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The map label for this gene is mtaD [H]

Identifier: 119898878

GI number: 119898878

Start: 2866190

End: 2867509

Strand: Direct

Name: mtaD [H]

Synonym: azo2587

Alternate gene names: 119898878

Gene position: 2866190-2867509 (Clockwise)

Preceding gene: 119898877

Following gene: 119898879

Centisome position: 65.5

GC content: 65.98

Gene sequence:

>1320_bases
GTGAGCAACACAGTCGATCTCCTCATCTTCGCGCGCTGGATCATCCCGATCGAGCCGGCCGCCACGGTTCTAGAAAACCA
CGCGCTCGCGGTGCGCGACGGACGCATCATCGCGCTGCTACCGAGCACCGAGGCGCGCGCGCAGTACACCGCCACCCGCG
AGTTCCTGCTGGACCACCACGTCCTGCTGCCCGGGCTGGTCAATGCCCACACCCATGCTGCGATGAATCTGATGCGCGGC
ATCGCTGACGACCTGCCGCTGATGCGATGGCTGCAGGAGGCGATCTGGCCGGTGGAAGGACAGCACGTCAGCGCCGAATT
CGTGCGCGACGGCACACTGCTTGCGATCGCCGAAATGCTGCGAGGCGGCATCACGACCTTCAACGACATGTACTTCCATC
CCGAGGCCGCGGCCGAAGCCGCCGACATGCTGGGGATGCGCGCGCTACTGGGGCTCGTCGTCATCGACGCGCCGACTCCC
TACGCCAGTGACGCCGATGATTACCTCGCCAAGGGGCTCGCGGTAAGGGACCGCTGGCGCAGCCACCCGCGGATCGGCTT
CGCCCTGGCGCCCCACGCGCCGTACACCGTGTCCGACCGGAGCTTCGAACGCATTGCCAGCTTTGCCGGCGAACTCGACC
TCCCGGTCCACATCCACCTGCACGAAAGCGCGGACGAGATCCGGGGCTCGCTCGCCGAACATCAGTTGCGCCCGATTTCA
CGTCTCGCGCACCTCGGCCTTCTCGGCGAGAACCTGCTCGGCATCCATGCCGTGCATCTCGACGACAGCGACATCGACCT
CCTTGCCCGTCACCGTTGCGCGATCGCGCACTGCCCCACATCGAACATGAAGTTGGCCAGCGGCATCGCCCCGATCGCGC
GCGCCGCGTCGGCTGGCATCACCGTTGCCTTGGGAACGGACGGCGCAGCCAGCAACAACCGGCTCGACATCCTGCAGGAA
ATGCGCCACGCAGCCCTGCTGGCGAAGGTCTCCACCGGCGACGCGAGCGCACTGCCCGCTCACCAGGTGCTGCGCATGGC
GACGCTAAACGGCGCATGCGCACTCGGGCTCGACGAGCGCATCGGCTCACTCGCGGTGGGCAAGCAGGCCGACCTGTGCG
CGATCGACCTGTCCTCGATCGCGACCCAACCCTGCTTCGACCCCGCCTCGCACGTGGTCTATGCTGCCGGCCGCGAGCAC
GTCTCCCACGTCTGGATTGACGGCGAAACCCGCGTGGATCAAGGCATTGCGCTGTTGCAAATAAGCGACAGAGAATTGCT
CAGGCTCGCAGCGCTGTGGCAAACTAAACTCGTTAATTGA

Upstream 100 bases:

>100_bases
TGTTGTTCGGTTGCCCGCGTACCAACAACAACGCATCCGACCTGCCCGCACGGCGTGACGACGACCCCTGCCGGCGCGAC
GAACACCTGGAGCCACAAGC

Downstream 100 bases:

>100_bases
ACTGGATAATTCAGCTAATCCGGCTCGATCCGACAAGAATTCGGCTATGTTGAGGCTGTATTCCTGCTTTAATTCGAAAG
CAGCGGCGCTTTCAGTCTTT

Product: N-ethylammeline chlorohydrolase

Products: NA

Alternate protein names: MTA/SAH deaminase [H]

Number of amino acids: Translated: 439; Mature: 438

Protein sequence:

>439_residues
MSNTVDLLIFARWIIPIEPAATVLENHALAVRDGRIIALLPSTEARAQYTATREFLLDHHVLLPGLVNAHTHAAMNLMRG
IADDLPLMRWLQEAIWPVEGQHVSAEFVRDGTLLAIAEMLRGGITTFNDMYFHPEAAAEAADMLGMRALLGLVVIDAPTP
YASDADDYLAKGLAVRDRWRSHPRIGFALAPHAPYTVSDRSFERIASFAGELDLPVHIHLHESADEIRGSLAEHQLRPIS
RLAHLGLLGENLLGIHAVHLDDSDIDLLARHRCAIAHCPTSNMKLASGIAPIARAASAGITVALGTDGAASNNRLDILQE
MRHAALLAKVSTGDASALPAHQVLRMATLNGACALGLDERIGSLAVGKQADLCAIDLSSIATQPCFDPASHVVYAAGREH
VSHVWIDGETRVDQGIALLQISDRELLRLAALWQTKLVN

Sequences:

>Translated_439_residues
MSNTVDLLIFARWIIPIEPAATVLENHALAVRDGRIIALLPSTEARAQYTATREFLLDHHVLLPGLVNAHTHAAMNLMRG
IADDLPLMRWLQEAIWPVEGQHVSAEFVRDGTLLAIAEMLRGGITTFNDMYFHPEAAAEAADMLGMRALLGLVVIDAPTP
YASDADDYLAKGLAVRDRWRSHPRIGFALAPHAPYTVSDRSFERIASFAGELDLPVHIHLHESADEIRGSLAEHQLRPIS
RLAHLGLLGENLLGIHAVHLDDSDIDLLARHRCAIAHCPTSNMKLASGIAPIARAASAGITVALGTDGAASNNRLDILQE
MRHAALLAKVSTGDASALPAHQVLRMATLNGACALGLDERIGSLAVGKQADLCAIDLSSIATQPCFDPASHVVYAAGREH
VSHVWIDGETRVDQGIALLQISDRELLRLAALWQTKLVN
>Mature_438_residues
SNTVDLLIFARWIIPIEPAATVLENHALAVRDGRIIALLPSTEARAQYTATREFLLDHHVLLPGLVNAHTHAAMNLMRGI
ADDLPLMRWLQEAIWPVEGQHVSAEFVRDGTLLAIAEMLRGGITTFNDMYFHPEAAAEAADMLGMRALLGLVVIDAPTPY
ASDADDYLAKGLAVRDRWRSHPRIGFALAPHAPYTVSDRSFERIASFAGELDLPVHIHLHESADEIRGSLAEHQLRPISR
LAHLGLLGENLLGIHAVHLDDSDIDLLARHRCAIAHCPTSNMKLASGIAPIARAASAGITVALGTDGAASNNRLDILQEM
RHAALLAKVSTGDASALPAHQVLRMATLNGACALGLDERIGSLAVGKQADLCAIDLSSIATQPCFDPASHVVYAAGREHV
SHVWIDGETRVDQGIALLQISDRELLRLAALWQTKLVN

Specific function: Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine [H]

COG id: COG0402

COG function: function code FR; Cytosine deaminase and related metal-dependent hydrolases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MTA/SAH deaminase family [H]

Homologues:

Organism=Homo sapiens, GI4758426, Length=395, Percent_Identity=26.0759493670886, Blast_Score=141, Evalue=1e-33,
Organism=Escherichia coli, GI1789249, Length=334, Percent_Identity=30.8383233532934, Blast_Score=145, Evalue=4e-36,
Organism=Escherichia coli, GI87082177, Length=405, Percent_Identity=22.7160493827161, Blast_Score=70, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17540282, Length=392, Percent_Identity=25.2551020408163, Blast_Score=110, Evalue=1e-24,
Organism=Saccharomyces cerevisiae, GI6319963, Length=336, Percent_Identity=26.7857142857143, Blast_Score=123, Evalue=5e-29,
Organism=Drosophila melanogaster, GI24643849, Length=430, Percent_Identity=27.6744186046512, Blast_Score=146, Evalue=4e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006680
- InterPro:   IPR011059 [H]

Pfam domain/function: PF01979 Amidohydro_1 [H]

EC number: =3.5.4.28 [H]

Molecular weight: Translated: 47445; Mature: 47314

Theoretical pI: Translated: 6.17; Mature: 6.17

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNTVDLLIFARWIIPIEPAATVLENHALAVRDGRIIALLPSTEARAQYTATREFLLDHH
CCCCCEEHEEHHHHCCCCHHHHHHHCCEEEEECCEEEEEECCCCHHHHHHHHHHHHHHHH
VLLPGLVNAHTHAAMNLMRGIADDLPLMRWLQEAIWPVEGQHVSAEFVRDGTLLAIAEML
HHHCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCEEEHHHHCCCHHHHHHHHH
RGGITTFNDMYFHPEAAAEAADMLGMRALLGLVVIDAPTPYASDADDYLAKGLAVRDRWR
HCCCCCCCCEEECCHHHHHHHHHHHHHHHHCEEEEECCCCCCCCCHHHHHHCHHHHHHHC
SHPRIGFALAPHAPYTVSDRSFERIASFAGELDLPVHIHLHESADEIRGSLAEHQLRPIS
CCCCEEEEECCCCCCEECCHHHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHHHHHHHHH
RLAHLGLLGENLLGIHAVHLDDSDIDLLARHRCAIAHCPTSNMKLASGIAPIARAASAGI
HHHHHHHHCCCCEEEEEEEECCCCHHHHHHCCEEEEECCCCCCCHHHCHHHHHHHHCCCE
TVALGTDGAASNNRLDILQEMRHAALLAKVSTGDASALPAHQVLRMATLNGACALGLDER
EEEECCCCCCCCCHHHHHHHHHHHHHHEEECCCCCCCCCHHHHHHHHHCCCCEEECHHHH
IGSLAVGKQADLCAIDLSSIATQPCFDPASHVVYAAGREHVSHVWIDGETRVDQGIALLQ
HCCEECCCCCCEEEEEHHHHCCCCCCCCHHHEEEECCCCCCEEEEECCCCCCCCCEEEEE
ISDRELLRLAALWQTKLVN
ECCHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SNTVDLLIFARWIIPIEPAATVLENHALAVRDGRIIALLPSTEARAQYTATREFLLDHH
CCCCEEHEEHHHHCCCCHHHHHHHCCEEEEECCEEEEEECCCCHHHHHHHHHHHHHHHH
VLLPGLVNAHTHAAMNLMRGIADDLPLMRWLQEAIWPVEGQHVSAEFVRDGTLLAIAEML
HHHCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCEEEHHHHCCCHHHHHHHHH
RGGITTFNDMYFHPEAAAEAADMLGMRALLGLVVIDAPTPYASDADDYLAKGLAVRDRWR
HCCCCCCCCEEECCHHHHHHHHHHHHHHHHCEEEEECCCCCCCCCHHHHHHCHHHHHHHC
SHPRIGFALAPHAPYTVSDRSFERIASFAGELDLPVHIHLHESADEIRGSLAEHQLRPIS
CCCCEEEEECCCCCCEECCHHHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHHHHHHHHH
RLAHLGLLGENLLGIHAVHLDDSDIDLLARHRCAIAHCPTSNMKLASGIAPIARAASAGI
HHHHHHHHCCCCEEEEEEEECCCCHHHHHHCCEEEEECCCCCCCHHHCHHHHHHHHCCCE
TVALGTDGAASNNRLDILQEMRHAALLAKVSTGDASALPAHQVLRMATLNGACALGLDER
EEEECCCCCCCCCHHHHHHHHHHHHHHEEECCCCCCCCCHHHHHHHHHCCCCEEECHHHH
IGSLAVGKQADLCAIDLSSIATQPCFDPASHVVYAAGREHVSHVWIDGETRVDQGIALLQ
HCCEECCCCCCEEEEEHHHHCCCCCCCCHHHEEEECCCCCCEEEEECCCCCCCCCEEEEE
ISDRELLRLAALWQTKLVN
ECCHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA