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The map label for this gene is fabI2 [H]

Identifier: 119898421

GI number: 119898421

Start: 2335612

End: 2336391

Strand: Direct

Name: fabI2 [H]

Synonym: azo2130

Alternate gene names: 119898421

Gene position: 2335612-2336391 (Clockwise)

Preceding gene: 119898419

Following gene: 119898422

Centisome position: 53.37

GC content: 65.51

Gene sequence:

>780_bases
ATGAACCCGATCATCAACCTTGAAGGCAAAGTCGGCCTCATCACCGGCATCGCCAACGAAAAGTCGATCTCCACCGGCGT
CGCAGAGGCCTGCGCCCAAGCCGGCGCCAAGCTCATCATCACGTATCAGAACGAAAAGACGCGCGCTTTCATCGAGCCGG
TCATCAACCGCCTGGGCGTAGAGGACGTCTTTCTGCTCGACGTGACCCAGCCCGATACGCTCGATGCCGCGTTCGCGGAG
ATCGAAGCGCGCCACGGCAAGCTCGATTTCGCCGTGCACAGCATGGCGTTTGCCAAGCGCGACGACCTTCACGGCCGCGT
CGTCGACACCTCGCCCGATGGTTTCGCGCTGGCGATGGACGTGTCCACCCACTCCTTCGTACGTCTGGCGCGCAAGGCCG
AACCGCTGATGGAAAAGGCCGGCGGCGGCGCCCTGGTGACGATGACCTATCTGGGCTCGGAAAAGGTGATTCCGCACTAC
GGCGTGATGGGGCTGTGCAAAGCAGCACTCGAAGCCGCCACACGCTACATGGCGGCGGAACTGGGCGCCAAGAACATCCG
TGTGAACGCGGTGTCGCCGGGCCCCCTGATGACCCGCGCGGCGTCCGGCATCGCCGGTTTCGACGGCCTGATGGCGGCGG
CGGTGGACCGCTCCCCGCTGCACAGCCTGGTGACGCCGGAAGACATCGGCGCGCTCACCGCCTTCCTCGTCTCCGACGCC
GGCCGCCTGATCTCCGGCGGGGTGCACTTCGTCGACGCCGGCTACAACGTCATGGGCTGA

Upstream 100 bases:

>100_bases
TGCGGGCGCCGCGTATCATCACCGCCAGTACGCGTGTCATACGCAGGTGAGACAAGCGGTTGCGCATTATCCCTACCCTC
ATCCGAATCGGAGCCCGAGC

Downstream 100 bases:

>100_bases
GGATCGCGTCATGATCGACCTCGCCGCGGCCCGCGTGAAACTCGGCCGGGACCCGATCGTCCTGCCGGACCCCGTTCCGG
CCCATCCGCTGCTGGACGGC

Product: enoyl-[acyl-carrier-protein] reductase

Products: NA

Alternate protein names: NADH-dependent enoyl-ACP reductase 1 [H]

Number of amino acids: Translated: 259; Mature: 259

Protein sequence:

>259_residues
MNPIINLEGKVGLITGIANEKSISTGVAEACAQAGAKLIITYQNEKTRAFIEPVINRLGVEDVFLLDVTQPDTLDAAFAE
IEARHGKLDFAVHSMAFAKRDDLHGRVVDTSPDGFALAMDVSTHSFVRLARKAEPLMEKAGGGALVTMTYLGSEKVIPHY
GVMGLCKAALEAATRYMAAELGAKNIRVNAVSPGPLMTRAASGIAGFDGLMAAAVDRSPLHSLVTPEDIGALTAFLVSDA
GRLISGGVHFVDAGYNVMG

Sequences:

>Translated_259_residues
MNPIINLEGKVGLITGIANEKSISTGVAEACAQAGAKLIITYQNEKTRAFIEPVINRLGVEDVFLLDVTQPDTLDAAFAE
IEARHGKLDFAVHSMAFAKRDDLHGRVVDTSPDGFALAMDVSTHSFVRLARKAEPLMEKAGGGALVTMTYLGSEKVIPHY
GVMGLCKAALEAATRYMAAELGAKNIRVNAVSPGPLMTRAASGIAGFDGLMAAAVDRSPLHSLVTPEDIGALTAFLVSDA
GRLISGGVHFVDAGYNVMG
>Mature_259_residues
MNPIINLEGKVGLITGIANEKSISTGVAEACAQAGAKLIITYQNEKTRAFIEPVINRLGVEDVFLLDVTQPDTLDAAFAE
IEARHGKLDFAVHSMAFAKRDDLHGRVVDTSPDGFALAMDVSTHSFVRLARKAEPLMEKAGGGALVTMTYLGSEKVIPHY
GVMGLCKAALEAATRYMAAELGAKNIRVNAVSPGPLMTRAASGIAGFDGLMAAAVDRSPLHSLVTPEDIGALTAFLVSDA
GRLISGGVHFVDAGYNVMG

Specific function: Fatty acid biosynthesis pathway; second reduction step. [C]

COG id: COG0623

COG function: function code I; Enoyl-[acyl-carrier-protein] reductase (NADH)

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family. FabI subfamily [H]

Homologues:

Organism=Homo sapiens, GI32483357, Length=253, Percent_Identity=24.1106719367589, Blast_Score=69, Evalue=3e-12,
Organism=Homo sapiens, GI126723750, Length=258, Percent_Identity=23.2558139534884, Blast_Score=66, Evalue=3e-11,
Organism=Escherichia coli, GI1787545, Length=252, Percent_Identity=42.8571428571429, Blast_Score=193, Evalue=7e-51,
Organism=Escherichia coli, GI1787905, Length=251, Percent_Identity=28.2868525896414, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI87082100, Length=256, Percent_Identity=26.171875, Blast_Score=79, Evalue=3e-16,
Organism=Escherichia coli, GI1787335, Length=258, Percent_Identity=29.0697674418605, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI1790717, Length=266, Percent_Identity=25.5639097744361, Blast_Score=68, Evalue=7e-13,
Organism=Escherichia coli, GI1789208, Length=256, Percent_Identity=26.5625, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI87082160, Length=263, Percent_Identity=26.2357414448669, Blast_Score=62, Evalue=5e-11,
Organism=Caenorhabditis elegans, GI17562910, Length=243, Percent_Identity=28.8065843621399, Blast_Score=71, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI17560332, Length=267, Percent_Identity=27.7153558052434, Blast_Score=70, Evalue=8e-13,
Organism=Caenorhabditis elegans, GI17562906, Length=243, Percent_Identity=29.2181069958848, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17536025, Length=262, Percent_Identity=27.0992366412214, Blast_Score=69, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI193204405, Length=201, Percent_Identity=31.8407960199005, Blast_Score=68, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI17562908, Length=242, Percent_Identity=28.5123966942149, Blast_Score=67, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17531453, Length=241, Percent_Identity=26.9709543568465, Blast_Score=66, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17561402, Length=248, Percent_Identity=24.5967741935484, Blast_Score=64, Evalue=8e-11,
Organism=Saccharomyces cerevisiae, GI6324126, Length=262, Percent_Identity=25.9541984732824, Blast_Score=64, Evalue=2e-11,
Organism=Drosophila melanogaster, GI21355319, Length=242, Percent_Identity=26.0330578512397, Blast_Score=72, Evalue=3e-13,

Paralogues:

None

Copy number: 200 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR014358
- InterPro:   IPR002347
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: =1.3.1.9 [H]

Molecular weight: Translated: 27197; Mature: 27197

Theoretical pI: Translated: 5.89; Mature: 5.89

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNPIINLEGKVGLITGIANEKSISTGVAEACAQAGAKLIITYQNEKTRAFIEPVINRLGV
CCCCEECCCCEEEEEECCCCCHHHHHHHHHHHHCCCEEEEEEECCCHHHHHHHHHHHCCC
EDVFLLDVTQPDTLDAAFAEIEARHGKLDFAVHSMAFAKRDDLHGRVVDTSPDGFALAMD
CEEEEEECCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCEEEECCCCCEEEEEE
VSTHSFVRLARKAEPLMEKAGGGALVTMTYLGSEKVIPHYGVMGLCKAALEAATRYMAAE
CCHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHH
LGAKNIRVNAVSPGPLMTRAASGIAGFDGLMAAAVDRSPLHSLVTPEDIGALTAFLVSDA
CCCCCEEEEEECCCCHHHHHHCCCCCHHHHHHHHHCCCHHHHCCCCHHHHHHHHHHHHCC
GRLISGGVHFVDAGYNVMG
CHHHHCCEEEEECCCCCCC
>Mature Secondary Structure
MNPIINLEGKVGLITGIANEKSISTGVAEACAQAGAKLIITYQNEKTRAFIEPVINRLGV
CCCCEECCCCEEEEEECCCCCHHHHHHHHHHHHCCCEEEEEEECCCHHHHHHHHHHHCCC
EDVFLLDVTQPDTLDAAFAEIEARHGKLDFAVHSMAFAKRDDLHGRVVDTSPDGFALAMD
CEEEEEECCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCEEEECCCCCEEEEEE
VSTHSFVRLARKAEPLMEKAGGGALVTMTYLGSEKVIPHYGVMGLCKAALEAATRYMAAE
CCHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHH
LGAKNIRVNAVSPGPLMTRAASGIAGFDGLMAAAVDRSPLHSLVTPEDIGALTAFLVSDA
CCCCCEEEEEECCCCHHHHHHCCCCCHHHHHHHHHCCCHHHHCCCCHHHHHHHHHHHHCC
GRLISGGVHFVDAGYNVMG
CHHHHCCEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11481430 [H]