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The map label for this gene is xdhB [H]

Identifier: 119898503

GI number: 119898503

Start: 2423317

End: 2425656

Strand: Direct

Name: xdhB [H]

Synonym: azo2212

Alternate gene names: 119898503

Gene position: 2423317-2425656 (Clockwise)

Preceding gene: 119898502

Following gene: 119898504

Centisome position: 55.38

GC content: 69.87

Gene sequence:

>2340_bases
ATGCATCCATCTGAGCTGGGAACGGTCGATGCGGCGGCCATCCGCGGCGGGGTCGGCACCGCGCAGACGCACGACTCGGC
CCACCTGCACGTGACCGGCTGCGCCAGCTACATCGACGACCTGCCTGAACTGCGTGGCACCCTGCATGCCGCGCTCGGAC
TGTCGCAGCGCGCTCATGCCCGCGTCGTCGCCCTCGACCTCGCGCCGGTCCGTTCCGCGCCGGGCGTGGTCGCGGTTTAT
ACGGCGGCCGACGTCCCCGGCCTCAACGACTTCGGTCCGGTCATCCACGACGATCCGATCTTTGCCTCCGACGAGGTGCA
GTTCCACGGCCAGGCCCTGTTCGTGGTCGTGGCGCACGACATGCGCGCGGCCCGGATGGCGGCCCGTCTGGCGCGGGTGG
AGTACGAAGACCTGCCCGCGTTGCTGACCACCGACGAGGCGCTCGCGGCCGGCAGCACCGTGCTGCCCGACGCGACGCTG
CGCCGCGGCGACGCCGATGCCGCGATCGGCGCGGCGCCGCACCGTCTCGCCGGCAGCGTGCGGCTGGGCGGGCAGGACCA
CTTCTATCTCGAAACCCACATCGCCTACGCAATCCCGCGCGAAGACCGCACGCTGCACGTGCATTCCTCCAGCCAGCATC
CGGGCGAGGTACAGCTGCAGGTTGCGCACGCGCTGGGCGTCGACGCCAAGGATGTGGTGATCGAATGCCGGCGCATGGGC
GGCGGCTTCGGCGGCAAGGAGAGCCAGCCCGGGCAGATCGCCGCGATCGCGGCAATCGCCGCATGGCACACCGGGCACCC
GGTCAAGCTGCGACTTGACCGCGACGACGACATGGCGCTGACCGGCAAGCGCCACGATTTCCGCATCGACTGGGAAGCCG
GCTTCGACGATGACGGCCTCATCCTCGGCGTGCGTTTCATGCACGGCTGCCGCGCCGGCTACTCGGCCGACCTCACCGGC
GCCATCGCCGACCGCGCGATGTTCCACGCCGACAACGCCTACTACCTCGGCGACGTGACGATCGAGTCGCACCGCTGCAA
GACGCACACGGTGTCCAACACCGCCTTTCGCGGATTCGGCGGTCCTCAGGGCATGTTCGGCATCGAAGAGGTGATCGACG
CCATCGCCCGCCACCTCGGGCGCGACCCGCTGGAGGTGCGCAAACTCAACTACTACGGCACCGACGCGCGCAACACCACG
CACTACGGCCAGACGATCACCGACAACGTCATCCACACGCTCACCGCCAGGCTCGAAGCCGAGTGCGACTACCCCGCCCG
GCGCGCAGCGCTGCGCGCGTGGAACGGCGCCAGCCCGGTCATCAAGAAGGGCATCGCGCTGACGCCGGTGAAGTTCGGCA
TCTCCTTCACCGCCACCCACCTCAACCAGGCCGGCGCCCTGCTCCACGTCTATACCGACGGCACCGTGCTGCTCAACCAC
GGCGGCACCGAAATGGGCCAGGGCCTGTTCACCAAGGTGGCGCAGGTGGTGGCCGAAGAGCTGCAGATCGACCTCGACCG
CATCCGCGTCACCGCGTCGGACACCTCGCGCGTACCCAACGCCTCCGCCACCGCTGCGTCCAGCGGCGCGGACCTCAACG
GCAAGGCGGCGCAGGATGCCGCGCGCAAGATCAAGGCACGCCTCGCCGGATTCGCCGCGGCCCGGTTCGGCGTGCGCGAG
GACGAGGTGGTGTTCCGCGCCAACCGTGTCCACGCCGGCACCGCCAGCCTCAGCTTTGCCGAACTCGCCCACGCGGCCTG
GATGGCGCGGGTGTCGCTGTCGGCCACCGGCTTCTACCGCACTCCCAAAATCTCCTACGACCGCGCGACCCTGTCCGGGC
GGCCGTTCTACTACTACGCCTACGGCGTGGCCTGCAGCGAAGTCGCCATCGACACCCTTACCGGCGAATCGCGCGTATTG
CGCGTCGACATCCTGCACGACGCCGGCCGCTCCCTGAATCCGGCAATCGACCTCGGCCAGGTGGAAGGCGGCTTCATCCA
GGGCATGGGCTGGCTGACGATGGAAGCCCTGCGCTGGGACGCTTCAGGCCGGCTGCTGACCCACGCGCCGTCCACCTACA
AGATTCCCGCGGTGTCGGACCTGCCGCCGGTGTTCAACGTGCGCCTGTGGGAAGACGGCCACAACAGCGAGGACGCGATC
TTCCGCTCCAAGGCCGTGGGCGAGCCGCCCTTCATGCTGGCGCTGTCGGTCTGGCACGCGATCAAGGACGCAGTCGCCGC
CGCGGCGGACTACCGCGTCACGCCCCGGCTCGACGCGCCCGCCACCGCGGAGGAAATCCTCCGCGCGGTGGACGCCGCCC
GCCAGGCCGCAGGCGTCTGA

Upstream 100 bases:

>100_bases
CGGATGCGGGTCGCGCAGAACCTGCTGACGCGCCTGCAACTCGAAACAAGCGGAGGGGCGCGGGCCGCCTCCAGCCTTGC
CGACCTGGGAGACGGGGGAC

Downstream 100 bases:

>100_bases
AGGCCCACCGATGCGGACCGCCGATCTGCTCGCTGCCCTGCACCGCCAGCTCGACGCCGGCCACCCCGCGGTGTGGGTGA
GCGTGGCGGCGACACGCGGT

Product: xanthine dehydrogenase

Products: NA

Alternate protein names: XDHase subunit D [H]

Number of amino acids: Translated: 779; Mature: 779

Protein sequence:

>779_residues
MHPSELGTVDAAAIRGGVGTAQTHDSAHLHVTGCASYIDDLPELRGTLHAALGLSQRAHARVVALDLAPVRSAPGVVAVY
TAADVPGLNDFGPVIHDDPIFASDEVQFHGQALFVVVAHDMRAARMAARLARVEYEDLPALLTTDEALAAGSTVLPDATL
RRGDADAAIGAAPHRLAGSVRLGGQDHFYLETHIAYAIPREDRTLHVHSSSQHPGEVQLQVAHALGVDAKDVVIECRRMG
GGFGGKESQPGQIAAIAAIAAWHTGHPVKLRLDRDDDMALTGKRHDFRIDWEAGFDDDGLILGVRFMHGCRAGYSADLTG
AIADRAMFHADNAYYLGDVTIESHRCKTHTVSNTAFRGFGGPQGMFGIEEVIDAIARHLGRDPLEVRKLNYYGTDARNTT
HYGQTITDNVIHTLTARLEAECDYPARRAALRAWNGASPVIKKGIALTPVKFGISFTATHLNQAGALLHVYTDGTVLLNH
GGTEMGQGLFTKVAQVVAEELQIDLDRIRVTASDTSRVPNASATAASSGADLNGKAAQDAARKIKARLAGFAAARFGVRE
DEVVFRANRVHAGTASLSFAELAHAAWMARVSLSATGFYRTPKISYDRATLSGRPFYYYAYGVACSEVAIDTLTGESRVL
RVDILHDAGRSLNPAIDLGQVEGGFIQGMGWLTMEALRWDASGRLLTHAPSTYKIPAVSDLPPVFNVRLWEDGHNSEDAI
FRSKAVGEPPFMLALSVWHAIKDAVAAAADYRVTPRLDAPATAEEILRAVDAARQAAGV

Sequences:

>Translated_779_residues
MHPSELGTVDAAAIRGGVGTAQTHDSAHLHVTGCASYIDDLPELRGTLHAALGLSQRAHARVVALDLAPVRSAPGVVAVY
TAADVPGLNDFGPVIHDDPIFASDEVQFHGQALFVVVAHDMRAARMAARLARVEYEDLPALLTTDEALAAGSTVLPDATL
RRGDADAAIGAAPHRLAGSVRLGGQDHFYLETHIAYAIPREDRTLHVHSSSQHPGEVQLQVAHALGVDAKDVVIECRRMG
GGFGGKESQPGQIAAIAAIAAWHTGHPVKLRLDRDDDMALTGKRHDFRIDWEAGFDDDGLILGVRFMHGCRAGYSADLTG
AIADRAMFHADNAYYLGDVTIESHRCKTHTVSNTAFRGFGGPQGMFGIEEVIDAIARHLGRDPLEVRKLNYYGTDARNTT
HYGQTITDNVIHTLTARLEAECDYPARRAALRAWNGASPVIKKGIALTPVKFGISFTATHLNQAGALLHVYTDGTVLLNH
GGTEMGQGLFTKVAQVVAEELQIDLDRIRVTASDTSRVPNASATAASSGADLNGKAAQDAARKIKARLAGFAAARFGVRE
DEVVFRANRVHAGTASLSFAELAHAAWMARVSLSATGFYRTPKISYDRATLSGRPFYYYAYGVACSEVAIDTLTGESRVL
RVDILHDAGRSLNPAIDLGQVEGGFIQGMGWLTMEALRWDASGRLLTHAPSTYKIPAVSDLPPVFNVRLWEDGHNSEDAI
FRSKAVGEPPFMLALSVWHAIKDAVAAAADYRVTPRLDAPATAEEILRAVDAARQAAGV
>Mature_779_residues
MHPSELGTVDAAAIRGGVGTAQTHDSAHLHVTGCASYIDDLPELRGTLHAALGLSQRAHARVVALDLAPVRSAPGVVAVY
TAADVPGLNDFGPVIHDDPIFASDEVQFHGQALFVVVAHDMRAARMAARLARVEYEDLPALLTTDEALAAGSTVLPDATL
RRGDADAAIGAAPHRLAGSVRLGGQDHFYLETHIAYAIPREDRTLHVHSSSQHPGEVQLQVAHALGVDAKDVVIECRRMG
GGFGGKESQPGQIAAIAAIAAWHTGHPVKLRLDRDDDMALTGKRHDFRIDWEAGFDDDGLILGVRFMHGCRAGYSADLTG
AIADRAMFHADNAYYLGDVTIESHRCKTHTVSNTAFRGFGGPQGMFGIEEVIDAIARHLGRDPLEVRKLNYYGTDARNTT
HYGQTITDNVIHTLTARLEAECDYPARRAALRAWNGASPVIKKGIALTPVKFGISFTATHLNQAGALLHVYTDGTVLLNH
GGTEMGQGLFTKVAQVVAEELQIDLDRIRVTASDTSRVPNASATAASSGADLNGKAAQDAARKIKARLAGFAAARFGVRE
DEVVFRANRVHAGTASLSFAELAHAAWMARVSLSATGFYRTPKISYDRATLSGRPFYYYAYGVACSEVAIDTLTGESRVL
RVDILHDAGRSLNPAIDLGQVEGGFIQGMGWLTMEALRWDASGRLLTHAPSTYKIPAVSDLPPVFNVRLWEDGHNSEDAI
FRSKAVGEPPFMLALSVWHAIKDAVAAAADYRVTPRLDAPATAEEILRAVDAARQAAGV

Specific function: Oxidizes hypoxanthine and xanthine to uric acid [H]

COG id: COG4631

COG function: function code F; Xanthine dehydrogenase, molybdopterin-binding subunit B

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the xanthine dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI91823271, Length=760, Percent_Identity=42.3684210526316, Blast_Score=592, Evalue=1e-169,
Organism=Homo sapiens, GI71773480, Length=761, Percent_Identity=37.0565045992116, Blast_Score=480, Evalue=1e-135,
Organism=Escherichia coli, GI1789230, Length=758, Percent_Identity=27.5725593667546, Blast_Score=216, Evalue=4e-57,
Organism=Escherichia coli, GI1789246, Length=746, Percent_Identity=26.6756032171582, Blast_Score=187, Evalue=3e-48,
Organism=Escherichia coli, GI1786478, Length=747, Percent_Identity=26.2382864792503, Blast_Score=128, Evalue=1e-30,
Organism=Caenorhabditis elegans, GI17540638, Length=769, Percent_Identity=39.2717815344603, Blast_Score=503, Evalue=1e-142,
Organism=Caenorhabditis elegans, GI17539860, Length=762, Percent_Identity=31.3648293963255, Blast_Score=337, Evalue=1e-92,
Organism=Caenorhabditis elegans, GI32566215, Length=717, Percent_Identity=30.5439330543933, Blast_Score=335, Evalue=7e-92,
Organism=Drosophila melanogaster, GI17737937, Length=756, Percent_Identity=41.1375661375661, Blast_Score=557, Evalue=1e-158,
Organism=Drosophila melanogaster, GI24647199, Length=767, Percent_Identity=31.2907431551499, Blast_Score=316, Evalue=3e-86,
Organism=Drosophila melanogaster, GI24647193, Length=763, Percent_Identity=29.3577981651376, Blast_Score=284, Evalue=1e-76,
Organism=Drosophila melanogaster, GI24647201, Length=757, Percent_Identity=29.9867899603699, Blast_Score=282, Evalue=7e-76,
Organism=Drosophila melanogaster, GI24647195, Length=760, Percent_Identity=29.6052631578947, Blast_Score=260, Evalue=2e-69,
Organism=Drosophila melanogaster, GI24647197, Length=760, Percent_Identity=29.6052631578947, Blast_Score=260, Evalue=2e-69,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000674
- InterPro:   IPR008274
- InterPro:   IPR017609 [H]

Pfam domain/function: PF01315 Ald_Xan_dh_C; PF02738 Ald_Xan_dh_C2 [H]

EC number: =1.17.1.4 [H]

Molecular weight: Translated: 83446; Mature: 83446

Theoretical pI: Translated: 6.58; Mature: 6.58

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHPSELGTVDAAAIRGGVGTAQTHDSAHLHVTGCASYIDDLPELRGTLHAALGLSQRAHA
CCCCCCCCCHHHHHCCCCCCCCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHCCCCCCCE
RVVALDLAPVRSAPGVVAVYTAADVPGLNDFGPVIHDDPIFASDEVQFHGQALFVVVAHD
EEEEEEEECCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCCCCCEEECCCEEEEEEECC
MRAARMAARLARVEYEDLPALLTTDEALAAGSTVLPDATLRRGDADAAIGAAPHRLAGSV
HHHHHHHHHHHHCCHHHCCEEEECCHHHHCCCCCCCCHHHCCCCCCCCCCCCCHHHCCEE
RLGGQDHFYLETHIAYAIPREDRTLHVHSSSQHPGEVQLQVAHALGVDAKDVVIECRRMG
EECCCCCEEEEEEEEEEECCCCCEEEEECCCCCCCEEEEEEEHHHCCCHHHHHHHHHHHC
GGFGGKESQPGQIAAIAAIAAWHTGHPVKLRLDRDDDMALTGKRHDFRIDWEAGFDDDGL
CCCCCCCCCCCCEEEEEEEHHHCCCCCEEEEECCCCCEEEECCCCEEEEEECCCCCCCCE
ILGVRFMHGCRAGYSADLTGAIADRAMFHADNAYYLGDVTIESHRCKTHTVSNTAFRGFG
EEEEHHHHHHCCCCCCCCHHHHHHHHEEECCCEEEEEEEEEECCCCCEEECCCCCCCCCC
GPQGMFGIEEVIDAIARHLGRDPLEVRKLNYYGTDARNTTHYGQTITDNVIHTLTARLEA
CCCCCCCHHHHHHHHHHHHCCCCHHEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHCC
ECDYPARRAALRAWNGASPVIKKGIALTPVKFGISFTATHLNQAGALLHVYTDGTVLLNH
CCCCHHHHHHHHHCCCCCHHHHCCCEEEEEEECCEEEEEHHCCCCCEEEEEECCEEEEEC
GGTEMGQGLFTKVAQVVAEELQIDLDRIRVTASDTSRVPNASATAASSGADLNGKAAQDA
CCCHHHHHHHHHHHHHHHHHHHEEEEHEEEEECCCCCCCCCCCCCCCCCCCCCCHHHHHH
ARKIKARLAGFAAARFGVREDEVVFRANRVHAGTASLSFAELAHAAWMARVSLSATGFYR
HHHHHHHHHHHHHHHCCCCCCCEEEEECEEECCCCCCHHHHHHHHHHHHHEEEEECCEEE
TPKISYDRATLSGRPFYYYAYGVACSEVAIDTLTGESRVLRVDILHDAGRSLNPAIDLGQ
CCCCCCCCEECCCCCEEEEEECEEHHHHEEEEECCCCEEEEEEEEECCCCCCCCCEECCC
VEGGFIQGMGWLTMEALRWDASGRLLTHAPSTYKIPAVSDLPPVFNVRLWEDGHNSEDAI
CCCCEEECCHHHEEEHHEECCCCCEEEECCCCEECCCCCCCCCCEEEEEECCCCCCCHHH
FRSKAVGEPPFMLALSVWHAIKDAVAAAADYRVTPRLDAPATAEEILRAVDAARQAAGV
HHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCEECCCCCCCCCHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MHPSELGTVDAAAIRGGVGTAQTHDSAHLHVTGCASYIDDLPELRGTLHAALGLSQRAHA
CCCCCCCCCHHHHHCCCCCCCCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHCCCCCCCE
RVVALDLAPVRSAPGVVAVYTAADVPGLNDFGPVIHDDPIFASDEVQFHGQALFVVVAHD
EEEEEEEECCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCCCCCEEECCCEEEEEEECC
MRAARMAARLARVEYEDLPALLTTDEALAAGSTVLPDATLRRGDADAAIGAAPHRLAGSV
HHHHHHHHHHHHCCHHHCCEEEECCHHHHCCCCCCCCHHHCCCCCCCCCCCCCHHHCCEE
RLGGQDHFYLETHIAYAIPREDRTLHVHSSSQHPGEVQLQVAHALGVDAKDVVIECRRMG
EECCCCCEEEEEEEEEEECCCCCEEEEECCCCCCCEEEEEEEHHHCCCHHHHHHHHHHHC
GGFGGKESQPGQIAAIAAIAAWHTGHPVKLRLDRDDDMALTGKRHDFRIDWEAGFDDDGL
CCCCCCCCCCCCEEEEEEEHHHCCCCCEEEEECCCCCEEEECCCCEEEEEECCCCCCCCE
ILGVRFMHGCRAGYSADLTGAIADRAMFHADNAYYLGDVTIESHRCKTHTVSNTAFRGFG
EEEEHHHHHHCCCCCCCCHHHHHHHHEEECCCEEEEEEEEEECCCCCEEECCCCCCCCCC
GPQGMFGIEEVIDAIARHLGRDPLEVRKLNYYGTDARNTTHYGQTITDNVIHTLTARLEA
CCCCCCCHHHHHHHHHHHHCCCCHHEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHCC
ECDYPARRAALRAWNGASPVIKKGIALTPVKFGISFTATHLNQAGALLHVYTDGTVLLNH
CCCCHHHHHHHHHCCCCCHHHHCCCEEEEEEECCEEEEEHHCCCCCEEEEEECCEEEEEC
GGTEMGQGLFTKVAQVVAEELQIDLDRIRVTASDTSRVPNASATAASSGADLNGKAAQDA
CCCHHHHHHHHHHHHHHHHHHHEEEEHEEEEECCCCCCCCCCCCCCCCCCCCCCHHHHHH
ARKIKARLAGFAAARFGVREDEVVFRANRVHAGTASLSFAELAHAAWMARVSLSATGFYR
HHHHHHHHHHHHHHHCCCCCCCEEEEECEEECCCCCCHHHHHHHHHHHHHEEEEECCEEE
TPKISYDRATLSGRPFYYYAYGVACSEVAIDTLTGESRVLRVDILHDAGRSLNPAIDLGQ
CCCCCCCCEECCCCCEEEEEECEEHHHHEEEEECCCCEEEEEEEEECCCCCCCCCEECCC
VEGGFIQGMGWLTMEALRWDASGRLLTHAPSTYKIPAVSDLPPVFNVRLWEDGHNSEDAI
CCCCEEECCHHHEEEHHEECCCCCEEEECCCCEECCCCCCCCCCEEEEEECCCCCCCHHH
FRSKAVGEPPFMLALSVWHAIKDAVAAAADYRVTPRLDAPATAEEILRAVDAARQAAGV
HHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCEECCCCCCCCCHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377; 11344136 [H]