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The map label for this gene is clpP

Identifier: 119898362

GI number: 119898362

Start: 2273393

End: 2274031

Strand: Reverse

Name: clpP

Synonym: azo2071

Alternate gene names: 119898362

Gene position: 2274031-2273393 (Counterclockwise)

Preceding gene: 119898363

Following gene: 119898361

Centisome position: 51.97

GC content: 61.82

Gene sequence:

>639_bases
ATGAACGCAGGAACACCACAGCACAGCAGCGCCTGGGACCCGGTTGGACTGGGTCTGATCCCGATGGTCGTGGAACAGAG
CGGCCGCGGCGAACGCTCTTATGACATCTATTCCCGCCTCCTGAAGGAGCGCGTGGTGTTCCTGGTCGGTCCGGTGAATG
ACGTTACTGCCAACCTGATCGTCGCCCAGTTGCTGTTCCTCGAGTCCGAAAATCCGGACAAGGACATCTACTTCTACATC
AACTCGCCCGGCGGTTCCGTCACTGCCGGGTTGGCGATCTACGACACGATGCAGTTCATCAAGCCGAACGTCAGCACGTT
GTGCATCGGCCAGGCTGCGAGCATGGGAGCCTTCCTGCTCGCCGCGGGTGAGAAGGGCAAGCGCTTCTGCCTGCCCAACT
CCCGCGTGATGATTCACCAGCCGCTCGGCGGCTTCCAGGGCCAGGCGTCGGACATCGAGATTCATGCCCGCGAAATCCTG
TACCTGCGCGAGCGCCTGAACGGCATGCTGGCCAAGCACACCGGCCAAACCATCGAGCAGATCGAAAAGGATACCGACCG
CGACAACTTCATGTCCGCGACCGCCGCCGTGGAGTACGGCCTGGTGGACAAGGTCCTGACCAGCCGCGCCGATACCTGA

Upstream 100 bases:

>100_bases
CGTCGTCGCCTGGGTGCTGTCCAAGGCTCAGACCAGCGAGAAGTCGATCGCCTTCGATGATTTGATGGGCAATGCGGCCT
AATCCAAGTAAGGACTGACC

Downstream 100 bases:

>100_bases
ACCAGGAGAATCCGAAAATGACGGAAAAGAAGACGGGCGGCGAAAAGCTGCTTTACTGCTCGTTTTGTGGCAAGAGCCAG
CATGAGGTACGCAAGCTTAT

Product: ATP-dependent Clp protease proteolytic subunit

Products: NA

Alternate protein names: Endopeptidase Clp

Number of amino acids: Translated: 212; Mature: 212

Protein sequence:

>212_residues
MNAGTPQHSSAWDPVGLGLIPMVVEQSGRGERSYDIYSRLLKERVVFLVGPVNDVTANLIVAQLLFLESENPDKDIYFYI
NSPGGSVTAGLAIYDTMQFIKPNVSTLCIGQAASMGAFLLAAGEKGKRFCLPNSRVMIHQPLGGFQGQASDIEIHAREIL
YLRERLNGMLAKHTGQTIEQIEKDTDRDNFMSATAAVEYGLVDKVLTSRADT

Sequences:

>Translated_212_residues
MNAGTPQHSSAWDPVGLGLIPMVVEQSGRGERSYDIYSRLLKERVVFLVGPVNDVTANLIVAQLLFLESENPDKDIYFYI
NSPGGSVTAGLAIYDTMQFIKPNVSTLCIGQAASMGAFLLAAGEKGKRFCLPNSRVMIHQPLGGFQGQASDIEIHAREIL
YLRERLNGMLAKHTGQTIEQIEKDTDRDNFMSATAAVEYGLVDKVLTSRADT
>Mature_212_residues
MNAGTPQHSSAWDPVGLGLIPMVVEQSGRGERSYDIYSRLLKERVVFLVGPVNDVTANLIVAQLLFLESENPDKDIYFYI
NSPGGSVTAGLAIYDTMQFIKPNVSTLCIGQAASMGAFLLAAGEKGKRFCLPNSRVMIHQPLGGFQGQASDIEIHAREIL
YLRERLNGMLAKHTGQTIEQIEKDTDRDNFMSATAAVEYGLVDKVLTSRADT

Specific function: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins

COG id: COG0740

COG function: function code OU; Protease subunit of ATP-dependent Clp proteases

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S14 family

Homologues:

Organism=Homo sapiens, GI5174419, Length=191, Percent_Identity=60.7329842931937, Blast_Score=247, Evalue=7e-66,
Organism=Escherichia coli, GI1786641, Length=193, Percent_Identity=75.1295336787565, Blast_Score=320, Evalue=4e-89,
Organism=Caenorhabditis elegans, GI17538017, Length=188, Percent_Identity=60.1063829787234, Blast_Score=236, Evalue=8e-63,
Organism=Drosophila melanogaster, GI20129427, Length=196, Percent_Identity=56.6326530612245, Blast_Score=241, Evalue=3e-64,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): CLPP_AZOSB (A1K783)

Other databases:

- EMBL:   AM406670
- RefSeq:   YP_933575.1
- ProteinModelPortal:   A1K783
- SMR:   A1K783
- STRING:   A1K783
- MEROPS:   S14.001
- GeneID:   4608491
- GenomeReviews:   AM406670_GR
- KEGG:   azo:azo2071
- eggNOG:   COG0740
- HOGENOM:   HBG558421
- OMA:   LPNASIM
- PhylomeDB:   A1K783
- ProtClustDB:   PRK00277
- BioCyc:   ASP62928:AZO2071-MONOMER
- GO:   GO:0005737
- GO:   GO:0006508
- HAMAP:   MF_00444
- InterPro:   IPR001907
- InterPro:   IPR018215
- PANTHER:   PTHR10381
- PRINTS:   PR00127
- TIGRFAMs:   TIGR00493

Pfam domain/function: PF00574 CLP_protease

EC number: =3.4.21.92

Molecular weight: Translated: 23196; Mature: 23196

Theoretical pI: Translated: 5.29; Mature: 5.29

Prosite motif: PS00382 CLP_PROTEASE_HIS; PS00381 CLP_PROTEASE_SER

Important sites: ACT_SITE 114-114 ACT_SITE 139-139

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNAGTPQHSSAWDPVGLGLIPMVVEQSGRGERSYDIYSRLLKERVVFLVGPVNDVTANLI
CCCCCCCCCCCCCCCCCCHHHHHHHCCCCCCCCHHHHHHHHHHCEEEEECCCHHHHHHHH
VAQLLFLESENPDKDIYFYINSPGGSVTAGLAIYDTMQFIKPNVSTLCIGQAASMGAFLL
HHHHHHHCCCCCCCEEEEEEECCCCCEEEHHHHHHHHHHHCCCCCEEEECCHHCCCEEEE
AAGEKGKRFCLPNSRVMIHQPLGGFQGQASDIEIHAREILYLRERLNGMLAKHTGQTIEQ
EECCCCCEEECCCCEEEEECCCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHCCHHHHH
IEKDTDRDNFMSATAAVEYGLVDKVLTSRADT
HHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MNAGTPQHSSAWDPVGLGLIPMVVEQSGRGERSYDIYSRLLKERVVFLVGPVNDVTANLI
CCCCCCCCCCCCCCCCCCHHHHHHHCCCCCCCCHHHHHHHHHHCEEEEECCCHHHHHHHH
VAQLLFLESENPDKDIYFYINSPGGSVTAGLAIYDTMQFIKPNVSTLCIGQAASMGAFLL
HHHHHHHCCCCCCCEEEEEEECCCCCEEEHHHHHHHHHHHCCCCCEEEECCHHCCCEEEE
AAGEKGKRFCLPNSRVMIHQPLGGFQGQASDIEIHAREILYLRERLNGMLAKHTGQTIEQ
EECCCCCEEECCCCEEEEECCCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHCCHHHHH
IEKDTDRDNFMSATAAVEYGLVDKVLTSRADT
HHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA