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The map label for this gene is norM [H]

Identifier: 119898357

GI number: 119898357

Start: 2265492

End: 2266883

Strand: Direct

Name: norM [H]

Synonym: azo2066

Alternate gene names: 119898357

Gene position: 2265492-2266883 (Clockwise)

Preceding gene: 119898356

Following gene: 119898364

Centisome position: 51.77

GC content: 66.31

Gene sequence:

>1392_bases
GTGATCGCTCCATCCGGGAGCCTGGCTGCAACGAGTACCGATTCGACGCTTCACATTGCCCGTCGCCTGCTTGGCCACGC
GTGGCCGGTGTTGATTGCCCAGTTGCTGTCGATGGGGATGATGGTGGCCGACACCATCATCGCGGGTCGTTACGCCACTT
CCGACCTGGCCGCGGTTGCGGTGGGTAACGGCATCTACGTATCGCTCGTGATGCTGCTGGTAGGCGTTCTCCAGGCCGTG
GCGCCTACGGTCGCCCATCACGTCGGCGCCGGCGCCACTGGCGAACTCGTACCATCGCTTCACCAGGGGTTCTGGCTGGC
GATACTGCTCGCCGTGCCGGGCACCGCGATCCTGCTCTCACCCGGGGCACTGCTCGATCTGGCCGCCGTTCCACCTCCGC
TGGCGGCGAAGGTTGGCGACTACCTGCGCGCAACGGCTGCCGGGCTGCCGGCGGTTCTGCTGTACAGAACGTTCTATGCG
TTCGCCAATGCACTCGGCCGACCCCGCGTGCTGATGTTCATCAGTCTTGCCACCACCTGCATTCACGCACCGCTCGCGTG
GGCGCTGGTAAGCGGTGCCTTTGGCGTTCCATTGGGCGGGACGGGGTGCGGAGTTTCCACGTCCGTTGTCGCGTGGATCG
CGTTGGGCTGCGGCGCAATTGCGCTCGCGCGGCTCAGGGTTTTTCGCAAACTGCGCGCTTTTCGCAGCTGGACGCCTCCC
GACCCGGTCCGACTGTGGGCGCTGCTGCGACTCGGCTTTCCGATCGGGCTGTCGACCTTTATCGAGATCACCTCGTTCAC
ACTGATCGCGCTGCTGATCGCACGCCTTGGGCCCGACTGGGTTGCCGCGCACAGGGTCGTTGCCAACCTCGCGGCGCTGG
CCTATATGCTGCCGCTCTCGCTCGCCACGTCGGCGCTGGTGCTTGTGGGGCAAGCGGCCGGTGGGCTCGACTGGACGAGA
GCCGCGCGCTACGCCAAGGTCGCGATCGTCTTGACGTGCGCACTTTCGACCCTCCTGGGTGGCGTCCTGTGGCTGGCACG
AACTCCCGTGCTTCAGCTCTGGAGTTCGGACAACGCGGTGCGTCTGGCCGCCCTCAGCCTGCTTCCCTACATCTGTCTAT
ACCAGGTTTTCGACGCAGCGCAGACCGTGGCCTCCCATACGCTGCGGGCCTACAAGGTCACCGCTTTGCCGATGGTGGTG
CACACCCTGGCGTTCTGGGGCGTCGGCCTGGGGCTCGGATACTGGCTGGCATTTCACGCCGGCGCCCGCTCGGCCGAGGC
GTCGGTTGCCGCGTTCTGGCAGGCGGCGGTGCTGGCAACCGCCCTGGCCGCACTACTTTTTCTGGGCTTGCTACGCTTCG
TGGCGGGGCGGTCACAACGCCCCGGCCGATAA

Upstream 100 bases:

>100_bases
GGCAGGGGGTGGGCTTCTGGCTGATCATGGCAGGCATCCTCGGTTTTCTTGCCTGGCGGTACTGGCGCGGCAAGCTGCCC
CTGCGTAGCCGGGCATAGCC

Downstream 100 bases:

>100_bases
ATGCCTCAGTCGAACAGTTCGGCAACCCGCTCGGGCGGACGCGCCACAACCGCTCTTTCACCGCGCACCACGATCGGCCG
CTCCATCAGGATGGGATAAG

Product: multidrug resistance protein

Products: Proton [Cytoplasm]; multidrug [Periplasm] [C]

Alternate protein names: Multidrug-efflux transporter [H]

Number of amino acids: Translated: 463; Mature: 463

Protein sequence:

>463_residues
MIAPSGSLAATSTDSTLHIARRLLGHAWPVLIAQLLSMGMMVADTIIAGRYATSDLAAVAVGNGIYVSLVMLLVGVLQAV
APTVAHHVGAGATGELVPSLHQGFWLAILLAVPGTAILLSPGALLDLAAVPPPLAAKVGDYLRATAAGLPAVLLYRTFYA
FANALGRPRVLMFISLATTCIHAPLAWALVSGAFGVPLGGTGCGVSTSVVAWIALGCGAIALARLRVFRKLRAFRSWTPP
DPVRLWALLRLGFPIGLSTFIEITSFTLIALLIARLGPDWVAAHRVVANLAALAYMLPLSLATSALVLVGQAAGGLDWTR
AARYAKVAIVLTCALSTLLGGVLWLARTPVLQLWSSDNAVRLAALSLLPYICLYQVFDAAQTVASHTLRAYKVTALPMVV
HTLAFWGVGLGLGYWLAFHAGARSAEASVAAFWQAAVLATALAALLFLGLLRFVAGRSQRPGR

Sequences:

>Translated_463_residues
MIAPSGSLAATSTDSTLHIARRLLGHAWPVLIAQLLSMGMMVADTIIAGRYATSDLAAVAVGNGIYVSLVMLLVGVLQAV
APTVAHHVGAGATGELVPSLHQGFWLAILLAVPGTAILLSPGALLDLAAVPPPLAAKVGDYLRATAAGLPAVLLYRTFYA
FANALGRPRVLMFISLATTCIHAPLAWALVSGAFGVPLGGTGCGVSTSVVAWIALGCGAIALARLRVFRKLRAFRSWTPP
DPVRLWALLRLGFPIGLSTFIEITSFTLIALLIARLGPDWVAAHRVVANLAALAYMLPLSLATSALVLVGQAAGGLDWTR
AARYAKVAIVLTCALSTLLGGVLWLARTPVLQLWSSDNAVRLAALSLLPYICLYQVFDAAQTVASHTLRAYKVTALPMVV
HTLAFWGVGLGLGYWLAFHAGARSAEASVAAFWQAAVLATALAALLFLGLLRFVAGRSQRPGR
>Mature_463_residues
MIAPSGSLAATSTDSTLHIARRLLGHAWPVLIAQLLSMGMMVADTIIAGRYATSDLAAVAVGNGIYVSLVMLLVGVLQAV
APTVAHHVGAGATGELVPSLHQGFWLAILLAVPGTAILLSPGALLDLAAVPPPLAAKVGDYLRATAAGLPAVLLYRTFYA
FANALGRPRVLMFISLATTCIHAPLAWALVSGAFGVPLGGTGCGVSTSVVAWIALGCGAIALARLRVFRKLRAFRSWTPP
DPVRLWALLRLGFPIGLSTFIEITSFTLIALLIARLGPDWVAAHRVVANLAALAYMLPLSLATSALVLVGQAAGGLDWTR
AARYAKVAIVLTCALSTLLGGVLWLARTPVLQLWSSDNAVRLAALSLLPYICLYQVFDAAQTVASHTLRAYKVTALPMVV
HTLAFWGVGLGLGYWLAFHAGARSAEASVAAFWQAAVLATALAALLFLGLLRFVAGRSQRPGR

Specific function: Multidrug efflux pump [H]

COG id: COG0534

COG function: function code V; Na+-driven multidrug efflux pump

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family [H]

Homologues:

Organism=Homo sapiens, GI153792564, Length=394, Percent_Identity=23.3502538071066, Blast_Score=73, Evalue=6e-13,
Organism=Escherichia coli, GI48994890, Length=437, Percent_Identity=30.8924485125858, Blast_Score=194, Evalue=7e-51,
Organism=Saccharomyces cerevisiae, GI6321821, Length=261, Percent_Identity=23.7547892720307, Blast_Score=65, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002528 [H]

Pfam domain/function: PF01554 MatE [H]

EC number: NA

Molecular weight: Translated: 48365; Mature: 48365

Theoretical pI: Translated: 10.71; Mature: 10.71

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIAPSGSLAATSTDSTLHIARRLLGHAWPVLIAQLLSMGMMVADTIIAGRYATSDLAAVA
CCCCCCCCEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
VGNGIYVSLVMLLVGVLQAVAPTVAHHVGAGATGELVPSLHQGFWLAILLAVPGTAILLS
CCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEC
PGALLDLAAVPPPLAAKVGDYLRATAAGLPAVLLYRTFYAFANALGRPRVLMFISLATTC
CCHHHHHHCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
IHAPLAWALVSGAFGVPLGGTGCGVSTSVVAWIALGCGAIALARLRVFRKLRAFRSWTPP
HHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
DPVRLWALLRLGFPIGLSTFIEITSFTLIALLIARLGPDWVAAHRVVANLAALAYMLPLS
CHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHH
LATSALVLVGQAAGGLDWTRAARYAKVAIVLTCALSTLLGGVLWLARTPVLQLWSSDNAV
HHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHCCCCHH
RLAALSLLPYICLYQVFDAAQTVASHTLRAYKVTALPMVVHTLAFWGVGLGLGYWLAFHA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GARSAEASVAAFWQAAVLATALAALLFLGLLRFVAGRSQRPGR
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MIAPSGSLAATSTDSTLHIARRLLGHAWPVLIAQLLSMGMMVADTIIAGRYATSDLAAVA
CCCCCCCCEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
VGNGIYVSLVMLLVGVLQAVAPTVAHHVGAGATGELVPSLHQGFWLAILLAVPGTAILLS
CCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEC
PGALLDLAAVPPPLAAKVGDYLRATAAGLPAVLLYRTFYAFANALGRPRVLMFISLATTC
CCHHHHHHCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
IHAPLAWALVSGAFGVPLGGTGCGVSTSVVAWIALGCGAIALARLRVFRKLRAFRSWTPP
HHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
DPVRLWALLRLGFPIGLSTFIEITSFTLIALLIARLGPDWVAAHRVVANLAALAYMLPLS
CHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHH
LATSALVLVGQAAGGLDWTRAARYAKVAIVLTCALSTLLGGVLWLARTPVLQLWSSDNAV
HHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHCCCCHH
RLAALSLLPYICLYQVFDAAQTVASHTLRAYKVTALPMVVHTLAFWGVGLGLGYWLAFHA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GARSAEASVAAFWQAAVLATALAALLFLGLLRFVAGRSQRPGR
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; multidrug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + multidrug [Cytoplasm] = Proton [Cytoplasm] + multidrug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA