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The map label for this gene is groEL3

Identifier: 119898657

GI number: 119898657

Start: 2606556

End: 2608199

Strand: Direct

Name: groEL3

Synonym: azo2366

Alternate gene names: 119898657

Gene position: 2606556-2608199 (Clockwise)

Preceding gene: 119898656

Following gene: 119898659

Centisome position: 59.56

GC content: 67.4

Gene sequence:

>1644_bases
ATGGCCGCCAAACAAGTGCTTTTCGGTGACGACGCCCGCGCCAAGGTCGTGCAAGGCGTCAACATCCTCGCCAACGCCGT
CAAGGTGACCCTCGGCCCCAAGGGCCGCAACGTGGTGCTGGAGCGCTCCTTCGGCGCGCCCACCGTGACCAAGGACGGCG
TCTCGGTCGCCAAGGAAATCGAGCTGAAGGACAAGTTCGAGAACATCGGCGCGCAGCTGGTGAAGGAAGTCGCCTCCAAG
ACCGCCGACAACGCCGGTGACGGCACCACCACCGCCACCGTGCTGGCCCAGGCCATCGTGCGCGAAGGCTTCAAGTTCGT
CGCCGCCGGCTTCAACCCGGCCGACCTCAAGCGCGGCATCGACAAGGCGGTGGCCGCCATCGTCGACGAGCTGAAGGCCC
TGTCCAAGCCGACCACCACCAGCAAGGAAATCGCCCAGGTCGGCGCCATTTCCGCCAATTCGGACGCCGACATCGGCGAC
ATCATCGCCAAGGCCATCGACAAGGTGGGCAAGGAAGGCGTCATCACCGTCGAGGACGGCAAGTCGCTGAATAACGAACT
CGACGTGGTCGAGGGTCTGCAGTTCGACCGCGGCTACCTGTCGCCCTACTTCATCAACAACCCGGACAAGCAGGTCGCCG
AACTCGACAACCCCTTCATCCTGCTGTTCGACAAGAAGATCTCCAACATCCGCGAGCTGCTGCCGGTGCTGGAGCAGGTC
GCCAAGGCCGGCAGCCCGCTGCTGGTCGTCGCCGAGGATGTCGACGGCGAAGCGCTCGCCACCCTGGTGGTGAACACCAT
CCGCGGCATCCTCAAGGTGGTGGCGGTGAAGGCGCCGGGCTTCGGCGACCGCCGCAAGGCCATTCTGGAAGACATCGCCA
TCCTCACCGGCGGCCAGGTGATCGCCGAGGAAGTCGGCCTCAGCCTGGAAAAGGCCACGCTCGCCGACCTCGGCCAGGCC
AAGCGCGTCGAGGTGCAAAAGGAGAACACCACGCTGATCGACGGCGCCGGCAGTGTCGAGGCGATCAAGGCGCGCGTGTC
CTCGATCGACGCCCTGATCGCCGCCGCCACTTCCGACTACGACCGCGAGAAGCTGCAGGAACGCAAGGCCAAGCTGGCTG
GCGGCGTCGCCGTCATCAAGGTGGGCGCGGCCACCGAAGTGGAGCTGAAGGAGAAGAAGGCGCGCGTCGAGGATGCGCTG
CATGCCACCCGCGCCGCGGTGGAAGAAGGCATCGTGCCCGGCGGCGGCGTCGCCCTGCTGCGCGCCCGTGCCGCGATCAA
GGACCTGAAGGGCGACAACCACGAGCAGGACGCCGGCATCAAGATCGTGCTGCGCGCGGTGGAAGAGCCGCTGCGCCAGA
TCGTCGCCAACGCCGGCGACGAGGCCTCGGTGGTGGTGGCCCGCGTGCTCGAAGGCAGCGGCAACTTCGGCTACAACGCC
GCCAACGGCCAGTACGGCGATCTGGTGGAACAGGGCGTGCTGGACCCCGCCAAGGTCACCCGCTCCGCATTGCAGAACGC
CGCCTCGGTCGCGGCGCTGATCCTCACCACTGACGCGCTGGTGGCCGAACAGGCGGACGACAAGCCGGCCACGGCCGGCC
TGCCGCACGGCGGGCCGGGCGGGTTCGGCGGGCCGGAGTTCTAA

Upstream 100 bases:

>100_bases
AAGTGCTCGTCGTGCGCGAAGAAGACATTTTCGGCGTCATCGAATAAGCCGCCGCCCCCGCCGCCTCAACTCATCCAACA
CACAGCCAACGGAGCAATAC

Downstream 100 bases:

>100_bases
GGCCGCGTCGAAAGCGGTCGCCCAAGGAGGAAATGCCCCGCATCCGCGGGGCATTTTTTTTTGGGGCCGCGCTATCAACC
CGGCGCGTAGAGCCGCTCCA

Product: chaperonin GroEL

Products: NA

Alternate protein names: GroEL protein 2; Protein Cpn60 2

Number of amino acids: Translated: 547; Mature: 546

Protein sequence:

>547_residues
MAAKQVLFGDDARAKVVQGVNILANAVKVTLGPKGRNVVLERSFGAPTVTKDGVSVAKEIELKDKFENIGAQLVKEVASK
TADNAGDGTTTATVLAQAIVREGFKFVAAGFNPADLKRGIDKAVAAIVDELKALSKPTTTSKEIAQVGAISANSDADIGD
IIAKAIDKVGKEGVITVEDGKSLNNELDVVEGLQFDRGYLSPYFINNPDKQVAELDNPFILLFDKKISNIRELLPVLEQV
AKAGSPLLVVAEDVDGEALATLVVNTIRGILKVVAVKAPGFGDRRKAILEDIAILTGGQVIAEEVGLSLEKATLADLGQA
KRVEVQKENTTLIDGAGSVEAIKARVSSIDALIAAATSDYDREKLQERKAKLAGGVAVIKVGAATEVELKEKKARVEDAL
HATRAAVEEGIVPGGGVALLRARAAIKDLKGDNHEQDAGIKIVLRAVEEPLRQIVANAGDEASVVVARVLEGSGNFGYNA
ANGQYGDLVEQGVLDPAKVTRSALQNAASVAALILTTDALVAEQADDKPATAGLPHGGPGGFGGPEF

Sequences:

>Translated_547_residues
MAAKQVLFGDDARAKVVQGVNILANAVKVTLGPKGRNVVLERSFGAPTVTKDGVSVAKEIELKDKFENIGAQLVKEVASK
TADNAGDGTTTATVLAQAIVREGFKFVAAGFNPADLKRGIDKAVAAIVDELKALSKPTTTSKEIAQVGAISANSDADIGD
IIAKAIDKVGKEGVITVEDGKSLNNELDVVEGLQFDRGYLSPYFINNPDKQVAELDNPFILLFDKKISNIRELLPVLEQV
AKAGSPLLVVAEDVDGEALATLVVNTIRGILKVVAVKAPGFGDRRKAILEDIAILTGGQVIAEEVGLSLEKATLADLGQA
KRVEVQKENTTLIDGAGSVEAIKARVSSIDALIAAATSDYDREKLQERKAKLAGGVAVIKVGAATEVELKEKKARVEDAL
HATRAAVEEGIVPGGGVALLRARAAIKDLKGDNHEQDAGIKIVLRAVEEPLRQIVANAGDEASVVVARVLEGSGNFGYNA
ANGQYGDLVEQGVLDPAKVTRSALQNAASVAALILTTDALVAEQADDKPATAGLPHGGPGGFGGPEF
>Mature_546_residues
AAKQVLFGDDARAKVVQGVNILANAVKVTLGPKGRNVVLERSFGAPTVTKDGVSVAKEIELKDKFENIGAQLVKEVASKT
ADNAGDGTTTATVLAQAIVREGFKFVAAGFNPADLKRGIDKAVAAIVDELKALSKPTTTSKEIAQVGAISANSDADIGDI
IAKAIDKVGKEGVITVEDGKSLNNELDVVEGLQFDRGYLSPYFINNPDKQVAELDNPFILLFDKKISNIRELLPVLEQVA
KAGSPLLVVAEDVDGEALATLVVNTIRGILKVVAVKAPGFGDRRKAILEDIAILTGGQVIAEEVGLSLEKATLADLGQAK
RVEVQKENTTLIDGAGSVEAIKARVSSIDALIAAATSDYDREKLQERKAKLAGGVAVIKVGAATEVELKEKKARVEDALH
ATRAAVEEGIVPGGGVALLRARAAIKDLKGDNHEQDAGIKIVLRAVEEPLRQIVANAGDEASVVVARVLEGSGNFGYNAA
NGQYGDLVEQGVLDPAKVTRSALQNAASVAALILTTDALVAEQADDKPATAGLPHGGPGGFGGPEF

Specific function: Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions

COG id: COG0459

COG function: function code O; Chaperonin GroEL (HSP60 family)

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the chaperonin (HSP60) family

Homologues:

Organism=Homo sapiens, GI41399285, Length=522, Percent_Identity=53.0651340996169, Blast_Score=531, Evalue=1e-151,
Organism=Homo sapiens, GI31542947, Length=522, Percent_Identity=53.0651340996169, Blast_Score=531, Evalue=1e-151,
Organism=Escherichia coli, GI1790586, Length=523, Percent_Identity=72.6577437858509, Blast_Score=754, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17555558, Length=523, Percent_Identity=51.2428298279159, Blast_Score=521, Evalue=1e-148,
Organism=Caenorhabditis elegans, GI193210679, Length=205, Percent_Identity=50.2439024390244, Blast_Score=194, Evalue=8e-50,
Organism=Caenorhabditis elegans, GI17532603, Length=575, Percent_Identity=22.2608695652174, Blast_Score=70, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6323288, Length=526, Percent_Identity=51.7110266159696, Blast_Score=536, Evalue=1e-153,
Organism=Saccharomyces cerevisiae, GI6322524, Length=371, Percent_Identity=24.5283018867925, Blast_Score=65, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24641193, Length=522, Percent_Identity=51.9157088122605, Blast_Score=540, Evalue=1e-153,
Organism=Drosophila melanogaster, GI24641191, Length=522, Percent_Identity=51.9157088122605, Blast_Score=540, Evalue=1e-153,
Organism=Drosophila melanogaster, GI45550936, Length=522, Percent_Identity=50.3831417624521, Blast_Score=525, Evalue=1e-149,
Organism=Drosophila melanogaster, GI45550132, Length=522, Percent_Identity=50.3831417624521, Blast_Score=525, Evalue=1e-149,
Organism=Drosophila melanogaster, GI45550935, Length=522, Percent_Identity=50.3831417624521, Blast_Score=525, Evalue=1e-149,
Organism=Drosophila melanogaster, GI17864606, Length=529, Percent_Identity=44.6124763705104, Blast_Score=462, Evalue=1e-130,
Organism=Drosophila melanogaster, GI24584129, Length=525, Percent_Identity=38.0952380952381, Blast_Score=336, Evalue=2e-92,
Organism=Drosophila melanogaster, GI19921262, Length=525, Percent_Identity=38.0952380952381, Blast_Score=336, Evalue=2e-92,

Paralogues:

None

Copy number: 2180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 360 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 15012 Molecules/Cell In: Growth Phase,

Swissprot (AC and ID): CH602_AZOSB (A1K828)

Other databases:

- EMBL:   AM406670
- RefSeq:   YP_933870.1
- ProteinModelPortal:   A1K828
- SMR:   A1K828
- STRING:   A1K828
- GeneID:   4608941
- GenomeReviews:   AM406670_GR
- KEGG:   azo:azo2366
- eggNOG:   COG0459
- HOGENOM:   HBG625289
- OMA:   MAAKEIL
- PhylomeDB:   A1K828
- BioCyc:   ASP62928:AZO2366-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00600
- InterPro:   IPR018370
- InterPro:   IPR001844
- InterPro:   IPR002423
- PANTHER:   PTHR11353
- PRINTS:   PR00298
- TIGRFAMs:   TIGR02348

Pfam domain/function: PF00118 Cpn60_TCP1; SSF48592 GroEL-ATPase

EC number: NA

Molecular weight: Translated: 56951; Mature: 56819

Theoretical pI: Translated: 4.84; Mature: 4.84

Prosite motif: PS00296 CHAPERONINS_CPN60

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
0.2 %Met     (Translated Protein)
0.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.0 %Met     (Mature Protein)
0.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAAKQVLFGDDARAKVVQGVNILANAVKVTLGPKGRNVVLERSFGAPTVTKDGVSVAKEI
CCCCCCEECCCHHHHHHHHHHHHHHHHEEEECCCCCEEEEEECCCCCCCCCCCHHHHHHH
ELKDKFENIGAQLVKEVASKTADNAGDGTTTATVLAQAIVREGFKFVAAGFNPADLKRGI
HHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCEEECCCCHHHHHHHH
DKAVAAIVDELKALSKPTTTSKEIAQVGAISANSDADIGDIIAKAIDKVGKEGVITVEDG
HHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCCEEEECCC
KSLNNELDVVEGLQFDRGYLSPYFINNPDKQVAELDNPFILLFDKKISNIRELLPVLEQV
CCCCCHHHHHHCCCCCCCCCCCEEECCCHHHHHHCCCCEEEEECHHHHHHHHHHHHHHHH
AKAGSPLLVVAEDVDGEALATLVVNTIRGILKVVAVKAPGFGDRRKAILEDIAILTGGQV
HHCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCHH
IAEEVGLSLEKATLADLGQAKRVEVQKENTTLIDGAGSVEAIKARVSSIDALIAAATSDY
HHHHHCCCHHHHHHHHCCCCCEEEEECCCCEEEECCCCHHHHHHHHHHHHHHHHHHCCCH
DREKLQERKAKLAGGVAVIKVGAATEVELKEKKARVEDALHATRAAVEEGIVPGGGVALL
HHHHHHHHHHHHHCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHH
RARAAIKDLKGDNHEQDAGIKIVLRAVEEPLRQIVANAGDEASVVVARVLEGSGNFGYNA
HHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCC
ANGQYGDLVEQGVLDPAKVTRSALQNAASVAALILTTDALVAEQADDKPATAGLPHGGPG
CCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCC
GFGGPEF
CCCCCCC
>Mature Secondary Structure 
AAKQVLFGDDARAKVVQGVNILANAVKVTLGPKGRNVVLERSFGAPTVTKDGVSVAKEI
CCCCCEECCCHHHHHHHHHHHHHHHHEEEECCCCCEEEEEECCCCCCCCCCCHHHHHHH
ELKDKFENIGAQLVKEVASKTADNAGDGTTTATVLAQAIVREGFKFVAAGFNPADLKRGI
HHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCEEECCCCHHHHHHHH
DKAVAAIVDELKALSKPTTTSKEIAQVGAISANSDADIGDIIAKAIDKVGKEGVITVEDG
HHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCCEEEECCC
KSLNNELDVVEGLQFDRGYLSPYFINNPDKQVAELDNPFILLFDKKISNIRELLPVLEQV
CCCCCHHHHHHCCCCCCCCCCCEEECCCHHHHHHCCCCEEEEECHHHHHHHHHHHHHHHH
AKAGSPLLVVAEDVDGEALATLVVNTIRGILKVVAVKAPGFGDRRKAILEDIAILTGGQV
HHCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCHH
IAEEVGLSLEKATLADLGQAKRVEVQKENTTLIDGAGSVEAIKARVSSIDALIAAATSDY
HHHHHCCCHHHHHHHHCCCCCEEEEECCCCEEEECCCCHHHHHHHHHHHHHHHHHHCCCH
DREKLQERKAKLAGGVAVIKVGAATEVELKEKKARVEDALHATRAAVEEGIVPGGGVALL
HHHHHHHHHHHHHCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHH
RARAAIKDLKGDNHEQDAGIKIVLRAVEEPLRQIVANAGDEASVVVARVLEGSGNFGYNA
HHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCC
ANGQYGDLVEQGVLDPAKVTRSALQNAASVAALILTTDALVAEQADDKPATAGLPHGGPG
CCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCC
GFGGPEF
CCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA