=Caenorhabditis elegans, GI17508951, Length=288, Percent_Identity=35.7638888888889, Blast_Score=159, Evalue=2e-39,
Organism=Caenorhabditis elegans, GI17508953, Length=288, Percent_Identity=35.7638888888889, Blast_Score=159, Evalue=4e-39,
Organism=Caenorhabditis elegans, GI71985923, Length=290, Percent_Identity=29.3103448275862, Blast_Score=156, Evalue=2e-38,
Organism=Caenorhabditis elegans, GI71985930, Length=294, Percent_Identity=29.5918367346939, Blast_Score=155, Evalue=6e-38,
Organism=Caenorhabditis elegans, GI17558304, Length=315, Percent_Identity=34.2857142857143, Blast_Score=152, Evalue=5e-37,
Organism=Drosophila melanogaster, GI24583077, Length=285, Percent_Identity=33.3333333333333, Blast_Score=161, Evalue=1e-39,
Organism=Drosophila melanogaster, GI24583079, Length=285, Percent_Identity=33.3333333333333, Blast_Score=161, Evalue=1e-39,
Organism=Drosophila melanogaster, GI19921000, Length=285, Percent_Identity=33.3333333333333, Blast_Score=161, Evalue=1e-39,
Organism=Drosophila melanogaster, GI20129993, Length=221, Percent_Identity=28.0542986425339, Blast_Score=84, Evalue=2e-16,
Organism=Drosophila melanogaster, GI45549573, Length=221, Percent_Identity=27.1493212669683, Blast_Score=82, Evalue=1e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006180
- InterPro:   IPR006176
- InterPro:   IPR011967
- InterPro:   IPR006108
- InterPro:   IPR008927
- InterPro:   IPR013328
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00725 3HCDH; PF02737 3HCDH_N [H]

EC number: =1.1.1.157 [H]

Molecular weight: Translated: 53833; Mature: 53702

Theoretical pI: Translated: 6.30; Mature: 6.30

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAALAHSIKVAVVGAGAMGSGIAHVAARAGHTVYLYDMNAEAVARGKAGIEKDLRFLVGK
CCCHHCEEEEEEEECCCCCCHHHHHHHHCCCEEEEEECCHHHHHHCCCCHHHHHHHHHCC
GKLSEADCEATLARVQPTSRIEDLADAGLLIEAIVENLEIKQKLFRQLEEMVGSGAILAT
CCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEE
NTSSLSITAMGSALARPQQLAGLHFFNPAPRMALVEIVSGLATDPAVAATLYDTAKAWGK
CCCCEEEEECCHHHCCHHHHCCCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHCC
VPVHATSTPGFIVNRVARPYYAEALRVLAERAATPATLDAIMREACNFPMGPFELMDLIG
CCEEECCCCCHHHHHHCCHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCHHHHHHHHC
HDVNYAVTRSVFDAYFGDKRFTPSLIQQELTLAGRLGRKSGQGFYDYRDGADKPQPAVEP
CCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCC
HAAPAKAVSVSGDLGVAAPLLARLEAAGIPIEHCAGAPSHGGELLIGDARLLMSDGRTAT
CCCCCCEEECCCCCCHHHHHHHHHHHCCCCHHHHCCCCCCCCEEEEECHHEEECCCCHHH
HRAAEEGTPDLVLFDLARDYATTPRIALARADQCGEEAWQLVVGTLQAAGIAVSRLDDVA
HHHHHCCCCCEEEEEHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GLVALRTVCMLANEAADGVVQGIGSAADIDTAMRYGTNYPEGPLAWADRLGVDFVARVLT
HHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCHHHHHHHCHHHHHHHHH
NLRAHYGEERYRLSPLIQRRAYGRRGLL
HHHHHHCCHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
AALAHSIKVAVVGAGAMGSGIAHVAARAGHTVYLYDMNAEAVARGKAGIEKDLRFLVGK
CCHHCEEEEEEEECCCCCCHHHHHHHHCCCEEEEEECCHHHHHHCCCCHHHHHHHHHCC
GKLSEADCEATLARVQPTSRIEDLADAGLLIEAIVENLEIKQKLFRQLEEMVGSGAILAT
CCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEE
NTSSLSITAMGSALARPQQLAGLHFFNPAPRMALVEIVSGLATDPAVAATLYDTAKAWGK
CCCCEEEEECCHHHCCHHHHCCCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHCC
VPVHATSTPGFIVNRVARPYYAEALRVLAERAATPATLDAIMREACNFPMGPFELMDLIG
CCEEECCCCCHHHHHHCCHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCHHHHHHHHC
HDVNYAVTRSVFDAYFGDKRFTPSLIQQELTLAGRLGRKSGQGFYDYRDGADKPQPAVEP
CCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCC
HAAPAKAVSVSGDLGVAAPLLARLEAAGIPIEHCAGAPSHGGELLIGDARLLMSDGRTAT
CCCCCCEEECCCCCCHHHHHHHHHHHCCCCHHHHCCCCCCCCEEEEECHHEEECCCCHHH
HRAAEEGTPDLVLFDLARDYATTPRIALARADQCGEEAWQLVVGTLQAAGIAVSRLDDVA
HHHHHCCCCCEEEEEHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GLVALRTVCMLANEAADGVVQGIGSAADIDTAMRYGTNYPEGPLAWADRLGVDFVARVLT
HHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCHHHHHHHCHHHHHHHHH
NLRAHYGEERYRLSPLIQRRAYGRRGLL
HHHHHHCCHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9748275; 9097039; 9278503; 10766858 [H]