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The map label for this gene is tkt [H]

Identifier: 119899126

GI number: 119899126

Start: 3114267

End: 3116330

Strand: Direct

Name: tkt [H]

Synonym: azo2836

Alternate gene names: 119899126

Gene position: 3114267-3116330 (Clockwise)

Preceding gene: 119899125

Following gene: 119899127

Centisome position: 71.17

GC content: 67.83

Gene sequence:

>2064_bases
ATGCCGGTTTTTTCAGGCCGGCCCTCCGGCTTCGAGGAAACCATGTCGCAGTCGAGAAACGTCAAGCCCCCGGTCTTCAA
CCCCGTCACTGGCGCCATCCGCGCACTTGCGATGGATGCAGTGCAGCAGGCCAACTCCGGCCATCCGGGTGCGCCGATGG
GCATGGCGGAAATCGCCGAGGTGCTGTGGCGCCACCACCTCAAGCACAATCCGGCCAACCCGCATTGGGCCGACCGCGAC
CGCTTCGTGCTGTCCAACGGCCATGGCTCGATGCTGATCTACGCGCTGCTGCACCTCACCGGCTACGACCTGCCGATCGA
GGAAATCAAGCGCTTCCGCCAGCTGCACAGCAAGACGCCGGGCCATCCGGAATACGGCTACACCCCGGGCGTGGAAACCA
CCACCGGTCCGCTCGGCCAGGGCATCACCAACGCGGTCGGCATGGCCATCGCCGAAAAGGTGCTGGCGGCCGAATTCAAC
CGCGCCGGCCATGAAATCGTCGACCACCGCACTTGGGTCTTCCTGGGCGACGGCTGCCTGATGGAAGGCATCAGCCACGA
AGCCTGTTCGCTTGCCGGCACGCTCGGCCTGGGCAAGCTGGTCGCGTTCTACGACGACAACAATATCTCCATCGACGGCC
ACGTCGAAGGCTGGTTCACCGACGACACCCCCAAGCGCTTCGAAGCCTACGGCTGGCAGGTGATCCGTGACGTGCAGGGC
CACGACCCGGCCGAAATCGAAGCCGCCATCCAGCAGGCGCGGGCCAACACCACCCAGCCCACGCTGATCTGCTGCAAAAC
CGTCATCGGCGCCGGCGCCCCTAACAAGCAGGGCGGCCACGACGTGCACGGCGCGCCGCTCGGCACCACCGAAATCGACG
CCTGCCGCGCCCACATCGGCTGGACGCACGCTCCGTTCGAAATCCCGGCCGACGTCTATGCTGCGTGGGACGCGCGCCCG
GCCGGCGCCAGCGCCGAAGCCGGCTGGAACGACAAGTTCGCTGCCTACGCCGCCGCCTTCCCCGAACTCGCGGCCGAGTT
CAAGCGCCGCGTGCAGCAGCAGGCGCTGCCGGCCGACTGGGCGGCGCACGTCGCCACCGTGCTCGGCAAGATCAATGACA
AGGGCGAAACCATCGCCACCCGCAAGGCCAGCCAGAACAGCATCGAGGCCTTCGCGCCCAAGCTGCCCGAACTCATCGGC
GGCTCGGCCGACCTCGCCGGCTCCAACCTTACGCTGTGGTCGGGCGCCAAGGGCGTCAGCCGCGACACCGGCGGCAACTA
CATCTACTACGGCGTGCGCGAATTCGGCATGGCGGCCATCGCCAACGGCATCGCGCTGCATGGCGGCCTGATTCCCTACA
CCGCCACCTTCCTGATGTTCAGCGAATACGCCCGCAATGCCCTGCGCATGGCGGCGCTGATGAAGCTGCGCCAGATCTTC
GTGTTCACCCACGACTCCATCGGCCTTGGCGAAGACGGCCCCACCCACCAGCCGGTGGAACAGACCGCCACGCTGCGCCT
GATTCCCAACATGGACGTCTGGCGCCCGTGCGACACGATGGAGTCCGCGGTGGCCTGGGCGCACGCGATCGAGCGTAAGG
ACGGCCCGTCCTGCCTGCTGTTCTCGCGCCAGAACCTGCCCTTCCAGGCCCGCAGCGCCGAGCAGATCGACGCCATCCGC
CGGGGCGGCTACGTGCTGTCGGAAGCCGCGGGCGGCACGCCGAAGGCGGTCATCCTCGCCACCGGCTCGGAAGTCGCGCT
CGCGATGGCCGCGCAGAAGACGCTGGCCGAGGCCGGCATCGCGGTGCGCGTGGTGTCGATGCCGAGCACCAACGTATTCG
ACCGTCAGGATGCCGCCTACAAGGCCGCCGTCCTGCCCGCCGGCCTGCCGCGCATTGCGGTCGAAGCCGGCGTCACCGAC
GGCTGGCGCAAGTATGTCGGCCTCGAAGGCGAGGTGATCGGCCTCGACCGCTTCGGTGAATCCGCCCCCGCGGGCGAGCT
GTTCAAGTACTTCGGCATTACCGCCGACGCGGTCGTCGAAGCCGTCCGCAAGCTCGTCCGGTAA

Upstream 100 bases:

>100_bases
GGACAGCCCCTTCCAGGGCGAAAATTCACGCGCCGGACCAGACACTTACCACATCCTGTCACCAAGCCGAACTACCAATC
GGACCGGGTTATCGGCGATA

Downstream 100 bases:

>100_bases
TTCGCACGGCGATGGCAGGGACCCGATCAGACGCCCCGCCATCGCGCCGCCAACCAGTTCTGATGCCTGTGTTGCCCACG
CTCCTGGAGACTCCTCGATG

Product: transketolase

Products: NA

Alternate protein names: TK 1 [H]

Number of amino acids: Translated: 687; Mature: 686

Protein sequence:

>687_residues
MPVFSGRPSGFEETMSQSRNVKPPVFNPVTGAIRALAMDAVQQANSGHPGAPMGMAEIAEVLWRHHLKHNPANPHWADRD
RFVLSNGHGSMLIYALLHLTGYDLPIEEIKRFRQLHSKTPGHPEYGYTPGVETTTGPLGQGITNAVGMAIAEKVLAAEFN
RAGHEIVDHRTWVFLGDGCLMEGISHEACSLAGTLGLGKLVAFYDDNNISIDGHVEGWFTDDTPKRFEAYGWQVIRDVQG
HDPAEIEAAIQQARANTTQPTLICCKTVIGAGAPNKQGGHDVHGAPLGTTEIDACRAHIGWTHAPFEIPADVYAAWDARP
AGASAEAGWNDKFAAYAAAFPELAAEFKRRVQQQALPADWAAHVATVLGKINDKGETIATRKASQNSIEAFAPKLPELIG
GSADLAGSNLTLWSGAKGVSRDTGGNYIYYGVREFGMAAIANGIALHGGLIPYTATFLMFSEYARNALRMAALMKLRQIF
VFTHDSIGLGEDGPTHQPVEQTATLRLIPNMDVWRPCDTMESAVAWAHAIERKDGPSCLLFSRQNLPFQARSAEQIDAIR
RGGYVLSEAAGGTPKAVILATGSEVALAMAAQKTLAEAGIAVRVVSMPSTNVFDRQDAAYKAAVLPAGLPRIAVEAGVTD
GWRKYVGLEGEVIGLDRFGESAPAGELFKYFGITADAVVEAVRKLVR

Sequences:

>Translated_687_residues
MPVFSGRPSGFEETMSQSRNVKPPVFNPVTGAIRALAMDAVQQANSGHPGAPMGMAEIAEVLWRHHLKHNPANPHWADRD
RFVLSNGHGSMLIYALLHLTGYDLPIEEIKRFRQLHSKTPGHPEYGYTPGVETTTGPLGQGITNAVGMAIAEKVLAAEFN
RAGHEIVDHRTWVFLGDGCLMEGISHEACSLAGTLGLGKLVAFYDDNNISIDGHVEGWFTDDTPKRFEAYGWQVIRDVQG
HDPAEIEAAIQQARANTTQPTLICCKTVIGAGAPNKQGGHDVHGAPLGTTEIDACRAHIGWTHAPFEIPADVYAAWDARP
AGASAEAGWNDKFAAYAAAFPELAAEFKRRVQQQALPADWAAHVATVLGKINDKGETIATRKASQNSIEAFAPKLPELIG
GSADLAGSNLTLWSGAKGVSRDTGGNYIYYGVREFGMAAIANGIALHGGLIPYTATFLMFSEYARNALRMAALMKLRQIF
VFTHDSIGLGEDGPTHQPVEQTATLRLIPNMDVWRPCDTMESAVAWAHAIERKDGPSCLLFSRQNLPFQARSAEQIDAIR
RGGYVLSEAAGGTPKAVILATGSEVALAMAAQKTLAEAGIAVRVVSMPSTNVFDRQDAAYKAAVLPAGLPRIAVEAGVTD
GWRKYVGLEGEVIGLDRFGESAPAGELFKYFGITADAVVEAVRKLVR
>Mature_686_residues
PVFSGRPSGFEETMSQSRNVKPPVFNPVTGAIRALAMDAVQQANSGHPGAPMGMAEIAEVLWRHHLKHNPANPHWADRDR
FVLSNGHGSMLIYALLHLTGYDLPIEEIKRFRQLHSKTPGHPEYGYTPGVETTTGPLGQGITNAVGMAIAEKVLAAEFNR
AGHEIVDHRTWVFLGDGCLMEGISHEACSLAGTLGLGKLVAFYDDNNISIDGHVEGWFTDDTPKRFEAYGWQVIRDVQGH
DPAEIEAAIQQARANTTQPTLICCKTVIGAGAPNKQGGHDVHGAPLGTTEIDACRAHIGWTHAPFEIPADVYAAWDARPA
GASAEAGWNDKFAAYAAAFPELAAEFKRRVQQQALPADWAAHVATVLGKINDKGETIATRKASQNSIEAFAPKLPELIGG
SADLAGSNLTLWSGAKGVSRDTGGNYIYYGVREFGMAAIANGIALHGGLIPYTATFLMFSEYARNALRMAALMKLRQIFV
FTHDSIGLGEDGPTHQPVEQTATLRLIPNMDVWRPCDTMESAVAWAHAIERKDGPSCLLFSRQNLPFQARSAEQIDAIRR
GGYVLSEAAGGTPKAVILATGSEVALAMAAQKTLAEAGIAVRVVSMPSTNVFDRQDAAYKAAVLPAGLPRIAVEAGVTDG
WRKYVGLEGEVIGLDRFGESAPAGELFKYFGITADAVVEAVRKLVR

Specific function: Unknown

COG id: COG0021

COG function: function code G; Transketolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family [H]

Homologues:

Organism=Homo sapiens, GI205277463, Length=666, Percent_Identity=26.7267267267267, Blast_Score=172, Evalue=1e-42,
Organism=Homo sapiens, GI4507521, Length=666, Percent_Identity=26.7267267267267, Blast_Score=172, Evalue=1e-42,
Organism=Homo sapiens, GI133778974, Length=677, Percent_Identity=25.5539143279173, Blast_Score=141, Evalue=2e-33,
Organism=Escherichia coli, GI48994911, Length=659, Percent_Identity=67.5265553869499, Blast_Score=951, Evalue=0.0,
Organism=Escherichia coli, GI1788808, Length=659, Percent_Identity=62.8224582701062, Blast_Score=882, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17539652, Length=674, Percent_Identity=25.3709198813056, Blast_Score=160, Evalue=2e-39,
Organism=Saccharomyces cerevisiae, GI6325331, Length=666, Percent_Identity=48.7987987987988, Blast_Score=595, Evalue=1e-171,
Organism=Saccharomyces cerevisiae, GI6319593, Length=666, Percent_Identity=44.8948948948949, Blast_Score=542, Evalue=1e-155,
Organism=Drosophila melanogaster, GI45551847, Length=674, Percent_Identity=25.8160237388724, Blast_Score=160, Evalue=3e-39,
Organism=Drosophila melanogaster, GI45550715, Length=674, Percent_Identity=25.8160237388724, Blast_Score=160, Evalue=3e-39,
Organism=Drosophila melanogaster, GI24666278, Length=589, Percent_Identity=25.8064516129032, Blast_Score=148, Evalue=1e-35,
Organism=Drosophila melanogaster, GI24645119, Length=646, Percent_Identity=25.3869969040248, Blast_Score=141, Evalue=2e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR005478
- InterPro:   IPR020826
- InterPro:   IPR005476
- InterPro:   IPR005474 [H]

Pfam domain/function: PF02779 Transket_pyr; PF02780 Transketolase_C; PF00456 Transketolase_N [H]

EC number: =2.2.1.1 [H]

Molecular weight: Translated: 73770; Mature: 73639

Theoretical pI: Translated: 6.40; Mature: 6.40

Prosite motif: PS00801 TRANSKETOLASE_1 ; PS00802 TRANSKETOLASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPVFSGRPSGFEETMSQSRNVKPPVFNPVTGAIRALAMDAVQQANSGHPGAPMGMAEIAE
CCCCCCCCCCHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHH
VLWRHHLKHNPANPHWADRDRFVLSNGHGSMLIYALLHLTGYDLPIEEIKRFRQLHSKTP
HHHHHHHCCCCCCCCCCCCCCEEEECCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCC
GHPEYGYTPGVETTTGPLGQGITNAVGMAIAEKVLAAEFNRAGHEIVDHRTWVFLGDGCL
CCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCEEEEECCCHH
MEGISHEACSLAGTLGLGKLVAFYDDNNISIDGHVEGWFTDDTPKRFEAYGWQVIRDVQG
HHCCCHHHHHHHHHCCCCEEEEEEECCCEEECCEEEEEECCCCCHHHHHHHHHHHHHCCC
HDPAEIEAAIQQARANTTQPTLICCKTVIGAGAPNKQGGHDVHGAPLGTTEIDACRAHIG
CCHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCC
WTHAPFEIPADVYAAWDARPAGASAEAGWNDKFAAYAAAFPELAAEFKRRVQQQALPADW
CCCCCCCCCHHHHEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHH
AAHVATVLGKINDKGETIATRKASQNSIEAFAPKLPELIGGSADLAGSNLTLWSGAKGVS
HHHHHHHHHHCCCCCCEEEECCCCCCHHHHHHHHHHHHHCCCCCCCCCCEEEECCCCCCC
RDTGGNYIYYGVREFGMAAIANGIALHGGLIPYTATFLMFSEYARNALRMAALMKLRQIF
CCCCCCEEEECHHHHHHHHHHCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VFTHDSIGLGEDGPTHQPVEQTATLRLIPNMDVWRPCDTMESAVAWAHAIERKDGPSCLL
EEECCCCCCCCCCCCCCCHHHCEEEEECCCCCCCCCHHHHHHHHHHHHHHHCCCCCCEEE
FSRQNLPFQARSAEQIDAIRRGGYVLSEAAGGTPKAVILATGSEVALAMAAQKTLAEAGI
EECCCCCCCCCCHHHHHHHHHCCEEEECCCCCCCCEEEEECCCHHHHHHHHHHHHHHCCC
AVRVVSMPSTNVFDRQDAAYKAAVLPAGLPRIAVEAGVTDGWRKYVGLEGEVIGLDRFGE
EEEEEECCCCCCCCCCCHHHHHHHCCCCCCHHHHCCCCCHHHHHHHCCCCCEEEHHHCCC
SAPAGELFKYFGITADAVVEAVRKLVR
CCCHHHHHHHHCCCHHHHHHHHHHHHC
>Mature Secondary Structure 
PVFSGRPSGFEETMSQSRNVKPPVFNPVTGAIRALAMDAVQQANSGHPGAPMGMAEIAE
CCCCCCCCCHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHH
VLWRHHLKHNPANPHWADRDRFVLSNGHGSMLIYALLHLTGYDLPIEEIKRFRQLHSKTP
HHHHHHHCCCCCCCCCCCCCCEEEECCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCC
GHPEYGYTPGVETTTGPLGQGITNAVGMAIAEKVLAAEFNRAGHEIVDHRTWVFLGDGCL
CCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCEEEEECCCHH
MEGISHEACSLAGTLGLGKLVAFYDDNNISIDGHVEGWFTDDTPKRFEAYGWQVIRDVQG
HHCCCHHHHHHHHHCCCCEEEEEEECCCEEECCEEEEEECCCCCHHHHHHHHHHHHHCCC
HDPAEIEAAIQQARANTTQPTLICCKTVIGAGAPNKQGGHDVHGAPLGTTEIDACRAHIG
CCHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCC
WTHAPFEIPADVYAAWDARPAGASAEAGWNDKFAAYAAAFPELAAEFKRRVQQQALPADW
CCCCCCCCCHHHHEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHH
AAHVATVLGKINDKGETIATRKASQNSIEAFAPKLPELIGGSADLAGSNLTLWSGAKGVS
HHHHHHHHHHCCCCCCEEEECCCCCCHHHHHHHHHHHHHCCCCCCCCCCEEEECCCCCCC
RDTGGNYIYYGVREFGMAAIANGIALHGGLIPYTATFLMFSEYARNALRMAALMKLRQIF
CCCCCCEEEECHHHHHHHHHHCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VFTHDSIGLGEDGPTHQPVEQTATLRLIPNMDVWRPCDTMESAVAWAHAIERKDGPSCLL
EEECCCCCCCCCCCCCCCHHHCEEEEECCCCCCCCCHHHHHHHHHHHHHHHCCCCCCEEE
FSRQNLPFQARSAEQIDAIRRGGYVLSEAAGGTPKAVILATGSEVALAMAAQKTLAEAGI
EECCCCCCCCCCHHHHHHHHHCCEEEECCCCCCCCEEEEECCCHHHHHHHHHHHHHHCCC
AVRVVSMPSTNVFDRQDAAYKAAVLPAGLPRIAVEAGVTDGWRKYVGLEGEVIGLDRFGE
EEEEEECCCCCCCCCCCHHHHHHHCCCCCCHHHHCCCCCHHHHHHHCCCCCEEEHHHCCC
SAPAGELFKYFGITADAVVEAVRKLVR
CCCHHHHHHHHCCCHHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10952301 [H]