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The map label for this gene is todE [H]

Identifier: 119898257

GI number: 119898257

Start: 2163648

End: 2164532

Strand: Reverse

Name: todE [H]

Synonym: azo1966

Alternate gene names: 119898257

Gene position: 2164532-2163648 (Counterclockwise)

Preceding gene: 119898258

Following gene: 119898256

Centisome position: 49.46

GC content: 67.57

Gene sequence:

>885_bases
ATGGCACAGGTAAAAAGACTGGCCTACATCCAGATCGAAACCGAAGACGTGGCGGCATGGACCGCCTTCGCGCGCAATGT
GCTGGCCTGTGAAGTGGTGGACGGCAGCAACGAGGCCGAGGCCTGCCTGCGGGTGGACGACCGCCCGTGGCGCATCCACC
TGACCCGCGGACCGCGCAACGACATCGTTGCGCTCGGGCTGGAAGCAGACACCCTCGCGGACGTGGAAGCCCTGCACCAG
GGGCTGGCCGCCGCCGGGCACGCGGTGGAGGTCGGTTCGGCCGAAGCCTGCAAGGCGCGCGGCGTGCAGGCACTGCGCCG
CTTTGCCGACCCCGCCGGGCTTACCGTCGAACTGTCCTGCGGATCACTCGTGCGTCCCCAGCAGCCCTTCCACGCGCCAG
TGGCGCACGGGGGCTTCGTCACCGGCGGCCAGGGCCTCGGCCATGTGATGCTGGTGGTGGAGAACGTGGCCGAGGTGCAC
GACTTCTACTGCCGCCTGCTCGGCTTCACCACCAGCGACTTCGTCTCCACCGCCGACTACGGCGGGCGCAAGGGCGACTT
CGTCTTCATGCGCTGCAACGAACGTCACCACAGCCTCGCAATCGGCTATCTTCCGATCGGCAGGCGGCTTGGCCACCTGA
TGCTGCAGGTGCGCGAATTCGACGATGTCGGCCGCGCCCTCGACCGCGTGCATCGCCACGGGGCCAGGCAGACGCGGGCG
CTGGGCCGCCATATCAACGACCAGATGTTCTCGTTCTACGTGCAAAGCCCGTCGGACGCGCAGATCGAATACGGCTGGGG
CGGCCTGGAAGTGGATGAAGGCAGTCACGAGGTGCGGACCTACGACGTCACCAGCGCGTGGGGCCACCAGCACCTGAACA
CCTGA

Upstream 100 bases:

>100_bases
GCGCATCGAAGAAGGCACCAGCGAGGCGCGCACCGCGATCCTCGCCTGGCGACGCGCGGCCGGCGGCCGCGCCTGACGAC
AAGAGGGAGAGGCGACGAAG

Downstream 100 bases:

>100_bases
TGCAGCACCGGGCCGTTCGCGGCCCCGCCGGCCCGGGGCCGGCTTGCAGATCGCGCCTCCGGCATCGCCAGACCCGCAAC
GAGCGGGCAGGGGGCGCGCC

Product: 3-methylcatechol 2,3-dioxygenase

Products: 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate; H2O

Alternate protein names: NA

Number of amino acids: Translated: 294; Mature: 293

Protein sequence:

>294_residues
MAQVKRLAYIQIETEDVAAWTAFARNVLACEVVDGSNEAEACLRVDDRPWRIHLTRGPRNDIVALGLEADTLADVEALHQ
GLAAAGHAVEVGSAEACKARGVQALRRFADPAGLTVELSCGSLVRPQQPFHAPVAHGGFVTGGQGLGHVMLVVENVAEVH
DFYCRLLGFTTSDFVSTADYGGRKGDFVFMRCNERHHSLAIGYLPIGRRLGHLMLQVREFDDVGRALDRVHRHGARQTRA
LGRHINDQMFSFYVQSPSDAQIEYGWGGLEVDEGSHEVRTYDVTSAWGHQHLNT

Sequences:

>Translated_294_residues
MAQVKRLAYIQIETEDVAAWTAFARNVLACEVVDGSNEAEACLRVDDRPWRIHLTRGPRNDIVALGLEADTLADVEALHQ
GLAAAGHAVEVGSAEACKARGVQALRRFADPAGLTVELSCGSLVRPQQPFHAPVAHGGFVTGGQGLGHVMLVVENVAEVH
DFYCRLLGFTTSDFVSTADYGGRKGDFVFMRCNERHHSLAIGYLPIGRRLGHLMLQVREFDDVGRALDRVHRHGARQTRA
LGRHINDQMFSFYVQSPSDAQIEYGWGGLEVDEGSHEVRTYDVTSAWGHQHLNT
>Mature_293_residues
AQVKRLAYIQIETEDVAAWTAFARNVLACEVVDGSNEAEACLRVDDRPWRIHLTRGPRNDIVALGLEADTLADVEALHQG
LAAAGHAVEVGSAEACKARGVQALRRFADPAGLTVELSCGSLVRPQQPFHAPVAHGGFVTGGQGLGHVMLVVENVAEVHD
FYCRLLGFTTSDFVSTADYGGRKGDFVFMRCNERHHSLAIGYLPIGRRLGHLMLQVREFDDVGRALDRVHRHGARQTRAL
GRHINDQMFSFYVQSPSDAQIEYGWGGLEVDEGSHEVRTYDVTSAWGHQHLNT

Specific function: Unknown

COG id: COG0346

COG function: function code E; Lactoylglutathione lyase and related lyases

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the extradiol ring-cleavage dioxygenase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017626
- InterPro:   IPR004360
- InterPro:   IPR000486 [H]

Pfam domain/function: PF00903 Glyoxalase [H]

EC number: 1.13.11.39

Molecular weight: Translated: 32321; Mature: 32190

Theoretical pI: Translated: 6.40; Mature: 6.40

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAQVKRLAYIQIETEDVAAWTAFARNVLACEVVDGSNEAEACLRVDDRPWRIHLTRGPRN
CCCCCEEEEEEEECHHHHHHHHHHCCEEEEEEECCCCCCCCEEEECCCCEEEEEECCCCC
DIVALGLEADTLADVEALHQGLAAAGHAVEVGSAEACKARGVQALRRFADPAGLTVELSC
CEEEEECCCHHHHHHHHHHHHHHHCCCEEECCCCHHHHHHHHHHHHHHCCCCCCEEEECC
GSLVRPQQPFHAPVAHGGFVTGGQGLGHVMLVVENVAEVHDFYCRLLGFTTSDFVSTADY
CCCCCCCCCCCCCCCCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCC
GGRKGDFVFMRCNERHHSLAIGYLPIGRRLGHLMLQVREFDDVGRALDRVHRHGARQTRA
CCCCCCEEEEEECCCCCEEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHH
LGRHINDQMFSFYVQSPSDAQIEYGWGGLEVDEGSHEVRTYDVTSAWGHQHLNT
HHHHHCCCCEEEEEECCCCCEEEECCCCEEECCCCCCEEEEEECCCCCCCCCCC
>Mature Secondary Structure 
AQVKRLAYIQIETEDVAAWTAFARNVLACEVVDGSNEAEACLRVDDRPWRIHLTRGPRN
CCCCEEEEEEEECHHHHHHHHHHCCEEEEEEECCCCCCCCEEEECCCCEEEEEECCCCC
DIVALGLEADTLADVEALHQGLAAAGHAVEVGSAEACKARGVQALRRFADPAGLTVELSC
CEEEEECCCHHHHHHHHHHHHHHHCCCEEECCCCHHHHHHHHHHHHHHCCCCCCEEEECC
GSLVRPQQPFHAPVAHGGFVTGGQGLGHVMLVVENVAEVHDFYCRLLGFTTSDFVSTADY
CCCCCCCCCCCCCCCCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCC
GGRKGDFVFMRCNERHHSLAIGYLPIGRRLGHLMLQVREFDDVGRALDRVHRHGARQTRA
CCCCCCEEEEEECCCCCEEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHH
LGRHINDQMFSFYVQSPSDAQIEYGWGGLEVDEGSHEVRTYDVTSAWGHQHLNT
HHHHHCCCCEEEEEECCCCCEEEECCCCEEECCCCCCEEEEEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: biphenyl-2,3-diol; O2

Specific reaction: biphenyl-2,3-diol + O2 = 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate + H2O

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2670929 [H]