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The map label for this gene is copS [H]

Identifier: 119899235

GI number: 119899235

Start: 3231842

End: 3233239

Strand: Reverse

Name: copS [H]

Synonym: azo2945

Alternate gene names: 119899235

Gene position: 3233239-3231842 (Counterclockwise)

Preceding gene: 119899236

Following gene: 119899234

Centisome position: 73.89

GC content: 71.67

Gene sequence:

>1398_bases
ATGAGCGCGCGCGCACCGCTTTCGCTCACCGCGCGGCTGGCGCTGCTGTTCGCCGCGCTCGCCGCCAGCCTGCTGATCGT
CGTCGGCCTGGTGATGGGGCGCGCGGTCGAGGCGCACTTCCGCGAACTCGACGACCATGAACTGTCGGGCAAGCTGATGC
TGATCGAAAGCCTGCTGCAGCGCGCCGACGATGCCGCGGCGCTGGCTGGCGTGCGCCAGCGCCTGGACGAAGCCTTCGTC
GGCCACGACACCGTGGCGGTGCTGATGCGCGATGCCGGTGACGCGGTGGTCTATGCACTGCATGCCGACCACTTCGCCGC
CGCTCAGCGCGACGGCGCGCCGCTTGCGGGGGGCGGAATGTGGACCGAAGGCGGCCGCCATTACATCGGCCGCGAGGCGG
ACATCGCGCTGCCGGCGGGCAGCGGCGCCGCGGCCGGGCCGCTGCGGGTGCTGCTCGGGCTGGACATTTCGCATCACGTG
CATTTCCTCGACGACGTCCGCAACCGGTTGTGGGCCGGCATATCGCTATCGGCGGTCGCGGCGGCGGTGCTTGGCTGGCT
GGCGGCGCACAAGGGGCTGGCCCCGCTGCGCCGGGTGACGGCGGCGGCCGAGCGGCTGTCGGCCGAACGCCTGGGCGAGC
GGCTGGCCGAGGGCGCGGCGCCCGCCGAGGTGCGCGAACTGGTCGAGGCCTTCAACGGCATGCTCGAACGGCTGGAATCG
TCGTTCCGCCGGCTGTCGGACTTTTCTGCGGACATCGCCCACGAGCTGCGCACGCCGGTGTCCAACCTGATGACGCAGAC
CGAAGTAGCGCTGTCGCACGCGCGCAGCCCGGACGAATACCGCGAGGTGCTAGCCTCCAACCTGGAAGAGTACGAACGCA
TCGCCCGCATGGTGAGCGACATGCTGTTCCTGGCCCAGGCCGAAAACGGCCGCCTGCCGCGCCCCGAGGAGCGGGTGGCG
CTGCAGGATGAGGCGCGGGCGCTGGCCGAGTTCTACGAGGCGCTGGCGGAGGAGCAGGGCGTGACGATCACCGTGCAGGG
CGCGGCGGAGGTCACCGGCGATCGCCTGATGCTGCGCCGCGCGCTGGCCAACCTGTTGTCCAACGCGCTGCGCCACACGC
CGCGTGGCGGCACGGTCGAGATCGTCATCGATGCCGGTCAGGCCACGGTGACGCTGGCGGTGCGCAATCCGGGCGAGACG
ATTGCGCCCGAGGAGTTGCCGCGCATCTTCGAGCGCTTCCACCGCGCCAGCCGCGAACGCGAGCGTCATGGCGAAGGCGC
CGGGCTGGGGCTGGCGATCACCCGCTCCATCGTGGAGGTGCATGGCGGCCGGGTGACGGCGGAGTCCGCCGCAGGGCTGA
CCACCTTCCGGATCGAGCTTCCACTGGCCGCCGCGTGA

Upstream 100 bases:

>100_bases
CGGTGCGCCGGTTGCGCGCGAAGGTGGACGACAGCTTCGAACCCAAGCTGATCCGCACTGTGCGCGGGATGGGTTACGTG
CTGGAGGCGCCGGGGGCGGC

Downstream 100 bases:

>100_bases
ACGGTCACGTCGGCCGCAGCCGAATCAAATCGAGAGGATTCATCATGAAAATGCGCATTCCGGACCGCTGCAGCCTGATG
CTGGTGGCACTGCTGGCGGG

Product: two component sensor kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 465; Mature: 464

Protein sequence:

>465_residues
MSARAPLSLTARLALLFAALAASLLIVVGLVMGRAVEAHFRELDDHELSGKLMLIESLLQRADDAAALAGVRQRLDEAFV
GHDTVAVLMRDAGDAVVYALHADHFAAAQRDGAPLAGGGMWTEGGRHYIGREADIALPAGSGAAAGPLRVLLGLDISHHV
HFLDDVRNRLWAGISLSAVAAAVLGWLAAHKGLAPLRRVTAAAERLSAERLGERLAEGAAPAEVRELVEAFNGMLERLES
SFRRLSDFSADIAHELRTPVSNLMTQTEVALSHARSPDEYREVLASNLEEYERIARMVSDMLFLAQAENGRLPRPEERVA
LQDEARALAEFYEALAEEQGVTITVQGAAEVTGDRLMLRRALANLLSNALRHTPRGGTVEIVIDAGQATVTLAVRNPGET
IAPEELPRIFERFHRASRERERHGEGAGLGLAITRSIVEVHGGRVTAESAAGLTTFRIELPLAAA

Sequences:

>Translated_465_residues
MSARAPLSLTARLALLFAALAASLLIVVGLVMGRAVEAHFRELDDHELSGKLMLIESLLQRADDAAALAGVRQRLDEAFV
GHDTVAVLMRDAGDAVVYALHADHFAAAQRDGAPLAGGGMWTEGGRHYIGREADIALPAGSGAAAGPLRVLLGLDISHHV
HFLDDVRNRLWAGISLSAVAAAVLGWLAAHKGLAPLRRVTAAAERLSAERLGERLAEGAAPAEVRELVEAFNGMLERLES
SFRRLSDFSADIAHELRTPVSNLMTQTEVALSHARSPDEYREVLASNLEEYERIARMVSDMLFLAQAENGRLPRPEERVA
LQDEARALAEFYEALAEEQGVTITVQGAAEVTGDRLMLRRALANLLSNALRHTPRGGTVEIVIDAGQATVTLAVRNPGET
IAPEELPRIFERFHRASRERERHGEGAGLGLAITRSIVEVHGGRVTAESAAGLTTFRIELPLAAA
>Mature_464_residues
SARAPLSLTARLALLFAALAASLLIVVGLVMGRAVEAHFRELDDHELSGKLMLIESLLQRADDAAALAGVRQRLDEAFVG
HDTVAVLMRDAGDAVVYALHADHFAAAQRDGAPLAGGGMWTEGGRHYIGREADIALPAGSGAAAGPLRVLLGLDISHHVH
FLDDVRNRLWAGISLSAVAAAVLGWLAAHKGLAPLRRVTAAAERLSAERLGERLAEGAAPAEVRELVEAFNGMLERLESS
FRRLSDFSADIAHELRTPVSNLMTQTEVALSHARSPDEYREVLASNLEEYERIARMVSDMLFLAQAENGRLPRPEERVAL
QDEARALAEFYEALAEEQGVTITVQGAAEVTGDRLMLRRALANLLSNALRHTPRGGTVEIVIDAGQATVTLAVRNPGETI
APEELPRIFERFHRASRERERHGEGAGLGLAITRSIVEVHGGRVTAESAAGLTTFRIELPLAAA

Specific function: Member of the two-component regulatory system CusS/CusR. Copper ion sensor. Could also be a silver ion sensor. Probably activates CusR by phosphorylation [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1786783, Length=473, Percent_Identity=39.7463002114165, Blast_Score=320, Evalue=2e-88,
Organism=Escherichia coli, GI1788279, Length=285, Percent_Identity=33.6842105263158, Blast_Score=176, Evalue=3e-45,
Organism=Escherichia coli, GI1788393, Length=277, Percent_Identity=32.129963898917, Blast_Score=115, Evalue=7e-27,
Organism=Escherichia coli, GI1789403, Length=466, Percent_Identity=25.9656652360515, Blast_Score=109, Evalue=4e-25,
Organism=Escherichia coli, GI1786600, Length=223, Percent_Identity=30.0448430493274, Blast_Score=101, Evalue=8e-23,
Organism=Escherichia coli, GI1790346, Length=282, Percent_Identity=31.9148936170213, Blast_Score=95, Evalue=8e-21,
Organism=Escherichia coli, GI1787894, Length=332, Percent_Identity=33.1325301204819, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI1788713, Length=251, Percent_Identity=24.7011952191235, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI145693157, Length=242, Percent_Identity=26.0330578512397, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1786912, Length=229, Percent_Identity=30.5676855895196, Blast_Score=79, Evalue=6e-16,
Organism=Escherichia coli, GI1789149, Length=343, Percent_Identity=23.9067055393586, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1790551, Length=260, Percent_Identity=28.8461538461538, Blast_Score=75, Evalue=8e-15,
Organism=Escherichia coli, GI1790861, Length=289, Percent_Identity=27.681660899654, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI1790436, Length=220, Percent_Identity=26.3636363636364, Blast_Score=69, Evalue=6e-13,
Organism=Escherichia coli, GI87082128, Length=273, Percent_Identity=25.6410256410256, Blast_Score=68, Evalue=1e-12,
Organism=Escherichia coli, GI1789808, Length=249, Percent_Identity=28.5140562248996, Blast_Score=65, Evalue=1e-11,
Organism=Escherichia coli, GI48994928, Length=233, Percent_Identity=24.0343347639485, Blast_Score=64, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR006290
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 49962; Mature: 49830

Theoretical pI: Translated: 5.73; Mature: 5.73

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSARAPLSLTARLALLFAALAASLLIVVGLVMGRAVEAHFRELDDHELSGKLMLIESLLQ
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHH
RADDAAALAGVRQRLDEAFVGHDTVAVLMRDAGDAVVYALHADHFAAAQRDGAPLAGGGM
HCCHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCEEEEEEECHHHHHHCCCCCCCCCCCC
WTEGGRHYIGREADIALPAGSGAAAGPLRVLLGLDISHHVHFLDDVRNRLWAGISLSAVA
CCCCCCEECCCCCCEEECCCCCCCCCHHHHHHHCCHHHHHHHHHHHHHHHHCCCCHHHHH
AAVLGWLAAHKGLAPLRRVTAAAERLSAERLGERLAEGAAPAEVRELVEAFNGMLERLES
HHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHH
SFRRLSDFSADIAHELRTPVSNLMTQTEVALSHARSPDEYREVLASNLEEYERIARMVSD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHH
MLFLAQAENGRLPRPEERVALQDEARALAEFYEALAEEQGVTITVQGAAEVTGDRLMLRR
HHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCHHHHHHHHHHHH
ALANLLSNALRHTPRGGTVEIVIDAGQATVTLAVRNPGETIAPEELPRIFERFHRASRER
HHHHHHHHHHHCCCCCCEEEEEEECCCEEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHH
ERHGEGAGLGLAITRSIVEVHGGRVTAESAAGLTTFRIELPLAAA
HHCCCCCCCHHHHHHHHHHHCCCEEEECCCCCEEEEEEECCCCCC
>Mature Secondary Structure 
SARAPLSLTARLALLFAALAASLLIVVGLVMGRAVEAHFRELDDHELSGKLMLIESLLQ
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHH
RADDAAALAGVRQRLDEAFVGHDTVAVLMRDAGDAVVYALHADHFAAAQRDGAPLAGGGM
HCCHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCEEEEEEECHHHHHHCCCCCCCCCCCC
WTEGGRHYIGREADIALPAGSGAAAGPLRVLLGLDISHHVHFLDDVRNRLWAGISLSAVA
CCCCCCEECCCCCCEEECCCCCCCCCHHHHHHHCCHHHHHHHHHHHHHHHHCCCCHHHHH
AAVLGWLAAHKGLAPLRRVTAAAERLSAERLGERLAEGAAPAEVRELVEAFNGMLERLES
HHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHH
SFRRLSDFSADIAHELRTPVSNLMTQTEVALSHARSPDEYREVLASNLEEYERIARMVSD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHH
MLFLAQAENGRLPRPEERVALQDEARALAEFYEALAEEQGVTITVQGAAEVTGDRLMLRR
HHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCHHHHHHHHHHHH
ALANLLSNALRHTPRGGTVEIVIDAGQATVTLAVRNPGETIAPEELPRIFERFHRASRER
HHHHHHHHHHHCCCCCCEEEEEEECCCEEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHH
ERHGEGAGLGLAITRSIVEVHGGRVTAESAAGLTTFRIELPLAAA
HHCCCCCCCHHHHHHHHHHHCCCEEEECCCCCEEEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]